• Bulletin of the Korean Chemical Society
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• 제35권6호
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• pp.1789-1793
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• 2014

Pseudo-first-order rate constants ($k_{obsd}$) have been measured spectrophotometrically for the reactions of 5-nitro-8-quinolyl nicotinate (4) and 5-nitro-8-quinolyl isonicotinate (5) with alkali metal ethoxides (EtOM; M = K, Na and Li) in anhydrous ethanol at $25.0{\pm}0.1^{\circ}C$. The plots of $k_{obsd}$ vs. [EtOM] curve slightly upward for the reactions with EtOK and EtONa but are linear for the reactions with EtOLi and for those with EtOK in the presence of 18-crown-6-ether. Dissection of $k_{obsd}$ into $k_{EtO^-}$ and $k_{EtOM}$ (i.e., the second-order rate constants for the reactions with the dissociated $EtO^-$ and ion-paired EtOM, respectively) has revealed that the reactivity increases in the order $EtO^-{\approx}EtOLi$ < EtOK < EtONa for the reactions of 4 and EtOLi < $EtO^-$ < EtOK < EtONa for the reactions of 5. Comparison of the kinetic results for the reactions of 4 and 5 with those reported previously for the corresponding reactions of 5-nitro-8-quinolyl benzoate (2) and picolinate (3) has revealed that the esters possessing a pyridine ring (i.e., 3-5) are significantly more reactive than the benzoate ester 2 due to the presence of the electronegative N atom (e.g., 2 << 3 < 4 < 5). It has been concluded that $M^+$ ion catalyzes the reactions of 3-5 by increasing the electrophilicity of the reaction center through a five-membered cyclic transition state (TS) for the reaction of 3 and via a four-membered cyclic TS for the reactions of 4 and 5.

• Bulletin of the Korean Chemical Society
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• 제28권12호
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• pp.2261-2265
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• 2007

Prevention of thermal aggregation of the denatured protein by the group II chaperonin from the aerobic hyperthermophilic crenarchaeon Aeropyrum pernix K1 (ApcpnA) has been investigated. ApcpnA exists as a homo-oligomer in a ring structure, which protects thermal aggregation of the chemically denatured bovine rhodanese at 50 oC. ApcpnA alone is not sufficient for chaperonin activity, but the chaperonin activity is greatly enhanced in the presence of manganese ion and ATP. Compared to the mesophilic chaperonin GroEL/GroES, ApcpnA is more activated at a higher temperature and protects the aggregation-prone unfolded state of the denatured rhodanese from thermal aggregation. Binding of ATP is sufficient for ApcpnA to perform the chaperonin function in vitro, but hydrolysis of ATP is not necessarily required. We propose that utilization of Mn2+ and adenosine nucleotide regardless of ATP hydrolysis may be one of peculiar properties of archaeal chaperonins.

• Archives of Pharmacal Research
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• 제13권1호
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• pp.82-96
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• 1990

Ten (E)-and (Z)-isomers of 2-phenylcyclopropylamine (PCA), 1-Me PCA, 2-Me-PCA, N-Me-PCA, and N, N-diMe PCA and fifteen o-. m-, p- isomers of (E) PCA with substituents of Me, Cl, F, OMe, OH were synthesized in this laboratory and tested for the inhibition of rat brain mitochondrial MAO-A and MAO-B. The effects of substituents, their positions, and stereochemistry on the inhibition were assessed for the compounds with substituents at cyclopropyl and amino groups and QSAR analyses were performed using the potency data of ring-substituted compounds. The best correlated QSAR equations are as follows : pI$_{50}$ = 0.804 $\pi^2$-0.834 Blo-1.069 Blm + 0.334 Lp-1.709 HDp +7.897 (r = 0.945, s =0.211, F = 16.691, p = 0.000) for the inhibition of MAO-A;PI$_{50}$= 1.815$\pi$-0.825 $\pi^2$-1.203R + 0.900 Es$^2$ + 0.869 Es$^3$ + 0.796 Es$^4$-0.992 HDp + 0.562 HAo + 3.893 (r = 0.982, s =0.178, F = 23.351, p = 0.000) for the inhibition of MAO-B. Based on the potency difference between stereoisomers of cyclopropylamine-modified compounds and an QSAR cavity near para position, two hydrophobic carities interacting with Me group, a hydrophobic site near para position, and an amino group binding site and that in addition to the same two hydrophotic cavities, hydrophotic area, steric boundaries, hydrogen-acceptor site, and amino group binding site, another steric boundary near para position and a hydrogen donating site near ortho position constitute active sites of MAO-B.

• 한국경제지리학회지
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• 제21권2호
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• pp.107-118
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• 2018

급속한 경제발전에 따라 중국 베이징에서 교통혼잡이 심각한 문제로 대두되고 있다. 혼잡통행료는 도로의 정체를 해결해주는 매우 효율적인 방법인데, 이의 시행에 있어 가장 중요한 과제는 혼잡통행료의 산출모형을 개발하는 것이다. 기존연구와 달리 본 논문은 이론적 논의에 그치지 않고 세 가지의 현실적 문제, 즉, 통행속도와 밀도의 관계, 통행의 시간비용, 최적통행량 산정방법의 도출에 집중하였다. 먼저 회귀분석을 통하여 통행속도와 밀도의 관계를 파악하고, 이어 설문조사 결과를 이용하여 통행의 시간비용을 추정하였다. 또한 수요곡선에 대한 정확한 정보가 없더라도 시행착오를 거쳐서 최적통행량을 산정할 수 있음을 보였다. 마지막으로 베이징 제2순환도로의 혼잡통행료 책정시스템을 설계하고 요금의 적절한 징수방안을 제안하였다.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제48권12호
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• pp.761-767
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• 1999

Poly-Si TFTs(polycrystalline silicon thin film transistors) fabricated on a low cost glass substrate have attracted a considerable amount of attention for pixel elements and peripheral driving circuits in AMLCS(active matrix liquid crystal display). In order to apply poly-Si TFTs for high resolution AMLCD, a high operating frequency and reliable circuit performances are desired. A new poly-Si TFT with CLBT(counter doped lateral body terminal) is proposed and fabricated to suppress kink effects and to improve the device stability. And this proposed device with BC(buried channel) is fabricated to increase ON-current and operating frequency. Although the troublesome LDD structure is not used in the proposed device, a low OFF-current is successfully obtained by removing the minority carrier through the CLBT. We have measured the dynamic properties of the poly-Si TFT device and its circuit. The reliability of the TFTs and their circuits after AC stress are also discussed in our paper. Our experimental results show that the BC enables the device to have high mobility and switching frequency (33MHz at $V_{DD}$ = 15 V). The minority carrier elimination of the CLBT suppresses kink effects and makes for superb dynamic reliability of the CMOS circuit. We have analyzed the mechanism in order to see why the ring oscillators do not operate by analyzing AC stressed device characteristics.

• 대한전자공학회논문지TC
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• 제47권7호
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• pp.128-134
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• 2010

본 논문에서는 저부엽과 저손실 특성을 갖는 고전력 20-출력 스트립라인 전력분배기를 설계, 제작하고 측정하였다. 20-출력전력분배기는 S 대역 선형 배열 안테나의 급전회로를 위해 설계되었으며, 좁은 빔폭과 매우 낮은 저부엽 특성을 위해 Dolph-Chebyshev 전류 분포를 활용하였다. 20-출력 전력분배기는 8-출력 분배기 1개, 4-출력 분배기 3개와 링 하이브리드 전력분배기 3개로 구성되었으며, 전력분배의 기본적인 구조로는 T-접합 분배 구조를 사용하였다. 삽입손실과 반사손실을 개선하기 위해서 노치를 T-접합 분배 구조에 적용하였으며 N형 커넥터와 스트립라인 사이의 천이구조를 수정하였다. 설계, 제작된 전력분배기는 대역 내에서 약 0.3 dB의 삽입손실과 8o 보다 작은 rms 위상 부정합 특성을 보였다. 20-출력 전력분배기 2개를 대칭적으로 구성할 경우 40 dB 이상의 저부엽 특성 결과를 20-출력 전력분배기 측정 결과로부터 합성할 수 있었다.

• 한국전자통신학회논문지
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• 제12권1호
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• pp.25-30
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• 2017

본 논문에서는 음의 투자율(negative values permeability)을 가지는 CSRR(: Complementary split ring resonator)를 안테나의 그라운드면에 적용하여 이중대역에서 사용가능한 마이크로스트립 패치안테나를 최적설계하였다. SRR의 음각형태인 CSRR을 안테나의 급전선 뒷면에 배치하여 대역저지특성을 만들고 이를 이용해서 위성통신에 사용하는 L-band의 두주파수 f1(1.53GHz), f2(1.63GHz)에서 사용가능한 안테나를 제안하였다. 제안한 안테나는 마이크로스트립라인을 이용하여 배열이 가능하고 기존의 패치안테나에 비해 소형으로 제작이 가능하다. 제작된 안테나는 f1과 f2에서 각각 -12.5dB, -14.5dB의 입력반사계수와 2.0dB, -0.8dB의 이득을 얻을 수 있어 이중대역에서 충분한 성능을 나타내는 것을 확인하였다.

• Journal of Mechanical Science and Technology
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• 제17권12호
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• pp.1835-1843
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• 2003

This paper introduces the development of the caliper system for a geometry PIG (Pipeline Inspection Gauge). The objective of the caliper system is to detect and measure dents, wrinkles, and ovalities affect the pipe structural integrity. The developed caliper system consists of a finger arm, an anisotropic permanent magnet, a back yoke, pins, pinholes and a linear hall effect sensor. The angle displacement of the finger arm is measured by the change of the magnetic field in sensing module. Therefore the sensitivity of the caliper system mainly depends on the magnitude of the magnetic field inside the sensing module. In this research, the ring shaped anisotropic permanent magnet and linear hall effect sensors were used to produce and measure the magnetic field. The structure of the permanent magnet, the back yoke and pinhole positions were optimized that the magnitude of the magnetic field range between a high of 0.1020 Tesla and a low of zero by using three dimensional nonlinear finite element methods. A simulator was fabricated to prove the effectiveness of the developed caliper system and the computational scheme using the finite element method. The experimental results show that the developed caliper system is quite efficient for the geometry PIG with good performance.

• 한국가금학회:학술대회논문집
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• 한국가금학회 2005년도 제22차 정기총회 및 학술발표회
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• pp.31-43
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• 2005

Isoflavones are naturally occurring plant chemicals belonging to the 'phytoestrogen' class. The isoflavones are strikingly similar in chemical structure to natural estrogens. The phenolic ring is a key structural element of most compounds that bind to estrogen receptors. Dietary components that recently have received attention for their action as phytoestrogens are soy isoflavones. Soy products are the most significant dietary sources of isoflavones. Recently It is concerned clinical nutrition of isoflavone that is driven by reason of alternative sources of exogenous estrogen are constantly being needed. Estrogen therapy after the menopause offers protection from cardiovascular disease, reduces the extent of osteoporosis and relieves menopausal symptoms. Exogenous estrogen treatment is a fear of possible increased risk of developing breast cancer and because of side effects. Daily intake of soybean or soy food can affirmative effect to disease occurrence, that is based on mechanical investigation, experimental results of animals and human. Research into isoflavone is going on various field to relieve hormone - dependent disease such as cancer, menopausal symptom, cardiovascular disease and osteoporosis. Isoflavone is plenty in soybean meal, soy by-product, but only limited information is available on isoflavone efficacy into animal husbandry. Thus we conducted three experiments to investigate the effects of dietary isoflavone on productivities, antioxidative responses and bone metabolism in poultry. Dietary supplementation of isoflavone resulted in preventing the lipid oxidation of plasma and egg yolk. Dietary isoflavone improved bone development in egg-type growing chicks and broilers in terms of tibial strength. It was suggested that the proper use of feed additives such as isoflavone might provide means of improving antioxidative effect, skeletal strength, egg and eggshell quality.

• 대한기계학회논문집A
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• 제34권7호
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• pp.805-811
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• 2010

체결류는 일반 제품을 설계할 때 널리 사용되며, 일반 부품에 비하여 표준화가 잘 되어 규격화 되어있다는 특징이 있다. 그래서 체결류를 설계할 때에는 먼저 수식을 사용하여 원하는 기능을 가진 체결류를 계산하고, 최종 사양은 규격에서 계산된 용량을 만족하는 것을 선택한다. 이 연구에서는 이러한 체결류 설계의 특징을 살리며 삼차원 CAD 시스템에서 편리하게 체결류 설계를 할 수 있는 시스템에 대한 연구를 수행하였다. 이 시스템에서 자동으로 설계하기에 적합한 체결류 형상을 정의하였으며, 체결류 설계에 필요한 설계 인자와 형상 치수를 규격에서 추출하여 데이터베이스를 구축하였다. 또한 체결류를 설계할 때 사용하는 설계식을 구현하여 설계식의 입력 인자와 출력 인자를 규격으로부터 추출한 데이터베이스 및 형상 치수와 연결시켰다.