• 한국미생물·생명공학회지
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• 제2권1호
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• pp.45-50
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• 1974

1. L-cysteine을 pyruvate, sulfide 및 ammonia로 분해하는 반응을 촉매하는 효소인 cysteinedesulfhydrase의 촉매기능에 대해 연구해온 바 Aerobacter aerogenes로부터 유도생산한 cysteinedesulfhydrase를 사용하여 분해반응의 역반응에 의해 pyruvate, ammonia 및 sulfide로부터 cysteine의 유도체인 S-methyl-L-cysteine 및 S-ethyl-L-cysteine을 합성하였다. 2. 합성반응에 있어서 S-methyl-L-cysteine 및 S-ethyl-L-cysteine의 생성량은 반응시간과 효소량에 비예적인 관계를 나타내었고 반응의 최적 pH는 10.0이었다. 3. 효소적 합성법에 의해 생산된 S-methyl-L-cysteine 및 S-ethyl-L-cysteine을 반응액으로 부터 단리, 결정화해서 이들 합성산물에 대한 Ion exchange chromatogram, NMR spectrum, element analysis, molecular weight 및 melting point 측정 등의 분석시험을 행한 바 이들 화합물에 대한 이론치와 잘 일치되는 결과를 얻었다.

• Journal of Korean Neurosurgical Society
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• 제61권4호
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• pp.427-433
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• 2018

Obsessive compulsive disorder is a debilitating condition characterized by recurrent obsessive thoughts and compulsive reactions. A great portion of the obsessive compulsive disorder (OCD) patients are managed successfully with psychiatric treatment such as selective serotonin-reuptake inhibitor and cognitive behavioral psychotherapy, but more than 10% of patients are remained as non-responder who needs neurosurgical treatments. These patients are potential candidates for the neurosurgical management. There had been various kind of operation, lesioning such as leucotomy or cingulotomy or capsulotomy or limbic leucotomy, and with advent of stereotaxic approach and technical advances, deep brain stimulation was more chosen by neurosurgeon due to its characteristic of reversibility and adjustability. Gamma knife radiosurgery are also applied to make lesion targeting based on magnetic resonance (MR) imaging, but the complication of adverse radiation effect is not predictable. In the neurosurgical field, MR guided focused ultrasound has advantage of less invasiveness, real-time monitored procedure which is now growing to attempt to apply for various brain disorder. In this review, the neurosurgical treatment modalities for the treatment of OCD will be briefly reviewed and the current state of MR guided focused ultrasound for OCD will be suggested.

• 대한약리학회지
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• 제27권2호
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• pp.99-108
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• 1991

Racemic ketamine을 사용하여 개구리의 좌골신경 및 toe muscle에 대한 작용을 관찰하였다. 실험방법으로는 214 mM sucrose을 사용하여 서로 다른 두 종류의 투여 방법으로 세포막의 활동 전압에 대한 영향을 electric recording으로 관찰하였다. 즉, intracellular 투여는 single sucrose gap technique으로, extracellar 투여는 double sucrose gap technique을 사용하였으며 그 실험 결과는 아래와 같았다. 1. Racemic ketamine은 개구리의 좌골신경 및 toe muscle의 활동전압을 intracellular 및 extracellular 투여시 모두 의의 있게 억제하였다. 2. 개구의 toe muscle에서 $K^+$-수축을 억제하였다. 3. naloxone은 ketamine의 억제작용을 완전히 차단하지는 못하였다.

• 한국조경학회지
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• 제32권6호
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• pp.68-81
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• 2005

The styles of contemporary landscape design have diversified since the emergence of Postmodernism in landscape architecture. The diversification was mostly influenced by contemporary fine arts and architecture. This study examines the pluralistic development of Postmodern landscape design through the investigation of the influences from those sister arts. In this point of view, the main approaches of Postmodern landscape design are thought to be classified into three categories;'the formal abstract approach', 'the figurative approach' and 'the new picturesque approach'. The first category of the formal abstract approach was formulated with the concepts and vocabulary of Minimal Art and Installation Art. Its representative icons such as 'point grids' and 'stripes', and the main concepts such as the sense of 'flahess', 'expansion' and 'materiality' are mostly thought to be originated from these art forms. The second category of the figurative approach is characterised by the concepts and vocabulary of Pop Art and New Image Paintings. Its representative icons such as 'map' or 'figurative forms' and main concepts like the sense of 'reality', 'context' and 'symbolism' are mostly thought to be originated from these art forms. The third category of the new picturesque approach was formulated with the concepts and vocabulary of Land Art and Late Deconstructive Architecture. Its representative icons such as 'hybrid', 'layer' and 'fold', and the main concepts such as the sense of 'complexity', 'continuity' and 'reversibility' are thought to be originated from these art forms. The research shows that the main stream of contemporary landscape design seems to be gradually moving toward the second and third approach above, in step with the cultural orientation and the dynamism of contemporary urban life. Therefore, the study focused especially on the new picturesque approach which would be in greater need for coping with the hybrid culture today.

• 정보처리학회논문지B
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• 제17B권4호
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• pp.275-286
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• 2010

디지털 콘텐츠의 원본 품질을 유지할 수 있고 지적 재산권을 보호할 수 있는 가역 워터마킹 기술에 대한 다양한 연구가 진행되고 있다. 특히 원본 품질을 중요시하는 의료, 군사, 예술작품 분야에서 가역 워터마킹의 필요성이 증대되고 있다. 본 논문에서는 추정 오차 확장 및 오류 예측 보정을 통한 고용량 가역 워터마킹 기술을 제안한다. 보간 기법을 사용하여 픽셀의 값을 추정하고, 추정값과 원본값의 차이에 대한 히스토그램을 계산한 후에 이를 확장하여 워터마크 메시지를 삽입한다. 기존의 인접 픽셀 사이의 차이값이 아닌 추정치를 활용함으로써 메시지가 삽입되는 히스토그램 값의 집중도를 높여서 높은 삽입 용량을 달성하였다. 삽입된 워터마크는 추정값과 원본값의 차이에 대한 히스토그램을 복원하여 검출한다. 삽입 후에 발생할 수 있는 오버플로우 및 언더플로우 문제는 오류 예측 기법을 통하여 해결하였다. 제안하는 가역 워터마킹 알고리즘의 성능을 검증하기 위하여 다양한 영상을 활용하여 기존 알고리즘과 비교 분석을 수행하였다. 그 결과에 따르면 제안한 알고리즘은 완전한 가역성을 갖으며, 삽입 후에도 높은 영상 품질을 유지하고, 높은 삽입 용량을 얻을 수 있었다.

• 한국재료학회지
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• 제21권1호
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• pp.21-27
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• 2011

A nano-porous structure of tin oxide was prepared using an anodic oxidation process and the sample's electrochemical properties were evaluated for application as an anode in a rechargeable lithium battery. Microscopic images of the as-anodized sample indicated that it has a nano-porous structure with an average pore size of several tens of nanometers and a pore wall size of about 10 nanometers; the structural/compositional analyses proved that it is amorphous stannous oxide (SnO). The powder form of the as-anodized specimen was satisfactorily lithiated and delithiated as the anode in a lithium battery. Furthermore, it showed high initial reversible capacity and superior rate performance when compared to previous fabrication attempts. Its excellent electrode performance is probably due to the effective alleviation of strain arising from a cycling-induced large volume change and the short diffusion length of lithium through the nano-structured sample. To further enhance the rate performance, the attempt was made to create porous tin oxide film on copper substrate by anodizing the electrodeposited tin. Nevertheless, the full anodization of tin film on a copper substrate led to the mechanical disintegration of the anodic tin oxide, due most likely to the vigorous gas evolution and the surface oxidation of copper substrate. The adhesion of anodic tin oxide to the substrate, together with the initial reversibility and cycling stability, needs to be further improved for its application to high-power electrode materials in lithium batteries.

• 한방안이비인후피부과학회지
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• 제18권1호
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• pp.221-233
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• 2005

Background and Objectives : Despite of high prevalence, Tinnitus remains obscure because the cause and mechanism is poorly understood. In the absence of a suitable animal model, past investigations tool place in humans. Recently, the animal model with sodium salicylate ototoxicity is broadly used because of its reversibility. Balyangtongum-Tang had been used clinically to treat tinnitus and other hearing problems. We investigated the effects of Balyangtongum-Tang on cochlear morphologic change induced by sodium salicylate ototoxicity and were to find out its therapeutic effects on ototoxicity in rat model. Materials and Methods : Healthy ten Sprague-Dawley rats were divided into normal(2), control(4) and sample(4) groups. The sample group was given extract of Balyangtongum - Tang(1cc/100g) once a day for 4 days. After 3 hours when last medication were given, the sample and control groups were injected intraperitoneally with sodium salicylate(500mg/kg). We observed the cochlear morphologic changes of rats every 1, 2, 3 and 5 hours after injection. Results : The electron microscopic finding of outer hair cell shows some changes in the curticular plate and cytoplasm. Some vacuoles were found in the control and sample groups. Vacuolization in the curticular plate and cytoplasm of the sample group after 3, 5 hours were similar to the control group. But the curticular plate of the sample group after 1, 2 hours did not from vacuole. On the other hand the control group after 1, 2 hours formed vacuoles in the curticular plate. Light microscopic findings of cochlear duct in control and sample groups didn't find any difference. Conclusion : The results suggest that extract of Balyangtongum-Tang reduces the morphologic changes induced by sodium salicylate ototoxicity and the effects are remarkable in frist 2 hours. However the effective times are different with previous studies, it seems to due to the difference of tolerance and sensitivity of laboratory animals.

• 전기화학회지
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• 제21권1호
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• pp.1-5
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• 2018

본 연구에서는 수소화 붕소 나트륨 ($NaBH_4$)를 이용하여 고온에서 이산화탄소 ($CO_2$)를 환원시켜 붕소가 도핑된 카본을 제조하였고, 이를 카본 펠트에 코팅하여 바나듐 레독스 흐름전지용 전극으로 적용하였다. 전기화학적 성능 평가 결과, 순수 카본펠트 대비 붕소 도핑된 카본으로 코팅된 카본펠트의 가역성이 약 20% 향상되었고 전하 전달 저항이 60% 감소하였다. 충/방전 결과에서는, 에너지 밀도와 에너지 효율이 각각 21%와 12.4% 향상되었다. 이러한 결과는 $CO_2$를 환원시켜 제조한 탄소가 레독스 흐름전지용 전극소재로 사용될 수 있는 가능성을 보여준다.

• 한국정보통신학회논문지
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• 제7권3호
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• pp.532-543
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• 2003

본 논문은 저작권보호를 위해 디지털영상의 라벨링을 위한 reversible DTCNN(discrete-time cellular neural network) 구조를 제안한다. 이러한 저작권보호 라벨링을 위해서 2차원 이진 pseudo 랜덤 영상열에 사용할 수 있는 새로운 reversible DTCNN의 구조와 개념을 설명하고 이에 대한 복잡행위를 보여주기 위해 reversible DTCNN의 서로 다른 방법들의 예시를 들어 설명한다. 또한 서로 다른 2진영상인 원영상과 복사된 영상은 서로 다른 2진 랜덤 영상키를 사용한다. 이 영상키는 원영상을 스크램블하는데 사용된다. 따라서 reversible DTCNN를 다시 역변환시켜서 저작권보호가 라벨링된 영상으로부터 복사된 영상임을 찾아낼 수 있다. 그러나 이러한 동영상을 처리하는 데는 S/W에서는 많은 시간이 소요되므로 고속 DTCNN 칩을 사용하여 실시간에서 동영상이나 비디오영상을 저작권보호를 위한 라벨링에 사용할 수 있으며, 이러한 결과를 컴퓨터에서 시뮬레이션됨을 보인다.

• 한국한의학연구원논문집
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• 제18권1호
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• pp.85-92
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• 2012

Objective : The purpose of this study was to investigate the anti-cancer effects of Sophorae Radix and the effects of 5-Fluorouracil (5-FU) in human gastric adenocarcinoma cells (AGS). Method : We used human gastric adenocarcinoma cell line, AGS cells. We examined cell death by MTT assay and caspase 3 assay with Sophorae Radix. To examine the inhibitory effects of Sophorae Radix, cell cycle (sub G1) analysis was done the AGS cells after three days with Sophorae Radix. The reversibility of Sophorae Radix was examined on one day to five days treatment with 100 ${\mu}g/ml$ Sophorae Radix. Result : Sophorae Radix inhibited the growth of AGS cells in a dose-dependent fashion. Also we showed that Sophorae Radix induced apoptosis in AGS cells by MTT assay, caspase 3 assay and sub-G1 analysis. Sophorae Radix combined with 5-FU markedly inhibited the growth of AGS cells compared to Sophorae Radix or 5-FU alone. After 3 days treatment of AGS cells with Sophorae Radix, the fraction of cells in sub-G1 phase was much higher than that of the control group. Conclusion : Our findings provide insight into unraveling the effects of Sophorae Radix in human gastric adenocarcinoma cells and developing therapeutic agents against gastric cancer.