• Title/Summary/Keyword: response generation

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The Mucosal Immune System for the Development of New Generation Vaccine

  • Yuki, Yoshikazu;Kiyono, Hiroshi
    • Proceedings of the Korean Society for Applied Microbiology Conference
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    • 2003.06a
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    • pp.55-62
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    • 2003
  • The mucosal immune system provides a first line of defense against invasion of infectious agents via inhalation, ingestion and sexual contact. For the induction of protective immunity at these invasion sites, one must consider the use of the CMIS, which interconnects inductive tissues, including PP and NALT, and effector tissues of the intestinal, respiratory and genitourinary tracts. In order for the CMIS to induce maximal protective mucosal immunity, co-administration of mucosal adjuvant or use of mucosal antigen delivery vehicle has been shown to be essential. When vaccine antigen is administered via oral or nasal route, antigen-specific Th 1 and Th2 cells, cytotoxic T lymphocytes(CTLs) and IgA B cell responses are effectively induced by the CMIS. In the early stages of induction of mucosal immune response, the uptake of orally or nasally administered antigens is achieved through a unique set of antigen-sampling cells, M cells located in follicle-associated epithelium(FAE) of inductive sites. After successful uptake, the antigens are immediately processed and presented by the underlying DCs for the generation of antigen-specific T cells and IgA committed B cells. These antigen-specific lymphocytes are then home to the distant mucosal effector tissues for the induction of antigen-specific humoral(e.g., IgA) and cell-mediated (e.g., CTL and Th1) immune responses in order to form the first line of defense. Elucidation of the molecular/cellular characteristics of the immunological sequence of mucosal immune response beginning from the antigen sampling and processing/presentation by M cells and mucosal DCs followed by the effector phase with antigen-specific lymphocytes will greatly facilitate the design of a new generation of effective mucosal antigen-specific lymphocytes will greatly facilitate the design of a new generation of a new generation of effective mucosal adjuvants and of a vaccine deliver vehicle that maximizes the use of the CMIS.

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Evaluation of Response Spectrum Shape Effect on Seismic Fragility of NPP Component (스펙트럼 형상이 원전 기기 지진취약도에 미치는 영향 평가)

  • 최인길;서정문;전영선;이종림
    • Journal of the Earthquake Engineering Society of Korea
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    • v.7 no.4
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    • pp.23-30
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    • 2003
  • The result of recent seismic hazard analysis indicates that the ground motion response spectra for Korean nuclear power plant site have relatively large frequency acceleration contents. In the ordinary seismic fragility analysis of nuclear power plant structures and equipments, the safety margin of design ground response spectrum is directly used as a response spectrum shape factor. The effects of input response spectrum shape on the floor response spectrum were investigated by performing the direct generation of floor response spectrum from the ground response spectrum. The safety margin included in the design ground response spectrum should be considered as a floor response spectrum shape factor for the seismic fragility analysis of the equipments located in a building.

Application of wavelet multiresolution analysis and artificial intelligence for generation of artificial earthquake accelerograms

  • Amiri, G. Ghodrati;Bagheri, A.
    • Structural Engineering and Mechanics
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    • v.28 no.2
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    • pp.153-166
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    • 2008
  • This paper suggests the use of wavelet multiresolution analysis (WMRA) and neural network for generation of artificial earthquake accelerograms from target spectrum. This procedure uses the learning capabilities of radial basis function (RBF) neural network to expand the knowledge of the inverse mapping from response spectrum to earthquake accelerogram. In the first step, WMRA is used to decompose earthquake accelerograms to several levels that each level covers a special range of frequencies, and then for every level a RBF neural network is trained to learn to relate the response spectrum to wavelet coefficients. Finally the generated accelerogram using inverse discrete wavelet transform is obtained. An example is presented to demonstrate the effectiveness of the method.

Bi-directional DC-DC Converter Design and Control for Fuel Cell System (연료전지 시스템용 양방향 DC-DC컨버터 설계 및 제어)

  • Kim Sung Ho;Jang Han Keun;Jang Su Jin;Won Chung Yuen;Kim yoon ho
    • Proceedings of the KIPE Conference
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    • 2004.07b
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    • pp.479-483
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    • 2004
  • Fuel Cell (FC) has slow response characteristic for load variation. During a load step, the inverter cannot pull more power from the fuel cell than is currently available so supplemental power must be provide by some sort of energy storage elements. In this paper, hi-directional do-dc converter for FC generation system is proposed to improve load response characteristic. The hi-directional converter interfaces the low voltage battery to the inverter dc link of FC generation system. The converter is based on a active full bridge in the primary side and on a half bridge in the secondary of a high frequency isolation transformer. The complete operating principles and simulation results in presented.

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Neural network-based generation of artificial spatially variable earthquakes ground motions

  • Ghaffarzadeh, Hossein;Izadi, Mohammad Mahdi;Talebian, Nima
    • Earthquakes and Structures
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    • v.4 no.5
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    • pp.509-525
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    • 2013
  • In this paper, learning capabilities of two types of Arterial Neural Networks, namely hierarchical neural networks and Generalized Regression Neural Network were used in a two-stage approach to develop a method for generating spatial varying accelerograms from acceleration response spectra and a distance parameter in which generated accelerogram is desired. Data collected from closely spaced arrays of seismographs in SMART-1 array were used to train neural networks. The generated accelerograms from the proposed method can be used for multiple support excitations analysis of structures that their supports undergo different motions during an earthquake.

Harmonic Generation and System Response Chartcteristics in Electrified Railway(II) - Focused on Measurement and Analysis - (전기철도에서의 고조파 발생과 계통응답특성(II) - 고조파 측정분석을 중심으로 -)

  • Oh Kwang-Hae;Lee Han-Min
    • Proceedings of the KSR Conference
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    • 2003.05a
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    • pp.499-504
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    • 2003
  • Harmonic current originating from electric locomotives can be magnified due to the impedance characteristics of power supply circuit and bring about various problems. That is, electromagnetic interference with communication lines, operational trouble in signaling, overheat and/or vibration in power capacitor, mis-operation in protection relay and so on. Therefore, the exact assessment of the harmonic current flow must be undertaken at design and planning stage for the electric traction systems. For these reasons, this study propose a new approach to model and to analyse traction power feeding system focused on system response to current and voltage harmonic(PART I ). Measurements of harmonics are also performed for railway power supply systems under normal operation. Spectrum and distortion analyses in measurement data are variously described in PART II

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Harmonic Generation and System Response Characteristics in Electrified Railway(II) - Focused on Measurement and Analysis - (전기철도에서의 고조파 발생과 계통응답특성(II) - 고조파 측정분석을 중심으로 -)

  • 오광해;이한민
    • Journal of the Korean Society for Railway
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    • v.7 no.1
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    • pp.65-69
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    • 2004
  • In reference to this study, Part Ⅰ showed how the system respond to the harmonics originated from electric locomotives. That is, the system response to the harmonics was derived by computational algorithm with numerical formulas in theoretical aspects. However, Real catenary system has complex configuration of conductors and it is an important point that if we can consider the circuit element of catenary conductors as an uniformly distributed RLC element. Moreover, harmonic characteristics in electric locomotive depend on its operational modes. From these point of view, measurements of harmonics are performed for real railway power supply systems under the various operational modes, and spectrum and distortion analyses in measurement data are described.

A Study on the Participation of Virtual Power Plant Based Technology Utilizing Distributed Generation Resources in Electricity Market (분산발전자원을 활용한 가상발전소 기반 기술의 전력시장 참여 방안에 대한 연구)

  • Lee, Yun-Hwan
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.65 no.2
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    • pp.94-100
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    • 2016
  • A virtual power plant (VPP) technology is a cluster of distributed generation installations. VPP system is that integrates several types of distributed generation sources, so as to give a reliable overall power supply. Virtual power plant systems play a key role in the smart grids concept and the move towards alternative sources of energy. They ensure improved integration of the renewable energy generation into the grids and the electricity market. VPPs not only deal with the supply side, but also help manage demand and ensure reliability of grid functions through demand response (DR) and other load shifting approaches in real time. In this paper, utilizing a variety of distributed generation resources(such as emergency generator, commercial generator, energy storage device), activation scheme of the virtual power plant technology. In addition, through the analysis of the domestic electricity market, it describes a scheme that can be a virtual power plant to participate in electricity market. It attempts to derive the policy support recommendation in order to obtain the basics to the prepared in position of power generation companies for the commercialization of virtual power plant.

In-Cabinet Response Spectrum Generation Using Frequency Domain Analysis Method (진동수영역해석법을 이용한 캐비닛내부응답스펙트럼 생성 기법)

  • Cho, Sung Gook;So, Gihwan
    • Journal of the Earthquake Engineering Society of Korea
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    • v.24 no.2
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    • pp.103-110
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    • 2020
  • Seismic qualification of instruments and devices mounted on electrical cabinets in a nuclear power plant is performed in this study by means of the in-cabinet response spectrum (ICRS). A simple method and two rigorous methods are proposed in the EPRI NP-7146-SL guidelines for generating the ICRS. The simple method of EPRI can give unrealistic spectra that are excessively conservative in many cases. In the past, the time domain analysis (TDA) methods have been mostly used to analyze a structure. However, the TDA requires the generation of an artificial earthquake input motion compatible to the target response spectrum. The process of generating an artificial earthquake may involve a great deal of uncertainty. In addition, many time history analyses should be performed to increase the accuracy of the results. This study developed a numerical analysis program for generating the ICRS by frequency domain analysis (FDA) method. The developed program was validated by the numerical study. The ICRS calculated by FDA thoroughly matched with those obtained from TDA. This study then confirms that the method it proposes can simply and efficiently generate the ICRS compared to the time domain method.

The Effects of Components of Social Information Processing and Emotional Factors on Preschoolers' Overt and Relational Aggression (사회정보처리 구성요소와 정서요인이 유아의 외현적 공격성과 관계적 공격성에 미치는 영향)

  • Choi, In-Suk;Lee, Kang-Yi
    • Korean Journal of Child Studies
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    • v.31 no.6
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    • pp.15-34
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    • 2010
  • The present study examines the sex differences in 5-year-old preschoolers' aggression according to the type of aggression (overt, relational) and the effect of components of social information processing (SIP : interpretation, goal clarification, response generation, response evaluation) and emotional factors (emotionality, emotional knowledge, emotion regulation) on their aggression. The subjects were 112 5-year-olds (56 boys, 56 girls) and their 11 teachers recruited from 9 day-care centers in Seoul and Kyung-Ki province. Each child's SIP and emotional knowledge were individually assessed with pictorial tasks and teachers reported on children's aggression, emotionality, and emotion regulation by questionnaires. Results indicated that there was a significant sex difference only in the preschoolers' overt aggression. Overtly aggressive response generation in SIP was the strongest predictor of preschoolers' overt aggression while anger of negative emotionality in emotional factors was the strongest predictor of preschoolers' relational aggression.