• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3269-3273
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• 2012

In this study, we report a new method for the high contrast imaging of biomolecular interactions at roller printed protein surfaces using thermotropic liquid crystals (LCs). Avidin was roller printed and covalently immobilized onto the obliquely deposited gold surface that was decorated with carboxylic acid-terminated self-assembled monolayers (SAMs). The optical response of LCs on the roller printed film of avidin contrasted sharply with that on the obliquely deposited gold surface. The binding of biotin-peroxidase to the roller printed avidin was then investigated on the obliquely deposited gold substrate. LCs exhibited a non-uniform and random orientation on the roller printed area decorated with the complex of avidin and biotin-peroxidase, while LCs displayed a uniform and planar orientation on the area without roller printed proteins. The orientational transition of LCs from uniform to non-uniform state was triggered by the erasion of nanometer-scale topographies on the roller printed surface after the binding of biotin-peroxidase to the surface-immobilized avidin. The specific binding events of protein-receptor interactions were also confirmed by atomic force microscopy and ellipsometry. These results demonstrate that the roller printing of proteins on obliquely deposited gold substrates could provide a high contrast signal for imaging biomolecular interactions using LC-based sensors.

• 부모자녀건강학회지
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• 제18권2호
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• pp.88-99
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• 2015

Purpose: This study was conducted to examine mother-child interactions and the quality of life of preschool children with epilepsy as perceived by mothers, and to investigate the relation between mother-child interactions and the quality of life of preschool children with epilepsy. Methods: Participants for this study consist of 92 mothers of children with epilepsy aged three to six years who were treated at university hospitals and a city hospital located in Seoul, Korea. The instruments used for this study were mother-child interactions of preschool children scale and the Korean version of the TAPQOL (TNO-AZL Preschool children Quality of Life). Results: The level of mother-child interactions for preschool children with epilepsy showed a mean score 125.91. The category of dyadic domain was rated the highest while the child domain category was rated the lowest. The level of mother-child interactions for preschool children with epilepsy showed a significant difference according to the mother-child relationship, birth history, seizure frequency, number of antiepileptic drugs and combined disabilities. The quality of life of children with epilepsy showed a significant difference according to the mother-child relationship, birth history, seizure frequency, number of antiepileptic drugs and combined disabilities. There is a statistically significant positive correlation between mother-child interactions and quality of life of preschool children with epilepsy. Conclusion: This study suggests that the mother-child interaction of preschool children with epilepsy showed a tendency to be led by mothers. In order to stimulate mother-child interactions, mothers should help their children enhance their reaction and participation.

• International Journal of Human Ecology
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• 제11권1호
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• pp.85-96
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• 2010

This study examined how the quality of teacher-child interactions and the teachers' beliefs about their influence on children's social behaviors were related to children's social behaviors. The subjects were 206 children at the age of five and 52 of their teachers in 49 daycare centers. Children's social behaviors were recorded using observational categories. The quality of teacher-child interactions was measured by a rating scale that originated from the OSDCP (Rhee et al., 2003). The results were as follows: 1) Children who experienced high-quality interactions with their teachers showed fewer purposeless solitary behaviors and negative behaviors toward their peers and interacted toward their teachers more frequently than did those who experienced low-quality interactions with their teachers. 2) Children whose teachers believed that they had a great deal of influence on children's social behaviors displayed fewer purposeless solitary behaviors and more positive behaviors toward peers than did children whose teachers considered their influence less important. 3) After controlling the contributions of children's gender and teacher's training experience, the quality of teacher-child interactions and teachers' beliefs explained about 14% of the total variance of children's purposeless solitary behaviors. In addition, the quality of teacher-child interactions and teachers' beliefs accounted for 6% of the total variance of children's positive behaviors toward peers. Also, the amount of explanation of the predictive variables accounts for 9% of the total variance of children's behaviors toward their teachers.

• 한국보육학회지
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• 제18권2호
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• pp.1-15
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• 2018

본 연구는 교사의 전문성 인식, 교수 의도 행동, 교사-영유아 상호작용이 교사의 학력과 경력에 따라 차이가 있는지 알아보고, 각 변인 간의 관계를 살펴보고자 하였다. 연구 대상은 서울 및 경기 지역에 소재한 국공립, 민간, 직장 어린이집 22곳에 재직 중인 만 2세~만 5세 교사 50명이었다. 교사-영유아 상호작용을 측정하기 위해 최소영과 신혜영(2015)이 번안한 Arnett(1989)의 교사 상호작용 척도(Caregiver Interaction Scale: CIS)를 수정하여 사용하였고, 교사의 전문성 인식을 측정하기 위해 Wang(2005)이 개발하고 정아람(2016)이 번안, 수정한 평정척도(Current Status and Self-Desire for Professional Competence)를 사용하였다. 교수 의도 행동은 Wilcox-Herzog와 Ward(2004)의 교수 의도 행동 척도를(Teaching Intention Scale: TIS) 본 연구자가 번안, 수정하여 사용하였다. 교사-영유아 상호작용은 연구자와 연구 보조자가 직접 기관을 방문하여 교사 관찰을 실시하였고, 교사의 전문성 인식과 교수 의도 행동은 교사용 설문지를 통해 측정하였다. 자료 분석을 위해 t-검증과 Pearson의 적률상관분석을 실시하였다. 연구 결과 첫째, 교사-영유아 상호작용은 교사의 학력과 경력에 따라 유의한 차이가 나타나지 않았다. 둘째, 교사의 경력이 많을수록 전문성을 높게 인식하고 있었다. 셋째, 교수 의도 행동은 교사의 학력과 경력에 따라 유의한 차이가 나타나지 않았다. 넷째, 전문성 인식 수준이 높은 교사가 긍정적인 교사-영유아 상호작용을 더 많이 하였다. 특히 교수 능력, 운영관리 능력의 전문성 인식 수준이 높은 교사가 좀 더 긍정적인 교사-영유아 상호작용을 하였다. 다섯째, 교사의 교수 의도 행동 수준이 높을수록 교사-영유아의 민감한 상호작용 수준이 높았다. 결론적으로 교사-영유아 상호작용은 교사의 전문성 인식과 관계가 있었고, 교사의 교수 의도 행동은 교사-영유아의 민감한 상호작용과 관계가 있었다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 춘계학술대회 논문집
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• pp.1637-1646
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• 2008

Deformations of bridge deck ends on abutment can cause extreme deformations on track. Especially, since slab track was fixed onto the bridge deck slab on concrete slab track installed bridges, deformations of bridge deck ends directly affect the slab track behavior, and thus these interactions can bring about the premature failure of rail fastenings or other deteriorations to lower the serviceability. In this study, a foreign standard to evaluate forces on track components caused by the track-bridge interactions and the behavior of bridge deck ends was investigated and for real scale bridges. It was found that rail support spring coefficients, as well as toe loads, support spacing were very important parameters.

• Interaction and multiscale mechanics
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• 제5권1호
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• pp.27-40
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• 2012

The two-dimensional incompressible flow of a linear viscoelastic fluid we considered in this research has rapidly oscillating initial conditions which contain both the large scale and small scale information. In order to grasp this double-scale phenomenon of the complex flow, a multiscale analysis method is developed based on the mathematical homogenization theory. For the incompressible flow of a linear viscoelastic Maxwell fluid, a well-posed multiscale system, including averaged equations and cell problems, is derived by employing the appropriate multiple scale asymptotic expansions to approximate the velocity, pressure and stress fields. And then, this multiscale system is solved numerically using the pseudospectral algorithm based on a time-splitting semi-implicit influence matrix method. The comparisons between the multiscale solutions and the direct numerical simulations demonstrate that the multiscale model not only captures large scale features accurately, but also reflects kinetic interactions between the large and small scale of the incompressible flow of a linear viscoelastic fluid.

• Journal of Preventive Medicine and Public Health
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• 제42권6호
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• pp.356-359
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• 2009

In the more than 100 genome wide association studies (GWAS) conducted in the past 5 years, more than 250 genetic loci contributing to more than 40 common diseases and traits have been identified. Whilst many genes have been linked to a trait, both their individual and combined effects are small and unable to explain earlier estimates of heritability. Given the rapid changes in disease incidence that cannot be accounted for by changes in diagnostic practises, there is need to have well characterized exposure information in addition to genomic data for the study of gene-environment interactions. The case-control and cohort study designs are most suited for studying associations between risk factors and occurrence of an outcome. However, the case control study design is subject to several biases and hence the preferred choice of the prospective cohort study design in investigating geneenvironment interactions. A major limitation of utilising the prospective cohort study design is the long duration of follow-up of participants to accumulate adequate outcome data. The GWAS paradigm is a timely reminder for traditional epidemiologists who often perform one- or few-at-a-time hypothesis-testing studies with the main hallmarks of GWAS being the agnostic approach and the massive dataset derived through large-scale international collaborations.

• Genomics & Informatics
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• 제20권2호
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• pp.16.1-16.12
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• 2022

Various methodologies for the genetic analysis of longitudinal data have been proposed and applied to data from large-scale genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with traits of interest and to detect SNP-time interactions. We recently proposed a grid-based Bayesian mixed model for longitudinal genetic data and showed that our Bayesian method increased the statistical power compared to the corresponding univariate method and well detected SNP-time interactions. In this paper, we further analyze longitudinal obesity-related traits such as body mass index, hip circumference, waist circumference, and waist-hip ratio from Korea Association Resource data to evaluate the proposed Bayesian method. We first conducted GWAS analyses of cross-sectional traits and combined the results of GWAS analyses through a meta-analysis based on a trajectory model and a random-effects model. We then applied our Bayesian method to a subset of SNPs selected by meta-analysis to further discover SNPs associated with traits of interest and SNP-time interactions. The proposed Bayesian method identified several novel SNPs associated with longitudinal obesity-related traits, and almost 25% of the identified SNPs had significant p-values for SNP-time interactions.

• 디지털융복합연구
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• 제9권6호
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• pp.343-354
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• 2011

인문학 수업에서 교수와 학생간에 상호작용은 매우 중요하다. 그러나 많은 학생들이 수강하는 대규모 집합 교육의 경우, 수많은 학생들과 교수가 의견을 교환하기는 어렵다. 본 논문에서는 안드로이드 폰의 앱(app)을 개발하여, 대규모 집합 교육에서 발생할 수 있는 상호작용의 제한성을 극복하고자한다. 본 논문에서 개발한 앱은 스마트폰의 정보처리 기능과 무선 통신 기능을 활용하였다. 대규모 집합 교육의 보조 기구로 사용하여 대규모 집합 교육의 교육 효과를 높이는데 목적이 있다.

• 대한간호학회지
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• 제21권2호
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• pp.150-167
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• 1991

The intent of this longitudinal descriptive correlational study is to investigate the change of the mother - infant interactions over the periods of one month, three months and six months of the infant's age. This study is also intended to explore the interrelationships among three major factors- the perception of pregnancy, the mother -infant inter-action and the maternal attitude. The samples participated are 36 pairs of mother and infant from two university hospitals in Seoul. A data collection was made, from October in 1988 to September in 1989, for each subject at five periods of time ; prenatal period (after 36 weeks in pregnancy), postpartum two or three days, one month, three months and six months of infant's age. The research tools used in this investigation are Mother - Infant Play Interaction Scale (MIPIS), Prenatal Self- Evaluation Questionnaire and Cohler's Maternal Attitude Scale. Some of the findings are as follows ; 1. There is a significant increase in the mother - infant interaction from one month to three months and six months of infant's age. The highest score of the mother - infant interaction during three periods is at the time of three months. 2. The primipara's mother -infant interaction is not affected by the demographic characteristics, such as age, education and vocation of mother, types of delivery, or sex of infant. 3. Among seven categories of the perception of pregnancy, the most positively perceived categories by primiparas are acceptance of pregnancy and identification of. a motherhood role : whereas the negative ones are preparation for labor, concern for well -being of self and baby, md fear of pain, helplessness and loss of control in order of negativity. 4. There is no significant relationship between the perception of pregnancy and the mother - infant interactions. 5. There is no significant change in the maternal attitude over the period of one month, three months, and six months of infant's age. 6. There is no significant relationship between the maternal attitude and the mother - infant interactions. 7, The significant relationships are (end between the perception of pregnancy and maternal attitude, especially in the categories of concern for well -being of self and baby, accetance of pregnancy, identification of a motherhood role, fear of pain, helplessness and loss of control, and relationship with husband. In conclusion, it is confirmed that primipara's mother-infant interactions change over time period, and that perception of pregnancy and the maternal attitude do not affect the mother-infant interactions despite a significat relationship between those two variables. The implications of this investigation include a suggestion that nurses need to teach and demonstrate to mothers how to care for and interact with their infants, with a view to improving the mother-infant interactions which can be obtained through the improvement of maternal sensitivity to their infants.