• Journal of Periodontal and Implant Science
• /
• v.37 no.4
• /
• pp.849-857
• /
• 2007

Purpose: The purposes of this study were to compare and quantify the expressions of RANK and RANKL in the gingival tissues of non-periodontitis patient and patients with chronic periodontitis, in order to understand the contribution of these proteins to periodontal destruction. Material and methods: Gingival tissue samples were obtained during periodontal surgery or tooth extraction. According to the patient's systemic condition & clinical criteria of gingiva, each gingival sample was divided into two groups. Group 1 (n=8) is clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from non-periodontitis patients. Group 2 (n=8) is inflammed gingiva from patients with chronic periodontitis. Tissue samples were prepared and analyzed by Western blotting. The quantification of RANK and RANKL were performed using a densitometer and statistically analyzed by Student's t-Test. Results: The expression of RANK were similar in group 1 and 2. The difference between group 1 and 2 was not statistically significant. And the mean amount of RANKL was more increased in group 2 than group 1. The difference between group 1 and group 2 was statistically significant. Conclusion: The expression level RANK didn't show any significant difference between healthy tissue from non-periodontitis patients and inflamed tissue from chronic periodontitis, but the expression level of RANKL in inflammed tissue from chronic periodontitis showed significantly increased tendency compared to healthy gingiva from non-periodontitis patients. Therefore, characteristics of RANK and RANKL in progress of chronic periodontitis would be basis of further studies in diagnostic method and treatment index of the disease.

• The Korean Journal of Health Service Management
• /
• v.8 no.3
• /
• pp.75-87
• /
• 2014

The purpose of this study was to identify job satisfaction and organizational commitment depends on their organizational cultures. A survey, including the Organizational Culture Scale, Job Satisfaction Scale and Organizational Commitment Scale, was administered to 276 nurses working at 4 small to medium sized hospitals in B city. The dominant organizational culture of nursing organization was relation-oriented culture. The mean score of job satisfaction and organizational commitment was 2.68 and 4.25 respectively. Job satisfaction and organizational commitment were positively correlated with innovation-oriented, task-oriented and relation-oriented culture. Organizational commitment was negatively correlated with rank-oriented culture. Innovation-oriented, clinical career, relation-oriented and rank-oriented culture were variables influencing on job satisfaction and innovation-oriented and rank-oriented culture were major variables influencing organizational commitment. In conclusion, innovation-oriented and rank-oriented culture had a significant influence on nurses' job satisfaction and organizational commitment. Therefore, we have to develop strategies to enhancing the innovation-oriented culture and to reducing the rank-oriented culture.

• Proceedings of the Korean Statistical Society Conference
• /
• 2002.05a
• /
• pp.45-48
• /
• 2002

Consider the mean distance of Brownian motion on Riemannian manifolds. We obtain the first three terms of the asymptotic expansion of the mean distance by means of Stochastic Differential Equation(SDE) for Brownian motion on Riemannian manifold. This method proves to be much simpler for further expansion than the methods developed by Liao and Zheng(1995). Our expansion gives the same characterizations as the mean exit time from a small geodesic ball with regard to Euclidean space and the rank 1 symmetric spaces.

• Journal of the Korean Data and Information Science Society
• /
• v.13 no.1
• /
• pp.165-175
• /
• 2002

We consider the problem of estimating the change-point in mean change model with the one change-point. Lombard (1987) suggested change-point estimation based on score functions. Gombay and Huskova (1998) derived a class of change-point estimators with the score function of rank. Various change-point estimators with the log score functions of ranks are suggested and compared via simulation.

• Proceedings of the IEEK Conference
• /
• 2001.09a
• /
• pp.337-340
• /
• 2001

본 논문에서는 MPEG가 비디오 스트림의 형상 정보를 클러스터링 하여 VO(Visual Object)의 동작을 요약하는 새로운 방법을 제안한다. 제안하는 방법은 MPEG-4 비트 스트림의 디코딩 없이 형상 정보를 근사화 한다. 그리고 사용자가 입력한 질의 VOP(Video Object Plane)와 VO의 각 VOP와의 NMHD(Normalized Mean Hausdorff Distance)를 구한 후 클러스터링을 수행하여 키 영역을 분리해낸다. 클러스터링에 의해 시간적으로 분리된 영역의 지속성을 고려하여 Rank를 매김으로써 사용자가 원하는 수의 키 VOP를 선택할 수 있게 한다. 제안하는 방법은 클러스터링을 사용함으로써 키 VOP를 선정하였으며, Rank와 질의 VOP를 사용하여 사용자와의 상호작용이 가능하다.

• Communications for Statistical Applications and Methods
• /
• v.6 no.2
• /
• pp.467-478
• /
• 1999

This paper deals with the problem of change-point estimation where there is one level change in location with iid errors. A change-point estimator using rank average is proposed with the proof of its consistency. A comparison study of various change-point estimators is done by simulation on the mean the proportion and the variance when the errors are from the normal and the double exponential distributions.

• Journal of the Korean Data and Information Science Society
• /
• v.28 no.2
• /
• pp.435-442
• /
• 2017

Consider the problem of estimating a $p{\times}1$ mean vector ${\theta}$ (p ${\geq}$ 3) under the quadratic loss from multi-variate normal population. We find a James-Stein type estimator which shrinks towards the projection vectors when the underlying distribution is that of a variance mixture of normals. In this case, the norm ${\parallel}{\theta}-K{\theta}{\parallel}$ is known where K is a projection vector with rank(K) = q. The class of this type estimator is quite general to include the class of the estimators proposed by Merchand and Giri (1993). We can derive the class and obtain the optimal type estimator. Also, this research can be applied to the simple and multiple regression model in the case of rank(K) ${\geq}2$.

• The Korean Journal of Food And Nutrition
• /
• v.27 no.6
• /
• pp.979-989
• /
• 2014

The purpose of this study was to investigate the association between dietary behavior and temperament & character in preschool children, and to offer basic data that can be applied for nutrition education and counseling. A total of 211 parents of preschool children aged 3~5 years performed the Korean version of Preschool Temperament and Character Inventory (K-psTCI), a questionnaire based on Cloninger's seven-factor model of personality, along with a questionnaire about the dietary behaviors of their children. K-psTCI represented seven factors such as harm avoidance (HA), novelty seeking (NS), reward dependence (RD), persistence (P), self-directedness (SD), cooperativeness (CO), and self-transcendence (ST). The subjects were divided into either the high rank group or low rank group based on the mean score of each factor. The high rank group of HA showed significantly less physical activity and less appetite than the low rank group of HA. The children in the high rank of NS were more likely to have picky eating and a late night snack. The children in the low rank of SD or CO were more likely to have undesirable dietary behaviors, such as picky eating, too much snacking, and lower appetite than those in the high rank of SD or CO. In conclusion, individual temperament & character in preschool children may be associated with their dietary behavior, and understanding temperament & character in children may be important facts to screen and to develop an effective nutrition education program for children.

• Journal of KIISE
• /
• v.44 no.8
• /
• pp.782-790
• /
• 2017

The service, 'Hot Search Keywords', provides a list of the most hot search terms of different web services such as Naver or Daum. The service, bases the changes in rank of a specific search keyword on changes in its users' interest. This paper introduces a temporal modelling framework for predicting the rank change of hot search keywords using past rank data and machine learning. Past rank data shows that more than 70% of hot search keywords tend to disappear and reappear later. The authors processed missing rank value, using deletion, dummy variables, mean substitution, and expectation maximization. It is however crucial to calculate the optimal window size of the past rank data. We proposed an optimal window size selection approach based on the minimum amount of time a topic within the same or a differing context disappeared. The experiments were conducted with four different machine-learning techniques using the Naver, Daum, and Nate 'Hot Search Keywords' datasets, which were collected for 2 years.

• The Korean Journal of Pain
• /
• v.30 no.2
• /
• pp.86-92
• /
• 2017

Osteoblasts, originating from mesenchymal cells, make the receptor activator of the nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in order to control differentiation of activated osteoclasts, originating from hematopoietic stem cells. When the RANKL binds to the RANK of the pre-osteoclasts or mature osteoclasts, bone resorption increases. On the contrary, when OPG binds to the RANK, bone resorption decreases. Denosumab (AMG 162), like OPG (a decoy receptor), binds to the RANKL, and reduces binding between the RANK and the RANKL resulting in inhibition of osteoclastogenesis and reduction of bone resorption. Bisphosphonates (BPs), which bind to the bone mineral and occupy the site of resorption performed by activated osteoclasts, are still the drugs of choice to prevent and treat osteoporosis. The merits of denosumab are reversibility targeting the RANKL, lack of adverse gastrointestinal events, improved adherence due to convenient biannual subcutaneous administration, and potential use with impaired renal function. The known adverse reactions are musculoskeletal pain, increased infections with adverse dermatologic reactions, osteonecrosis of the jaw, hypersensitivity reaction, and hypocalcemia. Treatment with 60 mg of denosumab reduces the bone resorption marker, serum type 1 C-telopeptide, by 3 days, with maximum reduction occurring by 1 month. The mean time to maximum denosumab concentration is 10 days with a mean half-life of 25.4 days. In conclusion, the convenient biannual subcutaneous administration of 60 mg of denosumab can be considered as a first-line treatment for osteoporosis in cases of low compliance with BPs due to gastrointestinal trouble and impaired renal function.