• Transactions of the Korean Society of Automotive Engineers
• /
• v.13 no.2
• /
• pp.162-169
• /
• 2005

To achieve rapid new car developments and cost saving, new approaches for automotive general assembly in manufacturing preparations are needed. In this paper, CAD and DMU technologies for design and evaluation of machines and equipments are discussed. Digital Mock-up based on 3-D CAD models usually apply in the area of concept design and design review. We focus on manufacturing preparations of the machine and equipment. Detail procedures, examples and considerations of DMU are suggested in this paper. By applying DMU in the manufacturing preparations of general assembly, time, cost and quality of engineering can be enhanced through engineering collaboration.

• YAKHAK HOEJI
• /
• v.46 no.5
• /
• pp.337-342
• /
• 2002

Propofol(2,6-diisopropyl phenol) is a phenol derivative that is chemically distinct from other intravenous sedative hypnotics. It has been extensively used as a short term anesthetic agent, because of the rapid onset and short duration of action. Propofol microemulsion system was prepared with different concentrations of ethyl oleate, $Solutol^{(R)}$ HS 15 and $Kollidon^{(R)}$ 17 PF. Propofol microemulsions were studied by transmittance, viscosity, particle size, in vitro release and pharmacokinetics. The range of transmittance of A group with 4% ethyl oleate and that of B group with 5% ethyl oleate were 92.6~95.1 and 91.3~94.2%, respectively. Transmittance 1~2% decreased as concentration of $Kollidon^{(R)}$ 17 PF was increased and increased 0.8~3.3% when 10 times diluted with normal saline. The viscosity of A and B group were in the range of 3.9~4.1 mPaㆍsec and 4.4~5.3 mPaㆍsec, respectively. The particle sizes of A and B group increased as amount of $Kollidon^{(R)}$ 17 PF. Also, release of propofol was slowly increased as the amount of $Kollidon^{(R)}$ 17 PF was increased. Propofol plasma concentration by i.v injection showed 2-compartment model. Pharmacokinetics of A-5 was similar to that of commercial emuision(POFOL).

• Journal of Welding and Joining
• /
• v.17 no.6
• /
• pp.53-61
• /
• 1999

The use of thick plate in increasing in recent years due to the rapid expansion of chemical plants, nuclear plants, ships and other industrial plants. Welding is the most popular joining techniques employed in manufacturing industrial machineries and structures. Normally, Groove shapes are prepared according to appropriate rules and regulations such as KS, JIS, AWS, LR, DNV and etc. for various thicknesses of plate. However those groove angles tend to be too large. As a result of large groove angle, residual stress, deformation of material and strength reduction is obtained. Therefore, the reliability and safety of structures and machinery tend to be decreasing. Therefore, in this paper, theoretical as well as experimental study are carried out to find optimum groove shapes for T-welded joint of mild steel. The test specimen are made in same condition with simulation model. Welding residual stresses measurement by sectional cutting method. ⅰ) The mechanical difference for change the thickness of plate and groove angle are not appeared. ⅱ) In a mechanical point of view minimum preparation angle(40°) is more suitable than maximum groove angle(60℃). ⅲ) The measurement value and distribution of welding residual stresses are not effected largely by groove angle. It is mechanical restraint that mainly affect welding residual stresses distribution. In mechanical point of view minimum groove angle is more suitable than maximum groove angle. Therefore, it is appropriate to minimize the size of groove shape in strength and safety.

• Journal of the Korean Chemical Society
• /
• v.62 no.5
• /
• pp.352-357
• /
• 2018

Celecoxib (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) is a cyclooxygenase-2 inhibitor used in the treatment of arthritis, acute pain, and dysmenorrhoea. Celecoxib is a Biopharmaceutics Classification System (BCS) class II compound whose oral bioavailability is highly limited owing to its poor aqueous solubility. Several polymorphs of celecoxib have been identified as Form I, Form II, and Form III with melting points of about $162.8^{\circ}C$, $161.5^{\circ}C$, and $160.8^{\circ}C$, respectively. Form IV was generated from the precipitated suspension in the presence of HPMC (Hydroxypropyl methylcellulose) and Polysorbate 80. A rapid rate of dissolution is useful because the rate of dissolution of a drug typically increases its bioavailability. The aim of this study was to investigate the possibility of production of new crystal form of celecoxib that has higher solubility than Form III. New crystal form of celecoxib (Form A) has been isolated by recrystallization and characterized by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis and powder X-ray diffractometry (PXRD). Form A was dissolved faster than Form III. At 30 minutes, the dissolution of Form A was 97.3%, whereas the dissolution of Form III was 82.2% (p < 0.1). After storage of three months at $20^{\circ}C$, in 24% RH (Relative Humidity), the crystal form was not transformed.

• Journal of the East Asian Society of Dietary Life
• /
• v.22 no.6
• /
• pp.802-811
• /
• 2012

This study was conducted to test the characteristics of dough made with rice flour for preparation of steamed cakes containing rice flour. We used a RVA (Rapid Visco Analyser), farinogram and alveogram to analyze cake flour and mixed powder containing 10, 20, and 30% rice flour for the water activity, texture, and, color changes after different storage periods. We found that rice flour inhibited starch aging, and that gluten free rice flour made the cakes more delicate. However, steamed cakes containing rice flour were harder than wheat cakes during storage. Because the cake was steamed, it had more moisture and was softer than cakes baked in an oven. The steamed cake prepared with rice flour became brighter than the control. The results of the consumer acceptance test and sensory characteristics showed that the steamed cake containing 20% rice flour obtained the highest score, indicating that this is the most appropriate level for making steamed cakes.

• Korean Journal of Veterinary Research
• /
• v.45 no.1
• /
• pp.63-70
• /
• 2005

African swine fever (ASF) is an infectious disease of domestic and wild pigs for which there is no vaccine in the world. A proper surveillance of viral activity and a timely response to ASF outbreaks depend upon the rapid diagnosis of ASF viral infection. Internationally prescribed enzyme-linked immunosorbent assay (ELISA) is a fast, sensitive test routinely used in the diagnosis of the ASF. However, inactivated whole ASF virus antigen used in this test is a tedious to prepare and has a risk of outside exposure of infectious virus by laboratory accident during the preparation. An ASF virus noninfectious recombinant antigen is a safe and easily produced alternative antigen for use in diagnostic assay. We have cloned the ORF O61R gene of the ASF virus to generate a recombinant baculovirus producing the p12 protein in insect cells under control of the polyhedrin promoter as non-fusion protein. When used in an indirect ELISA, the p12 antigen showed reactivity with all known ASF positive pig sera but not with negative pig sera. Our results indicated that the p12 protein would be one of alternative antigens for diagnosis of the ASF.

• Korean journal of food and cookery science
• /
• v.27 no.5
• /
• pp.577-587
• /
• 2011

In this study, lotus leaf was added to a Takju (Korean milky rice wine) preparation to evaluate its effects on physicochemical and fermentation properties. For rapid saccharification Takju was stored at 25$^{\circ}C$ for 2 days and then temperature was switched to 18$^{\circ}C$ to mature the wine for 21 days. From the start of fermentation to 2-days, the pH of Takju decreased rapidly and acidity increased. Maltose, a byproduct of starch saccharification, increased for 2 days then rapidly decreased. Glucose fluctuated for 7 days and of the 21-days fermentation. The ethanol production rate was highest during the first 7 days, then slowed. Total viable yeast and lactic acid bacterial counts increased rapidly for 2 days and then decreased gradually thereafter. Leuconostoc spp. grew rapidly for 1 day and sharply disappeared with decreasing pH. DPPH radical scavenging activity was significantly higher for Takju prepared with lotus leaf than without. The overall acceptance of Takju tended to increase when it was prepared with lotus leaf.

• Journal of The Korea Institute of Healthcare Architecture
• /
• v.16 no.3
• /
• pp.57-68
• /
• 2010

The purpose of this study is to investigate the current characteristics of healthcare and welfare policies in Japan focused on the related policies in 2000's. In Japan, with the perspectives of entering the super-aged society by 2005 and the movement of all of the baby boom generation into the elderly generation by 2015, more rapid progress to the aging society is expected. From this situation, Japanese government has developed diverse elderly-oriented strategies such as "structural reform of social security", "nursing care system" and "gold plan 21" in 2000's. However, most of the related researches targeted the period to early 2000's, excluding the papers about the individual policies. Recently in our country, many related policies have been developed such as the enforcement of "long term care insurance system for the elderly" by 5 year period reevaluations and the preparation for 2nd step of "Plan for Ageing Society and Population"(2011~2015). At this moment, the investigation on the related policies of Japan could give appropriate references to us, a late starter of aging society.

• Korean Institute of Interior Design Journal
• /
• v.14 no.3 s.50
• /
• pp.156-164
• /
• 2005

Like other countries undergoing the aging of the population, increases in the aged population have raised serious issues in Korea. The proportion of elderly will be foreseen over $14\%$ of population in 2019, over $20\%$ in 2026 in korea. Due to the rapid increasing in the aged population, it calls for social countermeasures urgently, And recent researches about attitude to the aged find out in general negative attitude to the aged of other generations. It is thought desirable that comprehension to the aged of the commonalty should be educated on the school basis or a variety of informal ways. The study aims to determine the space formation of the senior simulation center that suggest to be considered for the effective education and preparation for the aging of all social members, particularly for the younger generation. In such space formation, it is important to work out a plan of efficiency education according to the systematic environmental setting with a focus on the minimization of problematic behaviors and living disabilities of aging, as interactive experiences gain malfunctions by aging. This study is expected to promote a focus on the integration of the whole generations and improved design management for the environment of a welfare policy for the aged.

• Korean Chemical Engineering Research
• /
• v.50 no.2
• /
• pp.204-210
• /
• 2012

Nickel oxide thin films with 2.3 ${\mu}m$ thickness were prepared in order to overcome limitations of thickness with nm dimension by anodizing. For the electrolyte, ethylene glycol was used as solvent, and $NH_4F$ was added for source of $F^-$ ions. The anodizing experiments were carried out on various voltages such as 40, 60 V and 80 V for 12 hours. The thickness of NiO was changed according to the anodizing time and the voltage. However, destruction of Ni caused by rapid oxidation reaction occurred at 80 V. XRD results show that NiO was successfully created by anodizing.