• Food Science of Animal Resources
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• v.35 no.4
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• pp.479-485
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• 2015

This experiment investigated whether yogurt containing fermented pepper juice (FPJY) affects cholesterol level in high fat and high cholesterol diet (HFCD) fed rat. Twenty five Sprague-Dawley male rats of 7 wk were divided into 5 groups, and fed following diets for 9 wk; CON (control diet), HFCD (HFCD), PY (HFCD supplemented with 2% of plain yogurt), LFY (HFCD supplemented with 2% of FPJY), and HFY (HFCD supplemented with 5% of FPJY). In the LFY group, hepatic total lipid level decreased significantly compared to the HFCD group (p<0.05). Serum HDL cholesterol level tended to increase and hepatic total cholesterol level decreased and were comparable to the CON group (p>0.05). In HFY group, body weight and hepatic total lipid level significantly decreased over the HFCD group (p<0.05). Serum and hepatic total cholesterol level, kidney, and body fat weights decreased, and were compared to the CON group (p>0.05). Liver weight decreased as FPJY content was increased. Results suggested FPJY would inhibit organ hypertrophy and accumulation of body fat, hepatic lipid, and cholesterol in HFCD fed rat.

• Journal of Food Hygiene and Safety
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• v.18 no.3
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• pp.166-170
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• 2003

This study was carried out to investigate the inhibitive effect of Saururus chinenesis Baill (SCB) on lipid peroxidation in Sprague-Dawely rat (SD-rat) accutely exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Saururus chinenesis Baill (200 mg/kg) was administered into rats intraperitoneally for four weeks, seven days after the injection of TCDD (1 ${\mu}$g/kg). we examined th lipid parameters by measuring the levels of Total Cholestero, Triglyceride(TG), HDL-Cholestero, and LDL-Cholesterol in serum and Malone Dialdehyde (MDA) in liver tissue of rats. Cholesterol was siginificantly elevated in TCDD-treated abnormal group (TTA). The higher level of HDL-Cholesterol was found in Saururus chinenesis Baill and TCDD administered group (STT), which showed the lower levels of Total-Cholesterol and LDL-Cholesterol. TG content in the TTA was 34.84% increased compared to Non TCDD-treated group (NTT). That of STT was inhibited by 18.90% compared to TTA. MDA content in the TTA was 44.72% increased compared to NTT. That of STT was inhibited by 17.14% compared to TTA.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1138-1142
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• 2002

Dansamchunghyul-tang(丹參淸血湯) is a new formula consist of Salviae Miltiorrhizae Radix and some oriental herbs to treatment of hyperlipidemia. In this study, we investigated the effects of the water extract of Dansamchunghyul-tang(DCT) on hyperlipidemia of the rat. We here studied the influence of DCT on hyperlipidemia in Sprague-Dawley rats. The hyperlipidemia was induced by Triton WR-1339 (tyloxapol) intravenous injection at 200mg/kg body weight. After 18 h, blood was collected for the determination of plasma total cholesterol, triglyceride, phospholipid, HDL-cholesterol, and LDL-cholesterol concentrations. In the model of hyperlipidemia induced by triton WR-1339 in rats, DCT showed decreasing effects on total cholesterol, triglyceride, phospholipid level significantly, in a dose-dependent fashion. DCT showed dose-dependent effects on HDL-cholesterol and LDL-cholesterol level insignificantly. In conclusion, DCT showed significant effects on hyperlipidemia, and the present findings indicate that DCT may prove potentially useful for treatment of hyperlipidemia.

• Korean Journal of Acupuncture
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• v.20 no.2
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• pp.93-100
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• 2003

Effects of Wisoo and Baekwhe acupuncture on serum glucose and lipid composition were investigated in high fat diet induced diabetic rat. Plasma glucose, free fatty acids and $\Beta-lipoprotein$ concentration showed a high reduction in wisoo acupuncture group compared to those of control group, however the values of baekwhe acupuncture group showed no significantly different those of control group. Plasma triglyceride and LDL-cholesterol concentration showed a tendency to decrease in the wisoo acupuncture groups, however the values of baekwhe showed no significantly different those of control group. Total cholesterol concentration showed a high reduction in wisoo acupuncture groups and HDL-cholesterol concentration showed a high values in wisoo acupuncture group, however these values no significantly different in all treatment groups.

• The Journal of Internal Korean Medicine
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• v.24 no.2
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• pp.358-364
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• 2003

Effects of Cheunhwasangamibang on serum glucose and lipid composition were investigated in high fat diet induced diabetic rat. Plasma glucose and free fatty acids concentration showed a high reduction in Cheunhwasangamibang groups compared to those of control group and these values decreased to increasing Cheunhwasangamibang concentration. Plasma ${\beta}$-lipoprotein and triglyceride concentration showed a low values in Cheunhwasangamibang groups, however these values showed no significantly different in 4 ml and 6 ml treatment groups. Total cholesterol concentration showed no significantly different in control group and 2 ml Cheunhwasangamibang group, however these values in 4 ml and 6 ml treatment groups showed a reduction compared to those of control group. Plasma LDL-cholesterol concentration showed a reduction in Cheunhwasangamibang group and HDL-cholesterol showed no significantly different in all treatment groups.

• Journal of the Korean Society of Food Science and Nutrition
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• v.15 no.3
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• pp.306-312
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• 1986

Demonstration of the highly positive correlation between blood cholestrol levels and heart disease has made consumers wary of the fats in meat, milk and eggs. The egg, as perhaps the single largest common source of cholesterol, has been cited by many members of the medical and scientific world as a food contributing to heart disease. In light of decreasing per capita egg consumption and continuing dietary egg cholesterol controversy, many researchers have focused their efforts on egg nutrition. The results reported, however, are often contradictory. In spite of the disputable scientific evidence, the egg has been labelled (erroneously) as a highly cholesterogenic food. The objective of this presentation is to present a general picture of the problem and discuss our laboratory findings relevant to the problem. An isotope technique was utilized to incorporate $^{14}C$-cholesterol into egg yolk lipoproteins and study the metabolic fate of dietary ovo-cholesterol in rats. Two hundred and fifty micro-curies of 4-$^{14}C$-cholesterol, emulsified in corn oil, were orally administered to five Single Comb White Leghorn laying hens. Eggs were collected, hard-boiled, and the hot dried egg yolk powder (HEY) was prepared. Total radioactivity excreted via feces was determined. The rat groups fed egg yolk powder excreted more than 95% of the ingested ovo-cholesterol, whereas the rat chow group excreted only 47%. No difference was observed between HEY and CEY treatments. Therefore, an unknown lipid factor present in egg folk accelerates cholesterol turnover rate and excretion via feces.

• The Korea Journal of Herbology
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• v.23 no.3
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• pp.113-117
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• 2008

Objectives : Effects of Rhizoma Alismatis extract on lipid composition and TBARS (thiobarbituric acid reactive substances) formation were investigated in rat fed high fat diet. Methods : Seventy male Sprague-Dawley rats were used in these experiments and housed with food and water ad libitum and Twenty rats were selected healthy over 400g body weight and fed high fat diet for 8 weeks. Rhizoma Alismatis extract was administerd at dose 100mg/kg/day, 200mg/kg/day and 300mg/kg/day p.o. for 4 weeks. Then Triglyceride, Total cholesterol, HDL-cholesterol, LDL-cholesterol, TBARS concentration and ALT(Alanine Aminotransferase), AST(aspatate transaminase) activities were determined. Results : Plasma total LDL-cholesterol showed a tendancy to decrease in all treated group(P<0.05), however plasma HDL-cholesterol, total cholesterol, triglyceride showed no significantly different. Rhizoma Alismatis extract feedings resulted in a decrease in plasma TBARS(p<0.05) concentration and AST, ALT activites but contents of TBARS in liver showed no significantly different among all the treatments. Conclusions : Reviewing these experimental results, it appears that Rhizoma Alismatis extract was effective for inhibiting lipid peroxidation and decreasing LDL-cholesterol concentration.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.5
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• pp.548-553
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• 2007

This study was designed to investigate effects of KH-305 on erectile dysfunction in hyperlipidemic rat. KH-305 has been evaluated for antihyperlipidemic and antierectile dysfunction effects on experimental hyperlipidemic rats induced by high cholesterol-diet. After oral administration of KH-305 water extract (50, 100, 200, 300 mg/kg) to hyperlipidemic rats for 8 weeks, the variables including body weight, total cholesterol, HDL-, and LDL-cholesterol levels in serum, the expression of eNOS and nNOS in penis were measured. Also, erectile function was determined by the measurements of intracavernosal pressure (ICP) and maximal arterial pressure (MAP) after electrical stimulation of the cavernosal nerve. Oral administration of KH-305 extracts significantly inhibited the increase of serum total cholesterol and LDL-cholesterol levels and the decrease of serum HDL-cholesterol level in hyperlipidemic rats induced by high fat diet. The penile expression level of the two enzymes (eNOS, nNOS) were increased significantly after oral administration of the KH-305 extracts. Erectile function after 10 volts stimulation was significantly decreased in the hyperlipidemic rat compared with the normal rat, but increased in KH-305 group compared with hyperlipidemic group. These results suggest that KH-305 is effective for erectile dysfunction in hyperipidemia.

• Journal of Food Hygiene and Safety
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• v.18 no.2
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• pp.56-60
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• 2003

TCDD, one of the notorious toxic environmental pollutants, damages various organs including liver and is regarded as an endocrine disrupter. To investigate the effects of Houttuynia cordata Thunb (HCT) on the biochemical parameters of function, liver and serum of TCDD-treated rats were used. Seven days after the injection of TCDD (1 $\mu\textrm{g}$/kg), HCT (200 mg/kg) was administered to rats on every other day for four weeks. The lipidperoxide activity was examined by measuring the level of total cholesterol, HDL-cholesterol, LDL-cholesterol, total lipid and triglyceride (TG) in serum, and malondialdehyde (MDA) in liver tissue of rats. Result showed that lipidperoxidation was inhibited In the significant level when 2,3,7,8-TCDD-damaged rats were treated with HCT.

• Journal of Microbiology and Biotechnology
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• v.29 no.3
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• pp.473-481
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• 2019

Statins are a class of lipid-lowering drugs commonly used in the prevention of cardiovascular diseases. However, statin therapy presents many limitations, which have led to an increased interest in non-drug therapies, such as probiotics, to improve blood cholesterol levels. Indeed, probiotic strains such as Lactobacillus acidophilus have been found to improve blood lipid profiles, especially in reducing total cholesterol and LDL-C levels. In this study, we established a high-cholesterol rat model and studied the effect of Lactobacillus acidophilus administration alone or in combination with rosuvastatin. We were able to show that Lactobacillus exerts a cholesterol-lowering effect. Additionally, we observed that when administered together, rosuvastin and Lactobacillus exert a combined cholesterol-lowering effect. Altogether, our data advocate for the possibility of establishing probiotics as non-drug supplements for the treatment of hypercholesterolemia.