Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Potential for Dependence on Lisdexamfetamine - In vivo and In vitro Aspects

  • Yun, Jaesuk (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Lee, Kwang-Wook (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Eom, Jang-Hyeon (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Kim, Young-Hoon (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Shin, Jisoon (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Han, Kyoungmoon (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Park, Hye-Kyung (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Kim, Hyung Soo (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Cha, Hye Jin (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
  • Received : 2016.04.07
  • Accepted : 2016.11.15
  • Published : 2017.11.01
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Abstract

Although lisdexamfetamine is used as a recreational drug, little research exists regarding its potential for dependence or its precise mechanisms of action. This study aims to evaluate the psychoactivity and dependence profile of lisdexamfetamine using conditioned place preference and self-administration paradigms in rodents. Additionally, biochemical techniques are used to assess alterations in the dopamine levels in striatal synaptosomes following administration of lisdexamfetamine. Lisdexamfetamine increased both conditioned place preference and self-administration. Moreover, after administration of the lisdexamfetamine, dopamine levels in the striatal synaptosomes were significantly increased. Although some modifications should be made to the analytical methods, performing high performance liquid chromatography studies on synaptosomes can aid in predicting dependence liability when studying new psychoactive substances in the future. Collectively, lisdexamfetamine has potential for dependence possible via dopaminergic pathway.

Keywords

References

  1. Abekawa, T., Ohmori, T. and Koyama, T. (1994) Effects of repeated administration of a high dose of methamphetamine on dopamine and glutamate release in rat striatum and nucleus accumbens. Brain Res. 643, 276-281. https://doi.org/10.1016/0006-8993(94)90033-7
  2. Bozarth, M. A. (1987) Conditioned place preference: a parametric analysis using systemic heroin injections. In Methods of Assessing the Reinforcing Properties of Abused Drugs (M. A. Bozarth, Ed.), pp 241-273. Springer, New York.
  3. Drevets, W. C., Gautier, C., Price, J. C., Kupfer, D. J., Kinahan, P. E., Grace, A. A., Price, J. L. and Mathis, C. A. (2001) Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria. Biol. Psychiatry 49, 81-96. https://doi.org/10.1016/S0006-3223(00)01038-6
  4. Gonatas, N. K., Autilio-Gambetti, L., Gambetti, P. and Shafer, B. (1971) Morphological and biochemical changes in rat synaptosome fractions during neonatal development. J. Cell Biol. 51, 484-498. https://doi.org/10.1083/jcb.51.2.484
  5. Gorelick, D. A., Gardner, E. L. and Xi, Z. X. (2004) Agents in development for the management of cocaine abuse. Drugs 64, 1547-1573. https://doi.org/10.2165/00003495-200464140-00004
  6. Heal, D. J. and Pierce, D. M. (2006) Methylphenidate and its isomers. CNS Drugs 20, 713-738. https://doi.org/10.2165/00023210-200620090-00002
  7. Heal, D. J.,Cheetham, S. C. and Smith, S. L. (2009) The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety. Neuropharmacology 57, 608-618. https://doi.org/10.1016/j.neuropharm.2009.08.020
  8. Heal, D. J., Buckley, N. W., Gosden, J., Slater, N., France, C. P. and Hackett, D. (2013) A preclinical evaluation of the discriminative and reinforcing properties of lisdexamfetamine in comparison to D-amfetamine, methylphenidate and modafinil. Neuropharmacology 73, 348-358. https://doi.org/10.1016/j.neuropharm.2013.05.021
  9. Hurd, Y. L. and Ungerstedt, U. (1989) $Ca^{2+}$ dependence of the amphetamine, nomifensine, and Lu 19-005 effect on in vivo dopamine transmission. Eur. J. Pharmacol. 166, 261-269. https://doi.org/10.1016/0014-2999(89)90067-8
  10. Ivannikov, M. V., Sugimori, M. and Llinás, R. R. (2013) Synaptic vesicle exocytosis in hippocampal synaptosomes correlates directly with total mitochondrial volume. J. Mol. Neurosci. 49, 223-230. https://doi.org/10.1007/s12031-012-9848-8
  11. Janowsky, A., Neve, K. and Eshleman, A. J. (2001) Uptake and release of neurotransmitters. Curr. Protoc. Neurosci. Chapter 7, Unit7.9.
  12. Jasinski, D. R. and Krishnan, S. (2009) Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse. J. Psychopharmacol. 23, 419-427. https://doi.org/10.1177/0269881109103113
  13. Kamat, P. K., Kalani, A. and Tyagi, N. (2014) Method and validation of synaptosomal preparation for isolation of synaptic membrane proteins from rat brain. MethodsX 1, 102-107. https://doi.org/10.1016/j.mex.2014.08.002
  14. Koob, G. F. (1996) Drug addiction: the yin and yang of hedonic homeostasis. Neuron 16, 893-896. https://doi.org/10.1016/S0896-6273(00)80109-9
  15. Koob, G. F. (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmcaol. Sci. 13, 177-184. https://doi.org/10.1016/0165-6147(92)90060-J
  16. Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Rosenblatt, W., Zea-Ponce, Y., Zoghbi, S. S., Baldwin, R. M., Charney, D. S., Hoffer, P. B., Kung, H. F. and Innis, R. B. (1995) SPECT imaging of striatal dopamine release after amphetamine challenge. J. Nucl. Med. 36, 1182-1190.
  17. Mantle, T. J., Tipton, K. F. and Garrett, N. J. (1976) Inhibition of monoamine oxidase by amphetamine and related compounds. Biochem. Pharmacol. 25, 2073-2077. https://doi.org/10.1016/0006-2952(76)90432-9
  18. McKenna, D. J., Guan, X. M. and Shulgin, A. T. (1991) 3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of $^3H$-dopamine and $^3H$-5-hydroxytryptamine. Pharmacol. Biochem. Behav. 38, 505-512. https://doi.org/10.1016/0091-3057(91)90005-M
  19. Meyer, J. S. and Quenzer, L. F. (2013) Psychopharmacology: Drugs the Brain, and Behavior (2nd edition), p. 150. Sinauer Associates Inc., Sunderland.
  20. Mucha, R. F., van der Kooy, D., O'Shaughnessy, M. and Bucenieks P. (1982) Drug reinforcement studied by the use of place conditioning in rat. Brain Res. 243, 91-105. https://doi.org/10.1016/0006-8993(82)91123-4
  21. Nagy, A. and Delgado-Escueta, A. V. (1984) Rapid preparation of synaptosomes from mammalian brain using nontoxic isoosmotic gradient material (Percoll). J. Neurochem. 43, 1114-1123. https://doi.org/10.1111/j.1471-4159.1984.tb12851.x
  22. Narita, M., Akai, H., Nagumo, Y., Sunagawa, N., Hasebe, K., Nagase, H., Kita, T., Hara, C. and Suzuki, T. (2004) Implications of protein kinase C in the nucleus accumbens in the development of sensitization to methamphetamine in rats. Neuroscience 127, 941-948. https://doi.org/10.1016/j.neuroscience.2004.06.017
  23. National Research Center (2001) Guide for the Care and Use of Laboratory Animals (8th edition). National Academy of Sciences, Washington.
  24. Nestler, E. J. (2013) Cellular basis of memory for addiction. Dialogues Clin. Neurosci. 15, 431-443.
  25. Pennick, M. (2010) Absorption of lisdexamfetaminedimesylate and its enzymatic conversion to d-amphetamine. Neuropsychiatr. Dis. Treat. 6, 317-327.
  26. Rowley, H. L., Kulkarni, R. S., Gosden, J., Brammer, R. J., Hackett, D. and Heal, D. J. (2014) Differences in the neurochemical and behavioural profiles of lisdexamfetamine methylphenidate and modafinil revealed by simultaneous dual-probe microdialysis and locomotor activity measurements in freely-moving rats. J. Psychopharmacol. 28, 254-269. https://doi.org/10.1177/0269881113513850
  27. Sherman, A. D. (1989) Isolation of metabolically distinct synaptosomes on Percoll gradients. Neurochem. Res. 14, 97-101. https://doi.org/10.1007/BF00969765
  28. Taylor, C. Z. (2002) Religious addiction: obsession with spirituality. Pastor. Psychol. 50, 291-315. https://doi.org/10.1023/A:1014074130084
  29. Ward, A. S., Li, D. H., Luedtke, R. R. and Emmett-Oglesby, M. W. (1996) Variations in cocaine self-administration by inbred rat strains under a progressive-ratio schedule. Psychopharmacology (Berl.) 127, 204-212. https://doi.org/10.1007/BF02805995
  30. Whittaker, V. P., Michaelson, I. A. and Kirkland, R. J. (1964) The separation of synaptic vesicles from nerve-ending particles ('synaptosomes'). Biochem. J. 90, 293-303. https://doi.org/10.1042/bj0900293
  31. Whittaker, V. P. (1965) The application of subcellular fractionation techniques to the study of brain function. Prog. Biophys. Mol. Biol. 15, 39-96. https://doi.org/10.1016/0079-6107(65)90004-0
  32. Wislet-Gendebien, S., Visanji, N. P., Whitehead, S. N., Marsilio, D., Hou, W., Figeys, D., Fraser, P. E., Bennett, S. A. and Tandon, A. (2008) Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors. BMC Neurosci. 9, 92. https://doi.org/10.1186/1471-2202-9-92

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