• Title/Summary/Keyword: rational method

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LOVASTATIN 고생산성 균주 개발 및 반응표면분석법 (RSM)에 의한 생산배지 최적화

  • Kim, Je-Gyeong;Kim, Gyeong-Hui;Kim, Hyeon-Suk;Lee, Sang-Jong;Jang, Yong-Geun;Jeong, Yeon-Ho;Jeong, Yong-Seop;Jeon, Gye-Taek
    • 한국생물공학회:학술대회논문집
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    • 2003.04a
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    • pp.228-232
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    • 2003
  • Lovastatin produced by Aspergillus terreus via polyketide pathway is a secondary metabolite with high anti-hypercholesterolemic activity. In this paper we are going to present effective strain development strategies for lovastatin production by comparing the productivity of the mutants obtained through traditional rational screening process and protoplast fusion method. Mutants resistant against various antibiotics and/or antimetabolites showed significantly higher lovastatin productivity than the corresponding mother strains, demonstrating that rational screening method was very efficient in selecting high yielding producers. Recombinant fusants obtained using protoplast fusion between high producers were observed to have very different morphology and physiology as represented by the production and secretion of lovastatin, as well as cell growth pattern. In parallel with the strain development, optimization process for the production medium was carried out in order to find optimal concentrations of the medium components using such a powerful statistical method as response surface method (RSM). It was concluded that not only the optimum production medium but also good morphological characteristics of the high-yielding producers led to higher lovastatin production.

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Performance Improvement of OFDM Receivers by Using Rational Oversampling of the Received Signals (수신신호의 비정수배 과표본화를 이용한 OFDM 수신기의 성능 개선)

  • Lee, Young-Su;Seo, Bo-Seok
    • Journal of Digital Contents Society
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    • v.10 no.2
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    • pp.189-198
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    • 2009
  • In this paper, we propose a method to improve the performance of orthogonal frequency division multiplexing (OFDM) receivers by using oversampling the received signals. Demodulation of the received OFDM signals is to detect the amplitude and phase components of the subcarriers. From the oversampled OFDM signals, we can get redundant informations in frequency domain for the data, which are different in phase but the same in amplitude. By using these properties, we can obtain signal to noise ratio (SNR) gain by the oversampling ratio compared to the receivers which sampled with symbol rate. In this paper, we propose oversampled receivers whose oversampling ratio is expanded from integer to general rational number. Through computer simulations, we show the validity of the proposed methods by comparing the performance of the receivers with nonideal band-limiting filters.

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A Study on the Rational Selection of Experimental Facilities Using AHP (AHP를 이용한 전문대학 실험기자재 선정 방안)

  • Park, Byoung-Tae;Lim, Seok-Jin
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.32 no.4
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    • pp.153-160
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    • 2009
  • In the research-oriented university there are various laboratories in the departments according to a major field of study. Under these circumstances the budget to purchase experimental facilities has only to be distributed among research teams and then is spent within the confines of it without rein. However, in case of college the budget for experimental facilities needs to be considered other allocation methods because of no laboratory being managed by professor. In this paper the methodology for the rational selection of experimental facilities for college is proposed. It is composed of the following ; (1) the rational allocation method of the budget for experimental facilities in consideration of the characteristics of individual departments, and (2) the evaluation and selection of the alternative experimental facilities submitting in each department. To decide rationally importance of estimation index for the determination of budget and equipment is applied the Analytic Hierarchy Process(AHP) technique. First the proposed methods are presented and then discussed with simulation results.

The Influence of Organizational Culture on Job Satisfaction of Fire Officials (소방공무원의 조직문화가 직무만족도에 미치는 영향)

  • Choi, Eun-Sook;Yi, In-Soo;Jeong, Wan-Taek
    • The Korean Journal of Emergency Medical Services
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    • v.13 no.3
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    • pp.107-120
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    • 2009
  • Purpose : The purpose of this study was to investigate the influence of organizational culture on job satisfaction of fire officials. Method : The subjects of this study were 251 fire officials in Gongju and Choengju province and Daejeon City. Data were collected using self-administering questionnaire from February 20 to March 20 in 2006. Collected data were analyzed using SPSS 14.0 program. Real number, percentage, mean and standard deviation were calculated, and t-test, ANOVA, Pearson correlation coefficient, multiple regression were analyzed. Result : The results of this study were as follows : 1. The job satisfaction was found to be significant positive correlations with full organizational culture(r = .595, p = .000). 2. The job satisfaction was found to be in significant positive with rational goal culture, open system culture and human relation culture. 3. How organizational culture affects the job satisfactions was as follows; 25.2% of core values of manpower, 6.3% of rational goal culture, and 4.9% of job initiative. Conclusion : Enhancing the job satisfaction of fire officials would improve personalized factors and changes rational goal culture.

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A Study on the Message Orientation of Newspaper Advertisements - With a focus on apartment sales ads in Busan (신문광고의 메시지 지향성에 관한 연구 -부산시 아파트 분양광고를 중심으로)

  • Choi, Hyang
    • The Journal of the Convergence on Culture Technology
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    • v.4 no.3
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    • pp.127-132
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    • 2018
  • This study set out to examine message orientation in advertising expression through the content analysis of apartment sales advertisements in Busan. For this purpose, the study analyzed newspaper ads about apartment sales in the Busan area in terms of advertising appeal methods and message types. Advertising appeal methods(rational and emotional appeal) and message orientation(environmental, emotional, investment, and functional orientation) were categorized according to brands(nationwide and local brands). The findings show that most of apartment sales ads in Busan used a rational appeal method. While nationwide brands used rational and emotional appeal in similar percentage, local brands used a lot of rational appeal. Of the types of advertising message orientation, investment and emotional orientation recorded the highest percentage. Messages of investment orientation to show economic profit or premium were used most, being followed by messages of emotional orientation to show pride and happiness. These findings were interpreted to display differences in strategies for advertising expressions among brands. The findings are expected to offer useful practical implications for message strategies for apartment sales ads.

Study on midtower longitudinal stiffness of three-tower four-span suspension bridges with steel truss girders

  • Cheng, Jin;Xu, Hang;Xu, Mingsai
    • Structural Engineering and Mechanics
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    • v.73 no.6
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    • pp.641-649
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    • 2020
  • The determination of midtower longitudinal stiffness has become an essential component in the preliminary design of multi-tower suspension bridges. For a specific multi-tower suspension bridge, the midtower longitudinal stiffness must be controlled within a certain range to meet the requirements of sliding resistance coefficient and deflection-to-span ratio. This study presents a numerical method to divide different types of midtower and determine rational range of longitudinal stiffness for rigid midtower. In this method, influence curves of midtower longitudinal stiffness on sliding resistance coefficient and maximum vertical deflection-to-span ratio are first obtained from the finite element analysis. Then, different types of midtower are divided based on the regression analysis of influence curves. Finally, rational range for longitudinal stiffness of rigid midtower is derived. The Oujiang River North Estuary Bridge which is a three-tower four-span suspension bridge with two main spans of 800m under construction in China is selected as the subject of this study. This will be the first three-tower four-span suspension bridge with steel truss girders and concrete midtower in the world. The proposed method provides an effective and feasible tool for engineers to design midtower of multi-tower suspension bridges.

Transverse earthquake-induced forces in continuous bridges

  • Armouti, Nazzal S.
    • Structural Engineering and Mechanics
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    • v.14 no.6
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    • pp.733-738
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    • 2002
  • A simplified rational method is developed to evaluate transverse earthquake-induced forces in continuous bridges. This method models the bridge as a beam on elastic foundation, and assumes a sinusoidal curve for both vibration mode shape and deflected shape in the transverse direction. The principle of minimum total potential is used to calculate the displacements and the earthquake-induced forces in the transverse direction. This method is concise and easy to apply, and hence, offers an attractive alternative to a lengthy and time consuming three dimensional modeling of the bridge as given by AASHTO under its Single Mode Spectral Analysis Method.

A Study on the Combinational Allocation Method using Hand-Drawn Map Overlay Technique in Landscape Planning (조경계획에 있어서 수작도면중첩기법을 적용한 조합적 배분법에 관 한 연구)

  • 김영대
    • Journal of the Korean Institute of Landscape Architecture
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    • v.20 no.2
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    • pp.119-126
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    • 1992
  • The purpose of this study is to develop the allocation method which could be applied to the transitional stage between analysis and synthesis to select the best alternative in landscape planning process. By using the matrix of alternatives with site-planning elements locational drawing in each, the combinational allocation method can make the process more rational and also more efficient. Hand-drawn map overlay technique accommodates the work I handy way. The method is useful in building conceptual scheme in landscape planning especially when it is applied to small scale project.

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Implication and Rational Application of Equivalent Load Method in Prestressed

  • Oh, Byung-Hwan;Jeon, Se-Jin
    • Proceedings of the Korea Concrete Institute Conference
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    • 2000.04a
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    • pp.663-667
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    • 2000
  • The equivalent load method has been widely used in the design and analysis of prestressed concrete structures. The purpose of this paper is to explore several important method of obtaining equivalent loads and to clarify the advantages and limitations of each method. The methods devised in this study include the use of curvature of tendon, characteristics of primary moment, self-equilibrium conditions, and linear segments approximation of tendon. It is shown that equivalent lading system is not uniquely determined in some cases and careful engineering judgement is required from the view point of accuracy and practical convenience.

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Suggestion for a splitting technique of the square-root operator of three dimensional acoustic parabolic equation based on two variable rational approximant with a factored denominator (인수분해 된 분모를 갖는 두 변수 유리함수 근사에 기반한 3차원 음향 포물선 방정식 제곱근 연산자의 분할기법 제안)

  • Lee, Keunhwa
    • The Journal of the Acoustical Society of Korea
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    • v.36 no.1
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    • pp.1-11
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    • 2017
  • In this study, novel approximate form of the square-root operator of three dimensional acoustic Parabolic Equation (3D PE) is proposed using a rational approximant for two variables. This form has two advantages in comparison with existing approximation studies of the square-root operator. One is the wide-angle capability. The proposed form has wider angle accuracy to the inclination angle of ${\pm}62^{\circ}$ from the range axis of 3D PE at the bearing angle of $45^{\circ}$, which is approximately three times the angle limit of the existing 3D PE algorithm. Another is that the denominator of our approximate form can be expressed into the product of one-dimensional operators for depth and cross-range. Such a splitting form is very preferable in the numerical analysis in that the 3D PE can be easily transformed into the tridiagonal matrix equation. To confirm the capability of the proposed approximate form, comparative study of other approximation methods is conducted based on the phase error analysis, and the proposed method shows best performance.