• 한국응용곤충학회지
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• 제58권4호
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• pp.283-289
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• 2019

항생제의 오남용은 세균의 항생제 내성을 증가시켜 세균감염에 의한 질병 치료에 어려움을 초래한다. 본 연구에서는 동애등애유충으로부터 분리된 펩타이드의 신장에서의 폐렴간균 감염 억제 효능을 관찰하였다. 마우스는 비강을 통해 폐렴간균을 감염시키고 1일 후 펩타이드를 마우스에 근육 주사로 투여하였다. 10일 후 마우스를 희생하여 신장에서 세균 감염증을 조사하였다. 대조군에 비해 펩티드를 투여한 마우스의 신장에서 세균 감염증상, 몸무게의 감소가 유의하게 억제되었고 생존률이 농도 의존적으로 증가하는 것으로 나타났다. 이러한 결과들은 동애등애로부터 분리된 펩타이드가 폐렴 간균의 신장에서의 감염증상을 억제할 수 있음을 보여준다. 따라서 동애등애로부터 분리된 펩타이드는 효과적인 항생제 개발에서 가능성 높은 후보물질이 될 수 있을 것이다.

• Biomolecules & Therapeutics
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• 제28권4호
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• pp.344-353
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• 2020

This study aims to develop new potential therapeutic moracin M prodrugs acting on lung inflammatory disorders. Potential moracin M prodrugs (KW01-KW07) were chemically synthesized to obtain potent orally active derivatives, and their pharmacological activities against lung inflammation were, for the first time, examined in vivo using lipopolysaccharide (LPS)-induced acute lung injury model. In addition, the metabolism of KW02 was also investigated using microsomal stability test and pharmacokinetic study in rats. When orally administered, some of these compounds (30 mg/kg) showed higher inhibitory action against LPS-induced lung inflammation in mice compared to moracin M. Of them, 2-(3,5-bis((dimethylcarbamoyl)oxy)phenyl)benzofuran-6-yl acetate (KW02) showed potent and dose-dependent inhibitory effect on the same animal model of lung inflammation at 1, 3, and 10 mg/kg. This compound at 10 mg/kg also significantly reduced IL-1β concentration in the bronchoalveolar lavage fluid of the inflamed-lungs. KW02 was rapidly metabolized to 5-(6-hydroxybenzofuran-2-yl)-1,3-phenylene bis(dimethylcarbamate) (KW06) and moracin M when it was incubated with rat serum and liver microsome as expected. When KW02 was administered to rats via intravenous or oral route, KW06 was detected in the serum as a metabolite. Thus, it is concluded that KW02 has potent inhibitory action against LPS-induced lung inflammation. It could behave as a potential prodrug of moracin M to effectively treat lung inflammatory disorders.

• 공업화학
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• 제10권6호
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• pp.863-870
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• 1999

본 연구에서는 촉매로 Co-Mn-Br계를 사용하고, 상대적으로 온화한 반응조건에서 2,6-Dimethylnaphthalene(DMN)의 산화 반응 특성과 촉매가 반응에 미치는 영향을 고찰하였다. 이를 위해 $2{\ell}$의 회분식 반응기를 이용하여 촉매의 농도를 조절하며 실험하였다. 먼저 반응시간에 따른 반응중간생성물의 농도변화를 분석하여 반응경로를 확인하였고, 그 결과 2-formyl-6-naphthoic acid, 2-methyl-6-naphthoic acid, 그리고 2-hydroxymethyl-6-methylnaphthalene이 반응중간물임을 확인할 수 있었다. 또한, 2,6-naphthalene dicarboxylic acid(NDA)의 수율은 Co와 Br의 농도에 많은 영향을 받는다는 것을 알 수 있었고, 제품의 품질 척도 중 하나인 color-b는 Mn의 농도와 밀접한 관련이 있는 것으로 나타났으며, 용매연소는 Mn과 Br의 농도조절로 줄일 수가 있었다. 조촉매로 Ce/Cu 화합물을 첨가함으로 NDA의 수율을 증가시키고 용매연소를 줄이는 결과를 얻을 수 있었다.

• 한국분말재료학회지
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• 제23권4호
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• pp.303-306
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• 2016

An optimum route to synthesize Ti-Mo system powders is investigated by analyzing the effect of the heat treatment atmosphere on the formation of the reaction phase by dehydrogenation and hydrogen reduction of ball-milled $TiH_2-MoO_3$ powder mixtures. Homogeneous powder mixtures with refined particles are prepared by ball milling for 24 h. XRD analysis of the heat-treated powder in a hydrogen atmosphere shows $TiH_2$ and $MoO_3$ peaks in the initial powders as well as the peaks corresponding to the reaction phase species, such as $TiH_{0.7}$, TiO, $MoO_2$, Mo. In contrast, powder mixtures heated in an argon atmosphere are composed of Ti, TiO, Mo and $MoO_3$ phases. The formation of reaction phases dependent on the atmosphere is explained by the partial pressure of $H_2$ and the reaction temperature, based on thermodynamic considerations for the dehydrogenation reaction of $TiH_2$ and the reduction behavior of $MoO_3$.

• 한국철도학회논문집
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• 제19권5호
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• pp.656-662
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• 2016

본 연구에서는 휴대전화 이용자의 시간대별 기지국 위치정보를 기반으로 하여 이용자의 이동경로를 추적하고, 기/종점을 추출하여 OD를 구축하였다. OD 구축시 통행거리가 길어질수록 통신횟수가 많아짐을 고려하여 통행거리별 평균통신횟수를 산출/반영하였고, 가정기반 통행만을 대상으로 수도권 중심의 OD를 구축하였다. 셀 단위로 집계된 휴대전화 자료를 법정동 단위로 변환하고, 이를 행정동 단위로 변환하여 본 연구에서 구축한 OD를 KTDB OD와 비교분석 한 결과, 시/군/구 단위 OD와 동 단위 OD의 상관계수는 각각 0.98, 0.85로 나타나 상당한 연관성이 있는 것으로 분석되었다.

• 약학회지
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• 제22권3호
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• pp.163-174
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• 1978

차전자(Plantaginis Semen)은 우리나라 전국 각지의 원야와 노방의 자생하는 다년생 초목으로 Plantaginaceae(질경이과)에 속하는 Plantago major L. var. asiatica Decaisne 질경이의 종자를 말하며 그의 성분으로는 다량의 점액, 지방유, pentosan 및 galactan, succinic acid, plantanolic acid, adenine, choline. K-염등이 알려져 있다. 이 차전자는 한방과 민간에서 소염, 이뇨, 진해, 지사제로서 널리 사용되어 왔으며 그의 약리작용에 관해서는 이미 저자들이 가토를 이용한 실험에서 이의 methanol extract가 자궁수축작용, 호흡흥분작용, 혈압강하작용, 장관수축작용, 심장박동의 완제작용, 항이뇨작용이 있음을 보고한 바 있다. 그러나 그의 기전에 관해서는 거의 알려진 바가 없다. 따라서 저자들은 위의 여러가지 작용중 특히 혈압강하작용에 관한 본태를 파악하여 그의 실용성 여부를 구명코자 이 실험을 착수하였다.

• Archives of Pharmacal Research
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• 제25권2호
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• pp.197-201
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• 2002

${\beta}-lonone$ has been reported to induce the cytochrome P45O (P45O) 2B1 in rats. In this study, the effects of ${\beta}-ionone$ and an isomer, ${\alpha}-ionone$, on liver P45O IA and 2B expression in Sprague Dawley rats were investigated . Subcutaneous administration of ${\alpha}-$ and ${\beta}-lonone$ 72 and 48hr prior to sacrificing the animals induced the liver microsomal P45O 1A and 2B proteins. P45O 2Bl induction was associated with the accumulation of its corresponding mRNA. 1 Induction by ${\beta}-lonone$ was much higher than that by ${\alpha}-ionone$-ionone in both the mRNA and protein levels. When the route of administration was compared, P45O 2B was induced more strongly after oral administration compared to that after subcutaneous injection. A single oral dose of 100, 300 and 600 mg/kg of ${\alpha}-$ and ${\beta}-lonone$ for 24 h induced P45O 2B1 -selective pentoxyresorufin Odepentylase activity comparably in a dose-dependent manner In addition, ${\alpha}-$ and ${\beta}-lonone$ induced the P45O 1A and 2B proteins. These results suggest that ${\alpha}-$ and ${\beta}-lonone$ might be potent P45O 2Bl inducers in rats, and that both ionones may be useful for examining the role of metabolic activation in chemical-induced toxicity where metabolic activation is required.

• 한국해양공학회지
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• 제20권3호
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• pp.37-44
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• 2006

Each year, the coast of Busan is badly damaged, due to storm surge. The damages are greatly dependent upon the local peculiarities of the region in which the storm surge occurs. So, in order to prevent/reduce recurrence of the disaster due to the storm surge, it is very important to investigate the fluctuation characteristics of the storm surge height, related to the local peculiarities at each coastal area in which the occurrence of the disaster is expected. In this paper, using the numerical model, the storm surge was simulated to examine its fluctuation characteristics at the coast of Busan Typhoons of Sarah (5914), Thelma (8705) and Maemi (0314), which caused terrible damage to the coastal areas alongthe coast of Busan in the past, were taken as an object of the storm surge simulations. Moreover, the storm surge due to virtual typhoons, which were combined with the characteristics of each proposed typhoon (Maemi, Sarah, Thelma), compared to the travel routes of other typhoons, was predicted. As expected, the results revealed that the storm surge heights are enhanced at the coastal region with the concavity like a long-shaped bay. Also, the storm surge heights, due to each typhoon, were compared and discussed at major points along the coast of Busan, related to the local peculiarities, as well as the characteristics and the travel route of the typhoon.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권5호
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• pp.2338-2356
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• 2019

Vehicular ad-hoc network (VANET) is the name of technology, which uses 'mobile internet' to facilitate communication between vehicles. The aim is to ensure road safety and achieve secure communication. Therefore, the reliability of this type of networks is a serious concern. The reliability of VANET is dependent upon proper communication between vehicles within a given amount of time. Therefore a new formula is introduced, the terms of the new formula correspond 1 by 1 to a class special ST route (SRORT). The new formula terms are much lesser than the Inclusion-Exclusion principle. An algorithm for the Source-to-Terminal reliability was presented, the algorithm produced Source-to-Terminal reliability or computed a Source-to-Terminal reliability expression by calculating a class of special networks of the given network. Since the architecture of this class of networks which need to be computed was comparatively trivial, the performance of the new algorithm was superior to the Inclusion-Exclusion principle. Also, we introduce a mobility metric called universal speed factor (USF) which is the extension of the existing speed factor, that suppose same speed of all vehicles at every time. The USF describes an exact relation between the relative speed of consecutive vehicles and the headway distance. The connectivity of vehicles in different mobile situations is analyzed using USF i.e., slow mobility connectivity, static connectivity, and high mobility connectivity. It is observed that $p_c$ probability of connectivity is directly proportional to the mean speed ${\mu}_{\nu}$ till specified threshold ${\mu}_{\tau}$, and decreases after ${\mu}_{\tau}$. Finally, the congested network is connected strongly as compared to the sparse network as shown in the simulation results.

• 수산해양기술연구
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• 제54권4호
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• pp.343-352
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• 2018

In this study, a motion control problem for the vessels towed by tugboats or towing ships on the sea is considered. The towed vessel looks like the barge ship, which is used for many purposes. In these vessels, basically, the power propulsion system is not installed but just towed by a towing vessel such as tugboats with ropes and wires. It means that the motions of towed vessel are basically dependent on the tracking route of towing boat. Therefore, in some cases, undesirable and unpredictable motions may be made by environmental factors such as wave, wind attack and so on. As a result, a collision accident with others may occur during maneuvering situation. Based on these facts, the authors try to encourage the steering performance of the towed vessel by using controllable rudders without any propulsion system. In this study, especially, a controllable vessel with three rudders is considered, and a mathematical model is induced for the future study. The model is described as surge, sway motion and inertia moment by following the general representation method for the surface ship.