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http://dx.doi.org/10.12925/jkocs.2019.36.4.1365

The effect of Lycii radicis CORTEX extracts on the Rheumatoid arthritis related factors  

Jang, Ayeong (DaeJeonUniversity)
Seung, Otak (JoongBu University)
Lee, Myeongseon (DaeJeonUniversity)
Publication Information
Journal of the Korean Applied Science and Technology / v.36, no.4, 2019 , pp. 1365-1372 More about this Journal
Abstract
The present study aimed to evaluate the effect of Lycii radicis CORTEX extract on rheumatoid related factors in CIA-induced Rheumatoid Arthritis model of DBA/1 mice. Lycii radicis CORTEX extract was administered orally at doses of 200 mg/kg/day for 4 weeks after direct injection of CIA into the mice' right paw. We evaluated the treatment effects based on serum biomarkers, morphological and histopathological analyses of the paw. Compared with those in control mice, the Lycii radicis CORTEX extract treatments significantly reduced the serum concentration of cytokine, kemokine and immunoglobulin levels. In addition, the Lycii radicis CORTEX extract treatments effectively preserved the paw bone joint, that in the H&E staining and masson-trichrome staining showed that there were histopathological improvements in Lycii radicis CORTEX extract treated group compared to those of control group. The results indicate that Lycii radicis CORTEX extract alleviated rheumatoid arthritis symptoms. Thus, Lycii radicis CORTEX extract may be a novel therapeutic option for the management of rheumatoid arthritis.
Keywords
Rheumatoid arthritis; cytokine; immonoglobulin; Lycii radicis CORTEX extract; micro-CT; tissue;
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1 D. L. Scott, F. Wolfe, T. W. Huizinga, "Rheumatoid arthritis", Lancet, Vol.376, No.3, pp. 1094-1108, (2010).   DOI
2 A. J. Silman, J. E. Pearson, "Epidemiology and genetics of rheumatoid arthritis", Arthritis Res, Vol.4, No.2, pp. 265-272, (2002).   DOI
3 T. M. Hunter, N. N. Boytsov, X. Zhang, K. Schroeder, A. B. Araujo, "Prevalence of rheumatoid arthritis in the United States adult population in healthcare claims databases", Rheumatology international, Vol.37, No.9, pp. 1551-1557, (2017).   DOI
4 E. Minichiello, L. Semerano, M. C. Boissier, "Time trends in the incidence, prevalence, and severity of rheumatoid arthritis: a systematic literature review", Joint Bone Spine, Vol.83, No.6, pp. 625-630, (2016).   DOI
5 Y. R. Ki, "The Risk of Cardiovascular Disease and Diabetes in Rheumatoid Arthritis Patients: A Propensity Score Analysis", Korean Journal of Clinical Pharmacy, Vol.29, No.2, pp. 109-114. (2019).   DOI
6 http://kosis.kr/statHtml/statHtml.do?orgId=350&tblId=TX_35001_A061&conn_path=I2
7 Y. H. Cheon, H. O. Kim, Y. S. Suh, J. H. Hur, W. Jo, H. S. Lim, S. I. Lee, "Inhibitory effects for rheumatoid arthritis of dietary supplementation with resveratrol in collagen-induced arthritis", Journal of Rheumatic Diseases, Vol.22, No.2, pp. 93-101, (2015).   DOI
8 T. S. Kim, W. J. Park, S. B. Ko, M. H. Kang, "Development of extracts of Lycii folium having high antioxidant activity", J Korean Soc Food Sci Nutr, Vol.37, No.10, pp. 1318-1322, (2008).   DOI
9 M. Feldmann, F. M. Brennan, R. N. Mainil, "Role of cytokines in rheumatoid arthritis", Annual Review of Immunology, Vol.14, No.3, pp. 397-440, (1996).   DOI
10 S. H. Ahn, H. H. Ki, "Lonicerae Flos Inhibited COX-2 and MMP-9 in LPS Induced Arthrits of Mouse through Regulation of MI", Korean J. Oriental Physiology & Pathology, Vol.24, No.2, pp. 242-248, (2010).
11 C. W. Seo, Y. C. Lee, J. C. Lee, "The Effects of Lycium chinese Mill., Morus alba L. and Their Combination on the Asthmatic Murine Model", Herbal Formula Science. Vol.21, No.1, pp. 36-50, (2013).   DOI
12 Y. Han, Y. K. Park, "The comparisons of Lycii Radicis Cortex and Corni Fructus water extract effects on streptozotocin-induced diabetes in rats", The Korea Journal of Herbology. Vol.28, No.6, pp. 71-77, (2013).   DOI
13 D. K. Koh, T. H. Lee, "Antistress effects of Lycii Radicis Cortex in the passive avoidance test and the forced swimming test", The Korea Journal of Herbology. Vol.22, No.2, pp. 137-146, (2007).
14 W. P. Arend, J. M. Dayer, "Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis", Arthritis Rheum, Vol.38, No.2, pp. 151-160, (1995).   DOI
15 H. Matthew, S. Kirk, "The anti inflammatory and antiviral effects of hydroxy chloroquine in two patients with acquired immunodeficiency syndrome and active inflammatory arthritis", Arthritis Rheum, Vol.39, No.1, pp. 157-161, (1996).   DOI
16 J. S. Song, "Toward the cure of rheumatoid arthritis", The Korean Journal of Medicine, Vol.69, No.6, pp. 581-589, (2005).
17 J. M. Kim, H. Y. Kim, "Pathogenesis of rheumatoid arthritis", J Korean Med Assoc, Vol.53, No.10, pp. 853-861, (2010).   DOI
18 J. Sylvester, A. Liacini, W. Q. Li, F. Dehnade, M. Zafarullah, "Tripterygium wilfordii Hook F extract suppresses proinflammatory cytokine-induced expression of matrix metalloproteinase genes in articular chondrocytes by inhibiting activating protein-1 and nuclear factor-${\kappa}B$ activities", Molecular pharmacology, Vol.59, No.5, pp. 1196-1205, (2001).   DOI
19 P. F. Zangerle, D. De Groote, M. J. Lopez, R. J. Meuleman, Y. Vrindts, F. Fauchet, P. Franchimont, "Direct stimulation of cytokines (IL-1${\beta}$, TNF-${\alpha}$, IL-6, IL-2, IFN-${\gamma}$ and GM-CSF) in whole blood: II. Application to rheumatoid arthritis and osteoarthritis", Cytokine, Vol.4, No.6, pp. 568-575, (1992).   DOI
20 Y. W. Song, "Updated pathophysiology of rheumatoid arthritis", The Korean Journal of Medicine, Vol.76, No.1, pp. 1-6, (2009).
21 Korean College of Rheumatology, KCR Textbook of rheumatology. Seoul: GunJachulpansa, pp. 73, 187-200, (2014).
22 G. H. Son, Y. S. Kim, J. G. Jung, Y. G. Park, "Effect of Citri Pericarpium ethanol extract on collagen-induced arthritis in mice", The Korea Journal of Herbology, Vol.26, No.3, pp. 1-6, (2011).   DOI
23 S. M. Choi, K. Y. Lee, H. S. Lee, J. H. Hong, M. H. Lee, B. C. Lee, "A case of meningococcal meningitis with complement 9 deficiency", Korean Journal of Pediatrics, Vol.48, No.1, pp. 101-103, (2005).
24 B. J. Lee, S. Y. Yoon, H. W. Park, J. H. Park, I. Y. Cho, J. S. Lee, J. H. Ryu, "Effects of Concurrent Administration of Hyeolbuchukeo-tang and Aspirin on Atherosclerosis in the ApoE^(-/-) Mouse", Journal of Korean Medicine, Vol.32, No.1, pp. 164-174, (2011).