• The Journal of Korean Medicine
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• v.31 no.3
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• pp.17-27
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• 2010

Objectives: Cocaine has been well known as a representative drug of abuse for its strong reinforcing effect linked to the mesolimbic reward system including dopamine, and such reinforcement leads to the addiction. Acupuncture has been used widely in eastern Asia for the treatment of various diseases including mental disorders and psychiatric problems, and is gathering more interest as one of the complementary and alternative medicines in western countries. In a previous study, we demonstrated that acupuncture at HT7 could affect dopamine release in the mesolimbic system of rats sensitized to alcohol and morphine. This study was designed to investigate whether acupuncture at HT7 could attenuate cocaine intake or not. Material & Methods: Male Sprague-Dawley rats weighing 270-300 g at the start of experiment were trained to self-administer food pellets under a fixed ratio 1 schedule. After the success of acquisition of 100 pellets within 3 h for 3 consecutive days, animals were subjected to surgery whereby Silastic tubing was implanted into right jugular vein and secured with mesh under the anesthetization using pentobarbital injection (50 mg/kg, i.p.). Following recovery, rats were trained to self-administer cocaine (0.25 mg/kg) in daily 2 h sessions under fixed ratio 1 schedule over 10 days. Each treatment was performed on the next day of each establishment of baseline. Results: Results show that acupuncture at HT7, but not at control points, reduced cocaine intake significantly. Acupuncture at HT7 decreased selectively active lever response from $63.15{\pm}3.35$ to $51.46{\pm}3.99$ corresponding $82.12{\pm}5.31%$ compared to basal level. Also, it was demonstrated that the effect of acupuncture was mainly occurred at the half period. Nevertheless, acupuncture at HT7 did not influence the food taking behavior. Conclusions: From the results of this study, it may be suggested that acupuncture at HT7, at least in part, could contribute to the treatment of cocaine abuse.

• Journal of Pharmacopuncture
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• v.7 no.1 s.12
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• pp.53-61
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• 2004

Substantial evidence suggests that behavioral and reinforcing effects of cocaine can be mediated by the mesolimbic dopaminergic system. It has been shown that repeated injections of cocaine produce increase in locomotor activity, expression of the immediate-early gene, c-fos in the nucleus accumbens (NAc), which was one of the main dopaminergic terminal areas. Herbal-acupuncture as a therapeutic intervention has been widely used for the treatment of many functional disorders such as drug abuse. Coptidis Rhizoma (CR) and its main component, berberine (BER) were selected as herbal medicine of herbal-acupuncture. Both medicines have been known to have the therapeutic effect on the central nervous system. In order to investigate the effects of CR and BER herbalacupuncture at shenmen (HT7) point (CR/H and BER/H) on the cocaine-induced behavioral sensitization, the influence of CR/H and BER/H on repeated cocaine-induced locomotor activity, the change of c-Fos expression in the brain by immunohistochemistry were examined. Male SD rats were given CR/H (0.4mg/kg) and BER/H (0.1mg/kg) 30 min before daily injections of cocaine hydrochloride (15mg/kg. i.p.) 10 days. After 3 days withdrawal, rats received a challenge injection of cocaine (15mg/kg, i.p.). Systemic challenge with cocaine produced much larger increased locomotor activity, accumbal Fos-like immunoreactivity in the NAc. Pretreatment with CR/H and BER/H significantly inhibited cocaine-induced locomotor activity, the change of c-Fos expression in the rats. Our data demonstrated that the inhibitory effects of cocaine-induced behavioral sensitization by CR/H and BER/H were closely associated with the reduction of presynaptic dopamine release in the NAc. These results suggest that CR/H and BER/H can be effectively applied to cocaine addiction.

• Journal of the Korean Recycled Construction Resources Institute
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• v.9 no.4
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• pp.478-482
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• 2021

In this paper, methods for manufacturing shielding concrete by recycling steelmaking slag discarded as industrial waste and measuring the shielding effectiveness of the shielding concrete were studied. By comparing the result of shielding effectiveness measurement of this concrete block with shielding effectiveness measurement of the structure constructed with this concrete, the measurement system for measuring shielding effectiveness of the concrete block was verified. The size of the concrete stru ctu re is 2.9 × 2.9 × 3.4m and the concrete block is 0.3 × 0.3 × 0.2m. The frequ ency band u sed for mesu rement is 600MHz - 2GHz, the types of concrete u sed to measu re the shielding effectiveness are general concrete and concrete containing electric arc furnace oxidizing slag. In the case of the concrete structure, reinforcing rebars are installed at intervals of 15cm for stru ctu ral safety, as the frequ ency increase, the electromagnetic wave properties of rebars gradu ally decreased, there was a slight difference in the measurement results. In conclusion, the measurement result of shielding effectiveness of the concrete block is similar to the result of the concrete structure. It is thought that it can be sufficiently utilized for electromagnetic wave engineering design, and the concrete shielding effectiveness measurement system using standard specimens was verified.

• Journal of the Korea institute for structural maintenance and inspection
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• v.26 no.3
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• pp.11-20
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• 2022

The main purpose of this study is to investigate the applicability of the shear wave tomography technology as a non-destructive testing method to evaluate the debonding between the track concrete layer (TCL) and the hydraulically stabilized based course (HSB) of concrete slab tracks for the Korea high-speed railway system. A commercially available multi-channel shear wave measurement device (MIRA) is used to evaluate debonding defects in full-scaled mock-up test specimen that was designed and constructed according to the Rheda 200 system. A part of the mock-up specimen includes two artificial debonding defects with a length and a width of 400mm and thicknesses of 5mm and 10mm, respectively. The tomography images obtained by a MIRA on the surface of the concrete specimens are effective for visualizing the debonding defects in concrete. In this study, a simple image processing method is proposed to suppress the noisy signals reflected from the embedded items (reinforcing steel, precast sleeper, insert, etc.) in TCL, which significantly improves the readability of debonding defects in shear wave tomography images. Results show that debonding maps constructed in this study are effective for visualizing the spatial distribution and the depths of the debondiing defects in the railway concrete slab specimen.

• Journal of Energy Engineering
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• v.29 no.1
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• pp.85-99
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• 2020

This article analyzes the influence of sectoral system of innovation(i.e. technological regime, market demand, networks, and institution) on innovative performances(i.e. product-, process-, organizational-, marketing-, and environmental- innovation) in Korean environmental industry, conducting a multiple regression analysis based on survey data from 201 Korean environmental companies. As the results, product innovation is positively influenced by internal technology accumulation and market demand response, while not affected by external knowledge utilization, market competition, networks among market and non-market agents, government support and regulation. Process innovation is positively influenced by internal technology accumulation, networks among non-market agents and regulation, but not by external knowledge utilization, market demand response, market competition, networks among market agents, and government support. While organizational innovation is positively influenced by internal technology accumulation, external knowledge utilization and regulation, it is not affected by market demand response, market competition, networks among market and non-market agents, and government support. While marketing innovation is positively influenced by internal technology accumulation, networks among non-market agents, and government support, it is not affected by external knowledge utilization, market demand response, market competition, networks among market agents, and regulation. Environmental innovation is positively influenced by external knowledge utilization and regulation, but negatively influenced by market competition. It is not affected by internal technology accumulation, market demand response, networks among market and non-market agents, and government support. Such results suggests the following policy implications. First, it is necessary to expand the sphere of relating markets through the application of convergence technology, new regulations, and overseas markets. Second, reinforcing ecosystems among environmental market agents through demand-linked joint R&D should be revitalized. Third, it is needed to strengthen more supporting policies rather than regulation. This article has the limitation of using the survey data. And further researches on the environmental sectoral system of innovation structure itself will be tried.

• Journal of dental hygiene science
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• v.11 no.3
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• pp.189-197
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• 2011

Objectives : The systematic health education to form the basic healthy lifestyle should be realized from elementary school, so oral health education at elementary school can determine the whole lifetime oral health. The elementary school health teacher's recognition and behavior who in charge of health promotion of students is important. Therefore, the study was conducted to enhance oral health education. Methods : Total 114 people among of 131 from health teacher Gwangju elementary school. Survey system is configured by referring to PRECEDE model. Results : In behavioral diagnosis the proportion of oral Health Education is less than 10%(58.8%), mostly educated in activity time (86.0%), the health teachers educate when it is needed(53.5%). In predisposing diagnosis in the eight areas of health education, the oral health education is ranked as fourth, fifth. Even in the next year project, the oral health education ratio was 21.9 percent. In enabling diagnosing every year the Oral health education training experienced rate is 13.2%, satisfaction rate is 33.3%. In reinforcing diagnosing disability element in the regular education course are the lack of oral health-related information (46.7%), lack of materials needed for education (30.6%), lack of training opportunities (21.4%). Conclusion : In further research, oral health education textbooks, materials and methods should be developed. At the foundation of there developments, the elementary oral health education program should be more fully developed and conducted and also the evaluation of its effectiveness will need.

• Journal of the Korea Concrete Institute
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• v.26 no.1
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• pp.71-78
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• 2014

The long term integrity of concrete cask is very important for spent nuclear fuel dry storage system. However, there are serious concerns about early deterioration of concrete cask from creaking and corrosion of reinforcing steel by chloride ion because the cask is usually located in seaside, expecially by combined deterioration such as chloride ion and heat, carbonation. This study is to investigate the relation between temperature and chloride ion diffusion of concrete. Immersion tests using 3.5% NaCl solution that were controlled in four level of temperature, i.e. 20, 40, 65, and $90^{\circ}C$, were conducted for four months. The chloride ion diffusion coefficient of concrete was predicted based on the results of profiles of Cl- ion concentration with the depth direction of concrete specimens using the method of potentiometric titration by $AgNO_3$. Test results indicate that the diffusion coefficient of chloride ion increases remarkably with increasing temperature, and there was a linear relation between the natural logarithm values of the diffusion coefficients and the reciprocal of the temperature from the Arrhenius plots. Activation energy of concrete in this study was about 46.6 (W/C = 40%), 41.7 (W/C = 50%), 30.7 (W/C = 60%) kJ/mol under a temperature of up to $90^{\circ}C$, and concrete with lower water-cement ratio has a tendency towards having higher temperature dependency.

• Journal of the Korea Concrete Institute
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• v.18 no.1 s.91
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• pp.125-132
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• 2006

Recently, surface finishing and protection materials were developed to restore performance of the deteriorated concrete and inhibiting corrosion of the reinforcing-bar. For this purpose, surface protection agent as well as coatings are used. Coatings have the advantage of low Permeability of $CO_2,\;SO_2$ and water. However, for coatings such as epoxy, urethane and acryl, long-term adhesive strength is reduced and the formed membrane of those is blistered by various causes. Also when organic coatings are applied to the wet surface of concrete, those have a problem with adhesion. On the other hand, surface protection agent penetrates into pore structure in concrete through capillary and cm make a dense micro structure in concrete as a result of filling effect. Furthermore, the chemical reaction between silicate from surface protection agent and cement hydrates can also make a additional hydration product which is ideally compatible with concrete body. The aim of this study is to examine the effect of penetrative surface protection agent(SPA) by evaluating several concrete durability characteristics. The results show that the concrete penetrated surface protection agent exhibited higher durability characteristics for instance, carbonation velocity coefficient, resistance to chemical attack and chloride ion penetration than the plain concrete. These results due to formation of a discontinuous macro-pore system which inhibits deterioration factors of concrete by changed the pore structure(porosity and pore size distributions) of the concrete penetrated surface protection agent.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.8 no.1
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• pp.223-233
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• 2013

The purpose of this study is to analyze the factors giving effects to juvenile's suicide thinking and search for the method to protect juveniles from the risk factors of suicide thinking and reinforce protective factors. For this purpose, juvenile's depression and stress degree were analyzed as the factors giving effects to juvenile's suicide thinking and the effect of social support, which was assumed as a protective factor from suicide thinking, was verified. Analysis results are as follows. First, juvenile's daily stress showed significant deference from suicide thinking. There was a significant positive correlation between juvenile's daily life stress and suicide thinking. Therefore, it was found that the juveniles who suffer from stress have a lot of suicide thinking. Second, juvenile's depression gave a significant effect to suicide thinking. There was a significant positive correlation between juvenile's depression and suicide thinking. it was proved that the juveniles who suffer from depression have a lot of suicide thinking. Third, There was a significant negative correlation between social support and suicide thinking. The more the juveniles get social support, the less they have suicide thinking. The study results above reveal that juvenile's suicide shall be approached from the preventive aspect, for preventing juvenile's suicide, social support which mitigates suicide thinking factors is very important. Therefore this study proposed social attention on the juvenile's suicide thinking, and formation social support system that reinforce social support. Moreover, for preventing the factors reinforcing suicide thinking, preventive approach, alternative program such as case management and group program, and integrated management inined with juvenile related organizations and specialists are required. At the same time school environment shall be improved and changed.

• Journal of the Korea Concrete Institute
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• v.13 no.5
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• pp.430-437
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• 2001

Recently, there have been increased much concerns about repair and rehabilitation works for aged concrete structures. It is in particular known that due to repeated overburden vehicles, there are significantly increasing number of aged concrete bridge slabs, which are strongly needed to construct and rehabilitate by innovative construction method. The objective of this research is to develop the new construction method of concrete slab in bridge superstructure, which can contribute to minimize a traffic congestion during repair and rehabilitation works of aged concrete slab, and can sufficiently assure the quality through the minimization of in-situ works at the site. I-beams with punch holes, which are substituted instead of main reinforcing steels in concrete slabs, can be manufactured in accordance with the specification in the factory, and be preassembled into the panel. After erecting the preassembled panels in the site, concrete will be poured into the slab panel. This research is to investigate mechanical properties of I-beam with punch holes itself, and then to investigate structural properties of assembled I-beam panels through static test, of which result can be utilized for the development of the new constructional method for concrete slab in bridge superstructure.