Browse > Article
http://dx.doi.org/10.3746/jkfn.2007.36.5.548

The Effect of Herbal Formula KH-305 on Erectile Dysfunction in Hyperlipidemic Rat  

Lee, Eun-Jeong (Korea Medical Science Institute)
Kim, Hee-Seok (Korea Medical Science Institute)
Kim, Byoung-Chul (Korea Medical Science Institute)
Hwang, Sung-Wan (Korea Medical Science Institute)
Hwang, Sung-Yeoun (Korea Medical Science Institute)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.5, 2007 , pp. 548-553 More about this Journal
Abstract
This study was designed to investigate effects of KH-305 on erectile dysfunction in hyperlipidemic rat. KH-305 has been evaluated for antihyperlipidemic and antierectile dysfunction effects on experimental hyperlipidemic rats induced by high cholesterol-diet. After oral administration of KH-305 water extract (50, 100, 200, 300 mg/kg) to hyperlipidemic rats for 8 weeks, the variables including body weight, total cholesterol, HDL-, and LDL-cholesterol levels in serum, the expression of eNOS and nNOS in penis were measured. Also, erectile function was determined by the measurements of intracavernosal pressure (ICP) and maximal arterial pressure (MAP) after electrical stimulation of the cavernosal nerve. Oral administration of KH-305 extracts significantly inhibited the increase of serum total cholesterol and LDL-cholesterol levels and the decrease of serum HDL-cholesterol level in hyperlipidemic rats induced by high fat diet. The penile expression level of the two enzymes (eNOS, nNOS) were increased significantly after oral administration of the KH-305 extracts. Erectile function after 10 volts stimulation was significantly decreased in the hyperlipidemic rat compared with the normal rat, but increased in KH-305 group compared with hyperlipidemic group. These results suggest that KH-305 is effective for erectile dysfunction in hyperipidemia.
Keywords
erectile dysfunction; hyperlipidemia; ICP;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 De May JG, Vanhoutte PM. 1981. Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J Physiol 316: 347-355   DOI
2 통계청. 2003. 2002년 사망원인 통계결과. p 3-4
3 Lusis AJ. 1988. Genetic factors effecting blood lopoproteins. J Lipid Res 29: 397-429
4 Andersson KE, Wagner G. 1995. Physiology of penile erection. Physiol Rev 75: 191-236   DOI
5 Azadzoi KM, Saenz de Tajade I. 1991. Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. J Urol Res 146: 238-240   DOI
6 한국생약학교수협의회. 2004. 본초학. 아카데미서적, 서울. p 863, 865, 768
7 Richmond W. 1976. Use of cholesterol oxidase for assay of total and free cholesterol in serum by continuous flow analysis. Clin Chem 22: 1579-1588
8 Noma A, Nakayama KN, Kota M, Okabe H. 1978. Simultaneous determination of serum cholesterol in high and low density lipoprotein with use of heparin, $Ca^{2+}$ and an anion exchange resin. Clin Chem 24: 1504-1508
9 Fridewald WT, Levy RI, Fedreicson DS. 1972. Estimation of concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 18: 499-502
10 Park CS, Ryu SD, Hwang SY. 2004. Elevation of intracavernous pressure and NO-cGMP activity by a new herbal in penile tissure of aged and diabetic rats. J Ethnopharmcol 94: 85-89   DOI   ScienceOn
11 Juenemann KP, Aufenanger J, Konrad T, Pill J, Berle B, Persson- Juenemann C. 1991. The effect of impaired lipid metabolism on the smooth muscle cells of rabbits. Urol Res 19: 24-28   DOI
12 Lee HJ, Lee EJ, Kim HS, Kim SN, Hwang SY. 2006. Effects of KH-204 on the relaxation response of rabbit corpus cavernosum and reproductive function in male rats. J Korean Soc Food Sci Nutr 35: 847-852   과학기술학회마을   DOI   ScienceOn
13 Chung HC. 1995. Role of nitric oxide in penile erection. PhD Dissertation. Yeungnam Univ. p 35
14 Juenemann KP, Muth S, Rohr G, Siegsmund M, Alken P. 1992. Dose lipid metabolism influence the pathogenesis of vascular impotence? Int J Impot Res 4: 33-37
15 Ikegaski, Hattori T, Yamaguchi T. 2001. Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthase in rat. Eur J Pharmacol 427: 69-75   DOI   ScienceOn
16 노삼현, 최현숙, 이계웅, 이명렬. 2003. 고콜레스테롤혈증 흰쥐에서 산수유의 지질 저하 효과. 한국식품영양과학회 연합학술대회, 이화여자대학교, 서울. p 8-27   과학기술학회마을
17 Kim JH, Klyachkin ML, Svendsen E, Davies MG, Hagen PO. 1994. Experimental hypercholesterolemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction. J Urol 151: 198-205   DOI
18 이향림, 최상원, 최영선, 조성희. 2003. 복분자와 백출 메탄올 추출물의 난소절제 흰쥐의 지질대사에 미치는 영향 및 안전성. 한국식품영양과학회 제54차 학술발표회, 충북대학교, 청주. p 11-27
19 전영중. 2003. 복분자로부터 분리한 혈당강하 활성성분의 평가 및 이를 이용한 당뇨개선 기능성 제품개발. 아미코젠 주식회사 연구보고서. p 98
20 Ahn TY, Azadzoi KM, Saenz de Tejada I. 1992. Effects of oxidatively modified low density lipoprotein on corpus cavernisum smooth muscle tone. Int J Impot Res 4: 52-55
21 Kwak KM, Seo SI, Hwang TK. 2003. Short term effects of hypercholesterolemia on corpus cavernosal tissue in rabbits. J Kor Urol Soc 44: 1277-1282
22 국민의료보험관리공단. 1998. 97년 한국인의 사망원인통계. 최근의보동향 144: 64-76
23 Huh KB. 1990. The present status of nutrition-related diseased and its countermeasures. Korean J Nutrition 23: 197-207   과학기술학회마을