• Title/Summary/Keyword: safety risk

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A Scientific Critique of a Korean Court's Acquittal for Involuntary Manslaughter Related to 5-chloro-2-methylisothiazol-3(2H)-one/2-methylisothiazol-3(2H)-one (CMIT/MIT), a Humidifier Disinfectant (HD) Part I: Material safety, exposure and delivery to target organ from an HD perspective (CMIT/MIT 함유 가습기 살균제 제품의 제조 및 판매기업 형사판결 1심 재판 판결문에 대한 과학적 고찰 (I) - 제품 위험성과 노출평가 측면에서)

  • Park, Dong-Uk;Zoh, Kyung Ehi;Kim, Jiwon;Choi, Sangjun;Kwon, Jung-Hwan;Jun, Houngbae;Kim, Sungkyoon
    • Journal of Environmental Health Sciences
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    • v.47 no.2
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    • pp.111-122
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    • 2021
  • Objectives: There was a judgment of acquittal for the manufacturer SK Chemical and the vendor Aekyung regarding humidifier disinfectant (HD) containing 5-chloro-2-methylisothiazol-3(2H)-one/2-methylisothiazol-3(2H)-one (CMIT/MIT). The rationale used in this judgement is discussed here in the light of scientific consideration. Methods: The sentencing document for the judgements was obtained from the Korea Supreme Court Service. In particular, the judgements made by the court related to the risk of HD and external and internal exposure to CMIT/MIT are discussed based on scientific evidence. Results: Rendering a determination in a criminal trial of insufficient evidence of causation, the court dismissed the prosecution's motion that humidifier disinfectant-associated lung injuries (HDLI) and asthma were associated with the utilization of these products. However, CMIT/MIT, a strong sensitizing and corrosive substance, has been reported to be associated with brain toxicity, allergic contact dermatitis, and asthma. Furthermore, the judgment did not consider total consumption amounts or the cumulative dose of CMIT/MIT in the humidifier. Lastly, there are several cases supporting the fact that exposure to water-soluble substances including CMIT/MIT can cause lower respiratory tract diseases. In addition to cases of asthma among the workers exposed to CMIT/MIT, we identified lung injury victims who were exposed to HDs exclusively containing CMIT/MIT. Conclusions: We conclude that there is sufficient evidence supporting the assertion that HDs containing CMIT/MIT cause lung injuries, including asthma, contrary to the court's judgement.

Assessment of gene flow from insect-resistant genetically modified rice (Agb0101) to non-GM rice (해충저항성 유전자변형 벼(Agb0101) 유전자 이동성 평가)

  • Oh, Sung-Dug;Yun, Doh-Won;Sohn, Soo-In;Park, Soon Ki;Chang, Ancheol
    • Korean Journal of Breeding Science
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    • v.49 no.3
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    • pp.180-189
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    • 2017
  • Genetically modified (GM) crops have been developed worldwide through the recombinant DNA technology and commercialized by global agricultural companies. Until now, GM crops have not been cultivated commercially in Korea. Commercialization of GM crops requires a compulsory assessment of environmental risk associated with the release of GM crops. This study was conducted to evaluate the frequency of pollen mediated gene flow from Bt transgenic rice (Agb0101) to japonica non-GM rice (Nakdongbyeo), indica non-GM rice (IR36), and weedy rice (R55). A total of 729,917, 596,318 and 230,635 seeds were collected from Nakdongbyeo, IR36, and R55, respectively, which were planted around Agb0101. Selection of the hybrids was determined by repeated spraying of herbicide and Cry1Ac1 immunostrip assay. Finally, the hybrids were confirmed by PCR analysis using specific primer. The hybrids were found in all non-GM rice and out-crossing ranged from 0.0005% at IR36 to 0.0027% at Nakdongbyeo. All of hybrids were located within 1.2 m distance from the Agb0101 rice plot. The meteorological elements including rainfall and temperature during rice flowering time were found to be important factors to determine rice out-crossing rate. Consideration should be taken for many factors like the meteorological elements of field and physiological condition of crop to set up the safety management guideline to prevention of GM crops gene flow.

Factors Influencing Driving ability and Its Measurements in Older Driver: A Systematic Review (고령자의 운전능력 영향요인 및 측정도구에 대한 체계적 문헌고찰)

  • Woo, Ye-Shin;Shin, Ga-In;Park, Sang-Mi;Park, Hae Yean
    • 한국노년학
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    • v.38 no.1
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    • pp.225-241
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    • 2018
  • Self-driving is meaningful activity for older persons because it enlarges the range of activity and provides opportunities for social participation. Driving is a complex activity that requires integration of physical, cognitive and sensory functions and is influenced by human and psychological factors. Age related functional deterioration affects the driving ability of older drivers. The purpose of this study is to investigate the factors affecting the risk of accidents and driving cessation of elderly drivers through systematic literature review. MEDLINE, EMBASE, Cochrane Library, KoreaMed, Pubmed were used for searching articles published from 2007 to 2017. 'aged', 'aging', 'automobile driving', 'age factors' were used as search terms and 18 articles were finally selected for analysis among 1,458 articles. In result of the study, the most significant effect showed in the physical domain, the driving habit and the performance function. The most frequent used tools evaluated driving habit and the cognitive function. In demographic characteristics, there was a correlation with the driving discontinue according to sex and age. This study emphasizes the necessity of preparing measures for safety driving with elderly. In addition, it suggests the necessity of systematically services such as individual education programs based on various driving cessation related factors of the elderly.

Empirical Study on Injury Management System of Fire-Fighting Officer (소방공무원의 공상관리제도에 대한 실증연구)

  • Kwon, Seol A;Oh, Myeong Keun;Lee, Ju Ho;Lee, Min-Kyu;Park, Sang Ho;Hyeon, Seung Hyo;Ryu, Sang Il
    • The Journal of the Korea Contents Association
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    • v.19 no.3
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    • pp.114-125
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    • 2019
  • The frequency of official injury of fire-fighting officers exposed to an extreme situation in disaster areas has been continuously increased. In spite of increase of injury, procedures of injury approval are complex, so the working environment of fire-fighting officers is very poor in terms of safety management. This study was, therefore, conducted to provide basic data for improvement of the injury management system for fire-fighting officers, by empirically analyzing the system for those in Busan city. The findings of the empirical analysis are as follows: first, the frequency of injury experienced by them is higher than that of other occupations; second, application for injury is not actively made; third, fire-fighting officers should bear the expense if injury is approved. On the basis of such an analysis on actual conditions, an analysis on policy factors for improving the injury management system shows; first, various high-risk matters should be considered in the review of application for injury, for improvement factors of the application for injury, while it is necessary to extend the benefit and support project for injured officers, for operation improvement factors of the injury management system, and the compensation act should be improved, for the improvement factors of the injury system. Second, it is urgent to develop damage prevention and coping education program for improving the injury management system. In addition, the simplification of administrative procedures of application for injury and the extension of benefit and support project for injured officers should be realized as soon as possible, moreover, the enhancement of directors' interest and support is also required.

A Study on Improving the Storm and Wind Damage Management System of Coastal Cities (연안도시 풍수해 관리체계 개선방안에 관한 연구)

  • Oh, Sang-Baeg;Lee, Han-Seok
    • Journal of Navigation and Port Research
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    • v.43 no.3
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    • pp.209-218
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    • 2019
  • Coastal cities suffer a great deal of storm and wind damage. The storm and wind characteristics vary between cities. Therefore, a storm and wind damage management system suited for specific characteristics is required for each coastal city. In this study, we analyze the current situation and establish the problem of storm and wind damage management system in regards to urban management, coastal management and disaster management. We also review the storm and wind damage management system for the USA and Japan. We consequently propose a plan to improve the storm and wind damage management system. As a result of the study, in terms of city management, we recommend the compulsory identification of disaster prevention districts, implementation of the integrated coastal city management plan, designation of natural disaster risk mitigation area as disaster prevention district, the division of disaster prevention district into wind damage prevention district, storm damage prevention district, erosion damage prevention district, the building of restrictions at the disaster prevention district by ordinance, etc. In regards to coastal management, we suggest the delegation of authority to delegate coastal erosion management area to the local government, the subdivision of coastal erosion management area into erosion serious area, erosion progress area, erosion concern area, the building restrictions at coastal erosion management area by ordinance, development of erosion prediction chart, etc. In relation to disaster management, we recommend the integration of "countermeasures against natural disasters act" and "disasters and safety management basic act", the local government-led disaster prevention system, the local disaster management network, and the customized local disaster prevention plan, etc.

Prospects of future extreme precipitation in South-North Korea shared river basin according to RCP climate change scenarios (RCP 기후변화 시나리오를 활용한 남북공유하천유역 미래 극한강수량 변화 전망)

  • Yeom, Woongsun;Park, Dong-Hyeok;Kown, Minsung;Ahn, Jaehyun
    • Journal of Korea Water Resources Association
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    • v.52 no.9
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    • pp.647-655
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    • 2019
  • Although problems such as river management and flood control have occurred continuously in the Imjin and Bukhan river basin, which are shared by South and North Korea, efforts to manage the basin have not been carried out consistently due to limited cooperation. As the magnitude and frequency of hydrologic phenomena are changing due to global climate change, it is necessary to prepare countermeasures for the rainfall variation in the shared river basin area. Therefore, this study was aimed to project future changes in extreme precipitation in South-North Korea shared river basin by applying 13 Global Climate Models (GCM). Results showed that the probability rainfall compared to the reference period (1981-2005) of the shared river basin increased in the future periods of 2011-2040, 2041-2070 and 2071-2100 under the Representative Concentration Pathways (RCP)4.5 and RCP8.5 scenarios. In addition, the rainfall frequency over the 20-year return period was increased in all periods except for the future periods of 2041-2070 and 2071-2100 under the RCP4.5 scenario. The extreme precipitation in the shared river basin has increased both in magnitude and frequency, and it is expected that the region will have a significant impact from climate change.

Evaluation of Angle Dependence on Positional Radioisotope Source Detector using Monte Carlo Simulation in NDT (몬테카를로 시뮬레이션을 이용한 방사선원 위치 검출기의 각도의존성 연구)

  • Han, Moojae;Heo, Seunguk;Shin, Yohan;Jung, Jaehoon;Kim, Kyotae;Heo, Yeji;Lee, Deukhee;Cho, Heunglae;Park, Sungkwang
    • Journal of the Korean Society of Radiology
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    • v.13 no.1
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    • pp.141-146
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    • 2019
  • Radiation sources used in the field of industrial non-destructive pose a risk of exposure due to ageing equipment and operator carelessness. Thus, the need for a safety management system to trace the location of the source is being added. In this study, Monte Carlo Simulation was performed to analyse the angle dependence of the unit-cell comprising the line-array dosimeter for tracking the location of radiation sources. As a result, the margin of error for the top 10% of each slope was 5.90% at $0^{\circ}$, 8.08% at $30^{\circ}$, and 20.90% at $60^{\circ}$. The ratio of the total absorbed dose was 83.77% at $30^{\circ}$ and 53.36% at $60^{\circ}$ based on $0^{\circ}$(100%) and showed a tendency to decrease with increasing slope. For all gradients, the maximum number was shown at $30^{\circ}$ No. 9 pixels, and for No. 10, there was a tendency to drop 7.24 percent. This study has shown a large amount of angle dependence, and it is estimated that the proper distance between the source and line-array dosimeters should be maintained at a distance of not less than 1 cm to reduce them.

Perception and Practice level of Korean Medical Doctors on Infection Control and Prevention in Korean Medicine Facilities (한방의료기관 감염관리에 대한 한의사의 인식도와 수행도)

  • Shin, HeonTae
    • Journal of Society of Preventive Korean Medicine
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    • v.23 no.1
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    • pp.27-47
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    • 2019
  • Purpose : This study was designed to identify the perception and practice level of infection control among korean medical doctors and to identify factors that may influence the performance and practice level. Methods : Data were collected using the on­line survey method. Seven hundred and eighty four Korean medical doctors(KMD) participated the survey. The study was conducted from December 2018 to January 2019. Results : The results of this study are as follows. 1. Participants who experienced infection risk by needles or sharp instruments were 596(76%). and participants who had experienced blood or body fluid contact with the mucous membrane or skin of the patient during treatment were 226(28.8%) of them. 2. The degree of perception and practice of the infectious guideline was higher in the group over 50 years, in the doctor group, in the group with more than 6 years experience in clinic and in the group who work in the hospital. (p < 0.05) 3. In the performance of the infection control management related to the Korean medical treatment, the practice level of the article 'Discard the remaining needle that used for one patient' was the lowest at 4.02, 'Identify the patient and check the validity period of sterilization of medicines or instruments' was the second lowest in 4.16. 4. Among the contents of "Prevention of Nosocomial infection and Sanitary Safety Guidelines" issued by the Korean Medical Association in 2008, the guideline "Prevention of infection by pathogens such as HIV, MRSA, SARS" were lowest article in the perception and practice level of participants. 5. Regression analysis was performed to find out the factors affecting perception and performance of the participants. The regression model showed significant difference in the regression model of the working years. (p < 0.05) 6. In order to examine the effect of the variables on the perception and practice of the infectious guideline, the mediated effect of the knowledge and education level according to the years of working, age, education degree was found to be significant only in the education degree variable. (p < 0.05) In conclusion : in order to improve the perception and practice of infectious control of Korean medicine doctors, it is necessary to include the contents of infection management as essential education during the continuing education of Korean medicine association.

Accuracy Analysis for Slope Movement Characterization by comparing the Data from Real-time Measurement Device and 3D Model Value with Drone based Photogrammetry (도로비탈면 상시계측 실측치와 드론 사진측량에 의한 3D 모델값의 정확도 비교분석)

  • CHO, Han-Kwang;CHANG, Ki-Tae;HONG, Seong-Jin;HONG, Goo-Pyo;KIM, Sang-Hwan;KWON, Se-Ho
    • Journal of the Korean Association of Geographic Information Studies
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    • v.23 no.4
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    • pp.234-252
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    • 2020
  • This paper is to verify the effectiveness of 'Hybrid Disaster Management Strategy' that integrates 'RTM(Real-time Monitoring) based On-line' and 'UAV based Off-line' system. For landslide prone area where sensors were installed, the conventional way of risk management so far has entirely relied on RTM data collected from the field through the instrumentation devices. But it's not enough due to the limitation of'Pin-point sensor'which tend to provide with only the localized information where sensors have stayed fixed. It lacks, therefore, the whole picture to be grasped. In this paper, utilizing 'Digital Photogrammetry Software Pix4D', the possibility of inference for the deformation of ungauged area has been reviewed. For this purpose, actual measurement data from RTM were compared with the estimated value from 3D point cloud outcome by UAV, and the consequent results has shown very accurate in terms of RMSE.

Immune Checkpoint Inhibitors for Non-Small-Cell Lung Cancer with Brain Metastasis : The Role of Gamma Knife Radiosurgery

  • Lee, Min Ho;Cho, Kyung-Rae;Choi, Jung Won;Kong, Doo-Sik;Seol, Ho Jun;Nam, Do-Hyun;Jung, Hyun Ae;Sun, Jong-Mu;Lee, Se-Hoon;Ahn, Jin Seok;Ahn, Myung-Ju;Park, Keunchil;Lee, Jung-Il
    • Journal of Korean Neurosurgical Society
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    • v.64 no.2
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    • pp.271-281
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    • 2021
  • Objective : Immune checkpoint inhibitors (ICIs) are approved for treating non-small-cell lung cancer (NSCLC); however, the safety and efficacy of combined ICI and Gamma Knife radiosurgery (GKS) treatment remain undefined. In this study, we retrospectively analyzed patients treated with ICIs with or without GKS at our institute to manage patients with brain metastases from NSCLC. Methods : We retrospectively reviewed medical records of patients with brain metastases from NSCLC treated with ICIs between January 2015 and December 2017. Of 134 patients, 77 were assessable for brain responses and categorized into three groups as follows : group A, ICI alone (n=26); group B, ICI with concurrent GKS within 14 days (n=24); and group C, ICI with non-concurrent GKS (n=27). Results : The median follow-up duration after brain metastasis diagnosis was 19.1 months (range, 1-77). At the last follow-up, 53 patients (68.8%) died, 20 were alive, and four were lost to follow-up. The estimated median overall survival (OS) of all patients from the date of brain metastasis diagnosis was 20.0 months (95% confidence interval, 12.5-27.7) (10.0, 22.5, and 42.1 months in groups A, B, and C, respectively). The OS was shorter in group A than in group C (p=0.001). The intracranial disease progression-free survival (p=0.569), local progression-free survival (p=0.457), and complication rates did not significantly differ among the groups. Twelve patients showed leptomeningeal seeding (LMS) during follow-up. The 1-year LMS-free rate in treated with ICI alone group (69.1%) was significantly lower than that in treated with GKS before ICI treatment or within 14 days group (93.2%) (p=0.004). Conclusion : GKS with ICI showed no favorable OS outcome in treating brain metastasis from NSCLC. However, GKS with ICI did not increase the risk of complications. Furthermore, compared with ICI alone, GKS with ICI may be associated with a reduced incidence of LMS. Further understanding of the mechanism, which remains unknown, may help improve the quality of life of patients with brain metastasis.