• Journal of muscle and joint health
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• v.7 no.1
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• pp.25-39
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• 2000

This study was conducted to compare symptoms, living activities, self-efficacy and family support between rheumatoid arthritis patients and fibromyalgia patients. The subjects were consisted of 150 rheumatoid arthritis patients and 125 fibromyalgia patients at H Rheumatism Clinic. Data were collected by means of structured interview with questionnaires. The results were as follows: 1. Fibromyalgia patients have more symptoms than rheumatoid arthritis patients have. But the latter has more difficulties concerning living activities. 2. Self-efficacy score of fibromyalgia arthritis patients was higher than that of rheumatoid arthritis patients, but both the scores were at moderate level. 3. The level of family support of rheumatoid arthritis patients was moderate, similar as that of fibromyalgia patients. As self-efficacy and family support are important factors to relieve symptoms of both diseases, their promotion holds a key post.

• Journal of Acupuncture Research
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• v.21 no.1
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• pp.86-98
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• 2004

Objective: The purpose of this study is to examine the susceptibility of the patients diagnosed by rheumatoid arthritis to Sasang Typology. Methods: This study are planned to detect the susceptibility of the patients diagnosed by rheumatoid arthritis to Sasang Typology. In order to analyze the susceptibility of rheumatoid arthritis to Sasang Typology, 147 rheumatoid arthritis patients and 147 matched controls are assessed with QSCC II question for Sasang Typology. Then the frequencies of patients by Sasang constitution are compared to those of control, which are statistically analyzed and adjusted by age, sex, smoking status, alchol intake, BMI, and economic status. Results: The demographic characteristics of the study population are similar in sex and age distribution, smoking status, and alcohol intake(p>0.05). 147 rheumatoid arthritis patients and 147 matched controls are assessed with QSCC II question for Sasang constitution. Soeumin is the most susceptible to rheumatoid arthritis compared to Taeumin or Soyangin(Crude OR[95% CI]; 3.82 [2.19-6.64]). It is statistically significant after adjusting age, sex, smoking status, alcohol intake, BMI, and economic status(Adjusted OR[95% CI]; 3.01[1.47-6.15]). Conclusions: It is suggested that the specific Sasang Typology associated with rheumatoid arthritis is used as its susceptibility marker and further as basic data to prevent the risk factors for rheumatoid arthritis.

• Journal of muscle and joint health
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• v.4 no.2
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• pp.277-296
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• 1997

This study was conducted to investigate the influencing factors on the appraisal of uncertainty in patients having rheumatoid arthritis. Subjects of the study constituted 528 patients who visited outpatient clinics of two university hospitals and one general hospital in Seoul. Self report questionnaires were used to measure the variables influencing the appraisal of uncertainty. Reliability coefficients of these instruments were found Cronbach's Alpha=$.70{\sim}.96$. In data analysis, SPSS PC 6.0 program was utilized for descriptive statistics, Pearson's correlation, logistic and multiple regression analysis. The results of logistic and multiple regression analysis were as follows 1) Among the independent variables, significant factors to explain the appraisal of uncertainty in patients were uncertainty(p<.001), severity of illness(p<.05), educational level (p<.05) and age (p<.05). 2) When patients appraised uncertainty as "Danger", significant factors to explain the appraisal of uncertainty were uncertainty(p<.0001), age(p<.0005), severity of illness(p<.001), educational level (p<.05). 3) When patients appraised uncertainty as "Opportunity", significant factors to predict the appraisal of uncertainty were uncertainty(p<.0005), social support(p<.0005), severity of illness(p<.005), credible authority(p<.05), age(p<.05) and educational level (p<.05).

• Journal of muscle and joint health
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• v.14 no.1
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• pp.61-69
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• 2007

Purpose: The purpose of the study is to investigate the degree of fatigue and its related factors in women with rheumatoid arthritis. Method: The subjects were 143 patients with rheumatoid arthritis. Data were collected by questionnaires including Multi-Dimensional Assessment of Fatigue(Tack, 1991), Korean Health Assessment Questionnaire(Bae et al., 1991), numeric scale of pain(Lee & Song, 1987), Center for Epidemiologic StudiesDepression, and Korean Sleep Scale(Oh, et al., 1998). The data were analyzed by SPSS WIN 12.0 program using descriptive statistics, Pearson Correlation, and Stepwise Multiple Regression. Result: The result were as follows. 1. The scores of fatigue of subjects averaged $4.95{\pm}1.83$, degree of fatigue was $5.85{\pm}1.98$, and influence of fatigue was $4.04{\pm}2.09$. 2. The mean score of the degree of physical dysfunction, pain, sleep disorder, and depression were $1.42{\pm}0.38,\;8.15{\pm}3.58,\;1.86{\pm}0.67,\;and\;1.85{\pm}0.46$ points respectively. 3. The subject's total fatigue score, physical dysfunction, pain, sleep disorder, and depression was correlated positively(r=.44, r=.28, r=.29, r=.27, p< .01). 4. The main influencing factors on the fatigue were physical dysfunction and sleep disorder. These two main variables made it possible to explain 23.0% of the variance in fatigue. Conclusion: Therefore, nursing interventions for fatigue experienced women with rheumatoid arthritis would be focused to decrease physical dysfunction and sleep disorder.

• Journal of the Korean Applied Science and Technology
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• v.36 no.4
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• pp.1365-1372
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• 2019

The present study aimed to evaluate the effect of Lycii radicis CORTEX extract on rheumatoid related factors in CIA-induced Rheumatoid Arthritis model of DBA/1 mice. Lycii radicis CORTEX extract was administered orally at doses of 200 mg/kg/day for 4 weeks after direct injection of CIA into the mice' right paw. We evaluated the treatment effects based on serum biomarkers, morphological and histopathological analyses of the paw. Compared with those in control mice, the Lycii radicis CORTEX extract treatments significantly reduced the serum concentration of cytokine, kemokine and immunoglobulin levels. In addition, the Lycii radicis CORTEX extract treatments effectively preserved the paw bone joint, that in the H&E staining and masson-trichrome staining showed that there were histopathological improvements in Lycii radicis CORTEX extract treated group compared to those of control group. The results indicate that Lycii radicis CORTEX extract alleviated rheumatoid arthritis symptoms. Thus, Lycii radicis CORTEX extract may be a novel therapeutic option for the management of rheumatoid arthritis.

• Journal of muscle and joint health
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• v.5 no.2
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• pp.206-221
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• 1998

The purpose of this study was to validate translated Multidimensional Assessment of Fatigue(MAF) scale. The scale is a 16-item scale that measures four dimensions of fatigue : severity, distress, impact, timing. Fourteen items are numerical rating scales and 2 items have multiple choice responses. Data were collected from the 137 patients with rheumatoid arthritis after content validation. Criterion validity was tested by correlation coefficient with Piper Fatigue Scale, which resulted in 0.7573(p<.0000). Construct validity was tested by item analysis and factor analysis. Corrected item-total correlation coefficients were 0.63-0.88. And factor analysis showed 2 factors : fatigue degree factor and fatigue impact factor. These two factors explained 73.5% of total variance. Reliability of internal consistency was 0.96 in Cronbach's alpha. Further validation study is necessary in each factor in other settings with other subjects.

• Journal of muscle and joint health
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• v.6 no.1
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• pp.85-99
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• 1999

Chronic disease such as rheumatoid arthritis is believed to induce a significant psychosocial stressors. The concept of illness intrusiveness-illness induced life style disruptions-was hypothesized to affect psychosocial status. And demographic, socioeconomic, disease and social characteristics were hypotehsized to affect illness intrusiveness. Hierarchial multiple regression analyses were used. As a result, among the demographic factors gender was identified as contributor to directly increase the psychosocial stress and education level was identified to affect the psychosocial stress through illness intrusiveness. Among socioeconomic factors, the burden about the cost of medical treatment was found to indirectly affect the psychosocial stress through the illness intrusiveness. Also income and job were found to affect directly the psychosocial status. Among the disease characteristics, only the pain level was identified to increase the psychosocial stress through the illness intrusiveness. Among the social characteristics, perceived social support is identified to increase the psychosocial stress through the illness intrusiveness. Based upon these results, some suggestions were made for minimizing illness intrusiveness in rheumatoid arthritis and future research.

• Korean Journal of Adult Nursing
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• v.14 no.2
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• pp.184-193
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• 2002

Purpose: The purpose of this study was to assess the characteristics of the user of complementary alternative therapies(CAT) and to identify the important predictive factors associated with them. Method: This study included 142 patients attending outpatient rheumatology clinics of D Hospital in Busan between July and August in 2001. The multiple logistic regression model was developed to estimate the likelihood of user or nonuser of CAT. Result: The duration of illness and chance score of health locus of control were found to be significant factors through the estimated coefficients of using CAT. Duration of illness is longer and chance score of health locus of control is higher in patients who have used CAT in past than that of nonuser. When the model performance was evaluated by comparing the observed outcome with predicted outcome, the model correctly identified 95% of user of CAT and 31% of nonuser. Conclusion: In this survey, duration of illness and chance score of health locus of control are found to be significant factors in predicting utilization of CAT. Nurses who care for rheumatoid arthritis patients should take consideration into health locus of control in planning health education programs.

• Journal of muscle and joint health
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• v.4 no.2
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• pp.238-248
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• 1997

This study was conducted to identify the characteristics of uncertainty in patients having rheumatoid arthritis. Subjects of the study constituted 528 patients who visited outpatient clinics of two university hospitals and one general hospital in Seoul. A self report questionnaire was used to measure the uncertainty. Reliability coefficients of this instrument was found Cronbach's ${\alpha}=.84$. In data analysis, SPSS PC 6.0 computer program was utilized for descriptive statistics and factor analysis. Three factors were appointed on the basis of literature review for the principal component factor analysis method and Varimax Orthogonal Rotation. The results of factor analysis were as follows ; 1) Three factors for uncertainty were identified through the principal component analysis and varimax rotation, and these contributed 37.4% of the valiance in the total score. Twenty six items among the whole items in the scale loaded above .39 on one of 3 factors. 2) The naming of each factor was as follows : Factor 1 was 'ambiguity' and has 12 items, factor 2 was 'lack of information' and has 8 items, factor 3 was 'unpredictability' and has 7 items. 3) Cronbach's alpha for internal consistency was .84 for the total items and .81, .80, .50 for each of three subscales in that order.

• The Korea Journal of Herbology
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• v.29 no.6
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• pp.95-102
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• 2014

Objectives : The purpose of this study is to prove the effect of GamiBangkeehwangkee-tang (f$\acute{a}$ngj$\check{i}$hu$\acute{a}$ngq$\acute{i}$-t$\bar{a}$ng, BHT) ethanol extract on the immunity and rheumatoid arthritis related inflammatory cytokines. Methods : We checked viability in RAW 264.7 cell after treat by BHT. Then we measured inflammatory and immunity factors of DBA/1 mice with rheumatoid arthritis induced by collagen after BHT oral administration. Also, we checked micro-CT image, bone volume and bone inflammation ratio in micro-CT and structural parameter test. Results : BHT showed cell viability of 95% or higher in all concentration in RAW 264.7 cells. BHT treated group decreased level in serum of IgM and IgG test by 36% and 25% respectively. And BHT treated group showed significant decrease in WBC, neutrophil, lymphocyte and monocytes immune cell ratio in blood by 47%, 22%, 56% and 85% respectively. Also, BHT treated group decreased level in serum of $IL-1{\beta}$, IL-6, IL-17, $TNF-{\alpha}$ and hs-CRP tests by 29%, 33%, 32%, 24% and 56% respectively. Finally, BHT treated group showed increase ratio of bone volume that decrease ratio of bone inflammation. Conclusions : In this study, the results were observed rheumatoid arthritis factors cytokine decrease in serum. And BHT showed immunoglobulin and immune cells ratio decrease in serum and blood. Also, BHT depending on effects of inflammatory and immunity in hs-CRP test, micro-CT, structural parameter test. Thus, these results can used as a effective drug of BHT for inflammation and immunity.