• Molecules and Cells
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• v.43 no.2
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• pp.182-187
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• 2020

When cells are stimulated by growth factors, they make a critical choice in early G₁ phase: proceed forward to S phase, remain in G₁, or revert to G₀ phase. Once the critical decision is made, cells execute a fixed program independently of extracellular signals. The specific stage at which the critical decision is made is called the restriction point or R-point. The existence of the R-point raises a major question: what is the nature of the molecular machinery that decides whether or not a cell in G₁ will continue to advance through the cell cycle or exit from the cell cycle? The R-point program is perturbed in nearly all cancer cells. Therefore, exploring the nature of the R-point decision-making machinery will provide insight into how cells consult extracellular signals and intracellular status to make an appropriate R-point decision, as well into the development of cancers. Recent studies have shown that expression of a number of immediate early genes is associated with the R-point decision, and that the decision-making program constitutes an oncogene surveillance mechanism. In this review, we briefly summarize recent findings regarding the mechanisms underlying the context-dependent R-point decision.

• Molecules and Cells
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• v.42 no.12
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• pp.836-839
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• 2019

A tumor is an abnormal mass of tissue that arises when cells divide more than they should or do not die when they should. The cellular decision regarding whether to undergo division or death is made at the restriction (R)-point. Consistent with this, an increasingly large body of evidence indicates that deregulation of the R-point decision-making machinery accompanies the formation of most tumors. Although the R-point decision is literally a matter of life and death for the cell, and thus critical for the health of the organism, it remains unclear how a cell chooses its own fate. Recent work demonstrated that the R-point constitutes a novel oncogene surveillance mechanism operated by R-point-associated complexes of which RUNX3 and BRD2 are the core factors (Rpa-RX3 complexes). Here, we show that not only RUNX3 and BRD2, but also other members of the RUNX and BRD families (RUNX1, RUNX2, BRD3, and BRD4), are involved in R-point regulation.

• Journal of Environmental Science International
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• v.18 no.4
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• pp.389-400
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• 2009

In this research, we measured the number of lanes, distance, disposition of apartment that are affecting the road traffic noise to evaluate the current condition of G city's road traffic noise. We decide on a basis regarding an apartment price formation factor, and the apartment current price and the results that compared. To have a point scale, we set the maximum road traffic noise at a 8 lane road for 5 points, give 4 points for a 6 lane road, which has a $2.1{\sim}2.5\;dB(A)$ difference compared to a 8 lane road, give 3 points for a 4 lane road, which has a $5.2{\sim}5.5\;dB(A)$ difference compared to a 8 lane road, and set 2 points for a 2 lane road and lower. If we set the standard floor plan as horizontal and a living room facing the roadside, the horizontal and living room facing the opposite side of the road is 1 point because it differs by 14.1 dB(A), and the vertical is 3 points since the difference is 5.3 dB(A). If we make grades by the distance, making standard the fifth floor with little soundproof effect from apartment to road, we observe a measurement below 2.9 dB(A) at a distance of less than 10 m and 5 dB(A), decreased at a distance of 20 m. Therefore, 4 points were given for less than 10m, 3 points for $10{\sim}20\;m$, 2 points for more than 20 m as we can apply the effect of a decay distance of line sound source and the decrease in noise effects of more than 6 dB(A), 1 point for more than 40m, and 0 points for more that 80 m since it is negligible. 28 apartments got 0 points because there is no effect of road traffic noise from other apartments, and 50 apartments where only the road at one side effect them got $5{\sim}10$ points. 4 apartments (17-2, 6-3, 10-4, 3-3) received over 20 points. 15 cases showed a difference between developer price and resale price, and 11 cases (73%) among them showed the same trend (price increases with a low road traffic noise restriction factor point) with the point of road traffic noise restriction factor. 4 cases demonstrated the opposite trend, showing price increases with a high restriction factor point. Among the 4 cases, case numbers 2,6 and 9 appear to be more affected by the location factor (business district) than the road traffic noise restriction factor, and case number 1 appears to be affected by the building factor (openness and direction).

• Communications for Statistical Applications and Methods
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• v.12 no.1
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• pp.47-59
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• 2005

Expected mean square(EMS) is an important part of conducting the analysis of variance in the experimental design problem, especially in mixed or random models. We present a set of EMS rules for balanced factorial designs under no restriction on interaction. Also we point out how to use the variance component of SPSS or SAS procedure to obtain EMS.

• International Journal of Contents
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• v.10 no.4
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• pp.69-74
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• 2014

General location aware systems are only applied to indoor and outdoor environments using more than three transmitters to estimate a fixed object location. Those kinds of systems have environmental restrictions that require an already established infrastructure. To solve this problem, an Object Location Estimation (OLE) algorithm based on PTP (Point To Point) communication has been proposed. However, the problem with this method is that deduction of performance parameters is not enough and location estimation is very difficult because of unknown restriction conditions. From experimental tests in this research, we determined that the performance parameters for restriction conditions are a maximum transmission distance of CSS communication and an optimum moving distance interval between personal locations. In this paper, a system applied OLE algorithm based on PTP communication is implemented using a CSS (Chirp Spread Spectrum) communication module. A maximum transmission distance for CSS communication and an optimum moving distance interval between personal locations are then deducted and studied to estimate a fixed object location for generalization.

• Journal of Nutrition and Health
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• v.6 no.3
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• pp.1-8
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• 1973

Metabolic responses to the protein-free, high-carbohydrate diet and subsequent food restriction on the same diet at the level of 50% and 75% has been studied on the adult albino rats. The energy source was either corn starch or sugar. In experiment I, adult male rats weighing $509{\pm}8g$ were divided into two groups 10 rats each. Rats fed on the stock diet served as a control. Rats of restriction group received a protein free diet until they reduced their weight down to 400g and continue on a protein-calorie restriction diet until they reduced their weight down to 300g. In experiment II, 28 adult male rats and the same numbers of female rats weighing $329{\pm}5g$ and $223{\pm}4g$ respectively were divided into four groups, 7 males and females in each. Rats fed on a stock diet were sacrificed at the point when others started a protein free diet. These were served as the control. The protein free group received a protein free diet ad libitum for 4 weeks. The 50% restriction group and 75% restriction group were fed on a protein free diet coupled with food restriction at levels of 50% and 75% respectively for 3 weeks. In the result of this study: 1. The rate of body weight changes was similar between the males and the females. Feeding protein free diet ad lib. initiated a rapid weight lost of approximately 25% and protein free diet coupled with food restriction showed 37-43% reduction of their initial weight. 2. There was no significant differences in the value of the N concentration in liver, spleen, brain and muscle between controls and experimental groups. 3. Rats fed on protein free diet showed 1/10 value of the control in the nitrogen excretion in urine. However female showed less N excretion than male. 4. Observing blood picture, the effects of protein depletion and calorie restriction were not appeared any remarkable changes. 5. There was no sign of fatty liver which might result from protein depletion and calorie restriction. 6. Following semi-starvation, FAO and HMP-DH total enzyme activity was reduced, but activity per unit weight was relatively stable.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.13 no.22
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• pp.87-98
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• 1990

The performance analysis and capacity planning of Service Control Point which is real time response system is studied. The system is modeled by multiclass open queueing network. The analytical method is used to solve the queueing network. The solution of the model has product form solution. The focus of this paper is to investigate the capacity of system under the restriction of response time. To get the reasonable capacities, nonlinear programming problem is formulated and is solved by GINO. And the simulation model using SLAM II is formulated.

• Journal of the Korean Mathematical Society
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• v.46 no.1
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• pp.151-170
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• 2009

Let m be a positive integer. We show that for any given real number ${\alpha}\;{\in}\;[0,\;1]$ and complex number $\mu$ with $|\mu|{\leq}1$ which satisfy $e^{2{\pi}i{\alpha}}{\mu}^m\;{\neq}\;1$, there exists a Blaschke product B of degree 2m + 1 which has a fixed point of multiplier ${\mu}^m$ at the point at infinity such that the restriction of the Blaschke product B on the unit circle is a critical circle map with rotation number $\alpha$. Moreover if the given real number $\alpha$ is irrational of bounded type, then a modified Blaschke product of B is quasiconformally conjugate to some rational function of degree m + 1 which has a fixed point of multiplier ${\mu}^m$ at the point at infinity and a Siegel disk whose boundary is a quasicircle containing its critical point.

• Journal of the Korean Operations Research and Management Science Society
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• v.34 no.1
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• pp.29-37
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• 2009

This paper proposes a curtailed-sequential probability ratio test (SPRT) control chart. For using the conventional SPRT control chart, the number of items inspected in a sampling point should have no restriction since items in a sampling point are inspected one by one until an SPRT Is terminated. The number of observations taken in a sampling point, however, has an upper bound since sampling and testing of an item is time-consuming or expensive. When the sample size reaches the upper bound without evidence of an in-control or out-of-control state of a process, the proposed chart makes a decision using the sample mean of all observations taken in a sampling point. The properties of the Proposed chart are obtained by a Markov chain approach and the performance of the chart is compared with fixed sample size (FSS) and variable sample size (VSS) control charts. A comparative study shows that the proposed chart performs better than VSS control charts as well as conventional FSS control charts.

• Journal of Mechanical Science and Technology
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• v.17 no.1
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• pp.77-84
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• 2003

Virtual work in multibody systems is frequently expressed as the inner product of the virtual displacement and the resultant force at the centroid. But provided that the resultant force is converted into the equipollent forces there is no restriction on where the analysis reference point is placed. There are basically three candidate points : the centroid, joint point and the instant global origin. The traditional fully recursive formulation uses the centroid, but the present work verifies that the instant global origin always shows better efficiency (e.g. 86% CPU time of the centroid for quarter car model) and joint point shows the efficiency between that of the centroid and the instant global origin. A discussion on how important it is to define the analysis reference point properly in a fully recursive formulation is also presented.