• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3735-3740
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• 2015

Context: Insulin-like growth factor peptides play important roles in regulating cell growth, cell differentiation, and apoptosis, and have been demonstrated to promote the development of colorectal cancer (CRC). Objective: To examine the association of insulin-related biomarkers including insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and C-peptide with CRC risk and assess their relevance in predictive models. Materials and Methods: The odds ratios of colorectal cancer for serum levels of IGF-1, IGFBP-3 and C-peptide were estimated using unconditional logistic regression models in 100 colorectal cancer cases and 100 control subjects. Areas under the receiving curve (AUC) and integrated discrimination improvement (IDI) statistics were used to assess the discriminatory potential of the models. Results: Serum levels of IGF-1 and IGFBP-3 were negatively associated with colorectal cancer risk (OR=0.07, 95%CI: 0.03-0.16, P for trend <.01, OR=0.06, 95%CI: 0.03-0.15, P for trend <.01 respectively) and serum C-peptide was positively associated with risk of colorectal cancer (OR=4.38, 95%CI: 2.13-9.06, P for trend <.01). Compared to the risk model, prediction for the risk of colorectal cancer had substantially improved when all selected biomarkers IGF-1, IGFBP-3 and inverse value of C-peptide were simultaneously included inthe reference model [P for AUC improvement was 0.02 and the combined IDI reached 0.166% (95 % CI; 0.114-0.219)]. Conclusions: The results provide evidence for an association of insulin-related biomarkers with colorectal cancer risk and point to consideration as candidate predictor markers.

• Journal of the Korean Society of Marine Environment & Safety
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• v.18 no.5
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• pp.431-438
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• 2012

The representative risk evaluation techniques of the marine traffic environment are the FSA, PAWSA, & IWRAP. For the development of these techniques, the risk factors suitable to the marine traffic environment should be selected & the assessment criterion of the risk factors should be provided. The risk factors were selected as the factors that relate both to the frequency of casualty & to the consequence of casualty because the risk was defined as the frequency of casualty times the consequence of that casualty on the existing techniques. But, the risk factors relate to the consequence of casualty are excluded because the risk is defined as the sum of the risk factors including the frequency and the consequence by factors on this study. The 20 kinds of risk factors to compose the risk are selected and classified into 5 categories according to similar nature through the analysis of preceding study on the classification of the risk factors. Finally, as the foundation of risk assessment model's development for domestic marine traffic environment, the practical assessment criterion of the risk factors are suggested.

• Journal of Korean Society of Disaster and Security
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• v.10 no.1
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• pp.29-34
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• 2017

This Analyzed case study of measuring displacement, implemented laboratory investigation, and in-situ testing in order to interpret ground subsidence risk rating by excavation work. Since geological features of each country are different, it is necessary to objectify or classify quantitatively ground subsidence risk evaluation in accordance with Korean ground character. Induced main factor that could be evaluated and used to predicted ground subsidence risk through literature investigation and analysis study on research trend related to the ground subsidence. Major factors of ground subsidence might be classified by geological features as overburden, boundary surface of ground, soil, rock and water. These factors affect each other differently in accordance with type of ground that's classified soil, rock, or complex. Then rock could be classified including limestone element or not, also in case of the latter it might be classified whether brittle shear zone or not.

• Asian Oncology Nursing
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• v.8 no.2
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• pp.120-127
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• 2008

Purpose: The purpose of this study was secondary analysis to explore about risk factors with breast cancer on a basis of primary literature. Methods: This study was searched articles by using CINAHL, MEDLINE, Riss4u, Internet website regarding breast cancer. This study searched for the journal published in Korea and foreign countries from 2000 to 2008, about risk factors of breast cancer. This study was reviewed 42 articles (5 experimental study, 35 survey, 1 qualitative study, 1 report) suitable for the research objectives. Results: Magnitude of risk breast cancer (++) was age, geographic region, family history, mutations in BRCA1, BRCA2 genes and in other penetrance genes, radiation, history of benign breast disease, late age of menopause, early age of menarch, nulliparity and older age at first birth, high mammographic breast density, high insulin-like growth factor 1 level. Magnitude of risk factor (+) was hormone replacement therapy, oral contraceptives use, obesity, tall stature, alcohol consumption, high prolactin level, high saturated fat and well-done meat intake, polymorphisms in low penetrance gene, high socioeconomic status. Conclusion: A breast cancer screening protocol according to magnitude of risk factors is needed for disease prevention. The nurses need to educate and counsel women with risk factors of breast cancer.

• Women's Health Nursing
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• v.25 no.2
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• pp.154-168
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• 2019

Purpose: The purpose of this study is to identify knowledge, awareness, and risk of occurrence of venous thromboembolism among pregnant women. Methods: Subjects were 106 pregnant women treated as inpatients and outpatients at a women's health hospital in a metropolitan city February 19-March 22, 2018. Instruments consisted of questionnaires that included knowledge, awareness, and risk of occurrence of venous thromboembolism queries. Collected data were analyzed by t-test, one-way analysis of variance, Mann-Whitney U test and Kruskal-Wallis test. Results: Mean score of subjects' knowledge of venous thromboembolism was 4.47 (0-15), mean score of subjects' awareness of venous thromboembolism was 66.98 (25-100), and mean score of subjects' risk factor of venous thromboembolism was 0.98 (0-44). Conclusions: Pregnant women's level of knowledge and awareness of prevention and risk factors on venous thromboembolism, is significantly low. To raise their awareness of risk symptoms and prevent occurrence of the disease, it is essential for nurses as well as medical staffs to: 1) provide an educational program on venous thromboembolism for patients; 2) assess and monitor pregnant women with a risk factor of venous thromboembolism; and 3) implement proper prophylaxis for patients.

• Journal of agricultural medicine and community health
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• v.25 no.1
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• pp.11-21
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• 2000

This study was conducted to reveal the effects of musculoskeletal risk factor on farmer's syndrome. We sampled 97 farmers aged above 30 in 3 villages of Kyunggi-do. Self-administered questionnaire for general characteristics, farmer's syndrome, musculoskeletal risk factor, blood pressure, and laboratory tests were conducted. According to the score of musculoskeletal risk factor, we divide the subjects high risk group and low risk group. The most common musculoskeletal risk factor is repetitiveness, bending of waist and rapid movement in order. The prevalence of farmer's syndrome of all subjects is 28.9%. In female the prevalence of farmer's syndrome(45.2%) is higher than in male(16.4%) significantly. High musculoskeletal risk group had higher score of farmer's syndrome(5.9) than low musculoskeletal risk group(4.4). The most common symptom is lumbago(76.3%), the second was numb limb and shoulder stiffness(54.6%, 54.6%). The prevalence of numb limb and shoulder stiffness higher in high musculoskeletal risk group than low musculoskeletal risk group, but that of lumbago did not show significant differences. In linear regression, score of farmer's syndrome was related to musculoskeletal risk factor as well as gender. Blood pressure and laboratory test did not show significant differences between two groups. These results suggest that musculoskeletal risk factor would influence farmer's syndrome. Further ergonomic evaluation and intervention of farmer's works and musculoskeletal diseases are needed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.7
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• pp.3244-3251
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• 2012

In the construction and operation of large marine structure, hazard risk analysis is one of important factors. Therefore, this paper investigates the hazard risk indexes and evaluates the risk level in the construction and operation of SFT on the basis of expert survey and Fuzzy analytic hierarchy process. Hazard risk is divided into natural hazard risk (earthquake, typhoon, tsunami, and ice collision) and human factor hazard risk (fire, explosion, traffic accident, ship or submarine collision). Also, the influence of hazard risk indexes on SFT was evaluated in tunnel tube, supporting system, ventilation tower, foundation, and connection part. As the hazard risk level of SFT is compared with those of bridge, underwater tunnel, and immersed tunnel, the intrinsic risk level of SFT was evaluated. Tsunami and earthquake had higher risk level in natural hazard risk, and the risk levels of fire and explosion were higher in human factor hazard risk. Hazard risk level of SFT was 1.4 times higher than immersed tunnel, and 3.2 times higher than bridge.

• Environmental Analysis Health and Toxicology
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• v.25 no.3
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• pp.187-195
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• 2010

Nanotechnology is the fastest growing area in scientific research and it has important applications in a wide variety of fields. Nevertheless, consumers encountered this new technology without any identification of risks and benefits. Also until now, there are no specific safety evaluation methods for nanotechnology. For this reason, we studied risk communication strategy for nanotechnology to prepare its application in commercialized products on public. A survey was conducted to identify the differences in perception between public (N=110) and expert (N=37) toward applied nanotechnology in food, drugs and cosmetic products. The survey results were used to draw up a risk cognitive map which was introduced by Paul Slovic, and the perception level of public and expert on nanotechnology was evaluated. As a result of the survey, public recognized nanotechnology as "unknown but low dread" risk factor, but expert recognized it as "unknown and high dread" risk factor. These results indicate that there are perception differences between two groups. Several risk communication strategies are reported including care, consensus and risk communication. In the case of nanotechnology, it contains both risks and benefits. Considering the nature of nanotechnology, the "consensus communication" which informs consumers about risks and benefits of issues is the most appropriate strategy.

• Journal of Korea Technology Innovation Society
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• v.17 no.2
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• pp.289-308
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• 2014

We analyze the risk factors identified for ex-ante evaluation regarding government R&D programs. In particular, we empirically examined to what extent each risk factor is perceived to be important by the stage of R&D, technology field, researcher's career and experience. The empirical results show that technology risk is perceive to be less important for basic research, while market risk more perceived to be important in the IT field. Political risk is perceived to be less important for the university faculty, while researchers with government R&D project experience gave more value to legal risk factor.

• Journal of Food Hygiene and Safety
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• v.23 no.3
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• pp.276-283
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• 2008

To provide the research strategy for protection of children's health from hazardous chemical, we reviewed the hazardous chemicals can be exposed through maternity, children's life style and living environment. Recently, diseases related with children's living condition were focused as asthma, atopy, childhood developmental disability, congenital malformations and obesity. Children can be exposed to hazardous chemicals through an ambient air, water, soil, food, toys and other factors such as floor dust. Also children's health was deeply related with a wrong life style and neglectful caring by a lack of knowledge and information of harmful ones at parents and child care center's nursers. According to the previous study, the chemical risk factor of children's health were identified as inorganic arsenic, bisphenol A, 2,4-D, dichlorvos, methylmercury, PCBs, pesticide, phthalates, PFOA/PFOS, vinyl chloride, et al. Domestic studies for identification of causality between children exposure to chemicals and resulted hazardous effects were not implemented. The confirmation of chemical risk factors through simultaneously performing toxicological analysis, human effect study, environmental/human monitoring, and risk assessment is needed for good risk management. And also, inter-agency collaboration and sharing information can support confirming scientific evidence and good decision making.