• Journal of Oriental Neuropsychiatry
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• v.23 no.1
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• pp.93-114
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• 2012

Objective : This study aimed to review the performance of traditional herbal prescriptions for treating dementia and present a strategy for research on dementia therapy utilizing herbal medicine. Methods : A definition was made to clarify the technology regarding the development of herbal prescriptions for treating dementia. The queries were compounded based on the initial keywords provided by experts in the field, then applied to the Web of Science database search engines from January 1986 to September 2011 to search related scientific articles. Before performing the analysis, papers were extracted from the initial search reviewed by experts and 80 articles were selected. Then, the selected papers were analyzed in terms of publish year, country, and type of herbal prescriptions. Furthermore, the research performance evaluation for treating dementia by herbal prescriptions was also created in terms of country and organization based on forward citation analysis. In addition to, for the evaluation regarding research quality, we classified and reviewed papers into two types: clinical studies and experimental studies. Results : According to the quantitative information analysis of 80 articles, the number of papers has increased by 21.9% per the yearly mean from 1995, and Japan had the largest portion within this research field. There were 34 kinds of traditional herbal prescriptions, among them Ukgansan had the highest number of studies followed by Jodeungsan, Dangkisoosan and so on. In addition, quality index as calculated by cites per paper is higher than average in Switzerland, Turkey and Japan. In the view of the evaluation on quality there were 12 clinical studies, 8 RCT reported that herbal prescriptions had efficacy at cognition, behavioral & psychological symptoms (BPSD) and activity of daily life (ADL) in various type of dementia. In experimental studies most of the studies were performed using animal models. The studies using Ukgansan were aimed at improving BPSD. The papers studied with Jodeungsan and Dangkisoosan targeted vascular dementia. Conclusions : In this study, research to develop traditional herbal prescriptions for treating dementia has the potential to improve symptoms since herbal medicines work as both multi-function and multi-target in dementia with multiple pathological or neurotoxic pathways. Therefore, the results of the research should be used in order to establish strategies to develop technology for treating dementia with traditional herbal prescriptions in the future.

• Journal of the Ergonomics Society of Korea
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• v.27 no.4
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• pp.27-35
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• 2008

Recently, many studies have reported the fact that an excessively accumulated psychological and physical burden induced from physical labor conducted routinely in home and industry can be one of main reasons of musculoskeletal disorders in the working population. This fact makes increase interests in studies to reduce a risk of musculoskeletal disorders through grafting ergonomic considerations on working environment. However, there are currently limited methodologies in quantitative evaluations of new ergonomic suggestions to reduce a risk of musculoskeletal disorders. The current study is therefore performed to evaluate quantitatively effects of a design of washing machine as a new ergonomic suggestion onto prevention of musculoskeletal disorders, through application of a biomechanical evaluation methodology. For this, three-dimensional motion analysis by using musculoskeletal models with Rapid Entire Body Assessment (REBA), which has been generally used for a simple evaluation of a degree of harmfulness of the human body at specific working postures to be considered, was performed. The results of REBA did not give us enough information and their results were somewhat simple and inaccurate, but the results of the three-dimensional motion analysis give us enough information such as alteration of main muscle forces and joint moments required during washing work. All results showed that the main muscle strengths and joint moments were decreased effectively for reduction of a risk of musculoskeletal disorders during the washing work with newly designed washing machine evaluated in the current study, compared with those generated during the washing work with general washing machine. From these results, it can be concluded that a risk of the musculoskeletal disorders, which may be induced by a repetitive washing work, may be reduced through using the washing machine designed ergonomically and newly. Also, it is thought that if our ergonomic design can be applied for improvement of working environment in lifting and laying works conducted repeatedly for a treatment work of goods, which have a strong resemblance to the behaviors generated frequently during the washing work, a possibility of occurrence of the musculoskeletal disorders by the lifting and laying works may be reduced highly.

• Archives of design research
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• v.17 no.3
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• pp.413-420
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• 2004

New design method has been required for web designers to grasp the proper emotion, impression, and feeling of a web site and reflect these elements in web design. It is certain that such a new methodology can be a useful design tool, although web designers have only relied on their intuition and experience to induce users to perceive specific emotion of web sites. In this study, Kansei Engineering Type Ⅰ (Nagamachi, 2002 and Park, 2000) method was applied to develop the methodology. One hundred thirty six web sites believed to convey emotions effectively were first selected by recommendation of professional web designers and twenty two web sites were finally chosen and evaluated using questionnaire. The web sites were then objectively and quantitatively assessed by measuring the degree of utilization of the design elements, balance, overall density, and homogeneity. We examined the cause-and-effect between the results of emotional and quantitative analysis by multiple regression and introduced the design methodology based on the examination. The research method and procedures applied to this study would be applicable to design studies related to the emotional inducement.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.11
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• pp.1625-1630
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• 2007

A simulation study was conducted to evaluate the effect of reciprocal cross on the detection and characterization of Mendelian QTL in $F_2$ QTL swine populations. Data were simulated under two different mating designs. In the one-way cross design, six $F_0$ grand sires of one breed and 30 $F_0$ grand dams of another breed generated 10 $F_1$ offspring per dam. Sixteen $F_1$ sires and 64 $F_1$ dams were randomly chosen to produce a total of 640 $F_2$ offspring. In the reciprocal design, three $F_0$ grand sires of A breed and 15 $F_0$ grand dams of B breed were mated to generate 10 $F_1$ offspring per dam. Eight $F_1$ sires and 32 $F_1$ dams were randomly chosen to produce 10 $F_2$ offspring per $F_1$ dam, for a total of 320 $F_2$ offspring. Another mating set comprised three $F_0$ grand sires of B breed and 15 $F_0$ grand dams of A breed to produce the same number of $F_1$ and $F_2$ offspring. A chromosome of 100 cM was simulated with large, medium or small QTL with fixed, similar, or different allele frequencies in parental breeds. Tests between Mendelian models allowed QTL to be characterized as fixed (LC QTL), or segregating at similar (HS QTL) or different (CB QTL) frequencies in parental breeds. When alternate breed alleles segregated in parental breeds, a greater proportion of QTL were classified as CB QTL and estimates of QTL effects for the CB QTL were more unbiased and precise in the reciprocal cross than in the one-way cross. This result suggests that reciprocal cross design allows better characterization of Mendelian QTL in terms of allele frequencies in parental breeds.

• 한국연소학회:학술대회논문집
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• 2002.06a
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• pp.85-94
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• 2002

Computational flow dynamics(CFD) has been frequently applied to the waste incinerators to understand the flow performance for various design and operating parameters. Though it needs many simplifications and complicated flow models, the reasonability of its results is not fully evaluated. For example, the inlet condition is calculated from an arbitrarily assumed properties of combustion gas release from the waste bed, since the combustion in the bed is difficult to be predicted. In this study, the computational modeling and calculation procedures of CFD for the grate type waste incinerator were evaluated using comparative simulations. Though the assumption method on the generation of the combustion gas directly affected the temperature and gas species concentrations, the overall flow pattern was dominated by the secondary air jets. The gaseous reaction could be included by assuming the release of the products of incomplete combusion from the bed. However, the reaction effficiency cannot not be directly evaluated from the species concentration, since it is not possible to simulate the actual co-existence of fuel rich or oxygen rich puffs over the bed. In predicting the turbulence, the higher order model, such as Reynolds stress model, gave difference shape of local recirculation zones, but similar results was acquired from the standard $k-{\varepsilon}$ model. Introducing radiation model was required for accurate temperature prediction, but it also caused heat imbalance due to the fixed temperature of the inlet, i.e. the waste bed. Thus, the computational modeling procedures on incinerators and the analysis of the predicted results should be progressed carefully. Though not validated experimentally, current simulation method is capable of comparative evaluation on the flow-related parameters such as the furnace shape and secondary air injection using identical inlet conditions. Quantitative analysis using measures of the residence time and mixing is essential to compare the flow performance efficiently.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.3 no.3
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• pp.213-229
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• 2005

Nuclides in radioactive wastes are assumed to be transported in the geosphere by groundwater and probably discharged into the biosphere. Quantitative evaluation of doses to human beings due to nuclide transport in the geosphere and through the various pathways in the biosphere is the final step of safety assessment of the radioactive waste repository. To calculate the flux to dose conversion factors (DCFs) for nuclides appearing at GBIs with their decay chains, a template ACBIO which is an AMBER case file based on mathematical model for the mass transfer coefficients between the compartments has been developed considering material balance among the compartments in biosphere and then implementing to AMBER, a general and flexible software tool that allows to build dynamic compartment models. An illustrative calculation with ACBIO is shown.

• Journal of Korean Society of Transportation
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• v.36 no.1
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• pp.1-12
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• 2018

The purpose of this study is to establish a methodology for evaluating quantitative effects of transportation GHG (greenhouse gas) reduction-related policies that were implemented based on the reduction goals of transportation GHG and effective implementation plans. This study uses a modal utility function and demand estimation models as well as a GHG emission basic unit estimation model by each transportation mode based on actual traffic and emission data. The results showed that the effects of GHG reduction policies such as electric vary from region to region, and from vehicle to vehicle. It is also confirmed that an eco-drive promotion policy, one of the lowest budget policies, is expected to contribute to high reduction in GHG. In addition, not only automobile emission improvement policies but also the promotion policies of public transportation are expected to highly reduce GHG as confirmed quantitatively in this study. The results of this study are expected to be useful for national and local governments' evaluation of GHG reduction policies to cope with the post 2020.

• Journal of Dental Rehabilitation and Applied Science
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• v.24 no.3
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• pp.299-310
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• 2008

In this study, the regression analysis method was tested for the estimation of peak stress at stress concentration area in the cervical bone. Submerge type EZ plus implant (Megagen. Daegu, Korea), 4.1 mm in cervical diameter and 9.6 mm in endosseous length, were axisymmetrically modelled together with surrounding alveolar bone of which the width was 10 mm. Vertical force of 100 N was applied to a head of crown above 8.5 mm from the outer surface of the cortical bone. Four different mesh models were composed of differently sized elements in vicinity of sharp corners, and they include 6 stress monitoring points that are located in the same geometrical points regardless of the differences in the meshes. Primary consideration was given to the stresses in the cortical bone surrounding the implant neck. The results showed that virtually all the stresses were concentrated in the cortical bone regardless of mesh designs. The peak stresses were successfully calculated by a regression analysis in a stable manner, as far as the mesh is designed to represent the acute gradient of stresses near the sharp corner.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.12
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• pp.1805-1811
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• 2007

A simulation study was conducted to evaluate the effect of reciprocal cross on the detection and characterization of parent-of-origin (POE) QTL in $F_2$ QTL populations. Data were simulated under two different mating designs. In the one-way cross design, six $F_0$ grand sires of one breed and 30 $F_0$ grand dams of another breed generated 10 $F_1$ offspring per dam. Sixteen $F_1$ sires and 64 $F_1$ dams were randomly chosen to produce a total of 640 $F_2$ offspring. In the reciprocal design, three $F_0$ grand sires of A breed and 15 $F_0$ grand dams of B breed were mated to generate 10 $F_1$ offspring per dam. Eight $F_1$ sires and 32 $F_1$ dams were randomly chosen to produce 10 $F_2$ offspring per $F_1$ dam, totaling 320 $F_2$ offspring. Another mating set comprised three $F_0$ grand sires of B breed and 15 $F_0$ grand dams of A breed to produce the same number of $F_1$ and $F_2$ offspring. A chromosome of 100 cM was simulated with large, medium or small QTL with fixed or different allele frequencies in parental breeds. A series of tests between Mendelian and POE models were applied to characterize QTL as Mendelian, paternal, maternal or partial expression QTL. The overall detection powers were similar between the two mating designs. However, the proportions of paternally expressed QTL that were declared as paternal QTL type were greater in the reciprocal cross design than in the one-way cross, and vice versa for Mendelian QTL. When QTL alleles were segregating in parental breeds, a significant proportion of Mendelian QTL were spuriously declared POE QTL, suggesting that care must be taken to characterize imprinting QTL in a QTL mapping population with a small number of $F_1$ parents.

• Ocean and Polar Research
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• v.38 no.2
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• pp.149-159
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• 2016

The statistical measures of the coastal environmental data are used in a variety of statistical inferences, hypothesis tests, and data-driven modeling. If the measures are biased, then the statistical estimations and models may also be biased and this potential for bias is great when data contain some outliers defined as extraordinary large or small data values. This study aims to suggest more robust statistical measures as alternatives to more commonly used measures and to assess the performance these robust measures through a quantitative evaluation of more typical measures, such as in terms of locations, spreads, and shapes, with regard to environmental monitoring data in the Busan coastal sea. The detection of outliers within the data was carried out on the basis of Rosner's test. About 5-10% of the nutrient data were found to contain outliers based on Rosner's test. After removal (zero-weighting) of the outliers in the data sets, the relative change ratios of the mean and standard deviation between before and after outlier-removal conditions revealed the figures 13 and 33%, respectively. The variation magnitudes of skewness and kurtosis are 1.36 and 8.11 in a decreasing trend, respectively. On the other hand, the change ratios for more robust measures regarding the mean and standard deviation are 3.7-10.5%, and the variation magnitudes of robust skewness and kurtosis are about only 2-4% of the magnitude of the non-robust measures. The robust measures can be regarded as outlier-resistant statistical measures based on the relatively small changes in the scenarios before and after outlier removal conditions.