• Journal of Sasang Constitutional Medicine
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• v.19 no.3
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• pp.227-241
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• 2007

1. Objectives The purpose of this study is to investigate the anti-oxidative and immune regulatory effect of oral administration of Chungsimyeonja-tang decoction in aged rats. 2. Methods The rats in the normal group were 14 weeks old, and those in the control and Chungsimyeonja-tang groups were 40 weeks old. The rats in Chungsimyeonja-tang group were orally treated with chungsimyeonjatang decoction daily for 2 months. To observe the anti-oxidative effect and immune regulatory effect of Chungsimyeonja-tang, we performed blood chemistry analysis, histological analysis. 3. Results and Conclusions 1) The number of WBC in blood was significantly increased and the number of PLT in blood was significantly decreased by oral administration of Chungsimyeonja-tang decoction. 2) The levels of albumin, LDL cholesterol, ALP and GOT in serum were significantly decreased, and the level of glucose in serum was significantly increased by oral administration of Chungsimyeonja-tang decoction. 3) The concentrations of glutathione and catalase were significantly increased and the concentrations of NO and MDA were significantly decreased in the liver of early aged rats by oral administration of Chungsimyeonja-tang decoction. 4) The concentrations of SOD and catalase were significantly increased and the concentration of MDA was significantly decreased in the lung of aged rats by oral administration of Chungsimyeonja-tang decoction. 5) The levels of IL-4 and IL-6 were significantly decreased while the levels of IFN-${\gamma}$ were significantly increased in the spleen of early aged rats by oral administration of Chungsimyeonja-tang decoction.

• Journal of Physiology & Pathology in Korean Medicine
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• v.38 no.1
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• pp.16-21
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• 2024

Haepyoijin-tang and its main components have been used for phlegm, cough and dyspnea. Using a respiratory inflammation model, we intend to reveal the anti-inflammatory effect and pharmacological mechanism of Haepyoijin-tang. We induced the respiratory inflammation model by Aspergillus oryzae protease and ovalbumin administration. Female Balb/c mice (8 weeks old) were classified into four groups as follows: saline control group, aspergillus oryzae protease and ovalbumin induced respiratory inflammation group (vehicle), inflammation with Haepyoijin-tang (200 mg/kg) administration group, inflammation with dexamethasone (5 mg/kg) administration group (n=7). To identify the anti-inflammatory effects of Haepyoijin-tang water extracts, we measured the inflammatory cell number in bronchoalveolar lavage fluid (BALF) and total live lung cell number. In addition, we checked eosinophil ratio and number in BALF. And Interleukin (IL)-5 level was also measured in lung cell culture supernatant. To confirm the mechanism of anti-inflammatory effects, we analyzed the activated helper T cell (CD4⁺CD25⁺ cell) and Th2 cell (CD4⁺GATA3⁺ cell) ratio and number in lung by using flow cytometry. Finally, we attempted to confirm the immune mechanism by measuring the ratio and number of regulatory T cells (CD4⁺Foxp3⁺ cell). Haepyoijin-tang extracts treatment diminished inflammatory cell, especially, eosinophil number in BALF and total live lung cell number. Moreover, IL-5 level was reduced in Haepyoijin-tang treated group. Surprisingly, Haepyoijin-tang extracts administration not only decreased the activated helper T cell but also Th2 cell population in lung. Additionally, regulatory T cell population was increased in Haepyoijin-tang administration group. Our findings proved that Haepyoijin-tang extract have anti-inflammatory efficacy by suppressing Th2 cell activation and promoting regulatory T cell population.

• Clean Technology
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• v.2 no.2
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• pp.30-41
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• 1996

Air pollution problems are serious and present significant challenges to the engineering research community. EPA's engineering research programs have shifted from a primary focus on $SO_2$ and NOx pollution control to more complex and more difficult problems such as indoor air quality, air toxics, and global climate change. EPA research engineers are working closely with other research organizations in both the private sector and other federal research organizations to identify, evaluate, and develop cost-effective engineering solutions. The APPCE works closely with the EPA regulatory and regional offices to ensure that the best engineering information is utilized to formulate and implement the Agency's environmental protection program.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1997.11a
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• pp.57-74
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• 1997

To make a proposal for the revision of KGCP, ICH Harmonized Tripartite Guideline for Good Clinical Practice, which is on the stage of worldwide implementation, was compared with current GCPs of tripartite countries of ICH, namely USA, Europe and Japan as well as Korea. On the basis of the classification in ICH GCP, comprehensive comparisons among the corresponding articles of 4 regions or countries were made in the order of IRB / IEC, Investigator, Sponsor and Clinical Trial Protocol. Based on the comparisons of the contents in ICH-GCP with those in current GCPs, major suggestions for the revision of current KGCP can be made as follows. Firstly, the function of IRB / IEC needs to be strengthened for the initiation and continuation of clinical trial. Current 2-step approval system of IRB / IEC and Health Authorities requires to be converted into the system similar to that of developed countries. Secondly, sponsor's obligation needs to be tightened to control and assure the quality of clinical trial. Inspection of regulatory authorities should be made to perform during and / or after clinical trial, when it is necessary. In other words, sponsor should be made to establish written Standard Operating Procedures (SOPs) for all aspects of clinical trial including monitoring to ensure that trials are conducted and data are generated, documented, and reported in compliance with the protocol, GCP, and the applicable regulatory requirement (s). Besides, the provision of ‘Quality Control and Quality Assurance’ should be added to the protocol to establish the credibility of the result of the clinical trial.

• Journal of the Ergonomics Society of Korea
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• v.26 no.4
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• pp.121-125
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• 2007

The objective of this study is to develop short-term prevention measures for minimizing possible human error in nuclear power facilities. To accomplish this objective, a group of subject matter experts (SMEs) were formed, which is consisting of those from regulatory bodies, academia, industries and research institutes. Prevention measures were established for urgent execution in nuclear power facilities on a short-term basis. This study suggests short-term measures for reducing human error on three different areas; (1) strengthening worker management, (2) enhancing workplace environments and working methods, and (3) improving the technologies regulating human factors. Under the leadership of the Ministry of Science and Technology, these short-term measures will be pursued and implemented systematically by utility and regulatory agencies. The details of prevention measures are presented and discussed.

• Research in Plant Disease
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• v.24 no.2
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• pp.162-169
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• 2018

The GacS/GacA system in the root colonizer Pseudomonas chlororaphis O6 is a key regulatory system of many traits relevant to the plant probiotic nature of this bacterium. The work in this paper elucidates proteins using proteomics approach in P. chlororaphis O6 under the control of the cytoplasmic regulatory protein, GacA. A gacA mutant of P. chlororaphis O6 showed loss in production of phenazines, acyl homoserine lactones, hydrogen cyanide, and protease, changes that were associated with reduced in vitro antifungal activity against plant fungal pathogens. Production of iron-chelating siderophore was significantly enhanced in the gacA mutant, also paralleling changes in a gacS mutant. However, proteomic analysis revealed proteins (13 downregulated and 7 upregulated proteins in the mutant compared to parental strain) under GacA control that were not apparent by a proteomic study of a gacS mutant. The putative identity of the downregulated proteins suggested that a gacA mutant would have altered transport potentials. Notable would be a predicted loss of type-VI secretion and PEP-dependent transport. Study of mutants of these GacA-regulated proteins will indicate further the features required for probiotic potential in this rhizobacterium.

• Journal of Digital Convergence
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• v.14 no.3
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• pp.445-452
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• 2016

The purposes of this study were to examine the two processes of social comparison and self-comparison, and to suggest the applications of social comparison theories and self-comparison theories. For these purposes, social comparison theory, self-evaluation maintenance model, control theory, self-discrepancy theory, regulatory focus theory, and temporal comparison theory were reviewed. The processes of social comparison and self-comparison are different, but both comparisons are similar in that they have some effects on self-evaluation, emotion, motivation and behaviors. Suggestions on education, health, economic justice and interpersonal relationships were discussed.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.16 no.6
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• pp.119-130
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• 2021

This study is a study on the regulatory focus and entrepreneurship that affect entrepreneurial motivation under uncertainty. In the empirical analysis results between the prevention focus, risk taking, and economic entrepreneurial motive, which were not observed in previous studies in Korea, this study tried to supplementally verify the previous studies by focusing on the limitations of the sample suggested as limitations. In particular, under a special external environment where uncertainty is deepening due to COVID-19 and the economic situation is being severely hit, we regressively analyze regulatory focus and risk taking, which are innate personal characteristics that can affect entrepreneurial motives. The mediating effect of risk taking was demonstrated. As a result of the empirical results, it was found that the prevention focus, risk taking, and economic entrepreneurial motivation had a significant effect, and it was shown that risk taking had a mediating effect between the prevention focus and the economic entrepreneurial motivation. This result is meaningful as a result not observed in previous studies, and it is judged that the control focus, which is an individual characteristic with a large innate tendency, interacts with the risk taking of the acquired tendency to influence the motivation to start a business. The results of this study can be of practical help by understanding and concentrating on regulatory focus and risk taking when conducting entrepreneurship or entrepreneurship education programs to entrepreneurs who dream of or want to start a business amid the growing uncertainty of the external environment. On the other hand, it is necessary to confirm whether these results, which are different from previous studies, are the effect of sample diversity or the external environment such as Corona 19, and re-verification through additional research is needed in the future.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.21 no.12
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• pp.1177-1184
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• 2011

One of the main objectives of noise control act is to define and ensure application and respect of noise exposure limits. Most advanced countries have prepared a legal framework for noise limits either by national laws, ordinances or municipal by-laws. A large number of advaced countries have adopted the Leq index for the main sources of noise(road, railway, industry). The exception is aircraft noise for which regulatory practice is highly disparate. These differences in the indices adopted, the periods and areas to which regulations apply, definitions of measurement conditions and ways in which noise levels are calculated make it difficult to compare the current advanced countries standards. This study presents the current noise abatement policy of the advanced countries and proposes the improvement of the current noise abatement policy of Korea to catch up with it of the advanced countries.

• Environmental Analysis Health and Toxicology
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• v.17 no.4
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• pp.273-284
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• 2002

At present, the health risks associated with the natural radionuclides of ground water have become a concern as potential social problems. However, there are no regulatory actions or control strategies for such risks. Therefore, we have investigated and discussed the risks and associated management strategies for radionuclides in other countries. US EPA has proposed MCL (300 pCi/L) and AMCL (4,000 pCi/L) for radon, and 30 ppb for uranium, 15 pCi/L for gross-alpha and 5 pCi/L for radium as final MCLs. Also, Canada, WHO and European countries have their inherent management levels. Finally, we suggested several criteria for setting guidelines in our countries including exposure related criteria such as geological distribution, occurrence, exposure probability distribution, exposure population and multimedia exposure assessment, acceptable risk, and cost -benefit analysis. The national-scale exposure and risk assessment, and economic analysis should be conducted for producing and aggregating the representative information on these criteria.