• Title/Summary/Keyword: sapogenin

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A Saponin Complex, KPRG-C, and Its Sapogenin Complex, KPRG-D, Reduce Nociception and Inflammation in Animals

  • Nam, Jung-Hwan;Jung, Hyun-Ju;Choi, Jong-Won;Park, Hee-Juhn
    • Korean Journal of Plant Resources
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    • v.20 no.3
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    • pp.226-233
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    • 2007
  • To develop a clinically available saponin- or sapogenin complex from Oriental medicines, the EtOH extract (KPRG-A) was obtained by extracting from the four crude drugs, Kalopanacis Cortex, Platycodi Radix, Rubi Fructus and Glycyrrhizae Radis. The BuOH fraction (KPRG-B), a crude saponin complex, was prepared by fractionating KPRG-A, which were further completely hydrolyzed to afford the sapogenin complex (KPRG-D). In an attempt to find the antinoicpetive effects of the saponin complex and sapogenin complex, KPRG-C, and -D, were assayed by writhing-, hot plate-, and tail-flick tests using mice or rats. The three samples were also subjected to antiiflammatory tests using serotonin-induced and carrageenan-induced hind paw edema mice and rats, respectively. The three samples significantly reduced inflammations and pains of the experimental animal. The potency were found in the order of KPRG-D> KPRG-C> KPRG-B. The most active sample, KPRG-D, caused no death, no body increase or no anatomical pathlogic change even at 2,000 mg/kg dose. These results suggest that a sapogenin complex, KPRG-D, which was found to contain mainly hederagenin, platycodigenin, polygalacic acid, 23-hydroxytormentic acid, glycyrrhetic acid together with minor triterpene acids, could be a potential candidate for antiinflammatory therapeutics.

식물체내 sapogenin의 계절적변화

  • 백근제
    • YAKHAK HOEJI
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    • v.1 no.1
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    • pp.19-22
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    • 1948
  • Yucca schotti, Samuela carnerosana, Agave strita 각부분에 있어 결실전후의 steroidal sapogenin 분포상태를 연구하여 결실후에는 monohydroxy steroid는 존재치 않고 단지복합 polyhydroxy steroid만이 존재함을 증명하였다.

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Neochlorogenin from the Fruits of Solanum nigrum

  • Son, Kun-Ho;Do, Jea-Chul;Jung, Keun-Young;Kim, Chang-Min
    • Korean Journal of Pharmacognosy
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    • v.22 no.2
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    • pp.142-143
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    • 1991
  • A steroidal sapogenin, neochlorogenin, was isolated from Solanum nigrum. This is the first report from this plant.

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Isolation of a new sapogenin from alibizzia julibrissin

  • You, Yong-Hyo;Woo, Won-Sick;Park, Jae-Sue;Kang, Sam-Sik
    • Archives of Pharmacal Research
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    • v.5 no.2
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    • pp.33-38
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    • 1982
  • From the hydrosate of the strong uterotonic active saponin of Albizzia julibrissin a new sapogenin, mechaerinic acid mmethylester together with acacic acid lactone was isolated and characterized.

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Identification of Ginseng Sapogenin and Quantitative Determination of $Ginsenoside-Rb_1$ from Crude Drug Preparation Containing Bupleuri Radix (시호(柴胡)함유 생약제제(生藥製劑)중 인삼(人蔘) Sapogenin의 확인 및 $Ginsenoside-Rb_1$의 분리 정량)

  • Choi, Kang-Ju;Ko, Sung-Ryong;Jeon, Byeong-Seon;Sung, Hyun-Soon
    • Korean Journal of Pharmacognosy
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    • v.20 no.3
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    • pp.175-179
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    • 1989
  • From crude drug preparation(Soshiho-Tang) ginseng sapogenins were identified by TLC and $ginsenoside-Rb_1$ was determined quantitatively by HPLC. Panaxadiol, pandaxatriol, acid-hydrolysates of ginseng saponin, were identified by TLC with benzene/acetone(4 : 1, v/v). Rf values of which were measured as 0.26 and 0.14, respectively. The content of $ginsenoside-Rb_1$ was determined by HPLC on $Lichrosorb-NH_2$ column with $CH_3CN/H_2O/n-BuOH$(80 : 20 : 10, v/v). Its recovery rate in the extract granules, was as relatively low as $19.8{\pm}1.4%$ compared to the content in raw red ginseng.

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Anti-Inflammatory Action of the Fractions of Platycodi radix (길경(Platycodi radix) 분획물의 항염증 활성)

  • Kim, Sung-Yeun;Lee, Eun-Bang;Jeong, Eun-Ja
    • The Korean Journal of Food And Nutrition
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    • v.22 no.4
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    • pp.618-624
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    • 2009
  • The extract of Platycodi radix has long been used as an anti-inflammatory traditional medicine in Korea for the treatment of bronchitis, asthma and acute respiratory disease. In this study, the anti-inflammatory actions of the methanol extract of Platycodi radix administered via oral administration were evaluated. The results revealed that the extracts exhibited potent anti-inflammatory action. Of the hexane, chloroform, ethyl acetate, butanol and water fractions, the butanol fraction had the most potent anti-inflammatory action. Additioinally the sapogenin obtained through acid hydrolysis of the butanol fraction did not show anti-inflammatory action. These findings confirm the value of Platycodi radix as a traditional Korean medicine.

Study on 'Chu-Suk'(VI) -Prosapogenin in Pods of Gleditschia officinalis- (추석(秋石)에 관(關)한 연구(硏究)(VI) -조협 꼬투리의 Prosapogenin에 관하여-)

  • Lee, Eun-Ock;Yu, Chae-Seun
    • Korean Journal of Pharmacognosy
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    • v.9 no.2
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    • pp.93-97
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    • 1978
  • From the crude saponin obtained from the pods of Gleditschia officinalis seven spots were identified by TLC and quantity of gleditschia B was the highest among them. Ten kinds of prosapogenins were identified from the partial hydrolysates of crude saponin and found that prosapogenin E contain oleanolic acid as a sapogenin and prosapogenin F does echinocystic acid as the sapogenin. Hydrolysis of crude saponin yield glucose and rhamnose and the same sugar were also identified from the mixture of prosapogenin E and F.

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Studies on the Components of Fruits of Forsythia Koreana NAKAI (III). Occurrence of Ursolic Acid in the Fruits of Forsythia Koreana (Forsythia Koreana NAKAI 씨 (토연교)의 성분에 관한 연구 (III). Ursolic acid의 분리 및 확인)

  • Sae Hee Chang;Jae Soon Kim
    • Journal of the Korean Chemical Society
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    • v.17 no.6
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    • pp.444-449
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    • 1973
  • From the methanol extract of the fruits of Forsythia Koreana NAKAI a sapogenin and its derivatives were isolated. Through the mass spectra, ultraviolet spectra, nuclear magnetic resonance spectra, elemental analysis and chemical tests it was identified as ursolic acid.

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Content and Composition of Saponin Compounds of Panax Species (Panax(인삼)속 식물의 사포닌화합물 함량 및 조성)

  • 고성룡;최강주
    • Journal of Ginseng Research
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    • v.19 no.3
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    • pp.254-259
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    • 1995
  • The content and composition of saponin compounds of Panax species were analyzed according to their species, region and processing type of red and white ginseng. The species employed were Korean-, Chinese-, Japanese red ginsengs, and Korean white ginseng of Panax ginseng, American- and Canadian ginsengs of Panax quinquefolium, and Panax notoinseng. Twelve main saponin components in the ginseng were identified and quantified using TLC and HPLC. All three species had remarkably different content and composition. However, within each species they were similar. Twelve major ginsenosides were determined in P. ginseng, eight in p. quinquefolium, and six in P. notoginseng. Of the components of P ginseng Rf, $Rh_1$, $Rh_2$ and Ra were not detected in P quinquefolium, and $Rb_2$, Rc, Rf, $Rh_2$, Ra and Ro not detected in P. notoinseam. Crude saponin content and protopanaxadiol/protopanaxatriol saponin ratio were compared. They were 4.81~5.24% and 1.27~ 1.45 in p. ginsengs, 7.01~7.25% and 2.12~ 2.15 in p. quinquefolium, 9.80% and 0.99 in P. notoineng. The prosapogenin and sapogenin content were different among the Panax species.

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