Browse > Article
http://dx.doi.org/10.4062/biomolther.2014.032

L-Tetrahydropalmatine Ameliorates Development of Anxiety and Depression-Related Symptoms Induced by Single Prolonged Stress in Rats  

Lee, Bombi (Acupuncture and Meridian Science Research Center)
Sur, Bongjun (Graduate School of Basic Science of Korean Medicine, College of Korean Medicine, Kyung Hee University)
Yeom, Mijung (Acupuncture and Meridian Science Research Center)
Shim, Insop (Acupuncture and Meridian Science Research Center)
Lee, Hyejung (Acupuncture and Meridian Science Research Center)
Hahm, Dae-Hyun (Acupuncture and Meridian Science Research Center)
Publication Information
Biomolecules & Therapeutics / v.22, no.3, 2014 , pp. 213-222 More about this Journal
Abstract
Abnormal adaptation of the stress-response system following traumatic stress can lead to alterations in the hypothalamic-pituitaryadrenal (HPA) axis that may contribute to the development of post-traumatic stress disorder (PTSD). The present study used several behavioral tests to investigate the anxiolytic-like and antidepressant activity of L-tetrahydropalmatine (L-THP) in an experimental rat model of anxiety and depression induced by single prolonged stress (SPS), an animal model of PTSD. Male rats were treated intraperitoneally (i.p.) with vehicle or varied doses of THP 30 min prior to SPS for 8 consecutive days. Daily THP (50 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index, increased the risk assessment, and increased the number of head dips over the borders of the open arms after SPS. THP was also associated with increased time spent at the center of the open field, reduced grooming behaviors in the EPM test, and reduced time spent immobile in the forced swimming test (FST). It also blocked the decrease in neuropeptide Y (NPY) and the increase in corticotrophin-releasing factor (CRF) expression in the hypothalamus. This is the first study to determine that THP exerts pronounced anxiolytic-like and antidepressant effects on the development of the behavioral and biochemical symptoms associated with PTSD, indicating its prophylactic potential. Thus, THP reversed several behavioral impairments triggered by the traumatic stress of SPS and is a potential non-invasive therapeutic intervention for PTSD.
Keywords
Post-traumatic stress disorder; Single prolonged stress; Anxiety; Neuropeptide Y; L-tetrahydropalmatine;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Zhu, K. Y., Mao, Q. Q., Ip, S. P., Choi, R. C., Dong, T. T., Lau, D. T. and Tsim, K. W. (2012) A standardized chinese herbal decoction, kai-xin-san, restores decreased levels of neurotransmitters and neurotrophic factors in the brain of chronic stress-induced depressive rats. Evid. Based Complement. Alternat. Med. 2012, 149256.
2 Paxinos, G. and Watson, C. (1986) The rat brain in stereotaxic coordinates. 3th ed., 54-85, Academic Press, New York.
3 Roth, M. K., Bingham, B., Shah, A., Joshi, A., Frazer, A., Strong, R. and Morilak, D. A. (2012) Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity. Neuropharmacology 63, 1118-1126.   DOI
4 Serova, L. I., Laukova, M., Alaluf, L. G., Pucillo, L. and Sabban, E. L. (2014) Intranasal neuropeptide Y reverses anxiety and depressivelike behavior impaired by single prolonged stress PTSD model. Eur. Neuropsychopharmacol 24, 142-147.   DOI
5 Serova, L. I., Laukova, M., Alaluf, L. G. and Sabban, E. L. (2013a) Intranasal infusion of melanocortin receptor four (MC4R) antagonist to rats ameliorates development of depression and anxiety related symptoms induced by single prolonged stress. Behav. Brain Res. 250, 139-147.   DOI
6 Shea, A., Walsh, C., Macmillan, H. and Steiner, M. (2005) Child maltreatment and HPA axis dysregulation: relationship to major depressive disorder and post traumatic stress disorder in females. Psychoneuroendocrinology 30, 162-178.   DOI
7 Takahashi, T., Morinobu, S., Iwamoto, Y. and Yamawaki, S. (2006) Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats. Psychopharmacology (Berl) 189, 165-173.   DOI
8 Uliaszek, A. A., Zinbarg, R. E., Mineka, S., Craske, M. G., Sutton, J. M., Griffith, J. W., Rose, R., Waters, A. and Hammen, C. (2010) The role of neuroticism and extraversion in the stress-anxiety and stress-depression relationships. Anxiety Stress Coping 23, 363-381.   DOI   ScienceOn
9 Xi, Z. X., Yang, Z., Li, S. J., Li, X., Dillon, C., Peng, X. Q., Spiller, K. and Gardner, E. L. (2007) Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brainstimulation reward in rats. Neuropharmacology 53, 771-782.   DOI   ScienceOn
10 Zhao, N., Chen, Y., Zhu, J., Wang, L., Cao, G., Dang, Y., Yan, C., Wang, J. and Chen, T. (2014) Levo-tetrahydropalmatine attenuates the development and expression of methamphetamine-induced locomotor sensitization and the accompanying activation of ERK in the nucleus accumbens and caudate putamen in mice. Neuroscience 258, 101-110.   DOI
11 Kupferschmidt, D. A., Newman, A. E., Boonstra, R. and Erb, S. (2012) Antagonism of cannabinoid 1 receptors reverses the anxiety-like behavior induced by central injections of corticotropin-releasing factor and cocaine withdrawal. Neuroscience 204, 125-133.   DOI   ScienceOn
12 Jindal, A., Mahesh, R. and Kumar, B. (2013) Anxiolytic-like effect of linezolid in experimental mouse models of anxiety. Prog. Neuropsychopharmacol. Biol. Psychiatry 40, 47-53.
13 Kohda, K., Harada, K., Kato, K., Hoshino, A., Motohashi, J., Yamaji, T., Morinobu, S., Matsuoka, N., Kato, N. (2007) Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model. Neuroscience 148, 22-33.   DOI
14 Kozlovsky, N., Matar, M.A., Kaplan, Z., Zohar, J. and Cohen, H. (2009) The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder. Biol. Psychiatry 65, 383-391.   DOI
15 Lee, B., Sur, B., Kwon, S., Yeom, M., Shim, I., Lee, H. and Hahm, D. H. (2013) Chronic administration of catechin decreases depression and anxiety-like behaviors in a rat model using chronic corticosterone injections. Biomol. Ther. 21, 313-322.   DOI
16 Liu, Y. L., Liang, J. H., Yan, L. D., Su, R. B., Wu, C. F. and Gong, Z. H. (2005) Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice. Acta Pharmacol. Sin. 26, 533-538.   DOI
17 Mao, Q. Q., Ip, S. P., Ko, K. M., Tsai, S. H. and Che, C. T. (2009) Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary- adrenal function and brain-derived neurotrophic factor. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 1211-1216.   DOI   ScienceOn
18 Cohen, H., Liu, T., Kozlovsky, N., Kaplan, Z., Zohar, J. and Mathe, A. A. (2012) The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder. Neuropsychopharmacology 37, 350-363.   DOI
19 Marquez, C., Nadal, R. and Armario, A. (2006) Influence of reactivity to novelty and anxiety on hypothalamic-pituitary-adrenal and prolactin responses to two different novel environments in adult male rats. Behav. Brain Res. 168, 13-22.   DOI
20 Meyer, E. M., Long, V., Fanselow, M. S. and Spigelman, I. (2013) Stress increases voluntary alcohol intake, but does not alter established drinking habits in a rat model of posttraumatic stress disorder. Alcohol Clin. Exp. Res. 37, 566-574.   DOI
21 Colman, I. and Ataullahjan, A. (2010) Life course perspectives on the epidemiology of depression. Can. J. Psychiatry 55, 622-632.
22 Cui, H., Sakamoto, H., Higashi, S. and Kawata, M. (2008) Effects of single- prolonged stress on neurons and their afferent inputs in the amygdala. Neuroscience 152, 703-712.   DOI
23 Dabrowska, J., Hazra, R., Guo, J. D., Li, C., Dewitt, S., Xu, J., Lombroso, P. J. and Rainnie, D. G. (2013) Striatal-enriched protein tyrosine phosphatase-STEPs toward understanding chronic stressinduced activation of corticotrophin releasing factor neurons in the rat bed nucleus of the stria terminalis. Biol. Psychiatry 74, 817-826.   DOI   ScienceOn
24 Deligiannidis, K. M. and Freeman, M. P. (2010) Complementary and alternative medicine for the treatment of depressive disorders in women. Psychiatr. Clin. North Am. 33, 441-463.   DOI
25 Han, Y., Zhang, W., Tang, Y., Bai, W., Yang, F., Xie, L., Li, X., Zhou, S., Pan, S., Chen, Q., Ferro, A. and Ji, Y. (2012) l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischaemia-reperfusion injury in rats. PLoS One 7, e38627.   DOI
26 Fox, J. H. and Lowry, C. A. (2013) Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior. Front. Neurosci. 7, 169-173.
27 George, S. A., Knox, D., Curtis, A. L., Aldridge, J. W., Valentino, R. J. and Liberzon, I. (2013a) Altered locus coeruleus-norepinephrine function following single prolonged stress. Eur. J. Neurosci. 37, 901-909.   DOI
28 George, S. A., Stout, S. A., Tan, M., Knox, D. and Liberzon, I. (2013b) Early handling attenuates enhancement of glucocorticoid receptors in the prefrontal cortex in an animal model of post-traumatic stress disorder. Biol. Mood Anxiety Disord. 3, 22-23.   DOI
29 Castro, J. E., Diessler, S., Varea, E., Marquez, C., Larsen, M. H., Cordero, M. I. and Sandi, C. (2012) Personality traits in rats predict vulnerability and resilience to developing stress-induced depression- like behaviors, HPA axis hyper-reactivity and brain changes in pERK1/2 activity. Psychoneuroendocrinology 37, 1209-1223.   DOI
30 Ceremuga, T. E., Shellabarger, P., Persson, T., Fanning, M., Galey, P., Robinson, D., Bertsch, S., Ceremuga, G. A. and Bentley, M. (2013) Effects of tetrahydropalmatine on post-traumatic stress disorderinduced changes in rat brain gene expression. J. Integr. Neurosci. 12, 513-528.   DOI
31 Cryan, J. F. and Holmes, A. (2005) The ascent of mouse: advances in modelling human depression and anxiety. Nat. Rev. Drug Discov. 4, 775-790.   DOI   ScienceOn
32 Serova, L. I., Tillinger, A., Alaluf, L. G., Laukova, M., Keegan, K. and Sabban, E. L. (2013b) Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats. Neuroscience 236, 298-312.   DOI   ScienceOn
33 Kokras, N., Dalla, C., Sideris, A. C., Dendi, A., Mikail, H. G., Antoniou, K., and Papadopoulou-Daifoti, Z. (2012) Behavioral sexual dimorphism in models of anxiety and depression due to changes in HPA axis activity. Neuropharmacology 62, 436-445.   DOI
34 Hsiao, Y. T., Yi, P. L., Li, C. L. and Chang, F. C. (2012) Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats. Neuropharmacology 62, 373-384.   DOI   ScienceOn