• 성인간호학회지
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• 제18권1호
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• pp.10-21
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• 2006

Purpose: The purpose of this study was to identity the effects of a health promotion program for rural elderly people on self efficacy, health problems, farmers syndrome and quality of life. Method: The study was a nonequivalent control group pre-post experimental design. The data collection was performed from April 12th, 2003 to August 2nd, 2003. The subjects were selected at Mari Myun Geochang Gun in Korea. Fortyfour elders were included in the experimental group and 45 elders were included in the control group. The 16-week health promotion program was given to the experimental group. Data were analyzed by descriptive statistics, $X^2-test$, t-test, paired t-test with SPSS/Win 10.0 program. Result: The experimental group showed a lower scores of health problems and farmers syndrome than the control group, and higher scores of quality of life than the control group. There were no significant differences in self efficacy. Conclusion: From the above results, it can be concluded that the health promotion program for rural elderly is an effective intervention for improving the rural elderly's quality of life and reducing health problems and farmer's syndrome. Therefore, development of strategy that can spread the health promotion program for rural elderly to the elderly of other rural areas are needed.

• 대한간호학회지
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• 제42권5호
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• pp.689-698
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• 2012

Purpose: This study was done to develop and evaluate a drug dosage calculation training program using cognitive loading theory based on a smartphone application. Calculation ability, dosage calculation related self-efficacy and anxiety were measured. Methods: A nonequivalent control group design was used. Smartphone application and a handout for self-study were developed and administered to the experimental group and only a handout was provided for control group. Intervention period was 4 weeks. Data were analyzed using descriptive analysis, ${\chi}^2$-test, t-test, and ANCOVA with the SPSS 18.0. Results: The experimental group showed more 'self-efficacy for drug dosage calculation' than the control group (t=3.82, p<.001). Experimental group students had higher ability to perform drug dosage calculations than control group students (t=3.98, p<.001), with regard to 'metric conversion' (t=2.25, p =.027), 'table dosage calculation' (t=2.20, p =.031) and 'drop rate calculation' (t=4.60, p<.001). There was no difference in improvement in 'anxiety for drug dosage calculation'. Mean satisfaction score for the program was 86.1. Conclusion: These results indicate that this drug dosage calculation training program using smartphone application is effective in improving dosage calculation related self-efficacy and calculation ability. Further study should be done to develop additional interventions for reducing anxiety.

• 대한후두음성언어의학회지
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• 제9권2호
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• pp.115-127
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• 1998

Laryngopharyngeal reflux(LPR) is one firm of the gastroesophageal reflux diseases(GERD). It is known to cause various kinds of otolaryngologic symptoms such as hoarseness, foreign body sensation in throat, chronic throat clearing, chronic cough, etc. Disease entities diagnosed by otolaryngologists as posterior laryngitis, globus pharyngeus should be suspected as LPR-related diseases. In this multi-center trial, we tried to evaluate the effect of cisapride(10mg tid) on LPR-related symptoms as the part I study(CIS-KOR-051) in 19 centers, and as the part II study(CIS-KOR-052) comparative evaluation of effect between cisapride(10mg tid) and ranitidine(150mg bid) on LPR-related symptoms in 4 centers. In part I study, efficacy of cisapride on LPR-related symptoms after 4 weeks was 53.5% and that of after 8weeks was 77.9% in per protocol(PPA) analysis group. In part II study, efficacy of the cisapride was much better than that of ranitidine not only from 8 weeks trial(p<0.001) but also from 4 weeks trial(p<0.021) in PPA group. In the multiple logistic regression analysis among the parameters which affect the efficacy of the treatment, cisapride prescribed group showed 10 times greater than that of ranitidine prescribed group(p<0.0001, Odds ratio : 10) in PPA group. LPR was proved by 24Hr double probe pHmetry in 13 patients out of 19 patients tested(68.4%). Thus these results indicated that inducing the improvement of motility functions could affect the amelioration of the LPR-related symptoms much better than reducing acid secretion from the stomach. And maybe it suggests that LPR-related symptoms mainly developed by the reduced motility functions of the esophagus and/or delayed gastric emptying.

• 보건교육건강증진학회지
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• 제28권5호
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• pp.131-143
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• 2011

Objectives: This study is to develop a web-based prevention program of alcohol-related problem among university students and to examine its efficacy in changing drinking behaviors and reducing harms associated with alcohol use. Methods: An hour-length program was developed containing news paper articles, pictures, stories and questionnaires in a multimedia format such as flash, animation, and text. Survey data were analyzed to examine program efficacy from a convenient sample of 1,080 freshmen enrolled in a participating university. Results: Participation in the program has resulted in statistically significant changes in drinking behavior between pretest and follow-up, including reduction of frequency of drinking, heavy drinking, and intoxication, typical amount of drinking per occasion, and subjective norm of heavy drinking. Repeated ANOVA revealed significant increases in knowledge on alcohol related facts, including recommended drinking unit by WHO with substantial level of effect size and in making negative alcohol expectancy with very low effect size. Further studies are guaranteed with randomized controlled trial for the program effectiveness. Conclusions: A web-based prevention program of alcohol-related problems in this study was efficacious in changing drinking behavior, knowledge on alcohol-related fact, alcohol expectancy and subjective drinking norm.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5659-5665
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• 2014

Background: To investigate the antioxidant value and anticancer functions of mitragynine (MTG) and its silane-reduced analogues (SRM) in vitro. Materials and Methods: MTG and SRM was analyzed for their reducing power ability, ABTS radical inhibition and 1,1-diphenyl-2-picryl hydrazylfree radicals scavenging activities. Furthermore, the antiproliferation efficacy was evaluated using MTT assay on K 562 and HCT116 cancer cell lines versus NIH/3T3 and CCD18-Co normal cell lines respectively. Results: SRM and MTG demonstrate moderate antioxidant value with ABTS assay (Trolox equivalent antioxidant capacity (TEAC): $2.25{\pm}0.02$ mmol trolox / mmol and $1.96{\pm}0.04$ mmol trolox / mmol respectively) and DPPH ($IC_{50}=3.75{\pm}0.04mg/mL$ and $IC_{50}=2.28{\pm}0.02mg/mL$ respectively). Both MTG and SRM demonstrate equal potency ($IC_{50}=25.20{\pm}1.53$ and $IC_{50}=22.19{\pm}1.06$ respectively) towards K 562 cell lines, comparable to control, betulinic acid (BA) ($IC_{50}24.40{\pm}1.26$). Both compounds showed concentration-dependent cytototoxicity effects and exert profound antiproliferative efficacy at concentration > $100{\mu}M$ towards HCT 116 and K 562 cancer cell lines, comparable to those of BA and 5-FU (5-Fluorouracil). Furthermore, both MTG and SRM exhibit high selectivity towards HCT 116 cell lines with selective indexes of 3.14 and 2.93 respectively compared to 5-FU (SI=0.60). Conclusions: These findings revealed that the medicinal and nutitional values of mitragynine obtained from ketum leaves that growth in tropical forest of Southeast Asia and its analogues does not limited to analgesic properties but could be promising antioxidant and anticancer or chemopreventive compounds.

• Biomolecules & Therapeutics
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• 제22권3호
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• pp.260-266
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• 2014

This study evaluated the pharmacokinetic profile and therapeutic efficacy of piroxicam (PX), a long acting non-steroidal anti-inflammatory drug for the treatment of arthritis, following intra-articular (IA) injection in comparison to the pharmacokinetic profile and therapeutic efficacy of PX after intramuscular (IM) injection. In the pharmacokinetic study in rats, systemic exposure and pharmacokinetic parameters of PX after a single IA dose were compared with systemic exposure and pharmacokinetic parameters of PX after administration of the same dose IM (0.6 mg/kg). The anti-inflammatory and analgesic effects of IA PX were evaluated simultaneously in a monoiodoacetate-induced osteoarthritis rat model. The plasma PX concentration rapidly rose following IA injection, and it was comparable to the plasma PX concentration following IM injection, suggesting the rapid efflux of the drug molecule from the joint cavity. However, in the efficacy study, the IA PX administration significantly reduced the knee swelling by reducing the level of prostaglandin $E_2$ in the joint, compared to that following administration of IA vehicle and after administration of the IM PX dose. In addition, we found that the anti-inflammatory and anti-nociceptive efficacies of IA PX were synergistically increased upon co-treatment with hyaluronic acid (HA), a potent agent for the treatment of osteoarthritis, at the weight ratio of 1:1 or 1:2, and these effects were more pronounced than those following administration of HA or PX alone. In conclusion, this study demonstrated the efficacy of the IA use of PX alone and/or in combination with HA in osteoarthritis.

• 근관절건강학회지
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• 제27권1호
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• pp.12-21
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• 2020

Purpose: The study was to develop a tailored education and coaching program (TECP) for cancer patients, and to identify the effects of TECP on pain severity, daily living impairment, barriers on pain management, self-efficacy, and pain management satisfaction. Methods: A randomized controlled trial was used. Patients referred to an oncology nurse specialist from oncologists for pain management were randomly assigned to TECP (25) or usual education program (UEP, 22). The intervention was offered by educating the method of taking opioid medication, managing opioid-induced side effects, reducing pain misconceptions and enhancing self-efficacy for communicating with a medical team on cancer pain severity, and pain-related impairment. Patients completed questionnaires before the education program and on the next visit 3~4 weeks later. Data were analyzed by SPSS 19.0 program using percentage, frequency, mean, standard deviation, x² test and independent t-test. Results: At all levels, pain severity improved significantly in the experimental group-worst pain (8.16 to 3.80, p<.001), average pain (6.16 to 2.52 p=.008), and least pain (3.32 to 0.96, p=.038)-but not in the control group. Pain management satisfaction also showed significant differences (t=2.93, p=.005) between experimental (4.70±0.49) and control (4.17±0.73) groups. Interference with daily living, barriers to managing cancer pain, and self-efficacy for managing pain improved in both groups but there were no significant differences. Conclusion: The findings suggest that TECP should be considered for outpatients who need cancer pain management.

• 여성건강간호학회지
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• 제26권2호
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• pp.151-160
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• 2020

Purpose: The purpose of this study was to examine the effects of a video education program in women receiving high-intensity focused ultrasound (HIFU) treatment. Methods: This was a quasi-experimental study with a nonequivalent control group non-synchronized design. The participants were 54 patients who had benign uterine tumors and adenomyosis. The data were collected from June to August 2018. A 10-minute video education program on HIFU and post-procedural care was developed based on the literature. The experimental group was provided the video education program with a question-and-answer session for 10 minutes after viewing the video. The control group received usual care (i.e., verbal instructions on post-procedural self-care). The questionnaire survey was conducted twice: before the educational program and before being discharged from the hospital. Differences in uncertainty, emotions, and self-efficacy among patients were analyzed. Data were analyzed using the chi-square test, Shapiro-Wilk test, paired t-test, and t-test with SPSS version 23.0. Results: The participants in the experimental group showed a decrease in uncertainty (t=4.33, p<.001), improvements in anxiety (t=-4.07, p<.001) and depression (t=-3.55, p<.001), and an enhancement of self-efficacy (t=-4.39, p<.001) compared to the control group. Conclusion: This nursing intervention was effective at reducing uncertainty, improving emotions, and enhancing self-efficacy. This intervention is feasible for use in nursing practice as an aid for patients when considering treatment methods.

• 한국융합학회논문지
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• 제12권12호
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• pp.349-354
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• 2021

본 연구는 노인일자리전담기관의 종사자들을 대상으로 감정노동와 조직몰입의 관계, 그리고 자기효능감의 매개효과를 분석하였다. 대전과 충청 지역의 노인일자리전담기관 종사자 253명을 대상으로 설문조사를 진행하였다. SPSS와 AMOS 18.0 프로그램으로 빈도분석, 신뢰도분석 및 상관관계분석, 확인적 요인분석과 부트스트랩 검정 등을 실시하였다. 분석결과, 노인일자리전담기관 종사자의 감정노동이 조직몰입에 부적인 영향을 미치고 두 변수의 관계에서 자기효능감의 매개효과가 검증되었다. 분석결과와 기존 연구들을 검토하여 노인일자리전담기관 종사자의 조직몰입을 향상시킬 몇 가지 방안을 제안하고자 한다. 첫째, 종사자들의 조직몰입 향상을 위해 감정노동을 개선하기 위한 지침의 개발, 정기적인 점검과 교육, 관리자들의 적절한 조치 등이 요구된다. 둘째, 종사자들의 자기효능감을 높이기 위해 실무중심의 전문성 향상을 위한 교육의 실시, 윤리의식을 향상시킬 수 있는 교육과 행정의 지원, 정서지지 서비스의 제공 등이 필요하다.

• 한국콘텐츠학회논문지
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• 제19권4호
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• pp.651-662
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• 2019

본 연구는 경증치매노인의 행동심리증상과 가족의 부양스트레스 및 자기효능감의 관계를 파악함으로써 치매노인 가족의 부양스트레스를 감소시키는데 기초자료를 제공하기 위함이다. 이에 따른 관계를 규명하기 위한 분석은 기술통계, t-test, ANOVA를 이용하였다. 경증치매노인의 행동심리증상에 대한 가족의 부양스트레스와 자기효능감에 대해 알아본 결과, 치매노인의 행동심리증상과 가족의 부양스트레스는 양의 상관관계 (r=.655, p<.001), 치매노인 가족의 부양스트레스와 자기효능감은 음의 상관관계(r=-.334, p<.001)가 있었다. 본 연구결과를 토대로 경증치매노인의 행동심리증상에 대한 적절한 대처법 개발을 통해 지역사회 경증치매노인 가족의 부양스트레스를 감소시키고 자기효능감을 향상시키기 위한 방안이 필요할 것으로 사료된다.