• Geomechanics and Engineering
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• 제20권5호
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• pp.399-410
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• 2020

Cavities often develop behind the vault during the construction of double-arch tunnels, generally in the form of various defects. The study evaluates the impact of cavities behind the vault on the mechanical and failure behaviors of double-arch tunnels. Cavities of the same sizes are introduced at the vault and the shoulder close to the central wall of double-arch tunnels. Physical model tests are performed to investigate the liner stress variation, the earth pressure distribution and the process of progressive failure. Results reveal that the presence of cavities behind the liner causes the re-distribution of the earth pressure and induces stress concentration near the boundaries of cavities, which results in the bending moments in the liner inside the cavity to reverse sign from compression to tension. The liner near the invert becomes the weak region and stress concentration points are created in the outer fiber of the liner at the bottom of the sidewall and central wall. It is suggested that grouting into the foundation soils and backfilling injection should be carried out to ensure the tunnel safety. Changes in the location of cavities significantly impact the failure pattern of the liner close to the vault, e.g., cracks appear in the outer fiber of the liner inside the cavity when a cavity is located at the shoulder close to the central wall, which is different from the case that the cavity locates at the vault, whereas changes in the location of cavities have a little influence on the liner at the bottom of the double-arch tunnels.

• 대한간호학회지
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• 제29권6호
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• pp.1355-1364
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• 1999

Mother and infant relationship has a great influence on child's developments. In this study, nursing intervention to increase maternal sensitivity to the infant's cues was applied to 25 primiparas (Experimental Group). Mother and infant interacations of these primiparas were compared with those of 25 primiparas (Control Group) who did not receive the nursing intervention. Fifty primiparas and infants were recruited from a university hospital, a general hospital, and an OBGY clinic located in Taegu city. Mother and infant interactions were assessed at 6 weeks after birth using videotapes. Feeding situations were videotaped and two trained observers analyzed the tapes. Data were collected from March 23rd to July 27th of 1998. Mother and infant interactions during feeding were assessed by the response rating scale which was modified by the author based on NCAST feeding scale (Barnard, 1978a) and AMIS scale (Price, 1983). The validity of the modified rating scale was verified by faculty members and researchers who previously had research experience in the area. Cronbach's Alpha of the modified scale for this study was .90. The data was analyzed by SAS program, using wilcoxon rank sums test, chi square test, Fisher's exact test, and ANOVA. Findings were as follows: 1. Mothers in the experimental group were more likely to have higher scores in mother and infant interactions during feeding than mothers in the control group. 2. Mothers in the experimental group showed better sensitivity to infant's signals or cues, provided growth fostering, and had higher responsibility to the infant's distress than mothers in the control group. 3. Infants in the experimental group showed higher clarity of cues and responsibility to the mother's behaviors than infants in the control group. 4. Mothers and infants in the experimental group showed higher synchronic responses than mothers and infants in the control group. In conclusion, this study has shown that the applied nursing intervention promoted mother and infant interaction among primiparas. Therefore, this study suggests that the nursing interventions to increase maternal sensitivity to the infant's cues should be broadly applied to primiparas, which can be beneficial to the social, affective, and cognitive developments of their children.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2010년도 제39회 하계학술대회 초록집
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• pp.259-259
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• 2010

Periodically polarity inverted (PPI) ZnO structures on (0001) Al2O3 substrates are demonstrated by plasmas assisted molecular beam epitaxy. The patterning and re-growth methods are used to realize the PPI ZnO by employing the polarity controlling method. For the in-situ polarity controlling of ZnO films, Cr-compound buffer layers are used.[1, 2] The region with the CrN intermediate layer and the region with the Cr2O3 and Al2O3 substrate were used to grow the Zn- and O-polar ZnO films, respectively. The growth behaviors with anisotropic properties of PPI ZnO heterostructures are investigated. The periodical polarity inversion is evaluated by contrast images of piezo-response microscopy. Structural and optical interface properties of PPI ZnO are investigated by the transmission electron microcopy (TEM) and micro photoluminescence ($\mu$-PL). The inversion domain boundaries (IDBs) between the Zn and the O-polar ZnO regions were clearly observed by TEM. Moreover, the investigation of spatially resolved local photoluminescence characteristics of PPI ZnO revealed stronger excitonic emission at the interfacial region with the IDBs compared to the Zn-polar or the O-polar ZnO region. The possible mechanisms will be discussed with the consideration of the atomic configuration, carrier life time, and geometrical effects. The successful realization of PPI structures with nanometer scale period indicates the possibility for the application to the photonic band-gap structures or waveguide fabrication. The details of application and results will be discussed.

• 한국재료학회지
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• 제20권5호
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• pp.235-240
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• 2010

We investigated the carbon monoxide (CO) gas-sensing properties of nanostructured Al-doped zinc oxide thin films deposited on self-assembled Au nanodots (ZnO/Au thin films). The Al-doped ZnO thin film was deposited onto the structure by rf sputtering, resulting in a gas-sensing element comprising a ZnO-based active layer with an embedded Pt/Ti electrode covered by the self-assembled Au nanodots. Prior to the growth of the active ZnO layer, the Au nanodots were formed via annealing a thin Au layer with a thickness of 2 nm at a moderate temperature of $500^{\circ}C$. It was found that the ZnO/Au nanostructured thin film gas sensors showed a high maximum sensitivity to CO gas at $250^{\circ}C$ and a low CO detection limit of 5 ppm in dry air. Furthermore, the ZnO/Au thin film CO gas sensors exhibited fast response and recovery behaviors. The observed excellent CO gas-sensing properties of the nanostructured ZnO/Au thin films can be ascribed to the Au nanodots, acting as both a nucleation layer for the formation of the ZnO nanostructure and a catalyst in the CO surface reaction. These results suggest that the ZnO thin films deposited on self-assembled Au nanodots are promising for practical high-performance CO gas sensors.

• KIEAE Journal
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• 제11권6호
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• pp.109-115
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• 2011

Recently the Elderly with dementia is increasing in Korea with rapid aging of the population. In addition to increasing a number of nuclear family and women's advancement in society, people are less capable of supporting family with dementia. In response, the Seoul city increased welfare facilities for the elderly with dementia about two times for one year. I think that the quantitative portion of facility get to meet the requirements but it is lack of qualitative one in fact. Therefore, the space for the elderly can keep up with the falloff of mental and physical functions, dementia and geriatric diseases according to aging and careful consideration about the space considering stability and convenience is required. At this point, this study has the purpose to plan a daycare center which reflects the characteristics of the elderly to protect them within the community safely and comfortably. As for the research method, case study was conducted to understand the overall situation on the space plan of the daycare center for 3 daycare centers located in Seoul and found out problems. From the generalization of the above study, a space plan for a daycare center considering the characteristics of the elderly was provided. The composition of Dementia welfare facility should be carefully planned to fit characteristics of the patient's behaviors.

• 정보처리학회논문지A
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• 제19A권2호
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• pp.101-112
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• 2012

최근에 분산 실시간 소프트웨어가 다양한 분야에서 중요한 역할을 담당하고 있다. 실시간 소프트웨어는 반응 시간에 대한 시간제약성을 만족하여야 함으로 TMO(Time-triggered, Message-triggered Object), CORBA/RT, RTAI 등과 같은 미들웨어를 이용하여야 한다. 하지만 이러한 실시간 미들웨어에 친숙하지 않은 프로그래머들은 실시간 소프트웨어 개발에 어려움이 있다. 이 연구에서는 이러한 미들웨어에 대한 전문지식 없이도 실시간 소프트웨어 개발이 가능하도록 TMO 기반의 자동 코드 생성 도구를 제안하고자 한다. TMO 특성을 설계 모델에 반영하기 위해, 시간제약사항을 포함하는 SpM과 SvM 메소드를 클래스 다이어그램에 추가하고 상태 머신 다이어그램의 독립 영역으로 분할하여 이들의 행위를 표현한다. TMO 기반 코드 생성기는 이러한 모델 정보를 입력받아서 TMO 클래스 코드를 생성한다. 이러한 자동생성 접근 방법은 TMO에 대한 전문지식이 없더라도 실시간 소프트웨어를 생성할 수 있어, 소프트웨어 개발에 소요되는 비용과 시간을 줄이는 장점이 있다.

• The Korean Journal of Physiology and Pharmacology
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• 제22권5호
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• pp.525-538
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• 2018

Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported pharmacological properties of tetramethylpyrazine (TMP) include anti-cancer, anti-diabetic, anti-atherosclerotic, and neuropsychiatric activities. However, the anxiolytic-like effects of TMP and its mechanism of action in PTSD are unclear. This study measured several anxiety-related behavioral responses to examine the effects of TMP on symptoms of anxiety in rats after single prolonged stress (SPS) exposure by reversing the serotonin (5-HT) and hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Rats were given TMP (10, 20, or 40 mg/kg, i.p.) for 14 days after SPS exposure. Administration of TMP significantly reduced grooming behavior, increased the time spent and number of visits to the open arm in the elevated plus maze test, and significantly increased the number of central zone crossings in the open field test. TMP administration significantly reduced the freezing response to contextual fear conditioning and significantly restored the neurochemical abnormalities and the SPS-induced decrease in 5-HT tissue levels in the prefrontal cortex and hippocampus. The increased 5-HT concentration during TMP treatment might be partially attribute to the tryptophan and 5-hydroxyindoleacetic acid mRNA level expression in the hippocampus of rats with PTSD. These findings support a role for reducing the altered serotonergic transmission in rats with PTSD. TMP simultaneously attenuated the HPA axis dysfunction. Therefore, TMP may be useful for developing an agent for treating psychiatric disorders, such those observed in patients with PTSD.

• Biomolecules & Therapeutics
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• 제19권1호
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• pp.45-51
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• 2011

These experiments were designed to use typical makers from behaviors and molecular basis in addicted animals of morphine and cocaine. Morphine has been widely abused with a high physical dependence liability. Morphine withdrawal activates the intracellular cAMP signaling pathway and further leads to changes in the expression of the cAMP response element binding protein (CREB), which may be important to the development and expression of morphine dependence. From these experiments, repeated morphine (10 mg/kg, twice per day for 7 days) developed physical dependence. Withdrawal signs were precipitated by naloxone and also increased the expression of the CREB. In addition, repeated exposure of cocaine (15 mg/kg) to mice develops locomotor sensitization and produced lasting behavioral sensitivity. Cocaine- and amphetamine-regulated transcript peptide (CART) peptide was up-regulated by repeated administration of cocaine in the striatum. Therefore, repeated morphine induced the development of physical dependence and increased pCREB. In addition, repeated cocaine induced locomotor sensitization and over-expressed CART peptide. In conclusion, the development of physical dependence and pCREB for morphine, and locomotor sensitization and CART peptide over-expression for cocaine would be useful markers to predict the abuse potential of opioid analgesics and pychostimulant drugs in animals, respectively.

• 한국강구조학회 논문집
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• 제28권2호
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• pp.65-74
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• 2016

본 연구는 폭발하중을 받는 보강판으로 구성된 방폭벽 구조에 대하여 유한요소 동적해석을 수행하였다. 수치 시뮬레이션은 서로 다른 재료로 구성된 경우에 대하여 비교 검증하였으며, 폭발 시뮬레이션 데이터를 기반으로 폭발하중에 대한 방폭벽의 동적거동을 상세 규명하였다. 충격흡수력이 좋은 고망간 강재로 구성된 방폭벽의 경우 충격에 대한 성능이 상대적으로 우수한 것으로 나타났다. 본 연구에서는 LS-DYNA 프로그램을 적용하여 유한요소 충격해석을 수행하였으며, 고속 변형률 속도 효과를 추가로 고려하여 고망간 강재로 보강된 방폭벽에 대하여 확장하였다. 다양한 매개변수를 적용한 수치해석 결과는 폭발 시뮬레이션으로부터 보강된 방폭벽 구조의 동적 효과를 비교 분석하여 서로 다른 재료의 적용효과를 보여준다.

• Biomolecules & Therapeutics
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• 제22권3호
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• pp.213-222
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• 2014

Abnormal adaptation of the stress-response system following traumatic stress can lead to alterations in the hypothalamic-pituitaryadrenal (HPA) axis that may contribute to the development of post-traumatic stress disorder (PTSD). The present study used several behavioral tests to investigate the anxiolytic-like and antidepressant activity of L-tetrahydropalmatine (L-THP) in an experimental rat model of anxiety and depression induced by single prolonged stress (SPS), an animal model of PTSD. Male rats were treated intraperitoneally (i.p.) with vehicle or varied doses of THP 30 min prior to SPS for 8 consecutive days. Daily THP (50 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index, increased the risk assessment, and increased the number of head dips over the borders of the open arms after SPS. THP was also associated with increased time spent at the center of the open field, reduced grooming behaviors in the EPM test, and reduced time spent immobile in the forced swimming test (FST). It also blocked the decrease in neuropeptide Y (NPY) and the increase in corticotrophin-releasing factor (CRF) expression in the hypothalamus. This is the first study to determine that THP exerts pronounced anxiolytic-like and antidepressant effects on the development of the behavioral and biochemical symptoms associated with PTSD, indicating its prophylactic potential. Thus, THP reversed several behavioral impairments triggered by the traumatic stress of SPS and is a potential non-invasive therapeutic intervention for PTSD.