• Journal of agricultural medicine and community health
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• v.36 no.2
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• pp.120-129
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• 2011

The purposes of this study were to measure health related quality of life (HRQOL) of persons disabled by stroke dwelling in Gyeongju-si using EQ-5D and to estimate total QALYs loss of persons disabled by stroke in Korea. The eligible subjects were 982 persons with stroke aged 50 and over in Gyeongju-si disabled registry, as of March, 2008. Interviewers measured HRQOL of study subjects using EQ-5D. EQ-5D index, utility weight, was derived from the Korean valuation set. In order to compare the results of this study, we selected two comparison groups representing Korean healthy population and general population of Korean using the 4th Korean National Health & Nutrition Examination Survey. Finally, after age and gender standardization, we estimated the total QALYs losses of persons disabled by stroke in Korea. Of 982 eligible subjects, 566 persons participated in the survey (response rate: 57.6%). In both of female and male, utility weights in the 70s or 80s were lower than those of the 50s or 60s. Utility weights differences among persons with disability, general population, and healthy population in male were larger than those differences in female. Total estimated QALY losses of persons disabled by stroke were 67,011.6 QALYs lower than healthy control group and 54,167.1 QALYs lower than general population, respectively.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.65 no.3
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• pp.172-181
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• 2020

Koshihikari has been one of the most popular rice cultivars with good eating quality since the 1960s despite its susceptibility to blast disease and lodging. To map the genes controlling blast resistance and to develop promising blast-resistant breeding lines inheriting Koshihikari's high eating quality, a recombinant inbred line (RIL) population was developed from a cross between Koshihikari and a blast resistance donor with early maturity, Baegilmi. A total of 394 Koshihikari × Baegilmi RILs (KBRIL), and the two parents, were evaluated for blast resistance and major agronomic traits including heading date, culm length, panicle length, and tiller number. A linkage map encompassing 1,272.7 cM was constructed from a subset of the KBRIL (n = 142) using 130 single nucleotide polymorphisms. Two quantitative trait loci (QTL) for blast resistance, qBL1.1 harboring Pish/Pi35 and qBL2.1 harboring Pib, were mapped onto chromosomes 1 and 2, respectively. qBL1.1 was detected in both of the experimental sites, Namwon and Jeonju, while qBL2.1 was only detected in Namwon. qBL1.1 and qBL2.1 did not affect agronomic traits, including heading date, culm length, panicle length, and tiller number. From the 394 KBRILs, lines that were phenotypically similar to Koshihikari were selected according to heading date and culm length and were further divided into the following two groups based on blast resistance: Koshishikari-type blast resistant lines (KR, n = 15) and Koshishikari-type blast susceptible lines (KS, n = 15). Although no significant differences were observed in the major agronomic traits between the two groups, the KR group produced a greater mean head rice ratio than the KS group. The present study provides useful materials for developing blast-resistant cultivars that inherit both Koshihikari's high eating quality and Baegilmi's blast resistance.

• Journal of Food Hygiene and Safety
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• v.31 no.6
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• pp.451-457
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• 2016

The purpose of this study was to determine the antimicrobial effects of $ClO_2$ gas on pathogenic E. coli and Salmonella spp. colonizing on the fruit surface of strawberries for export. Factorial design was employed to treat strawberries inoculated with pathogenic E. coli or Salmonella spp. with a combination of $ClO_2$ gas concentrations (10, 20, 30, 40, and 50 ppmv), RH (50, 70, and 90%), and treatment time (0, 5, 10, 20, and 30 min). Interaction between the factors was observed to note that the reduced levels of microbial population were the highest when RH is set at 90% with gas concentration- and treatment time-dependent manner. With RH and gas concentration fixed at 90% and 50 ppmv, the populations of E. coli and Salmonella spp. decreased by 2.07 and 2.28 log CFU/g when treated for 20 min whereas population reduction by 0.5 and 0.7 log CFU/g were observed when treated for 5 min, respectively. The results help establish most effective conditions for $ClO_2$ gas treatment to enhance microbial safety of strawberries for export.

• Journal of agricultural medicine and community health
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• v.27 no.1
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• pp.143-153
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• 2002

This study was performed to examine the want for home-visit health care of health center and health sub-center in rural olders and to provide the basic data to develop strategies for efficient and effective home-visit health care delivery of public health facilities. The questionnaire survey by interview was conducted to 355 olders whose ages were all over 65 years, residing at a rural community, Myun, Gyeongsangbuk- do. Among study population, 64.5% replied that their self-rated health status were 'poor', 14.1% had low ADL and 14.9% had low IADL. Among study population, 73.5% replied that they had health problem which were in need of medical personnel's care. The existence of health problem were significantly different according to sex, age, marital status, health security status, occupation, economic status, circumstances for medical care, self-rated health status, ADL, and IADL(p<0.05). Among olders with health problem which were in need of medical personnel's care, 19.5% wanted to receive the home-visit health care. The degree of want for home-visit health care was higher significantly in olders whose ages were 75-year old or more(p<0.05), jobless olders(p<0.01), the aged persons who were not in harmony with other family members, olders whose self-rated health status were 'poor' and olders with low IADL. The major reasons why they wanted to receive the home-visit health care services were 'they had no helpers when they were sick' (64.7%), 'long distance to the medical facilities from their residence'(23.5%). The medication service was the most need service among home-visit health care services. The reasons why they didn't want to receive the home-visit health care services were 'we could walk and move' (60.0%), 'we wanted to have a direct contact with doctor' (25.7%) in the order of high rate. In multiple logistic regression analysis, the degree of want for home-visit health care were higher significantly in olders who were not in harmony with other family members and olders whose self-rated health status were 'poor'(p<0.05).

• Journal of The Korean Society of Grassland and Forage Science
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• v.38 no.2
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• pp.106-111
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• 2018

This study was conducted to investigate the relationship between changes of rumen microflora and bloat in Jersey cow. Jersey cows (control age: 42 months, control weight: 558kg; treatment age: 29 months, treatment weight 507kg) were fed on the basis of dairy feeding management at dairy science division in National Institute of Animal Science. The change of microbial population in rumen was analyzed by using next generation sequencing (NGS) technologies due to metabolic disease. The diversity of Ruminococcus bromii, Bifidobacterium pseudolongum, Bifidobacterium merycicum and Butyrivibrio fibrisolvens known as major starch fermenting bacteria was increased more than 36-fold in bloated Jersey, while cellulolytic bacteria community such as Fibrobacter succinogenes, Ruminococcus albus and Ruminococcus flavefaciens was increased more than 12-fold in non-bloated Jersey. The proportion of bacteroidetes and firmicutes was 33.4% and 39.6% in non-bloated Jersey's rumen, while bacteroidetes and firmicutes were 24.9% and 55.1% in bloated Jersey's. In conclusion, the change of rumen microbial community, in particular the increase in starch fermenting bacteria, might have an effect to occur the bloat in Jersey cow.

• Research in Plant Disease
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• v.25 no.4
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• pp.164-172
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• 2019

Rice blast disease caused by Magnaporthe oryzae is the most important disease of rice in both South and North Korea. Cultivation of disease-resistant cultivar is the best way to prevent this notorious disease, but M. oryzae races have been continuously changed to adapt a new cultivar. Therefore, it is important to get the information about the race and avirulence genes of the pathogen for developing blast-resistant rice cultivar. Since the entrance of North Korea was prohibited, the information about the races of M. oryzae in North Korea border areas and South Korea was collected to get the information about the diversity of rice blast pathogen in North Korea. The disease occurrence on monogenic lines carrying single resistant gene was investigated in Jeonju, Suwon, Cheorwon, Goseong, and Baengnyeongdo in Korea, and Dandong in China. The monogenic lines in Jeonju and Suwon showed diverse ranges of the response, while those in Baengnyeongdo and Dandong showed relatively high resistant responses to rice blast. All the field isolates of M. oryzae were characterized for rice blast races by the Korean differential varieties and screened for known avirulence genes to determine the spatial distribution of avirulence genes and the population of M. oryzae.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.91-91
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• 2017

Drought is the most serious abiotic stress limiting rice production. However, little progress has been made in the genetic analysis of drought tolerance, because it is a complex trait controlled by a number of genes and affected by various environmental factors. In here, we screened 218 rice genetic resources for drought tolerance at vegetative stage and selected 32 highly drought tolerant varieties in greenhouse. Under rain-fed conditions, Grain yield of Nagdong was decreased by 53.3% from 517 kg/10a to 241 kg/10a when compare to irrigation condition. By comparison, grain yield of Samgang was decreased by 23.6% from 550 kg/10a to 420 kg/10a. The variety Samgang exhibited strong drought tolerance and stable yield in rain-fed conditions and was selected for further study. To identify QTLs for drought tolerance, we examined visual drought tolerance (VDT) and relative water content (RWC) using a doubled haploid (DH) population consisted of 101 lines derived from a cross between Samgang (a drought tolerance variety) and Nagdong (a drought sensitive variety). Three QTLs for VDT were located on chromosomes 2, 6, and 11, respectively, and explained 41.8% of the total phenotypic variance. qVDT2, flanked by markers RM324 and S2016, explained 8.8% of the phenotypic variance with LOD score of 3.3 and an additive effect of -0.6. qVDT6 was flanked by S6022 and S6023 and explained 12.7% of the phenotypic variance with LOD score of 5.0 and an additive effect of -0.7. qVDT11, flanked by markers RM26765 and RM287, explained 19.9% of the phenotypic variance with LOD score of 7.1 and an additive effect of -1.0. qRWC11 was the only QTL for RWC to be identified; it was in the same locus as qVDT11. qRWC11 explained 19.6% of the phenotypic variance, with a LOD score of 4.0 and an additive effect of 9.7. To determine QTL effects on drought tolerance in rain-fed paddy conditions, seven DH lines were selected according to the number of QTLs they contained. Of the drought tolerance associated QTLs, qVDT2 and qVDT6 did not affect tiller formation, but qVDT11increased tiller number. Tiller formation was most stable when qVDT2 and qVDT11 were combined. DH lines with both of these drought tolerance associated QTLs exhibited the most stable tiller formation. These results suggest that qVDT11 is important for drought tolerance and stable tiller formation under drought stress condition in field.

• Journal of Life Science
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• v.29 no.10
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• pp.1104-1110
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• 2019

Recently, there has been an increase in the elderly population of the world. Consequently, bone metabolic diseases such as osteoporosis are emerging as a social problem. Osteoclasts play a role in bone resorption, and osteoporosis is induced when bone resorption occurs excessively. Because currently used bone resorption inhibitors may cause side effects when used for a long period of time, it is necessary to develop a new material that effectively inhibits osteoclast differentiation. This study aimed to confirm the inhibitory effect of ethanol extract of Locusta migratoria on RANKL-induced osteoclast differentiation and its mechanism. The toxicity and proliferation effects of LME on RAW264.7 osteoclasts were measured by an MTS assay. There was no cytotoxicity or proliferation when the osteoclasts were treated with up to $2,000{\mu}g/ml$ of LME. In order to confirm the effect of LME on the differentiation of osteoclasts, osteoclasts were treated with RANKL alone or with LME for 3 days. As a result of a TRAP (tartrate-resistant acid phosphatase) assay, the increasing osteoclast differentiation by RANKL decreased in a concentration-dependent manner with the treatment of LME. In addition, LME suppressed the expression of differentiation-related marker genes (TRAP, RANK, NFATc1, and CK) and proteins (NFATc1 and c-Src) that had been increased by RANKL. Also, LME influenced the $NF-{\kappa}B$, ERK and JNK signaling pathways, resulting in the inhibition of osteoclast differentiation. These results suggest that LME may be used as a novel functional material for the prevention and treatment of osteoporosis by playing a role in inhibiting bone absorption.

• Korean Journal of Soil Science and Fertilizer
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• v.45 no.3
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• pp.421-427
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• 2012

Nepal is one of the least urbanized countries in the world where more than 80% of the total population live in rural areas. In recent years, the rate of urbanization became rampant which ultimately accelerated immense pressure on municipal services, especially on managing the ever increasing amount of wastes. Due to lack of technology, infrastructure and financial capacity management of increasing amount of solid waste has become a major challenge in municipalities of Nepal. The indiscriminate dumping of solid wastes already affected the urban environment by creating a serious occupational health and environmental hazard to the vicinity of the dumping sites. However, there is great possibility of recovering methane from the landfill sites since the typical Nepalese municipal solid waste contains more than 65% of organic wastes. Despite having enormous potential of generating electricity from hydropower, Nepal is facing acute shortage of energy. Therefore, comprehensive scientific research and development is necessary for making solid waste to environmentally friendly by converting waste to the energy.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4221-4227
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• 2012

Cancer of the uterine cervix is a worldwide menace taking innumerable womens' lives. The literature is vast and a large number of studies have been conducted in this field. Analyses have shown significant differences exist in terms of screening and HPV testing facilities among high income and low to middle income countries. In addition, acute lack of awareness and knowledge among the concerned population is particularly noted in rural areas of the low income countries. A detailed review of Indian case studies revealed that early age of marriage and childbirth, multiparity, poor personal hygiene and low socio-economic status among others are the principal risk factors for this disease. This review concludes that a two pronged strategy involving strong government and NGO action is necessary to minimize the occurrence of cervical cancer especially in low and medium income countries.