• 약학회지
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• 제53권3호
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• pp.156-160
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• 2009

The present study was undertaken to determine whether transgelin participates in the regulation of vascular smooth muscle contraction and, if so, to investigate the mechanism. By PCR homology cloning, the cDNA sequence of ferret transgelin was determined and phosphorothioate antisense and random oligonucleotides were synthesized and introduced into strips of ferret aorta by a chemical loading procedure. Treatment of ferret aorta with transgelin antisense oligonucleotides resulted in a significant decrease in protein levels of transgelin to sham- or random sequence-loaded muscles, but no change in the protein levels of actin. Contraction in response to a phorbol ester was significantly decreased in antisense-treated muscles compared to sham- or random sequence-loaded controls. Neither basal intrinsic tone nor the contraction in response to phenylephrine was significantly affected by the antisense treatment. The data indicate that transgelin plays a significant role in the regulation of contraction and suggest that in a tonically active smooth muscle transgelin may function as a signalling protein to facilitate PKC or ERK-dependent signalling rather than thick filament regulation including $Ca^{2+}$ or calmodulin dependent regulation of myosin light chain kinase.

• International Journal of Computer Science & Network Security
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• 제22권1호
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• pp.39-48
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• 2022

Today the regulation of socio-economic development has been the subject of active scientific debate. The modern paradigm of regulatory policy in foreign countries involves a change in the role and strategy of the state, which determines the relevance of this topic. The aim of the article is to study the current state of regulatory policy research. The article is based on a bibliographic analysis of the study of regulatory policy. The study is based on the data search functions of the Scopus platform. It uses a set of VOSviewer program, online visualization of keywords in the titles of scientific journals and citations of publications. The study led to the conclusion that the number of publications that directly study the nature and features of regulatory policy is insignificant, but constantly growing. In our opinion, further research should determine the essence of regulatory policy as a separate category, a description of its features and factors of formation. It is also necessary to develop a common concept that governments should be actively involved in ensuring the quality of regulation, rather than responding to the shortcomings of regulation, which is evolving into regulatory governance.

• 한국건축시공학회지
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• 제4권4호
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• pp.117-126
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• 2004

Construction industry is faced with the problems such as the quickly changeable circumstance and increasing construction companies due to regulation mollification of company registration. In order to overcome these problems, new estimation system based on historical estimation cost is ready to introduce by government step by step. But the time of transition for estimation system causes another problems such as chaos addition to simultaneity of a standard of estimation system and new estimation system, lack of related regulation, accumulation of historical extensive cost data, and adjustment methodology when historical estimation data is applied to next projects. The purpose of this study is to suggest the change factors by activities for estimating historical cost for apartment housing projects. New estimation system is based on historical construction data. For application of this system, the standard adjustment methodology system is necessary. and extensive cost data should be accumulated under an unified construction work classification system. Therefore in this study, according to the construction work classification system, every apartment housing project was classified to 16 work classifications, and 7 major composed items which occupy more than 85% of construction costs are analyzed by detailed activities and by average ratio and maximum ratio each of them. In the result of the study, furniture work, foundation work and masonry work are the works which have big gap of costs between average ration and maximum ratio. In addition to suggestion of change factor by work species, 5 qualified construction specialists are interviewed and change factors in 7 major works are analyzed.

• 한국기후변화학회지
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• 제8권2호
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• pp.153-161
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• 2017

The purpose of this study is to screen for the effects of climate change and climate change adaptation in the insurance industry. There is now a consensus that the climate is changing, with potential risk to the global economy and human health and so on. On the other hand, unknown is the extent to which insurance business pattern have already been affected. But the increase in damage due to climate change is likely to raise insurance company losses. In this regard, I conduct especially an effects of the insurance industry on climate change. And than, I analyzed what insurance companies would do to lessen the impact of climate change. As a result, the impact of climate change on the insurance industry is a huge increases in claims due to disasters and diseases arising from climate change. And another thing is growth in climate change-related legislation, regulations and reporting requirements such as financial soundness regulation and climate change risk disclosure. Therefore, the insurance industry needs to build a climate change adaptation strategies include capital raising, liquidity of assets, faithful debt management and so forth.

• 통상정보연구
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• 제16권2호
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• pp.47-67
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• 2014

글로벌 금융위기 이후 금융기관의 건전서에 대한 비판이 일면서 바젤 III 등 새로운 금융규제가 제시되었다. 이들 제도는 중장기 금융산업의 경영과 구조변화 등에 많은 영향을 미칠 것으로 예상되며, 금융기관들은 이러한 규제강화에 대응하기 위한 사업모델의 재검토 등이 불가피할 것으로 판단된다. 현재 추진되고 있는 국제금융규제의 방향은 규제의 범위 확대, 글로벌 규제자본체계 도입, 글로벌 유동성 도입 등이다. 계량적 지표로는 바젤감독위원회가 추진하고 있는 계량영향평가(QIS)가 있으며, 법리적 관점에서는 이행시기에 대한 논의가 주로 이루어지고 있는 상황이다. 본 연구는 글로벌 금융위기 이후 각국의 규제 강화에 따른 국내 금융산업의 구조적 변화 및 상품에 따른 경쟁력 제고를 위한 전략을 제시하는데 목적이 있다. 연구결과를 살펴보면 글로벌 금융규제가 성공하기 위해서는 협약에 따른 준수여부가 중요한데, 은행을 중심으로 부정적 시간을 나타나고 있다. 뿐만아니라 금융선진국들의 규제강화에 대한 소극적 의사를 보이고 있는 것도 문제점을 제시되고 있다. 따라서 선후진국간 차등적 규제, 금융산업에 대한 이원적 규제, 선진국의 동참 등이 금융산업 구조변화에 선결될 요건일 것이다.

• 한국콘텐츠학회논문지
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• 제17권5호
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• pp.613-623
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• 2017

본 연구는 학급단위 집단미술치료프로그램이 아동의 정서조절과 학교생활적응력 향상에 미치는 효과성을 검증하고자 하였다. 본 연구는 대전시 00지역에 소재하고 있는 A초등학교에서 학생들을 대상으로 실시한 학교생활적응력 척도에서 3학년 최하수준 학급을 대상으로 구성되었다. 학급단위 집단미술치료프로그램은 2014년 10월 15일부터 11월 19일까지 주 1회, 40분씩 총 6회기를 진행하였다. 연구도구는 정서조절과 학교생활적응력 척도를 사전 사후로 비교하여 사용하였다. 본 연구의 효과검증을 위한 분석방법으로는 정서조절과 학교생활적응력 척도 변인의 사후검사 점수의 집단 간 비교에서 사전을 고려한 공분산분석(ANCOVA)을 하였다. 분석결과로는 첫째, 아동의 정서조절은 프로그램 실시 후 유의미하게 향상되었다. 둘째, 아동의 학교생활적응력은 프로그램 실시 후 유의미하게 향상되었다. 본 연구의 결론은 학급단위 집단미술치료프로그램을 진행하여 아동의 정서변화 과정을 통해 적절히 정서를 조절 할 수 있도록 하였고, 동시에 자연스럽게 학급친구들과 함께할 수 있는 자리를 마련하여 또래관계 형성을 바탕으로 학교생활적응력 향상에 긍정적인 도움을 주었다. 그리고 학교현장에서 다양하게 활용할 수 있도록 적합한 프로그램을 구축하여 즐거운 학교생활을 할 수 있도록 도움을 주는데 의의가 있다.

• 대한예방한의학회지
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• 제19권1호
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• pp.35-46
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• 2015

Objective : This study aims to investigate legal and regulatory status of traditional and complementary medicine (T&CM) focusing on regulation on health practitioners and health practice in 33 countries. Method : 33 countries were selected based on several factors such as interest of Korean medical doctors, strategic importance, and distribution over the world. The questionnaire was distributed to Korean embassies in 33 countries in March 2014 through Ministry of Foreign Affairs, and the answers from those countries were collected from April to September. 24 countries that provided sufficient information were included in the analysis. Results : 18 countries have law or regulation on T&CM. Only five countries regulate T&CM practitioners as medical personnel or health practitioner by law, and 12 countries have regulation on license or certificate. Half of 24 countries recognize license of T&CM practitioners issued abroad. There are nine countries that recognize T&CM practice as medical practice, and four of them regulate acupuncture as medical practice by western medical doctors or a few health practitioners recognized by the government. There are six countries that do not recognize T&CM practice as medical practice by law, but regulate it as practice that affect public health, and these countries have law or regulation on T&CM. Conclusion : As T&CM have great impact on public health, many countries have recently legislated law or regulation on T&CM. Rapid change in regulatory status of T&CM affects globalization of Korean medicine. Thus, development of timely strategies will be essential for it.

• 대한간호학회지
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• 제30권5호
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• pp.1303-1317
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• 2000

This study was conducted to identify a effect of the comprehensive self-regulation program for hypertensives as a nursing intervention on self-care performance and the physiologic parameters in rural areas. For this purpose, a nonequivalent control group and a pre and post-test quasi- experimental design was used. Fifty-four were evaluated subjects from two Community Health Practitioner Posts in the suburbs of Taejon City. The subjects of the control and experimental groups were matched for age and sex. The self-regulation program developed by author given to the experimental group. The program consisted of group education on hypertension and self-care, self-regulation including the blood pressure self-monitoring, recording of self-care activities, and encouraging and reinforcing self-efficacy. The whole program was carried out from September to November of 1999. The data were analyzed by repeated measure ANCOVA, t-test, and ANCOVA. The results were as follows ; There was significant improvement in the scores on knowledge (F=.68, P=.004), perceived self-efficacy (F=26.39, P=.000), self-care performance (F=26.11, P=.000) of the experimental group compared with those of the control group. There was no significant change on the score of locus of control, perceived benefits and perceived barrier, blood cholesterol level, body weight between two groups (P>.05). From these results, it can be concluded that the self-regulation program is an effective nursing strategy to promote self-care performance of hypertensives in rural area.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2017년도 학술발표회
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• pp.189-189
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• 2017

Climate changes have impacted to many sectors including water resources in Vietnam. Vietnam is agricultural development country having more than 6,000 earth dam reservoirs. These reservoirs play a very important role in flow regulation for water supply to economic sectors. In the context of undesirable impacts of climate change such as increasing temparature, evaporation, and changing rainfall and rainfall pattern, water demands and inflow to reservoirs also are being influenced. This leads to changes of resevoir exploitation effects that needs to be assessed for adaptation solutions. This article summarizes evaluations on climate change impacts to 16 reservoirs in 4 regions of North-West, North-East, Central Part, and Central Highland of Vietnam. Research results showed that in the context of climate change, safety of these reservoirs will be decreased from 8% to 20% in both water supply and flood control capacity.

• Reproductive and Developmental Biology
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• 제35권3호
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• pp.273-280
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• 2011

It was conducted the experiment, divided into three groups as normal, poor and polycystic ovary syndrome, to detect the change of protein patterns in follicular fluid on ovarian response following controlled ovarian hyperstimulation for human IVF outcome. In the normal group, it was confirmed reproducible 57 spots in the detected total 81 spots. Then 1 spot was not found in the other groups. In the poor responder group, it was found reproducible 53 spots in the detected total 98 spots. 6 spots were down-regulation and 7 spots were up-regulation comparable with normal group. There were not 5 spots in poor responder group comparable with other groups. In the polycystic ovary syndrome group, it was expressed reproducible 53 spots in the detected total 80 spots and 3 spots were just expressed in this group. However, 4 spots were not found in polycystic ovary syndrome. 9 spots were up-regulation comparable with normal group. Significant up and down-regulation spots among the each groups were identified. The results were a cytosolic carboxypeptidase, a signal-induced proliferation-associated protein 1, a ceruloplasmin, a keratin(type II cytoskeletal 1), a polypeptide N-acetylgalactosantinyltransferase 2, a serine/threonine-protein phosphatase 4 regulatory subunit 4. It was identified that 8 spots, 6 kinds of protein are corresponded with NCBInr database research, but 10 spots were failed in the identification. In conclusion, it has been confirmed change and expression of protein on the ovarian response following COH of human.