• 제목/요약/키워드: safety evaluation

검색결과 7,497건 처리시간 0.05초

Potential for Dependence on Lisdexamfetamine - In vivo and In vitro Aspects

  • Yun, Jaesuk;Lee, Kwang-Wook;Eom, Jang-Hyeon;Kim, Young-Hoon;Shin, Jisoon;Han, Kyoungmoon;Park, Hye-Kyung;Kim, Hyung Soo;Cha, Hye Jin
    • Biomolecules & Therapeutics
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    • 제25권6호
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    • pp.659-664
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    • 2017
  • Although lisdexamfetamine is used as a recreational drug, little research exists regarding its potential for dependence or its precise mechanisms of action. This study aims to evaluate the psychoactivity and dependence profile of lisdexamfetamine using conditioned place preference and self-administration paradigms in rodents. Additionally, biochemical techniques are used to assess alterations in the dopamine levels in striatal synaptosomes following administration of lisdexamfetamine. Lisdexamfetamine increased both conditioned place preference and self-administration. Moreover, after administration of the lisdexamfetamine, dopamine levels in the striatal synaptosomes were significantly increased. Although some modifications should be made to the analytical methods, performing high performance liquid chromatography studies on synaptosomes can aid in predicting dependence liability when studying new psychoactive substances in the future. Collectively, lisdexamfetamine has potential for dependence possible via dopaminergic pathway.

SAFETY EVALUATION OF SUNSCREENS (I) ; CORRELATION BETWEEN SUN PROTECTION FACTOR AND SKIN IRRITATION

  • Suh, Soo-Kyung;Kim, Jong-Won;Park, Ju-Young;Seo, Kyung-Won;Park, Chang-Won;Kim, Kyu-Bong;Kim, Kwang-Jin;Kim, Jong-Min;Lee, Sun-Hee
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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    • pp.138-138
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    • 2002
  • In recent years, the safety of sunscreens has been challenged based on the reports of its adverse effect on users; dermatitis, allergic contact dermatitis, photoallergic contact dermatitis. To investigate a correlation between sun protection factor (SPF) and the safety of sunscreens, we measured in vitro SPF index using homosalate as a standard and examined the toxicity tests on cosmetics; primary and cumulative skin irritation tests, ocular irritation test, and skin sensitization test.(omitted)

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Development and validation of an analytical method for the quantification of 2,6-diisopropylnaphthalene in agricultural products using GC-MS/MS

  • Lee, Han Sol;Park, Ji-Su;Lee, Su Jung;Shin, Hye-Sun;Chung, Yun mi;Choi, Ha na;Yun, Sang Soon;Jung, Yong-hyun;Oh, Jae-Ho
    • 분석과학
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    • 제34권1호
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    • pp.1-8
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    • 2021
  • An analytical method was developed and optimized for the quantification of a plant growth regulator, 2,6-diisopropylnaphthalene (2,6-DIPN), in agricultural products using gas chromatography-tandem mass spectrometry. The samples were extracted, partitioned, and were purified using a Florisil® cartridge. To validate the analytical method, its specificity, linearity, limit of detection (LOD) and limit of quantification (LOQ) of the instrument, LOQ of the analytical method (MLOQ), accuracy, and repeatability were considered. The method displayed excellent results during validation, and is suitable for the determination and quantification of the low residual levels of the analyte in the agricultural samples. All of the results with the optimized method were satisfactory and within the criteria ranges requested in the Codex Alimentarius Commission guidelines and the Ministry of Food and Drug Safety guidelines for pesticide residue analysis. The developed method is simple and accurate and can be used as a basis for safety management of 2,6-DIPN.

CORRELATION BETWEEN SPF INDEX AND SAFETY MARKER IN SUNCREENS

  • Kim, Jong-Won;Suh, Soo-Kyung;Park, Ju-Young;Park, Chang-Won;Seo, Kyung-Won;Kim, Kyu-Bong;Kim, Kwang-Jin;Kim, Jae-Hee;Lee, Sun-Hee
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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    • pp.195-195
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    • 2002
  • In recent years, the safety of sunscreens has been challenged based on the reports of its adverse effect on users; dermatitis, allergic contact dermatitis, photoallergic contact dermatitis. To investigate a correlation between sun protection factor (SPF) and the safety of sunscreens, we measured in vitro SPF index using homosalate as a standard and examined the toxicity tests on cosmetics; primary skin irritation tests, ocular irritation test, and skin sensitization test.(omitted)

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Multiresidue Method of Sulfonamides in Meat by HPLC

  • Jeong, Ji-Yoon;Kim, Jung-Mi;Im, Moo-Hyeong;Choi, Dong-Mi;Park, Kun-Sang;Hong, Moo-Ki;Lee, Chul-Won
    • 한국식품위생안전성학회:학술대회논문집
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    • 한국식품위생안전성학회 2004년도 제3회 식품안전의 날 기념 학술 세미나
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    • pp.245-245
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    • 2004
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전분의 주원료 판별을 위한 유전자 분석법 개발 및 적용 (Development and Application of DNA Analysis Method for Identificaion of Main Ingredients in Starch)

  • 박용춘;김미라;김용상;이호연;김규헌;이재황;김재이;이상재;이화정
    • 한국식품위생안전성학회지
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    • 제28권2호
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    • pp.181-187
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    • 2013
  • 전분의 사용원료를 확인하는 방법은 전분입자의 크기 또는 형태 등으로 분류하는 이화학적인 방법이 연구되었으나 원료별 또는 동일한 원료라도 품종에 따른 차이점으로 인하여 명확하게 확인하기 어려운 단점이 있어 유전자분석법을 시도하였다. 시료는 고구마 전분, 감자 전분, 옥수수 전분 및 타피오카 전분 등 총 11종을 사용하였으며, 유전자추출은 DNeasy plant mini 키트, magnetic DNA purification system 및 CTAB 방법으로 하였으며 추출유전자의 증폭을 위하여 WGA 키트로 처리하였다. 그리고 고구마, 감자, 옥수수 및 타피오카 검출을 위한 유전자 부위는 SSR (simple sequence repeat, ib-286-F/ib-286-R), 자당합성효소(potato sucrose synthase, Pss 01n-5'/Pss 01n-3'), 전분합성효소(starch synthase, SSllb 3-5'/SSllb 3-3') 및 SSR (SSRY26-F/SSRY26-R)를 각각 사용하였다. 그 결과 대부분의 경우 WGA를 처리한 경우에는 사용원료의 확인이 가능하였다.

Risk Assessment on Nitrate and Nitrite in Vegetables Available in Korean Diet

  • Suh, Junghyuck;Paek, Ock Jin;Kang, YoungWoon;Ahn, Ji Eun;Jung, Ji Sun;An, Yeong Soon;Park, Sun-Hee;Lee, Sang-Jae;Lee, Kwang-Ho
    • Journal of Applied Biological Chemistry
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    • 제56권4호
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    • pp.205-211
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    • 2013
  • Nitrate is a naturally occurring compound in plant and can be converted to nitrite in the nitrogen cycle and vice versa. Therefore, it is easy to find nitrate in plants including vegetables. Especially, it is known that high levels of nitrate found in leafy vegetables. Nitrate itself is relatively non-toxic but its metabolites and reaction products such as nitrite, nitric oxide and N-nitroso compounds, may produce adverse health effects such as methaemoglobinaemia and carcinogenesis. To execute the risk assessment of dietary nitrate and nitrite for the intake of vegetables, it is investigated that the levels of nitrate and nitrite in 23 vegetables (798 samples). The range of concentration were 0-6,719mg/kg for nitrate and 0-1,635mg/kg for nitrite, respectively. The Estimated daily intakes (EDI) were 0.85-1.38 mg/kg body weight/day for nitrate and 0.02-0.03 mg/kg body weight/day for nitrite by ages. We conclude that there are no health concerns for eating various vegetables since the EDI were below the Tolerable Daily Intake (3.7 mg/kg body weight/day for nitrate, 0.06 mg/kg body weight/day for nitrite) level established by WHO.

Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents

  • Cha, Hye Jin;Song, Min Ji;Lee, Kwang-Wook;Kim, Eun Jung;Kim, Young-Hoon;Lee, Yunje;Seong, Won-Keun;Hong, Sa-Ik;Jang, Choon-Gon;Yoo, Han Sang;Jeong, Ho-Sang
    • Biomolecules & Therapeutics
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    • 제22권6호
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    • pp.558-562
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    • 2014
  • Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

CORRELATION BETWEEN SPF INDEX AND SAFETY MARKER IN SUNCREENS

  • Kim, Jong-Won;Suh, Soo-Kyung;Choi, Ju-Young;Park, Chang-Won;Seo, Kyung-Won;Kim, Kyu-Bong;Kim, Kwang-Jin;Kim, Jae-Hee;Lee, Sun-Hee
    • 한국환경성돌연변이발암원학회:학술대회논문집
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    • 한국환경성돌연변이발암원학회 2002년도 Molecular and Cellular Response to Toxic Substances
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    • pp.195-195
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    • 2002
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