Inhibitory Effects of Locusta migratoria Ethanol Extracts on RANKL-induced Osteoclast Differentiation
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Baek, Minhee
(Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration)
Seo, Minchul (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) Lee, Joon Ha (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) Lee, Hwa Jeong (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) Kim, In-Woo (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) Kim, Sun Young (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) Kim, Mi-Ae (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) Kim, Sunghyun (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) Hwang, Jae-Sam (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) |
1 | Baek, M., Seo, M., Kim, M. A., Yun, E. Y. and Hwang, J. S. 2017. The antioxidant activities and hair-growth promotion effects of Tenebrio molitor larvae extracts (TMEs). J. Life Sci. 27, 1269-1275. DOI |
2 | Baek, M., Seo, M., Lee, J. H., Kim, I. W., Kim, M. A. and Hwang, J. S. 2018. Osteoblast activity of Locusta migratoria ethanol extracts on the MG-63 osteoblastic cell. J. Life Sci. 28, 1448-1454. DOI |
3 | Ballanti, P., Minisola, S., Pacitti, M. T., Scarnecchia, L., Rosso, R., Mazzuoli, G. F. and Bonucci, E. 1997. Tartrate-restistant acid phosphate activity as osteoclastic marker: sensitivity of cytochemical assessment and serum assay in comparison with standardized osteoclast histomorphometry. Osteoporosis Int. 7, 39-43. DOI |
4 | Boyle, W. J., Simonet, W. S. and Lacey, D. L. 2003. Osteoclast differentiation and activation. Nature 423, 337-342. DOI |
5 | Chao, D., Bahl, P., Houlbrook, S., Hoy, L., Harris, A. and Austyn, J. M. 1999. Human cultured dendritic cells show differential sensitivity to chemotherapy agents as assessed by the MTS assay. Br. J. Cancer 81, 1280-1284. DOI |
6 | Clarkson, C., Mirosa, M. and Birch, J. 2018. Potential of extracted Locust migratoria protein fractions as value-added ingredients. Insects 9, 20. DOI |
7 | Han, S. M., Lee, S. H., Yun, C. Y., Kang, S. W., Lee, K. G., Kim, I. S., Yun, E. Y, Lee, P. J., Kim, S. Y. and Hwang, J. S. 2006. Inhibition of nitric oxide production by ladybug extracts (Harmonia axyridis) in LPS-activated BV-2 cells. Kor. J. Appl. Entomol. 45, 31-36. |
8 | Hitoshi, H., Eiko, S., Kazuhiro, K., Kan, S., Ken-ichiro, M., Hideki, K., Noriaki, Y. and Koji, N. 2002. U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. J. Biol. Chem. 277, 47366-47372. DOI |
9 | Ikeda, F. Nishimura, R., Matsubara, T., Tanaka, S., Inoue, J. I. and Reddy, S. V. 2004. Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J. Clin. Investig. 114, 475-484. DOI |
10 |
Kang, M. R., Jo, S. A., Yoon, Y. D., Park, K. H., Oh, S. J., Yun, J., Lee, C. W., Nam, K. H., Kim, Y., Han, S. B., Yu, J., Rho, J. and Kang, J. S. 2014. Agelasine D suppresses RANKL-induced osteoclastogenesis via down-regulation of c-Fos, NFATc1 and NF- |
11 | Keigo, A., Yoshitaka, Y., Yoshiaki, D., Takashi, K., Tomokazu, H., Kanchu, T., Hisashi, S., Kuniaki, S. and Yoshimasa, K. 2012. Effect of bisphosphonates on osteoclastogenesis in RAW264.7 cells. Int. J. Mol. Med. 29, 1007-1015. DOI |
12 | Lee, S. M., Kim, M. G., Lee, S. Y. and Kang, T. H. 2010. Effects of Artemisia princeps extract on bone metabolism. J. Kor. Soc. Food Sci. Nutr. 39, 363-368. DOI |
13 | Kim, D. G., Kim, M. H., Kang, M. J. and Shin, J. H. 2015. Effect of spinach extract on RANKL-mediated osteoclast differentiation. J. Kor. Soc. Food Sci. Nutr. 44, 532-539. DOI |
14 | Kim, J. H., Kim, M., Jung, H. S. and Sohn, Y. 2019. Leonurus sibiricus L. ethanol extract promotes osteoblast differentiation and inhibits osteoclast formation. Int. J. Mol. Med. 44, 913-926. |
15 | Fuller, K., Lawrence, K. M., Ross, J. L., Grabowska, U. B., Shiroo, M., Samuelsson, B. and Chambers, T. J. 2008. Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts. Bone 42, 200-211. DOI |
16 | Kim, S. Y., Son, Y. J., Kim, S. H., Kim, A. N., Lee, G. Y. and Hwang, I. K. 2015. Studies on oxidative stability of Tenebrio molitor larvae during cold storage. Kor. J. Food Cook. Sci. 31, 62-71. DOI |
17 |
Lee, C. H., Kwak, S. C., Kim, J. Y., Oh, H. M., Rho, M. C., Yoon, K. H., Yoo, W. H., Lee, M. S. and Oh, J. 2014. Genipin inhibits RANKL-induced osteoclast differentiation through proteasome-mediated degradation of c-Fos protein and suppression of NF- |
18 | Lee, Z. H. and Kim, H. H. 2003. Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts. Biochem. Biophys. Res. Commun. 305, 211-214. DOI |
19 | Mariod, A. A., Saseed Mirghani, M. E. and Hussein, I. 2017. Unconventional oilseeds and oil sources, pp. 293-297, Cambridge, MA, USA. |
20 | Mohamed, E. H. A. 2015. Determination of Nutritive value of edible migratory locust Locusta migratoria, Linnaeus, 1758 (Orthoptera: Acrididae). Int. J. Adv. Pharm. Biol. Chem. 4, 144-148. |
21 | Nikhil, K., Sharan, S. and Roy, P. 2015. A pterostilbene derivative suppresses osteoclastogenesis by regulating RANKL-mediated NFkB and MAPK signaling in RAW264.7 cells. Pharmacol. Rep. 67, 1264-1272. DOI |
22 | Oonincx, D. G. A. B. and Van Der Poel, A. F. B. 2011. Effects of diet on the chemical composition of migratory locusts (Locusta migratoria). Zoo Biol. 30, 9-16. DOI |
23 | Park, J. S. and Lim, H. H. Effects of Pyrola japonica extracts on osteoclast differentiation and bone resorption. J. Kor. Med. Rehabil. 29, 135-147. |
24 | Thompson, W. R., Rubin, C. T. and Ribin, J. 2012. Mechanical regulation of signaling pathways in bone. Gene 503, 179-193. DOI |
25 | Paul, A., Frederich, M., Megido, R. C., Alabi, T., Malik, P., Uyttenbroeck, R., Francis, F., Bleccker, C., Haubruge, E. and Lognay, G. 2017. Insect fatty acids: A comparison of lipids from three Orthopterans and Tenebrio molitor L. larvae. J. Asia-Pac. Entomol. 20, 337-340. DOI |
26 | Rahman, M. M., Bhattacharya, A. and Fernandes, G. 2006. Conjugated linoleic acid inhibits osteoclast differentiation of RAW264.7 cells by modulating RANKL signaling. J. Lipid Res. 47, 1739-1748. DOI |
27 | Seo, J. H., Park, J. Y., Jeon, M. J., Cho, Y. I. and Jeon, M. S. 2018. Perception and selection attributes of edible insects intake in adults in Daejeon and Chungnam area. Culi. Sci. Hos. Res. 24, 170-182. |
28 | Takayanagi, H. 2007. The role of NFAT in osteoclast formation. Ann. N. Y. Acad. Sci. 1116, 227-237. DOI |
29 | Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M. and Yoshida, H. 2002. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3, 889-901. DOI |
30 |
Thummuri, D., Jeengar, M. K., Shrivastava, S., Nemani, H., Ramavat, R. N., Chaudhari, P. and Naidu, V. G. M. 2015. Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF- |
31 | Turkez, H., Incekara, U., Guner, A., Aydin, E., Dirican, E. and Togar, B. 2012. The cytogenetic effects of the aqueous extracts of migratory locust (Locusta migratoria L.) in vitro. Toxicol. Ind. Health 30, 233-237. DOI |
32 | Vaananen, H. K. and Laitala-Leinonen, T. 2008. Osteoclast lineage and function. Arch. Biochem. Biophys. 473, 132-138. DOI |
33 | Zungxia, Z., Jianzhong, S., Wei, C. and Yi-Pang, L. 2007. Osteoclast differentiation and gene regulation. Front. Biosci. 12, 2519-2529. DOI |
34 | Van Huis, A., Van Itterbeek, J., Klunder, H., Mertens, E., Halloran, A., Muir, A. and Vantomme, P. 2013. Edible insects: Future prospects for food and feed security. Food and Agriculture Organization of the United Nations, Rome, Italy. |
35 | Walsh, M. C., Kim, N., Kadono, Y., Rho, J., Lee, S. Y., Lorenzo, J. and Choi, Y. 2006. Osteoimmunology: interplay between the immune system and bone metabolism. Annu. Rev. Immunol. 24, 33-63. DOI |
36 |
Zeng, X. Z., He, L. G., Wang, S., Wang, K., Zhang, Y. Y., Tao, L., Li, X. J. and Liu, S. W. 2016. Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF- |
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