• Journal of Technology Innovation
• /
• 제14권2호
• /
• pp.93-116
• /
• 2006

The purpose of this study is to contribute reference material that provides insight into innovative process management that increases R&D output in commercializing new products. A model of a process from research to commercialization with the cumulative profit and loss curve is put forward and hypotheses related to success and failure are developed at the stages up to product launch. Seventeen large projects that have resulted in successful product launches have been examined from the initial research stage to commercialization. Prefect duration, standardized cumulative R&D expenditures and research resource concentration are analyzed in terms of statistical method and patterns in cumulative profit and loss curves after product sales, as well as the reasons for and other aspects of success/failure are investigated and analyzed. Consequently, valuable information on future management tasks has been obtained such as: (1) project duration differs depending on market sectors, product types and presence/absence of materials research (2) cumulative profit and loss curves can be categorized into four patterns (3) reasons for failure can be divided into technological and market problem categories and (4) these factors have an impact on product sales.

• Fire Science and Engineering
• /
• 제4권2호
• /
• pp.15-26
• /
• 1990

Building become higher. larger and more complex than ever before, showing abrupt changes in building structures. forms and mechanical systems. Likewise hazads of fire and the scale of fire losses become more and more greater. Therefore. considerations for fire safety take up great portion of the building design process. In this study, problems of high-rise building fires and basic directions for fire safety of high-rise building design were studied through the statistical analysis of 138 fire cases. The results of this study are summarized as follows : ·Most of the fires in high-rise building occur on the low floors and the fire frequencies are very low on the upper floors. Fire casualties are liable to be more on the upper floors than on tile floor of fire origin. ·The important causes of evacuation failures were analyzed as being late in escape and lack of stairwell enclosures. ·The main cause of vertical fire spread is lack of stairwell enclosures. However, the fire spreads mainly through the enterior windows in apartment houses. The combustible materials in buildings act on as the major factors of horizontal fire spread and the improper fire doors play role of another the critical causes. ·The basic directions for fire safety of high-rise building design put much stress firstly on the compartmentation of the buildings effectively performing the provision of safe escape routes and the safe refuse places in buildings.

• The Journal of the Korean bone and joint tumor society
• /
• 제3권1호
• /
• pp.9-17
• /
• 1997

Resistance to combination chemotherapy remains challenge in the treatment of osteosarcoma. One of the mechanisms of multiple drug resistance is an increased expression of the multidrug resistance gene(mdr1). Expression of the P-glycoprotein(mdr-1 gene product) was studied immunohistochemically and the mdr-1 gene by in situ hybridization in 33 osteosarcomas relating to various prognostic factors. Thirty cases out of 33 osteosarcomas(90.9%) showed positive cytoplasmic reactions with P-glycoprotein and nineteen instances(57.6%) were strong positive(2+). The older(>20 years) and female patients revealed more intense immunohistochemical reactions rather than those of the younger and male patients. Osteoblastic and chondroblastic osteosarcomas revealed more strong immunohistochemical reactions compared to fibroblastic types. There were no significant staining differences between the type of bony involvement, Broder's grade and the presence of necrosis. On follow-up, the mean survival rate was decreased in the strong positive group, however, this was not statistically significant. In situ hybridization for mdr-1 gene revealed positive signals in 22 cases out of 29 osteosarcomas(75.9%). Chemotherapy was done in 15 cases out of 28 patients(53.6%). The results of immunohistochemistry and in situ hybridization were not correlated with the protocols for chemotherapy. However, this result should be confirmed by a larger scale study about mdr1 mRNA expression.

• Journal of the Korean Society of Costume
• /
• 제22권
• /
• pp.333-344
• /
• 1994

In this study an experiment was made using the function of computer simulation os to whether the phenomenon of optical illusion takes place also in clothing on the human body three-dimensional space through the case study of the Gestalt illusion of planar con-traction and expension by amodal completion in perceptual organization. One woman of latter 30s was selected as the experimental subject. She was made to wear the experimental clothing and then the frontal picture was projected of in the experimental clothing which was scanned into the com-puter. For the sake of the contractive experiment 5 stages were divided by 5-15cm the thick-nes of the black vertical line in the center of the upper garmet as the variable and for the sake of the expansive experiment the skirt length was set as the variable. It length measured 50-90cm which was divided by 10cm into 5 stages and simulated using the CAD. The basic design and the experimental de-sign were made one pair and the pictures totalled 20 pictures such as ten pictures save the human body for the estimation of the up-per garmet alone and ten pictures for the ob-servation of the effect on the human body. The extimating panel consisting of 20 panellers estimated contraction/expansion in the estimation of the upper garmet and the tall effect/the slim effect in the estimation of optical illusion as the estimating factors on the 9-point scale. All the date from experiment were analyzed by ANOVA(analysis of variance) and DUNCAN'S multiple range. As a result the experimental designs all showed a significant optical illusion in comparision with the basic design.

• Proceedings of the Korea Society for Industrial Systems Conference
• /
• 한국산업정보학회 2008년도 추계 공동 국제학술대회
• /
• pp.96-103
• /
• 2008

The information systems audit is an proactive action to find out the predicted issues on proceeding the business beforehand, to make out whether the information systems satisfies the user's demand or not and to check up the result of the project with complementing the capabilities of self-diagnostics for the complicated and advanced information system. However, the results of the audited project are apt to be regarded as a failure in a case that an opinion of the audit area evaluation is described as 'insufficient' or 'negative' in the audit report that is submitted as the result of the audit. It makes a lot of arguments among the board of audit, the institution ordering the audit and the auditor. In this study, we made an attempt to finding out the factors affecting the audit area evaluation and verifying them objectively. A study model and hypothesis including the improvement type of the recommended subject to be improved, the importance, the audit time, the business scale of the audited object and the auditing company as a factor variable were established and the hypothesis was verified by analyzing the correlation between the factor variables and the audit area evaluation.

• Research in Community and Public Health Nursing
• /
• 제18권4호
• /
• pp.513-522
• /
• 2007

Purpose: The purpose of this study was to gain knowledge of successful aging for the Korean elderly and to identify the effects of an intervention program on the change of the knowledge Method: Data were collected from 134 elders from 3 schools for the elderly in H City. The Successful Aging Scale was used to collect data and modified CDSMP was applied as the intervention. Descriptive statistics, t-test, ANOVA and ANCOVA were used. Results : The total score of the knowledge of successful aging among the elderly cohort was 2.44 out of 3, and the scores of the factors making up old age were 2.66 for the success of children, 2.63 for self-control, 2.56 for self-efficacy, and 2.05 for happy marriage. Life satisfaction from the success of children and self-control were strongly correlated(r=0.7036, p=0.000). Conclusion: The self-management program brought positive changes to the knowledge of successful aging through the self-control parameter, and although it could not change the degree of knowledge of the overall successful aging among the elderly cohort, the program represents the first Korean nursing intervention focused on self-management techniques needed for successful aging.

• Genomics & Informatics
• /
• 제11권4호
• /
• pp.230-238
• /
• 2013

Many other human species appeared in evolution in the last 6 million years that have not been able to survive to modern times and are broadly known as archaic humans, as opposed to the extant modern humans. It has always been considered fascinating to compare the modern human genome with that of archaic humans to identify modern human-specific sequence variants and figure out those that made modern humans different from their predecessors or cousin species. Neanderthals are the latest humans to become extinct, and many factors made them the best representatives of archaic humans. Even though a number of comparisons have been made sporadically between Neanderthals and modern humans, mostly following a candidate gene approach, the major breakthrough took place with the sequencing of the Neanderthal genome. The initial genome-wide comparison, based on the first draft of the Neanderthal genome, has generated some interesting inferences regarding variations in functional elements that are not shared by the two species and the debated admixture question. However, there are certain other genetic elements that were not included or included at a smaller scale in those studies, and they should be compared comprehensively to better understand the molecular make-up of modern humans and their phenotypic characteristics. Besides briefly discussing the important outcomes of the comparative analyses made so far between modern humans and Neanderthals, we propose that future comparative studies may include retrotransposons, pseudogenes, and conserved non-coding regions, all of which might have played significant roles during the evolution of modern humans.

• Nuclear Engineering and Technology
• /
• 제52권1호
• /
• pp.109-114
• /
• 2020

This work presents the results of laboratory scale tests of the CARBOFLUOREX (CARBOnate FLUORide EXtraction) process - a novel technology for the recovery of U and Pu from the solid fluorides residue (fluorination ash) of Fluoride Volatility Method (FVM) reprocessing of spent nuclear fuel (SNF). To study the oxidative leaching of U from the fluorination ash (FA) by Na₂CO₃ or Na₂CO₃-H₂O₂ solutions followed by solvent extraction by methyltrioctylammonium carbonate in toluene and purification of U from the fission products (FPs) impurities we used a surrogate of FA consisting of UF₄ or UO₂F₂, and FPs fluorides with stable isotopes of Ce, Zr, Sr, Ba, Cs, Fe, Cr, Ni, La, Nd, Pr, Sm. Purification factors of U from impurities at the solvent extraction refining stage reached the values of 10⁴-10⁵, and up to 10⁶ upon the completion of the processing cycle. Obtained results showed a high efficiency of the CARBOFLUOREX process for recovery and separating of U from FPs contained in FA, which allows completing of the FVM cycle with recovery of U and Pu from hardly processed FA.

• The Journal of Internal Korean Medicine
• /
• 제37권4호
• /
• pp.645-652
• /
• 2016

Objectives: To compare the effects of Eastern-Western integrative medical care (EWIM) and Western single rehabilitation therapy (WSRT) on the functional recovery of stroke patients.Methods: Seventy-six stroke patients were recruited retrospectively. The participants were divided into two groups: EWIM and WSRT. Data on age, sex, stroke-related risk factors, stroke type, neurological deficits according to the National Institutes of Health Stroke Scale (NIHSS), elapsed time to the initiation of rehabilitation, duration from the onset to follow up, initial functional status, and function after therapy for 3 mon were obtained from a review of the patients’ medical records. Between-group differences in functional outcomes were analyzed before and after treatment using the functional ambulation category (FAC), Fugl-Meyer assessment (FMA), modified Barthel Index-Korean version (K-MBI), and Euro-Quality of Life-5 Dimension (EQ-5D).Results: At 3-mon poststroke, all the functional outcome measures had improved in both groups (P<0.05). However, the improvements were greater in the EWIM group, and the improvement was statistically significant in the K-MBI (P=0.048) and EQ-5D (P=0.042).Conclusions: With respect to activities of daily living and health-related quality of life, EWIM is a more effective stroke therapy than WSRT.

• Journal of Preventive Medicine and Public Health
• /
• 제42권6호
• /
• pp.356-359
• /
• 2009

In the more than 100 genome wide association studies (GWAS) conducted in the past 5 years, more than 250 genetic loci contributing to more than 40 common diseases and traits have been identified. Whilst many genes have been linked to a trait, both their individual and combined effects are small and unable to explain earlier estimates of heritability. Given the rapid changes in disease incidence that cannot be accounted for by changes in diagnostic practises, there is need to have well characterized exposure information in addition to genomic data for the study of gene-environment interactions. The case-control and cohort study designs are most suited for studying associations between risk factors and occurrence of an outcome. However, the case control study design is subject to several biases and hence the preferred choice of the prospective cohort study design in investigating geneenvironment interactions. A major limitation of utilising the prospective cohort study design is the long duration of follow-up of participants to accumulate adequate outcome data. The GWAS paradigm is a timely reminder for traditional epidemiologists who often perform one- or few-at-a-time hypothesis-testing studies with the main hallmarks of GWAS being the agnostic approach and the massive dataset derived through large-scale international collaborations.