• International Journal of Oral Biology
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• v.30 no.2
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• pp.59-63
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• 2005

Postantibiotic effects (PAE) refer to suppression of the bacterial growth following limited periods of exposure to an antibiotic and subsequent to the removal of the antibiotic agent. Fusobacterium nucleatum and Porphyromonas gingivalis are Gram-negative anaerobic bacteria associated with several periodontal diseases. In this study, postantibiotic effects (PAE), postantibiotic sub-MIC effect (PA SME) and sub-MIC effect (SME) of antibiotics on F. nucleatum ATCC 25586 and P. gingivalis W50 were investigated. The PAE was induced by 10X the MIC of antibiotic and antibiotic was eliminated by washing. The PA SMEs were studied by addition of 0.1, 0.2 and 0.3X MICs during the postantibiotic phase of the bacteria, and the SMEs were studied by exposition of the bacteria to antibiotic at the sub-MICs only. Amoxicillin, doxycycline and tetracycline induced PAE for F. nucleatum ATCC 25586 and P. gingivalis W50. But metronidazole and penicillin induced PAE for only F. nucleatum ATCC 25586. Metronidazole and doxycycline induced PA SME and SME for both species of anaerobic bacteria used in this study. The PA SME values for both strains were substantially longer than the SME values. The present study showed the existence of PAE, PA SME and SME for various antibiotics against F. nucleatum ATCC 25586 and P. gingivalis W50.

• 한국벤처창업학회:학술대회논문집
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• 2017.04a
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• pp.42-42
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• 2017

There are lots of specialized graduate schools such as law school, medical school, business school. These specialized graduate schools has been designed to train the special experts practically from 1990s in Korea. For all that, there are no specialized graduate schools supported by the Small and Medium Business Administration(SMBA). So we will research the establishment plan of SME(Small and Medium Enterprise) specialized school for the development of SMEs. Recently, the SMBA supports the 2 types of graduate school such as the entrepreneurship graduate school and consulting graduate school. However, it is clear that these 2 types of schools are yet insufficient in terms of efficiency and redundancy. As the representative specialized graduate schools are law school and MOT(Management of Technology) in Korea, we do the comparative study with law school and MOT school. Through the comparative study, we can find some implication for SME specialized graduate school. As a result, the SME school has to need the training system such as the special master's and doctor's degree, over 3 year course work, daytime class, many practical professors, specialized programs with industry like the MOT school. In conclusion, we suggest that : First, the SME specialized graduate school has to be designed for potential SME consultants. Second, the entrepreneurship graduate school and the consulting graduate school can be integrated into the SME specialized school easily. Third, the SME specialized graduate school can have new educational models.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.40 no.1
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• pp.144-149
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• 2017

This study empirically analyzes the effect of IT SME ventures' external information network diversity on their production period reduction and productivity improvement generated from technology development. This research constructs a mediating model based on the open innovation perspective and tests it with the 138 samples of South Korean IT SME ventures based on the ordinary least squares regression. This research is expected to make a good contribution by shedding a new light on the following three points about the critical role of IT SME ventures' external information network diversity in increasing their production period reduction and productivity improvement generated from technology development which has scarcely been illuminated in the extant studies in the field of the management of technology for SMEs. First, IT SME ventures' external information network diversity positively influences their production period reduction. Second, the external information network diversity positively influences IT SMEs' ventures' productivity improvement. Third, IT SME ventures' production period reduction partially mediates the influence of IT SME ventures' external network diversity on their productivity improvement. These three fresh points are expected to provide useful theoretical and practical implications. Related to the theoretical implication, this research provides a fresh implication that IT SME ventures' external information network diversity positively influences not only their production period reduction but also productivity improvement generated from technology development. Concerning the practical implication, this study suggests that the CEOs in IT SME ventures make strategic efforts to use more diverse external information sources in order to increase their production period reduction and productivity improvement generated from technology development.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.11a
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• pp.219-222
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• 2003

This paper is to propose e-business strategies for individual SME's(small and medium-sized enterprises). e-business maturity model is used to assess e-business maturity level of a target SME, and then corresponding e-business strategy is proposed based on the current maturity level. We studied two SME's to show how it works. Most SME's are small and do not have enough resources to invest on information systems. As it turns out, e-business strategies of SME should heavily depend on its relationship with customers and suppliers. One of the studied SME's is found to be in higher maturity level, because its manufacturing system is tightly related to its customer. One of major implications of this study is that e-business level of SME's should be upgraded considering how it is doing business with its customers and suppliers.

• International Journal of Oral Biology
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• v.34 no.3
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• pp.165-168
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• 2009

Postantibiotic effect (PAE) is defined as the length of time that bacterial growth is suppressed following brief exposure to an antibiotic. In this study, the in vitro PAE, postantibiotic sub-MIC effect (PA SME) and sub-MIC effect (SME) of antibiotics on Treponema denticola ATCC 35405 were investigated. The PAE of doxycycline and metronidazole were 20.3 h and 25.0 h, respectively. The PA SMEs examined by addition of 0.1, 0.2 and 0.3X MICs during the postantibiotic phase of the bacteria for metronidazole were longer than those for doxycycline. In contrast, the SMEs for doxycycline were longer than those for metronidazole. The PA-SME and SME values increased as the concentration of antibiotics increased. The present study illustrates the existence of PAE, PA-SME and SME for several antibiotics against T. denticola, thereby extending the pharmacodynamic advantages of these antibiotics.

• Asia-Pacific Journal of Business
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• v.7 no.1
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• pp.31-42
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• 2016

Small and Medium Enterprises (SMEs) are suitable to provide employment with lower investment in densely populated countries like Bangladesh. A stochastic frontier model is used to evaluate performance of SME Banking of the commercial banks in Bangladesh. Input (Total Deposit, Cost of Fund and Salary Expenditure) and output (Finance to SME) data are collected on 45 banks which are dealt with SME for 13 quarters from $1^{st}$quarter of 2010 to $2^{nd}$quarter of 2013. Average performance of the SME banking is 0.716 in Bangladesh. That is, banks have opportunity to increase 30% performance in SME banking from the same inputs. Bangladesh Development Bank has lowest performance (0.540) while Eastern bank has the highest performance (0.753). Highest (0.743) and lowest (0.662) performance is observed during the second quarter of 2013 and fourth quarter of 2010 respectively. Inefficient Bank might be benefited by following the rules of efficient banks.

• Korean Journal of Pharmacognosy
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• v.38 no.1
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• pp.62-66
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• 2007

Ethanol extract from Salvia miltiorrhiza (SME) was tested for breast cancer chemoprevention and metastasis by measuring the activites of cytochrome P45O 1A1, aromatase, ornithine decarboxylase (ODC), and matrix metalloproteinase (MMP)-9. SME significantly inhibited cytochrome P45O 1A1-mediated ethoxyresorufin O-deethylase (EROD) activity in a dose-dependent manner in a concentration range of 100${\sim}$l,200 ${\mu}g/ml$ (p<0.01). Microsomal aromatase (estrogen synthase) activity was suppressed 54.9%${\sim}$77.5% by the SME at concentration of 600${\sim}$l,200 ${\mu}g/ml$. ODC activity induced by 12-O-tet-radecanoylphorbol-13-acetate (TPA) was significantly reduced by the SME 900 and 1,200 ${\mu}g/ml$ (p<0.05) in MCF-7 breast cancer cells. In addition, SME (900 and 1,200 ${\mu}g/ml$) markedly inhibited MMP-9 activity, a key role in cancer metastasis. Therefore, SME is worth further investigation with respect to breast cancer chemoprevention or therapy.

• Industrial Engineering and Management Systems
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• v.10 no.2
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• pp.104-108
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• 2011

Technology is one of the major competitive advantages for small and medium enterprises (SME), especially ones operating in the manufacturing sector. Increasing technological capabilities is the basis for SME's business performance improvement. The main problem of SME's is a limitation in the areas of production facilities, technology, and human resources. Some of these constraints cause a decline in business performance and competitiveness of SME's. In this case analysis of technology components has to be carried out to determine the effect of technology on SME's business performance improvement. This study aims to measure the components of technology and to analyze the influence of each technology component on business performance of rattan processing SME's in South Kalimantan. The assessment is carried out on the technoware, humanware, inforware, and orgaware components using the technometric method (UNESCAP). Business performance is measured through a combination of financial and non-financial aspects deducted from financial and marketing figures. Analysis of the influence of technology components on business performance of SME's is done using the Structural Equation Model (SEM) with Partial Least Square software (PLS). Data is collected through interviews and questionnaires from 21 rattan processing SME's in South Kalimantan that produce rattan furnitures. The results show that the value of the contribution of technology (TCC) to the performance of rattan processing SME's in South Kalimantan is still quite low. Analysis of the results shows a direct influence of technoware and humanware on business performance, while orgaware influences business performance indirectly through humanware.

• Journal of the Korean Society of Systems Engineering
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• v.15 no.2
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• pp.79-86
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• 2019

Among the government-sponsored projects supported by Ministry of SMEs and Startups(MSS), the financial support of the Consulting Research Institutes of our university is scheduled to be ended this year. In this regard, this study is to develop a profit model for R&D center of Consulting Research Institute that can cultivate the financial independence of R&D center of Consulting Research Institutes and foster technology convergence consulting manpower to strengthen the competitiveness of SMEs in preparation for the Fourth Industrial Revolution. The profit model were derived from the current status of consulting industry and similar organizations, the current status of consulting graduate R&D centers, case studies of other universities, and focus group interviews. In order to select three high profit models and commercialize them, BMC (Biz Model Canvas) was used and business feasibility was examined. Therefore, three profit model of R&D center of Consulting Research Institute are: First, SCB (SME's Consulting Business: Total Solution Provider for SMEs through Technology Convergence Consulting), Second, SNB (SME's Network Business: Experts connection in Consulting Graduate School for Solving Problems and Problems of SMEs / Industry Consolidation) And third, SM (Sustainable Management: Financial independence through structural improvement of Consulting Research Institute), and the road-map was established. As an implementation plan, the company intends to seek financial independence by developing a profit model for R&D center of Consulting Research Institutes and by establishing business goals and strategies, manpower operation plan, organization, and investment plan for three years.

• Journal of Information Technology Applications and Management
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• v.22 no.4
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• pp.205-224
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• 2015

Information System is a critical success factor for overcoming the limitations of asset and capacity of Small and Medium Enterprises (SME), and for acquiring competitiveness. Although, the rate of adopting information system by SME has grown, the rate of its utilization has been stagnant. The purpose of this study is to identify the influencing factors that increase SME's information system utilization. We identify perception of strategic value, supplier's support capacity, and organizational characteristic by examining previous researches on information system utilization by SMEs, and verify their the influencing relationship with the information system utilization. This study verifies the research model and hypothesis using structural model. A date-set of 1209 samples from a survey on employees in charge of information system of SME was applied in verifying the research hypothesis. The result of this study shows that the information system utilization influences perception of strategic value and support of supply company, and partly, the structural characteristics. This study presents directions to establish strategy and policy making, and theoretically presents core factors of SME's information system utilization.