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http://dx.doi.org/10.5656/KSAE.2019.11.0.047

Peptide isolated from Hermetia illucens larvae inhibits mice from Klebsiella pneumoniae infection in the kidney  

Lee, Dong-Hun (Department of Biomedical Science, Graduate School, Kyung Hee University)
Chu, Ki-Back (Department of Biomedical Science, Graduate School, Kyung Hee University)
Kang, Hae-Ji (Department of Biomedical Science, Graduate School, Kyung Hee University)
Lee, Su-Hwa (Department of Biomedical Science, Graduate School, Kyung Hee University)
Quan, Fu-Shi (Department of Medical Zoology, Kyung Hee University School of Medicine)
Publication Information
Korean journal of applied entomology / v.58, no.4, 2019 , pp. 283-289 More about this Journal
Abstract
Overuse of antibiotics has significantly contributed to an increase in microbial antibiotic resistance, causing difficulties in the suppression of microbe-borne infectious diseases. In this study, we determined the anti-Klebsiella pneumoniae effect in the kidneys of mice induced by peptides isolated from H. illucens larvae. Mice were intranasally infected with a high dose of K. pneumoniae and 1 day later, peptides were introduced through the intramuscular route. Mice were sacrificed on day 10 upon K. pneumoniae infection to determine the bacterial loads in the kidneys. Mice receiving peptide treatment demonstrated significantly reduced bacterial loads, reduced bodyweight loss, and higher survival in a dose-dependent manner compared to control. These results indicate that peptide isolated from H. illucens larva inhibits K. pneumoniae infection in the kidney. The peptide from H. illucens larva could be a potential candidate for the development of an effective antibacterial drug.
Keywords
Hermetia illucens; Peptide; Klebsiella pneumoniae; Kidney;
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