• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.5037-5041
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• 2015

Background: An hCG regression curve has been used to predict the natural history and response to chemotherapy in gestational trophoblastic disease. We constructed hCG regression curves in high-risk gestational trophoblastic neoplasia (GTN) treated with EMA/CO and identified an optimal hCG level to detect EMA/CO resistance in GTN. Materials and Methods: Eighty-one women with GTN treated with EMA/CO were classified as primary high-risk GTN (n = 65) and single agent-resistance GTN (n = 16). The hCG levels prior to each course of chemotherapy were plotted in the 10th, 50th, and 90th percentiles to construct the hCG regression curves. Diagnostic performance was evaluated for an optimal cut-off value. Results: The median hCG levels were 264,482 mIU/mL mIU/mL and 495.5 mIU/mL mIU/mL for primary high-risk GTN and single agent-resistance GTN, respectively. The 50th percentile of the hCG level in primary high-risk GTN and single agent-resistance turned to normal before the 4th and the 2nd course of chemotherapy, respectively. The 90th percentile of the hCG level in primary high-risk GTN and single agent-resistance turned to normal before the 9th and the 2nd course of chemotherapy, respectively. The hCG level of ${\geq}118.6mIU/mL$ mIU/mL at the 5thcourse of EMA/CO predicted the EMA/CO resistance in primary high-risk GTN patients with a sensitivity of 85.7% and a specificity of 100%. Conclusion: EMA/CO resistance in primary high-risk GTN can be predicted by using an hCG regression curve in combination with the cut-off value of 118.6 mIU/mL at the 5thcourse of chemotherapy.

• 한국수소및신에너지학회논문집
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• 제35권1호
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• pp.66-74
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• 2024

This study addresses the escalating issue of worldwide hydrogen gas accidents, which has seen a significant increase in occurrences. To comprehensively evaluate the risks associated with hydrogen, a two approach was employed in this study. Firstly, a qualitative risk assessment was conducted using the bow-tie method. Secondly, a quantitative consequence analysis was carried out utilizing the areal locations of hazardous atmospheres (ALOHA) model. The study applied this method to two incidents, the hydrogen explosion accident occurred at the Muskingum River power plant in Ohio, USA, 2007 and the hydrogen storage tank explosion accident occurred at the K Technopark water electrolysis system in Korea, 2019. The results of the risk assessments revealed critical issues such as deterioration of gas pipe, human errors in incident response and the omission of important gas cleaning facility. By analyzing the cause of accidents and assessing risks quantitatively, the effective accident response plans are proposed and the effectiveness is evaluated by comparing the effective distance obtained by ALOHA simulation. Notably, the implementation of these measures led to a significant 54.5% reduction in the risk degree of potential explosions compared to the existing risk levels.

• East Asian Economic Review
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• 제19권1호
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• pp.3-38
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• 2015

Fama's (1984) volatility relations show that the risk premium in foreign exchange markets is more volatile than, and is negatively correlated with the expected rate of depreciation. This paper studies these relations from the perspective of goods markets frictions. Using a sticky-price general equilibrium model, we show that near-random walk behaviors of both exchange rates and consumption, in response to monetary shocks, can be derived endogenously. Based on this approach, the paper provides quantitative results on Fama's volatility relations.

• 대한교통학회지
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• 제24권1호
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• pp.19-28
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• 2006

항공수요의 급속한 팽창으로 항공기 운항의 증가와 공역 및 활주로의 혼잡도 심화로 인해 운영상 위험(Operational risk)이 급증하고 있어 체계적인 항공안전에 대한 위기관리시스템의 구축이 필요하다 항공안전 분야의 선진국일수록 평상시 비상대응체계 및 여러 가지 위험관리기법을 가동함으로써 조직의 긴장감 유지 및 예방안전의 도구로 활용하고 있다. 따라서 항공운송산업의 안전에 대해 총괄적인 관리 감독의 의무가 있는 항공안전본부 차원에서 이와 같은 과학적인 위기관리 모형을 이용한 위기관리체계의 도입이 필요하다. 위험요인분석 기법들은 데이터베이스가 구축되어 있거나, 충분한 정보와 자료가 있는 경우에는 사용될 수 있으나 현재의 국내 여건 상 충분한 자료의 확보가 곤란하여 실용적으로 사용되기가 어려운 것이 현실이다. 따라서 본 연구에서는 현재의 제한된 자료를 사용하여 실현가능 한 위험관리모형을 제시하기 위해 위험인자를 선정하고 각 위험인자에 대한 중요도와 발생빈도를 계산한 후 위험관리 모형을 제시하였다 이러한 위험관리 모형을 통해 항공운송분야에서 주기적 위험관리를 효과적으로 시행하기 위해서는 반드시 국가차원의 광범위한 자료의 수집이 선행되어야 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.5125-5135
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• 2015

Background: Total fat intake may be associated with increased risk of breast cancer, and fish oil has been suggested as a protection factor to breast cancer. But the effect of vegetable oils is inconclusive. We aimed to investigate the association with high vegetable oils consumption and breast cancer risk, and evaluated their dose-response relationship. Design: We systematically searched the MEDLINE, EMBASE, Cochrane databases, and CNKI updated to December 2014, and identified all observational studies providing quantitative estimates between breast cancer risk and different vegetable oils consumption. Fixed or random effect models were used to estimate summary odds ratios for the highest vs. lowest intake, and dose-response relationship was assessed by restricted cubic spline model and generalized least-squares trend (GLST) model. Results: Five prospective cohort studies and 11 retrospective case-control studies, involving 11,161 breast cancer events from more than 150,000 females, met the inclusion criteria. Compared with the lowest vegetable oils consumption, higher intake didn't increased the risk of breast cancer with pooled OR of 0.88 (95% CIs:0.77-1.01), and the result from dose-response analyses didn't show a significant positive or negative trend on the breast cancer risk for each 10g vegetable oil/day increment (OR=0.98, 95% CIs: 0.95-1.01). In the subgroup analyses, the oils might impact on females with different strata of BMI. Higher olive oil intake showed a protective effect against breast cancer with OR of 0.74 (95% CIs: 0.60-0.92), which was not significant among the three cohort studies. Conclusions: This meta-analyses suggested that higher intake of vegetable oils is not associated with the higher risk of breast cancer. Olive oil might be a protective factor for the cancer occurrence among case-control studies and from the whole. Recall bias and imbalance in study location and vegetable oils subtypes shouldn't be ignored. More prospective cohort studies are required to confirm the interaction of the impact of vegetable oils on different population and various cancer characteristic, and further investigate the relationship between different subtype oils and breast cancer.

• 한국수자원학회논문집
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• 제46권1호
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• pp.35-45
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• 2013

본 논문에서는 통합홍수위험관리 측면에서 지역의 홍수위험도에 따라 지구를 구분할 수 있는 홍수위험지수(Flood Risk Index, FRI)의 산정 및 적용방안을 제시하고자 하였다. 낙동강 유역에대하여 시 군 구 단위의 공간해상도로 홍수위험지수(FRI)를 산정하기 위해 P-S-R(Pressure-State-Response) 구조로 분류하여 3개의 홍수지수인 압력지수(PI), 현상지수(SI), 대책지수(RI)를 대표하는 총 17개 세부지표들을 엄선하였다. 세부지표들은 각기 다른 범위와 단위로 측정된 값이므로, T-Score 방법을 사용하여 동일한 범위로 변환되었다. 또한 엔트로피(Entropy) 가중치 산정방법에 의한 가중치를 사용하여 가중치 적용에 따른 주관적인 판정을 최소화하였다. 압력지수(PI), 현상지수(SI), 대책지수(RI)의 3개 지수를 통합하여 지역의 전반적인 홍수위험 상태를 파악할 수 있는 홍수위험지수(FRI)를 산정하고, 가중치 적용 유 무에 따른 홍수위험지수 산정결과와 2010년에 고시된 자연재해위험지구 중 침수위험지구와의 비교를 통해 제안된 홍수위험지수의 적용성을 검토하였다. 충분히 검증된 홍수위험지수를 활용하면 과거 홍수의 원인 및 현상별 홍수재해에 대하여 지역적 방재대책 수립이 가능할 것이라 기대된다.

• 경영과학
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• 제32권3호
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• pp.55-70
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• 2015

The main objective of this study is to investigate the moderating roles of the competitor's pricing strategy and the degree of consumer's risk-aversion on perceived risk and perceived benefit in responding to price increases and package downsizing. Based on Prospect Theory, several prior researches find that consumers perceive increased price as more loss than package downsizing and perceive package downsizing as more benefit than increased price. We extend these behavioral economics approach using the reference effect of competitor's pricing strategy. We focus on consumer heterogeneity on risk-aversion, measure the degree of consumer's risk-aversion, and divide the consumers into two groups of high levels of risk-aversion vs. low levels of risk-aversion. We find that the firm's pricing strategies of both price increases and package downsizing do not significantly influence the perceived benefit for relatively low risk-aversion consumers. We find that when the firm reduce the package size, relatively high risk-aversion consumers perceived more benefit and had higher purchase intention compared to price increases. We also find that the competitor's pricing strategies do not significantly influence the consumer's response for relatively low risk-aversion consumers. For relatively high risk-aversion consumers, they perceived more loss when the firm has different pricing strategy from the competitor's.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2006년도 정기학술발표대회 논문집
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• pp.571-573
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• 2006

본 연구에서는 리스크관리 인자별 중요도와 4D 객체 시각화방법론을 통한 리스크관리 정보의 시각화 모델을 제안한다. 리스크관리 프로세스 모델은 WBS(Work Breakdown Structure)와 RBS(Risk Breakdown Structure)를 통해 구성되며, RBS에서 분류된 리스크 인자는 퍼지 분석기법을 통해 중요도(Weight)가 분석된다. 이 중요도는 4D 시각화를 위한 건설공사 객체(Object)의 속성 데이터로 지정된다. 또한 Object의 4D 시각화를 위한 방안으로는 4D 시뮬레이션기법이 활용되며, 등급별로 구분된 리스크 인자의 중요도와 4D 시뮬레이션을 통해 직접적인 건설공사 부위별 리스크관리 수준 확인과 부위별 리스크 인자의 시각화가 가능하도록 하는 방법론을 제시한다.

• Environmental Analysis Health and Toxicology
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• 제19권1호
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• pp.49-58
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• 2004

It is important to select a risk based priority area for environmental policy formation and decision-making. We estimated the health risks and associated damage costs from exposure to fine particles and assigned priority areas for twenty -five districts in Seoul. In order to estimate the theoretical mortality incidence of the health risk, baseline risks were estimated from mortality rates in two low level areas of fine particles, Seocho Gu and Cheju city To estimate the damage cost from the risk estimates, we investigated and estimated the willingness to pay (WTP) for specific risk reduction. We assumed two different locations as the reference area, Cheju city as Scenario I and Seocho gu as Scenario II. From the results, the five districts, Kwangjin, Chungnang, Kangbuk, Nowon, and Kangnam, ranked high in the categories of both health risk and economic risk. Damage costs were over twenty billion won in each of these districts. As there are uncertainties in these results, the parameter values such as PM$_{2.5}$ level, dose -response slope factor, baseline risk, exposure population and WTP should be continuously validated and refined.d.

• 한국안전학회지
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• 제16권4호
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• pp.115-122
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• 2001

Recently construction enterprises involves more occurred with increase of size and complxity of construction works. Risk management is one of the key project management process. Numerous tools are available to support the various phases of the risk management process. We present the results of a study designed to identify the tools that are most widely used and those that are associated with successful project management in general, and in effective project risk management in particular. The study is based on a questionnaire administered to a sample of project managers from construction enterprises. The response data was analyzed in order to find which tools are mon likely to be used in the those organizations that report better project management performance and in those that value the contribution of risk management processes.