• Journal of the Korean housing association
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• v.22 no.1
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• pp.105-114
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• 2011

There are various kinds of Large-Scale apartment sites in Seoul. There are more households in apartment sites than single family houses. Nowadays, it is easy to find a lot of apartment sites built in the style of a high rise building. On the matter of space, a building is influenced by the buildings near it. The influence a building has to another is different in both qualitative and quantitative ways. Therefore, in the case of apartment sites, the environmental surroundings of each household is affected by the nearby buildings. For these reasons, the environment is having more and more influence on the price of each household in apartment sites. This paper has defined Sunshine and Sky as the major environmental elements. In order to be analyzed, they have to be measurable. Thus, there are two types of variables in environmental surrounding of apartment sites, -the Duration of Sunshine and the possible amount of visible Sky- the significant variables which influence the housing price. This paper deals with the relationship between the possible duration of sunshine and the possible amount of sky a household is visible to. It focused on 62 different apartment sites which were built after 1990. It is based on the 3-dimensional Geographic Information System & Computer Aided Engineering for analyzing the sunshine simulation and the viewing simulation. This paper will be helpful for designing the apartment sites considering the balance between sunshine and sky.

• Journal of The Korean Astronomical Society
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• v.29 no.1
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• pp.63-73
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• 1996

The previous study of chemical evolution of the Galaxy is extended to the radial properties of the Galactic disk. The present model includes radial dependency of the time-dependent bimodal IMF, radial flow of material in the disk, and the change of type I supernova explosion rate with radial distance from the disk center as model parameters and observed gas and stellar density distributions and metallicity abundance gradient as observational constraints. The results of two models in this study explain the observed gas and stellar density distributions well, with the slope of the gas density gradient in the region of 4.5 kpc$Y_1$ and -0.123dex/kpc in model $Y_2$, respectively, which fit well the observed gradient of -0.l1dex/kpc. The abundance gradient reproduced in model $Y_1$ is getting flatter with decreasing radius, while that in model $Y_2$ is getting steeper, which fits better the observed abundance gradient. This result shows the necessity of exponentially increasing type I supernova explosion rate with decreasing radius in order to explain the observed abundance gradient in the disk. The fitness of observed density distribution and star formation rate distribution justifies the reliability of time-dependent bimodal IMF as a compound quantitative chemical evolution model of the Galaxy. The temporal variations of metallicity gradients for carbon, nitrogen and oxygen are also shown.

• Journal of The Korean Digital Architecture Interior Association
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• v.9 no.3
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• pp.95-102
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• 2009

An architectural space can be considered a life form that interconnects a number of architectural elements such as the humans who live in it. It is difficult to understand and evaluate the complexity of the interrelation between each element, but there have been various attempts to understand and evaluate this architectural space. The Space Syntax that emerged in 1980s has been studied and used more frequently than other methods. Space Syntax is the space analysis tool that analyzes the physical structure of space and represents it as a graph. Space syntax enables its various applications in space analysis by quantifying each spatial property of a whole structure, analyzing it systemically and objectively based on mathematical logic, and representing the results as a quantitative value. Integration of Space Syntax, a widely used index, reflects human behavior in spatial configuration. Meanwhile, there have been various studies in the field of architectural environmental psychology about the relationships between space and human behavior by applying behavioral science to architectural plan. One of the most widely used one is spatial behavior simulation which uses models and simulates the behavioral characteristics to anticipate practical situations and investigate the behavior related spatial problems. In this study, which focuses on the accessibility of the space syntax model, the usefulness of space will be analyzed through the simulation of human behavior that moves through each space. Furthermore, the validity of index will be verified by displaying several examples and compared with integration in space syntax, which represents the usefulness of space.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.18 no.1
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• pp.1-10
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• 2014

Objectives Visual inspection is the first diagnostic method in Oriental medicine, and visual inspection of eyes is the one among them. This study was written in order to complement further understanding on visual inspection of eyes. Methods 1. Out of 102 photographs submitted to the Society of HyungSang Medicine in 2009, 27 portrait pictures were selected as samples in blind by 2 clinicians. The samples were copied to make 54 sample pictures, and then randomly assigned to 4 clinicians. 2. The 4 clinicians evaluated the 54 samples for excess and deficiency of the eyes. The results were recorded as 5-points-scale, and their average and standard deviation was calculated. 3. Intra and inter class reliability test were measured using SPSS 13. Results For intra- and inter-class correlation coefficient (ICC) values were measured as 0.654~0.967 and 0.756~ 0.783 respectively, with the P-value below 0.05. Out of 27 originally selected samples, 7 pictures were selected as Deficiency Samples (with 3 pictures of male and 4 of females), and 20 as Excess Samples (with 4 of male and 16 of female). Among them, Sample No. 1, 9, 22, and 26 were selected as models of 'Excessive Eyes' for females, no. 4 and 5 as 'Very Excessive Eyes' for male and females, and no. 15 as 'Moderate Eyes' for females. Conclusion This study is the first attempt of quantitative measurement of excess and deficiency using the Visual Inspection of eyes by the visual inspection experts. Still, additional studies are needed regarding the relationship visual inspection methods have with existing standards of diagnosis.

• The Journal of Korean Institute for Practical Engineering Education
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• v.5 no.1
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• pp.45-51
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• 2013

To improve the e-learning education quality in VietHanIT College (Vietnam-Korea Friendship Information Technology College), e-learning acceptance was evaluated based on the well-known Technology Acceptance Model (TAM). Quantitative data of the questionnaire survey were gathered from 158 lecturers and staffs of VietHanIT College and analyzed by using Statistical Package for the Social Sciences (SPSS). While designing the questionnaire various previous studies were considered and hypotheses and models of the study were set up accordingly. As the results, success model of e-learning system was built up and important factors were identified. And most of lectures and staffs in VietHanIT College were aware of the benefits of e-learning system and they were ready to apply e-learning method for their training and teaching.

• Journal of Korean Biological Nursing Science
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• v.18 no.4
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• pp.305-317
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• 2016

Purpose: Recent studies demonstrated disruption of the circadian clock gene is associated with the development of obesity and metabolic syndrome. Obesity is often caused by the high calorie intake, In addition, the chronic stress tends to contribute to the increased risk for obesity. To evaluate the molecular mechanisms, we examined the expression of circadian clock genes in high fat diet-induced mice models with the chronic stress. Methods: C57BL/6J mice were fed with a 45% or 60% high fat diet for 8 weeks. Daily immobilization stress was applied to mice fed with a 45% high fat for 16 weeks. We compared body weight, food consumption, hormone levels and metabolic variables in blood. mRNA expression levels of metabolic and circadian clock genes in both fat and liver were determined by quantitative RT-PCR. Results: The higher fat content induced more severe hyperglycemia, hyperlipidemia and hyperinsulinemia, and these results correlated with their relevant gene expressions in fat and liver tissues. Chronic stress had only minimal effects on metabolic variables, but it altered the expression patterns of metabolic and circadian clock genes. Conclusion: These results suggest that the fat metabolism regulates the function of the circadian clock genes in peripheral tissues, and stress hormones may contribute to its regulation.

• Molecules and Cells
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• v.39 no.8
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• pp.611-618
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• 2016

Fibroblast-like synoviocytes (FLS) with aberrant expression of microRNA (miRNA) are critical pathogenic regulators in rheumatoid arthritis (RA). Previous studies have found that overexpression or silencing of miRNA can contribute to the development of miRNA-based therapeutics in arthritis models. In this study, we explored the effects of miR-27a on cell migration and invasion in cultured FLS from RA patients. We found that miR-27a was markedly downregulated in the serum, synovial tissue, and FLS of RA patients. Meanwhile, the expression of follistatin-like protein 1 (FSTL1) was upregulated, which suggests that FSTL1 plays a key role in RA development. The results of a Transwell assay showed that miR-27a inhibited FLS migration and invasion. However, miR-27a inhibition promoted the migration and invasion of FLS. In addition, the down-regulated expression of matrix metalloproteinases (MMP2, MMP9, and MMP13) and Rho family proteins (Rac1, Cdc42, and RhoA) was detected after treatment with miR-27a in RA-FLS by quantitative reverse transcription-PCR and western blot analysis. Then, a luciferase reporter assay validated that miR-27a targeted the 3-untranslated region (3'-UTR) of FSTL1. Moreover, miR-27a caused a significant decrease of FSTL1. In addition, the expression of TLR4 and $NF{\kappa}B$ was inhibited by miR-27a but increased by FSTL1 overexpression. In conclusion, we found that miR-27a inhibited cell migration and invasion of RA-FLS by targeting FSTL1 and restraining the $TLR4/NF{\kappa}B$ pathway.

• Journal of the Korean Society for Nondestructive Testing
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• v.28 no.2
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• pp.112-118
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• 2008

In the present study, the dependence of ultrasonic phase velocity on porosity and frequency in cancellous bone was predicted using the Biot model and the modified Biot-Attenborough (MBA) model for propagation in fluid-saturated porous media. It was also compared with previously published measurements in human and bovine cancellous bones in vitro. It was shown that the phase velocity in cancellous bone decreased with increasing porosity and frequency The dependence of phase velocity on propagation angle in cancellous bone as predicted using the Schoenberg model together with the Biot model and tile MBA model which were modified to include the effect of angle. The theoretical models used in the present study advance our understanding of the interaction between ultrasound and cancellous bone and can be expected to be usefully employed for the diagnosis of osteoporosis.

• Journal of the Korean Society of Marine Environment & Safety
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• v.24 no.6
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• pp.670-678
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• 2018

In coastal waters where the traffic volume of the ship is high, there is a high possibility of a collision accident because complicated encounter situations frequently occurs between ships. To reduce the collision accidents at sea, a quantitative collision risk assessment is required in addition to the navigator's compliance with COLREG. In this study, a new collision risk assessment system was developed to evaluate the collision risk on ship's planned sailing routes. The appropriate collision risk assessment method was proposed on the basis of reviewing existing collision risk assessment models. The system was developed using MATLAB and it consists of three parts: Map, Bumper and Assessment. The developed system was applied to the test sea area with simple computational conditions for testing and to actual sea areas with real computational conditions for validation. The results show the length of own ship, ship's sailing time and sailing routes affect collision risks. The developed system is expected to be helpful for navigators to choose the optimum safe route before sailing.

• Bulletin of the Korean Chemical Society
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• v.35 no.12
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• pp.3637-3641
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• 2014

In this study, we analyzed the toxicity of mixtures of dimethylformamide (DMF) and methyl ethyl ketone (MEK) or DMF and toluene (TOL) and predicted their toxicity using quantitative structure-activity relationships (QSAR). A QSAR model for single substances and mixtures was analyzed using multiple linear regression (MLR) by taking into account the statistical parameters between the observed and predicted $EC_{50}$. After preprocessing, the best subsets of descriptors in the learning methods were determined using a 5-fold cross-validation method. Significant differences in physico-chemical properties such as boiling point (BP), specific gravity (SG), Reid vapor pressure (rVP), flash point (FP), low explosion limit (LEL), and octanol/water partition coefficient (Pow) were observed between the single substances and the mixtures. The $EC_{50}$ of the mixture of DMF and TOL was significantly lower than that of DMF. The mixture toxicity was directly related to the mixing ratio of TOL and MEK (MLR $EC_{50}$ equation = $1.76997-1.12249{\times}TOL+1.21045{\times}MEK$), as well as to SG, VP, and LEL (MLR equation $EC_{50}=15.44388-19.84549{\times}SG+0.05091{\times}VP+1.85846{\times}LEL$). These results show that QSAR-based models can be used to quantitatively predict the toxicity of mixtures used in manufacturing industries.