Browse > Article

Postantibiotic Effects and Postantibiotic Sub-MIC Effects of Antibiotics on Treponema Denticola  

Lee, Si-Young (Department of Oral Microbiology, College of Dentistry, Research Institute of Oral Science, Gangneung-Wonju National University)
Publication Information
International Journal of Oral Biology / v.34, no.3, 2009 , pp. 165-168 More about this Journal
Abstract
Postantibiotic effect (PAE) is defined as the length of time that bacterial growth is suppressed following brief exposure to an antibiotic. In this study, the in vitro PAE, postantibiotic sub-MIC effect (PA SME) and sub-MIC effect (SME) of antibiotics on Treponema denticola ATCC 35405 were investigated. The PAE of doxycycline and metronidazole were 20.3 h and 25.0 h, respectively. The PA SMEs examined by addition of 0.1, 0.2 and 0.3X MICs during the postantibiotic phase of the bacteria for metronidazole were longer than those for doxycycline. In contrast, the SMEs for doxycycline were longer than those for metronidazole. The PA-SME and SME values increased as the concentration of antibiotics increased. The present study illustrates the existence of PAE, PA-SME and SME for several antibiotics against T. denticola, thereby extending the pharmacodynamic advantages of these antibiotics.
Keywords
postantibiotic effect; Treponema denticola; minimal inhibitory concentration;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Hong J, Lee SY. Postnatibiotic effects and postantibiotic sub-MIC effects of antibiotics on Fusobacterium nucleatum and Porphyromonas gingivalis. Int J of Oral Biol. 2005;30:59-63   ScienceOn
2 Lowdin E, Odenholt TI, Bengtsson S, Cars O. A new method to determine postantibiotic effect and effects of subinhibitory antibiotic concentrations. Antimicrob Agents Chemother. 1993;37:2200-5   DOI   PUBMED   ScienceOn
3 Odenholt I. Pharmacodynamic effects of subinhibitory antibiotic concentrations. Int J Antimicrob Agents. 2001;17:1-8   PUBMED
4 Sela MN. Role of Treponema denticola in periodontal diseases. Crit Rev Oral Biol Med. 2001;12:399-413   DOI   ScienceOn
5 Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL, Jr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998;25:134-44   DOI   ScienceOn
6 Li RC, Lee SW, Kong CH. Correlation between bactericidal activity and postantibiotic effect for five antibiotics with different mechanisms of action. J Antimicrob Chemother. 1997;40:39-45   DOI   ScienceOn
7 Lee SY, Choe SJ. Penicillin-induced killing and postantibiotic effect in oral streptococci are enhanced by platelet microbicidal proteins. Int J Antimicrob Agents. 2004;23:457-61   DOI   ScienceOn
8 Odenholt TI, Lowdin E, Cars O. Postantibiotic sub-MIC effects of vancomycin, roxithromycin, sparfloxacin, and amikacin. Antimicrob Agents Chemother. 1992;36:1852-8   DOI   PUBMED   ScienceOn
9 Odenholt I, Holm SE, Cars O. An in vivo model for evaluation of the postantibiotic effect. Scand J Infect Dis. 1988;20:97-103   DOI   ScienceOn
10 Haapasalo M, Singh U, McBride BC, and Uitto VJ. Sulfhydryldependent attachment of Treponema denticola to laminin and other proteins. Infect Immun. 1991;59:4230-7   PUBMED
11 Paster BJ, Boches SK, Galvin JL et al. Bacterial diversity in human subgingival plaque. J Bacteriol. 2001;183:3770-83   DOI   ScienceOn
12 Gudmundsson S, Einarsson S, Erlendsdottir H, Moffat J, Bayer W, Craig WA. The post-antibiotic effect of antimicrobial combinations in a neutropenic murine thigh infection model. J Antimicrob Chemother. 1993;31 Suppl D:177-91.:177-91   PUBMED
13 Lee SY. Postantibiotic effects and postantibiotic sub-MIC effects of amoxicillin on Streptococcus gordonii and Streptococcus sanguis. J Chemother. 2000;12:379-84   ScienceOn
14 Zhanel GG, Hoban DJ, Harding GK. The postantibiotic effect: a review of in vitro and in vivo data. DICP. 1991;25:153-63   PUBMED
15 Page RC, Engel LD, Narayanan AS, Clagett JA. Chronic inflammatory gingival and periodontal disease. JAMA. 1978;240:545-50   DOI   PUBMED   ScienceOn