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http://dx.doi.org/10.4062/biomolther.2016.080

Potential for Dependence on Lisdexamfetamine - In vivo and In vitro Aspects  

Yun, Jaesuk (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Lee, Kwang-Wook (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Eom, Jang-Hyeon (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Kim, Young-Hoon (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Shin, Jisoon (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Han, Kyoungmoon (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Park, Hye-Kyung (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Kim, Hyung Soo (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Cha, Hye Jin (Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Publication Information
Biomolecules & Therapeutics / v.25, no.6, 2017 , pp. 659-664 More about this Journal
Abstract
Although lisdexamfetamine is used as a recreational drug, little research exists regarding its potential for dependence or its precise mechanisms of action. This study aims to evaluate the psychoactivity and dependence profile of lisdexamfetamine using conditioned place preference and self-administration paradigms in rodents. Additionally, biochemical techniques are used to assess alterations in the dopamine levels in striatal synaptosomes following administration of lisdexamfetamine. Lisdexamfetamine increased both conditioned place preference and self-administration. Moreover, after administration of the lisdexamfetamine, dopamine levels in the striatal synaptosomes were significantly increased. Although some modifications should be made to the analytical methods, performing high performance liquid chromatography studies on synaptosomes can aid in predicting dependence liability when studying new psychoactive substances in the future. Collectively, lisdexamfetamine has potential for dependence possible via dopaminergic pathway.
Keywords
Lisdexamfetamine; Dependence; Conditioned place preference; Self-administration; Synaptosome; Dopamine;
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1 Gonatas, N. K., Autilio-Gambetti, L., Gambetti, P. and Shafer, B. (1971) Morphological and biochemical changes in rat synaptosome fractions during neonatal development. J. Cell Biol. 51, 484-498.   DOI
2 Gorelick, D. A., Gardner, E. L. and Xi, Z. X. (2004) Agents in development for the management of cocaine abuse. Drugs 64, 1547-1573.   DOI
3 Heal, D. J. and Pierce, D. M. (2006) Methylphenidate and its isomers. CNS Drugs 20, 713-738.   DOI
4 Heal, D. J.,Cheetham, S. C. and Smith, S. L. (2009) The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety. Neuropharmacology 57, 608-618.   DOI
5 Heal, D. J., Buckley, N. W., Gosden, J., Slater, N., France, C. P. and Hackett, D. (2013) A preclinical evaluation of the discriminative and reinforcing properties of lisdexamfetamine in comparison to D-amfetamine, methylphenidate and modafinil. Neuropharmacology 73, 348-358.   DOI
6 Hurd, Y. L. and Ungerstedt, U. (1989) $Ca^{2+}$ dependence of the amphetamine, nomifensine, and Lu 19-005 effect on in vivo dopamine transmission. Eur. J. Pharmacol. 166, 261-269.   DOI
7 Ivannikov, M. V., Sugimori, M. and Llinás, R. R. (2013) Synaptic vesicle exocytosis in hippocampal synaptosomes correlates directly with total mitochondrial volume. J. Mol. Neurosci. 49, 223-230.   DOI
8 Janowsky, A., Neve, K. and Eshleman, A. J. (2001) Uptake and release of neurotransmitters. Curr. Protoc. Neurosci. Chapter 7, Unit7.9.
9 Jasinski, D. R. and Krishnan, S. (2009) Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse. J. Psychopharmacol. 23, 419-427.   DOI
10 Kamat, P. K., Kalani, A. and Tyagi, N. (2014) Method and validation of synaptosomal preparation for isolation of synaptic membrane proteins from rat brain. MethodsX 1, 102-107.   DOI
11 McKenna, D. J., Guan, X. M. and Shulgin, A. T. (1991) 3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of $^3H$-dopamine and $^3H$-5-hydroxytryptamine. Pharmacol. Biochem. Behav. 38, 505-512.   DOI
12 Koob, G. F. (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmcaol. Sci. 13, 177-184.   DOI
13 Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Rosenblatt, W., Zea-Ponce, Y., Zoghbi, S. S., Baldwin, R. M., Charney, D. S., Hoffer, P. B., Kung, H. F. and Innis, R. B. (1995) SPECT imaging of striatal dopamine release after amphetamine challenge. J. Nucl. Med. 36, 1182-1190.
14 Mantle, T. J., Tipton, K. F. and Garrett, N. J. (1976) Inhibition of monoamine oxidase by amphetamine and related compounds. Biochem. Pharmacol. 25, 2073-2077.   DOI
15 Narita, M., Akai, H., Nagumo, Y., Sunagawa, N., Hasebe, K., Nagase, H., Kita, T., Hara, C. and Suzuki, T. (2004) Implications of protein kinase C in the nucleus accumbens in the development of sensitization to methamphetamine in rats. Neuroscience 127, 941-948.   DOI
16 Meyer, J. S. and Quenzer, L. F. (2013) Psychopharmacology: Drugs the Brain, and Behavior (2nd edition), p. 150. Sinauer Associates Inc., Sunderland.
17 Mucha, R. F., van der Kooy, D., O'Shaughnessy, M. and Bucenieks P. (1982) Drug reinforcement studied by the use of place conditioning in rat. Brain Res. 243, 91-105.   DOI
18 Nagy, A. and Delgado-Escueta, A. V. (1984) Rapid preparation of synaptosomes from mammalian brain using nontoxic isoosmotic gradient material (Percoll). J. Neurochem. 43, 1114-1123.   DOI
19 National Research Center (2001) Guide for the Care and Use of Laboratory Animals (8th edition). National Academy of Sciences, Washington.
20 Koob, G. F. (1996) Drug addiction: the yin and yang of hedonic homeostasis. Neuron 16, 893-896.   DOI
21 Whittaker, V. P., Michaelson, I. A. and Kirkland, R. J. (1964) The separation of synaptic vesicles from nerve-ending particles ('synaptosomes'). Biochem. J. 90, 293-303.   DOI
22 Pennick, M. (2010) Absorption of lisdexamfetaminedimesylate and its enzymatic conversion to d-amphetamine. Neuropsychiatr. Dis. Treat. 6, 317-327.
23 Rowley, H. L., Kulkarni, R. S., Gosden, J., Brammer, R. J., Hackett, D. and Heal, D. J. (2014) Differences in the neurochemical and behavioural profiles of lisdexamfetamine methylphenidate and modafinil revealed by simultaneous dual-probe microdialysis and locomotor activity measurements in freely-moving rats. J. Psychopharmacol. 28, 254-269.   DOI
24 Sherman, A. D. (1989) Isolation of metabolically distinct synaptosomes on Percoll gradients. Neurochem. Res. 14, 97-101.   DOI
25 Taylor, C. Z. (2002) Religious addiction: obsession with spirituality. Pastor. Psychol. 50, 291-315.   DOI
26 Ward, A. S., Li, D. H., Luedtke, R. R. and Emmett-Oglesby, M. W. (1996) Variations in cocaine self-administration by inbred rat strains under a progressive-ratio schedule. Psychopharmacology (Berl.) 127, 204-212.   DOI
27 Whittaker, V. P. (1965) The application of subcellular fractionation techniques to the study of brain function. Prog. Biophys. Mol. Biol. 15, 39-96.   DOI
28 Wislet-Gendebien, S., Visanji, N. P., Whitehead, S. N., Marsilio, D., Hou, W., Figeys, D., Fraser, P. E., Bennett, S. A. and Tandon, A. (2008) Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors. BMC Neurosci. 9, 92.   DOI
29 Nestler, E. J. (2013) Cellular basis of memory for addiction. Dialogues Clin. Neurosci. 15, 431-443.
30 Abekawa, T., Ohmori, T. and Koyama, T. (1994) Effects of repeated administration of a high dose of methamphetamine on dopamine and glutamate release in rat striatum and nucleus accumbens. Brain Res. 643, 276-281.   DOI
31 Drevets, W. C., Gautier, C., Price, J. C., Kupfer, D. J., Kinahan, P. E., Grace, A. A., Price, J. L. and Mathis, C. A. (2001) Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria. Biol. Psychiatry 49, 81-96.   DOI
32 Bozarth, M. A. (1987) Conditioned place preference: a parametric analysis using systemic heroin injections. In Methods of Assessing the Reinforcing Properties of Abused Drugs (M. A. Bozarth, Ed.), pp 241-273. Springer, New York.