MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis |
Shi, Dong-liang
(No. 1 Department of Osteopathy, Henan Province Hospital of TCM)
Shi, Gui-rong (Shangqiu Medical College) Xie, Jing (No. 1 Department of Osteopathy, Henan Province Hospital of TCM) Du, Xu-zhao (No. 1 Department of Osteopathy, Henan Province Hospital of TCM) Yang, Hao (No. 1 Department of Osteopathy, Henan Province Hospital of TCM) |
1 | Abeles, A.M., and Pillinger, M.H. (2006). The role of the synovial fibroblast in rheumatoid arthritis: cartilage destruction and the regulation of matrix metalloproteinases. Bull. NYU Hosp. Jt. Dis. 64, 20-24. |
2 | Aletaha, D., Neogi, T., Silman, A.J., Funovits, J., Felson, D.T., Bingham, C.O., 3rd, Birnbaum, N.S., Burmester, G.R., Bykerk, V.P., Cohen, M.D., et al. (2010). 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 62, 2569-2581. DOI |
3 | Androulidaki, A., Iliopoulos, D., Arranz, A., Doxaki, C., Schworer, S., Zacharioudaki, V., Margioris, A.N., Tsichlis, P.N., and Tsatsanis, C. (2009). The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 31, 220-231. DOI |
4 | Bottini, N., and Firestein, G.S. (2013). Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat. Rev. Rheumatol. 9, 24-33. DOI |
5 | Chaly, Y., Marinov, A.D., Oxburgh, L., Bushnell, D.S., and Hirsch, R. (2012). FSTL1 promotes arthritis in mice by enhancing inflammatory cytokine/chemokine expression. Arthritis Rheum. 64, 1082-1088. DOI |
6 | Chen, W., Qi, J., Bao, G., Wang, T., Du, C.W., and Wang, M.D. (2015). Emerging role of microRNA-27a in human malignant glioma cell survival via targeting of prohibitin. Mol. Med. Rep. 12, 1515-1523. DOI |
7 | Clutter, S.D., Wilson, D.C., Marinov, A.D., and Hirsch, R. (2009). Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma. J. Immunol. 182, 234-239. DOI |
8 | Ding, Q.H., Ji, X.W., Cheng, Y., Yu, Y.Q., Qi, Y.Y., and Wang, X.H. (2013). Inhibition of matrix metalloproteinases and inducible nitric oxide synthase by andrographolide in human osteoarthritic chondrocytes. Mod. Rheumatol. 23, 1124-1132. DOI |
9 | Duroux-Richard, I., Presumey, J., Courties, G., Gay, S., Gordeladze, J., Jorgensen, C., Kyburz, D., and Apparailly, F. (2011) MicroRNAs as new player in rheumatoid arthritis. Joint Bone Spine 78, 17-22. DOI |
10 | Edris, B. (2011). A comparison of the Oligomap and TargetScan algorithms for miRNA target analysis. Bmi231.stanford.edu. |
11 | Fassbender, H.G., and Simmling-Annefeld, M. (1983). The potential aggressiveness of synovial tissue in rheumatoid arthritis. J. Pathol. 139, 399-406. DOI |
12 | Lao, M., Shi, M., Zou, Y., Huang, M., Ye, Y., Qiu, Q., Xiao, Y., Zeng, S., Liang, L., Yang, X., et al. (2016). Protein inhibitor of activated STAT3 regulates migration, invasion, and activation of fibroblastlike synoviocytes in rheumatoid arthritis. J. Immunol. 196, 596-606. DOI |
13 | Fukuda, H., Nakamura, S., Chisaki, Y., Takada, T., Toda, Y., Murata, H., Itoh, K., Yano, Y., Takata, K., and Ashihara, E. (2016). Daphnetin inhibits invasion and migration of LM8 murine osteosarcoma cells by decreasing RhoA and Cdc42 expression. Biochem. Biophys. Res. Commun. 471, 63-67. DOI |
14 | Gallo, A., Tandon, M., Illei, G., and Alevizos, I. (2014). Discovery and validation of novel microRNAs in Sjogren's syndrome salivary glands. Clin. Exp. Rheumatol. 32, 761-762. |
15 | Karouzakis, E., Gay, R.E., Gay, S., and Neidhart, M. (2009). Epigenetic control in rheumatoid arthritis synovial fibroblasts. Nat. Rev. Rheumatol. 5, 266-272. DOI |
16 | Lefevre, S., Knedla, A., Tennie, C., Kampmann, A., Wunrau, C., Dinser, R., Korb, A., Schnaker, E. M., Tarner, I. H., Robbins, P.D., et al. (2009). Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat. Med. 15, 1414-1420. DOI |
17 | Li, J., Wan, Y., Guo, Q., Zou, L., Zhang, J., Fang, Y., Fu, X., Liu, H., Lu, L., and Wu, Y. (2010). Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis. Arthritis Res. Ther. 12, R81. DOI |
18 | Li, G.F., Qin, Y.H., and Du, P.Q. (2015a). Andrographolide inhibits the migration, invasion and matrix metalloproteinase expression of rheumatoid arthritis fibroblast-like synoviocytes via inhibition of HIF-1alpha signaling. Life Sci. 136, 67-72. DOI |
19 | Li, X.Q., Lv, H.W., Wang, Z.L., Tan, W.F., Fang, B., and Ma, H. (2015c). MiR-27a ameliorates inflammatory damage to the blood-spinal cord barrier after spinal cord ischemia: reperfusion injury in rats by downregulating TICAM-2 of the TLR4 signaling pathway. J. Neuroinflammation 12, 25. DOI |
20 | Li, W.Q., Yu, H.Y., Zhong, N.Z., Hou, L.J., Li, Y.M., He, J., Liu, H.M., Xia, C.Y., and Lu, Y.C. (2015b). miR27a suppresses the clonogenic growth and migration of human glioblastoma multiforme cells by targeting BTG2. Int. J. Oncol. 46, 1601-1608. DOI |
21 | Liang, L.Q., Huang, M.C., Qiu, Q., Xiao, Y.J., Sun, M.Y., Zhan, Z.P., Ye, Y.J., Fan, J.J., Yang, X.Y., and Xu, H.S. (2013) [Modulation of RhoA/Rho kinase on migration, invasion and proliferation of fibroblast like synoviocytes from patients with rheumatoid arthritis]. Zhonghua Yi Xue Za Zhi 93, 1345-1348. |
22 | Liang, L., Huang, M., Xiao, Y., Zen, S., Lao, M., Zou, Y., Shi, M., Yang, X., and Xu, H. (2015). Inhibitory effects of niclosamide on inflammation and migration of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Inflamm Res. 64, 225-233. DOI |
23 | Luo, X., Tsai, L.M., Shen, N., and Yu, D. (2010). Evidence for microRNA-mediated regulation in rheumatic diseases. Ann. Rheum. Dis. 69 Suppl 1, i30-36. DOI |
24 | Lv, Q., Zhu, X.Y., Xia, Y.F., Dai, Y., and Wei, Z.F. (2015). Tetrandrine inhibits migration and invasion of rheumatoid arthritis fibroblastlike synoviocytes through down-regulating the expressions of Rac1, Cdc42, and RhoA GTPases and activation of the PI3K/Akt and JNK signaling pathways. Chin J. Nat. Med. 13, 831-841. |
25 | Lv, Y.N., Ou-Yang, A.J., and Fu, L.S. (2016). MicroRNA-27a negatively modulates the inflammatory response in lipopolysaccharide-stimulated microglia by targeting TLR4 and IRAK4. Cell Mol. Neurobiol. [Epub ahead of print] |
26 | O'Connell, R.M., Rao, D.S., and Baltimore, D. (2012). MicroRNA regulation of inflammatory responses. Annu. Rev. Immunol. 30, 295-312. DOI |
27 | McInnes, I.B., and Schett, G. (2011). The pathogenesis of rheumatoid arthritis. N Engl. J. Med. 365, 2205-2219. DOI |
28 | Murakami, K., Tanaka, M., Usui, T., Kawabata, D., Shiomi, A., Iguchi-Hashimoto, M., Shimizu, M., Yukawa, N., Yoshifuji, H., Nojima, T., et al. (2012). Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4. FEBS Lett. 586, 319-324. DOI |
29 | Nakasa, T., Shibuya, H., Nagata, Y., Niimoto, T., and Ochi, M. (2011). The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum. 63, 1582-1590. DOI |
30 | Okamoto, H., Shidara, K., Hoshi, D., and Kamatani, N. (2007). Antiarthritis effects of vitamin K(2) (menaquinone-4)--a new potential therapeutic strategy for rheumatoid arthritis. FEBS J. 274, 4588-4594. DOI |
31 | Pan, W., Wang, H., Jianwei, R., and Ye, Z. (2014). MicroRNA-27a promotes proliferation, migration and invasion by targeting MAP2K4 in human osteosarcoma cells. Cell Physiol. Biochem. 33, 402-412. DOI |
32 | Pratheeshkumar, P., and Kuttan, G. (2011). Andrographolide inhibits human umbilical vein endothelial cell invasion and migration by regulating MMP-2 and MMP-9 during angiogenesis. J. Environ. Pathol. Toxicol. Oncol. 30, 33-41. DOI |
33 | Shibanuma, M., Mashimo, J., Mita, A., Kuroki, T., and Nose, K. (1993). Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-beta 1-regulated genes, one of which seems to encode a follistatin-related polypeptide. Eur. J. Biochem. 217, 13-19. DOI |
34 | Yuan, H., Yang, P., Zhou, D., Gao, W., Qiu, Z., Fang, F., Ding, S., and Xiao, W. (2014). Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro. Mol. Biol. Rep. 41, 5157-5165. DOI |
35 | Tardif, G., Hum, D., Pelletier, J.P., Duval, N., and Martel-Pelletier, J. (2009). Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskelet Disord. 10, 148. DOI |
36 | Yang, S., and Yang, Y. (2015) Downregulation of microRNA221 decreases migration and invasion in fibroblastlike synoviocytes in rheumatoid arthritis. Mol. Med. Rep. 12, 2395-2401. DOI |
37 | Yoshihara, Y., and Yamada, H. (2007). Matrix metalloproteinases and cartilage matrix degradation in rheumatoid arthritis. Clin. Calcium 17, 500-508. |
38 | Zhang, X.H., Xu, X.X., and Xu, T. (2015). Ginsenoside Ro suppresses interleukin-1beta-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-kappaB. Chin J. Nat. Med. 13, 283-289. |
39 | Zhang, S., Ma, C., Pang, H., Zeng, F., Cheng, L., Fang, B., Ma, J., Shi, Y., Hong, H., Chen, J., et al. (2016). Arsenic trioxide suppresses cell growth and migration via inhibition of miR-27a in breast cancer cells. Biochem. Biophys. Res. Commun. 469, 55-61. DOI |
40 | Zhao, W., Zhang, C., Shi, M., Zhang, J., Li, M., Xue, X., Zhang, Z., Shu, Z., Zhu, J., Mu, N., et al. (2014). The discoidin domain receptor 2/annexin A2/matrix metalloproteinase 13 loop promotes joint destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes. Arthritis Rheumatol. 66, 2355-2367. DOI |
![]() |