• 한국주거학회논문집
• /
• 제22권1호
• /
• pp.105-114
• /
• 2011

There are various kinds of Large-Scale apartment sites in Seoul. There are more households in apartment sites than single family houses. Nowadays, it is easy to find a lot of apartment sites built in the style of a high rise building. On the matter of space, a building is influenced by the buildings near it. The influence a building has to another is different in both qualitative and quantitative ways. Therefore, in the case of apartment sites, the environmental surroundings of each household is affected by the nearby buildings. For these reasons, the environment is having more and more influence on the price of each household in apartment sites. This paper has defined Sunshine and Sky as the major environmental elements. In order to be analyzed, they have to be measurable. Thus, there are two types of variables in environmental surrounding of apartment sites, -the Duration of Sunshine and the possible amount of visible Sky- the significant variables which influence the housing price. This paper deals with the relationship between the possible duration of sunshine and the possible amount of sky a household is visible to. It focused on 62 different apartment sites which were built after 1990. It is based on the 3-dimensional Geographic Information System & Computer Aided Engineering for analyzing the sunshine simulation and the viewing simulation. This paper will be helpful for designing the apartment sites considering the balance between sunshine and sky.

• 천문학회지
• /
• 제29권1호
• /
• pp.63-73
• /
• 1996

The previous study of chemical evolution of the Galaxy is extended to the radial properties of the Galactic disk. The present model includes radial dependency of the time-dependent bimodal IMF, radial flow of material in the disk, and the change of type I supernova explosion rate with radial distance from the disk center as model parameters and observed gas and stellar density distributions and metallicity abundance gradient as observational constraints. The results of two models in this study explain the observed gas and stellar density distributions well, with the slope of the gas density gradient in the region of 4.5 kpc$Y_1$ and -0.123dex/kpc in model $Y_2$, respectively, which fit well the observed gradient of -0.l1dex/kpc. The abundance gradient reproduced in model $Y_1$ is getting flatter with decreasing radius, while that in model $Y_2$ is getting steeper, which fits better the observed abundance gradient. This result shows the necessity of exponentially increasing type I supernova explosion rate with decreasing radius in order to explain the observed abundance gradient in the disk. The fitness of observed density distribution and star formation rate distribution justifies the reliability of time-dependent bimodal IMF as a compound quantitative chemical evolution model of the Galaxy. The temporal variations of metallicity gradients for carbon, nitrogen and oxygen are also shown.

• 한국디지털건축인테리어학회논문집
• /
• 제9권3호
• /
• pp.95-102
• /
• 2009

An architectural space can be considered a life form that interconnects a number of architectural elements such as the humans who live in it. It is difficult to understand and evaluate the complexity of the interrelation between each element, but there have been various attempts to understand and evaluate this architectural space. The Space Syntax that emerged in 1980s has been studied and used more frequently than other methods. Space Syntax is the space analysis tool that analyzes the physical structure of space and represents it as a graph. Space syntax enables its various applications in space analysis by quantifying each spatial property of a whole structure, analyzing it systemically and objectively based on mathematical logic, and representing the results as a quantitative value. Integration of Space Syntax, a widely used index, reflects human behavior in spatial configuration. Meanwhile, there have been various studies in the field of architectural environmental psychology about the relationships between space and human behavior by applying behavioral science to architectural plan. One of the most widely used one is spatial behavior simulation which uses models and simulates the behavioral characteristics to anticipate practical situations and investigate the behavior related spatial problems. In this study, which focuses on the accessibility of the space syntax model, the usefulness of space will be analyzed through the simulation of human behavior that moves through each space. Furthermore, the validity of index will be verified by displaying several examples and compared with integration in space syntax, which represents the usefulness of space.

• 대한한의진단학회지
• /
• 제18권1호
• /
• pp.1-10
• /
• 2014

Objectives Visual inspection is the first diagnostic method in Oriental medicine, and visual inspection of eyes is the one among them. This study was written in order to complement further understanding on visual inspection of eyes. Methods 1. Out of 102 photographs submitted to the Society of HyungSang Medicine in 2009, 27 portrait pictures were selected as samples in blind by 2 clinicians. The samples were copied to make 54 sample pictures, and then randomly assigned to 4 clinicians. 2. The 4 clinicians evaluated the 54 samples for excess and deficiency of the eyes. The results were recorded as 5-points-scale, and their average and standard deviation was calculated. 3. Intra and inter class reliability test were measured using SPSS 13. Results For intra- and inter-class correlation coefficient (ICC) values were measured as 0.654~0.967 and 0.756~ 0.783 respectively, with the P-value below 0.05. Out of 27 originally selected samples, 7 pictures were selected as Deficiency Samples (with 3 pictures of male and 4 of females), and 20 as Excess Samples (with 4 of male and 16 of female). Among them, Sample No. 1, 9, 22, and 26 were selected as models of 'Excessive Eyes' for females, no. 4 and 5 as 'Very Excessive Eyes' for male and females, and no. 15 as 'Moderate Eyes' for females. Conclusion This study is the first attempt of quantitative measurement of excess and deficiency using the Visual Inspection of eyes by the visual inspection experts. Still, additional studies are needed regarding the relationship visual inspection methods have with existing standards of diagnosis.

• 한국실천공학교육학회논문지
• /
• 제5권1호
• /
• pp.45-51
• /
• 2013

베트남-한국 우호 정보기술대학의 이러닝(E-Learning) 교육 품질 향상을 위하여, 잘 알려진 기술수용모델(TAM)에 기반한 이러닝 수용성 평가를 수행하였다. 총 158명의 강사 및 직원으로부터 설문지를 통하여 데이터를 확보했으며, 통계패키지 SPSS를 이용하여 분석하였다. 설문지 작성 시는 다양한 이전 연구 결과를 고려하였으며, 그에 따라 연구 가설 및 모델을 설정하였다. 그 결과, 이러닝 시스템의 성공모델을 세웠으며, 중요 요소를 파악했다. 아울러 강사 및 직원들이 이러닝 시스템의 혜택을 잘 알고 있으며 그들의 훈련 및 교육에 이러닝 방법을 적용하고자 준비가 되었음을 파악했다.

• Journal of Korean Biological Nursing Science
• /
• 제18권4호
• /
• pp.305-317
• /
• 2016

Purpose: Recent studies demonstrated disruption of the circadian clock gene is associated with the development of obesity and metabolic syndrome. Obesity is often caused by the high calorie intake, In addition, the chronic stress tends to contribute to the increased risk for obesity. To evaluate the molecular mechanisms, we examined the expression of circadian clock genes in high fat diet-induced mice models with the chronic stress. Methods: C57BL/6J mice were fed with a 45% or 60% high fat diet for 8 weeks. Daily immobilization stress was applied to mice fed with a 45% high fat for 16 weeks. We compared body weight, food consumption, hormone levels and metabolic variables in blood. mRNA expression levels of metabolic and circadian clock genes in both fat and liver were determined by quantitative RT-PCR. Results: The higher fat content induced more severe hyperglycemia, hyperlipidemia and hyperinsulinemia, and these results correlated with their relevant gene expressions in fat and liver tissues. Chronic stress had only minimal effects on metabolic variables, but it altered the expression patterns of metabolic and circadian clock genes. Conclusion: These results suggest that the fat metabolism regulates the function of the circadian clock genes in peripheral tissues, and stress hormones may contribute to its regulation.

• Molecules and Cells
• /
• 제39권8호
• /
• pp.611-618
• /
• 2016

Fibroblast-like synoviocytes (FLS) with aberrant expression of microRNA (miRNA) are critical pathogenic regulators in rheumatoid arthritis (RA). Previous studies have found that overexpression or silencing of miRNA can contribute to the development of miRNA-based therapeutics in arthritis models. In this study, we explored the effects of miR-27a on cell migration and invasion in cultured FLS from RA patients. We found that miR-27a was markedly downregulated in the serum, synovial tissue, and FLS of RA patients. Meanwhile, the expression of follistatin-like protein 1 (FSTL1) was upregulated, which suggests that FSTL1 plays a key role in RA development. The results of a Transwell assay showed that miR-27a inhibited FLS migration and invasion. However, miR-27a inhibition promoted the migration and invasion of FLS. In addition, the down-regulated expression of matrix metalloproteinases (MMP2, MMP9, and MMP13) and Rho family proteins (Rac1, Cdc42, and RhoA) was detected after treatment with miR-27a in RA-FLS by quantitative reverse transcription-PCR and western blot analysis. Then, a luciferase reporter assay validated that miR-27a targeted the 3-untranslated region (3'-UTR) of FSTL1. Moreover, miR-27a caused a significant decrease of FSTL1. In addition, the expression of TLR4 and $NF{\kappa}B$ was inhibited by miR-27a but increased by FSTL1 overexpression. In conclusion, we found that miR-27a inhibited cell migration and invasion of RA-FLS by targeting FSTL1 and restraining the $TLR4/NF{\kappa}B$ pathway.

• 비파괴검사학회지
• /
• 제28권2호
• /
• pp.112-118
• /
• 2008

본 논문에서는 유체에 포화된 다공성 매질에 적용되는 Biot 모델 및 modified Biot-Attenborough (MBA) 모델을 이용하여 해면질골에서 다공율 및 주파수에 대한 초음파 위상속도의 의존성을 예측하였다. 또한 선행 연구자들에 의하여 사람 및 소의 해면질골에서 측정된 값과 비교하였다. 해면질골에서 위상속도는 다공율 및 주파수가 증가함에 따라 감소하는 것을 알 수 있었다. 또한 전파각 효과를 포함하도록 수정된 Biot 모델 및 MBA 모델뿐만 아니라 Schoenberg 모델을 이용하여 해면질골에서 전파각에 대한 위상속도의 의존성을 예측하였다. 본 논문에서 이용된 이론적인 모델들은 초음파와 해면질골의 상호작용에 대한 물리학적인 이해를 증진시키는데 기여할 뿐만 아니라 골다공증을 진단하기 위하여 유용하게 이용될 수 있을 것으로 기대된다.

• 해양환경안전학회지
• /
• 제24권6호
• /
• pp.670-678
• /
• 2018

선박의 통행량이 많은 연안해역은 선박들 사이에 복잡한 조우상황이 자주 발생하기 때문에 충돌사고의 가능성이 높다. 따라서 해상에서 충돌사고를 줄이기 위해서는 항해사의 국제충돌예방규칙(COLREG) 준수에 더하여 정량적인 충돌위험평가가 요구된다. 본 연구에서는 선박의 계획항로에 대한 충돌위험을 평가하기 위한 새로운 충돌위험도 평가시스템이 개발되었다. 먼저 기존의 충돌위험 평가모델들을 검토함으로써 적절한 충돌위험 평가방법이 제시되었다. 시스템은 MATLAB을 사용하여 개발되었으며 해도, 범퍼 및 평가의 세 부분으로 구성된다. 개발된 시스템은 시험을 위해 간단한 계산조건으로 시험해역에 적용되었으며, 그리고 검증을 위해 실제 계산조건으로 실제해역에 적용되었다. 그 결과 충돌위험은 자선의 길이, 항해시간 및 항로 등에 의해 영향을 받는 것으로 나타났다. 개발된 시스템은 항해사가 출항전 최적안전항로를 선택하는데 도움을 줄 수 있을 것으로 기대된다.

• Bulletin of the Korean Chemical Society
• /
• 제35권12호
• /
• pp.3637-3641
• /
• 2014

In this study, we analyzed the toxicity of mixtures of dimethylformamide (DMF) and methyl ethyl ketone (MEK) or DMF and toluene (TOL) and predicted their toxicity using quantitative structure-activity relationships (QSAR). A QSAR model for single substances and mixtures was analyzed using multiple linear regression (MLR) by taking into account the statistical parameters between the observed and predicted $EC_{50}$. After preprocessing, the best subsets of descriptors in the learning methods were determined using a 5-fold cross-validation method. Significant differences in physico-chemical properties such as boiling point (BP), specific gravity (SG), Reid vapor pressure (rVP), flash point (FP), low explosion limit (LEL), and octanol/water partition coefficient (Pow) were observed between the single substances and the mixtures. The $EC_{50}$ of the mixture of DMF and TOL was significantly lower than that of DMF. The mixture toxicity was directly related to the mixing ratio of TOL and MEK (MLR $EC_{50}$ equation = $1.76997-1.12249{\times}TOL+1.21045{\times}MEK$), as well as to SG, VP, and LEL (MLR equation $EC_{50}=15.44388-19.84549{\times}SG+0.05091{\times}VP+1.85846{\times}LEL$). These results show that QSAR-based models can be used to quantitatively predict the toxicity of mixtures used in manufacturing industries.