• Bulletin of the Korean Chemical Society
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• v.28 no.6
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• pp.947-952
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• 2007

Mycobacterium tuberculosis is a pathogen responsible for 2-3 million deaths every year worldwide. The emergence of drug-resistant and multidrug-resistant tuberculosis has increased the need to identify new antituberculosis targets. Acetohydroxy acid synthase, (AHAS, EC 2.2.1.6), an enzyme involved in branched-chain amino acid synthesis, has recently been identified as a potential anti-tuberculosis target. To assist in the search for new inhibitors and “receptor-based” design of effective inhibitors of tubercular AHAS (TbAHAS), we constructed four different structural models of TbAHAS and used one of the models as a target for virtual screening of potential inhibitors. The quality of each model was assessed stereochemically by PROCHECK and found to be reliable. Up to 89% of the amino acid residues in the structural models were located in the most favored regions of the Ramachandran plot, which indicates that the conformation of each residue in the models is good. In the models, residues at the herbicide-binding site were highly conserved across 39 AHAS sequences. The binding mode of TbAHAS with a sulfonylurea herbicide was characterized by 32 hydrophobic interactions, the majority of which were contributed by residue Trp516. The model based on the highest resolution X-ray structure of yeast AHAS was used as the target for virtual screening of a chemical database containing 8300 molecules with a heterocyclic ring. We developed a short list of molecules that were predicted to bind with high scores to TbAHAS in a conformation similar to that of sulfonylurea derivatives. Five sulfonylurea herbicides that were calculated to efficiently bind TbAHAS were experimentally verified and found to inhibit enzyme activity at micromolar concentrations. The data suggest that this time-saving and costeffective computational approach can be used to discover new TbAHAS inhibitors. The list of chemicals studied in this work is supplied to facilitate independent experimental verification of the computational approach.

• The Korean Journal of Pain
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• v.36 no.1
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• pp.84-97
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• 2023

Background: The concept of high-impact chronic pain (HICP) has been proposed for patients with chronic pain who have significant limitations in work, social life, and personal care. Recognition of HICP and being able to distinguish patients with HICP from other chronic pain patients who do not have life interference allows the necessary measures to be taken in order to restore the physical and emotional functioning of the affected persons. The aim was to reveal the risk factors and predictors associated with HICP. Methods: Patients with chronic pain without life interference (grade 1 and 2) and patients with HICP were compared. Significant data were evaluated with regression analysis to reveal the associated risk factors. Receiving operating characteristic (ROC) analysis was used to evaluate predictors and present cutoff scores. Results: One thousand and six patients completed the study. From pain related cognitive processes, fear of pain (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.87-0.98; P = 0.007) and helplessness (OR, 1.06; 95% CI, 1.01-1.12; P = 0.018) were found to be risk factors associated with HICP. Predictors of HICP were evaluated by ROC analysis. The highest discrimination value was found for pain intensity (cut-off score > 6.5; 83.8% sensitive; 68.7% specific; area under the curve = 0.823; P < 0.001). Conclusions: This is the first study in our geography to evaluate HICP with measurement tools that evaluate all dimensions of pain. Moreover, it is the first study in the literature to evaluate predictors and cut-off scores using ROC analysis for HICP.

• Journal of Digital Convergence
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• v.12 no.12
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• pp.561-570
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• 2014

In this study, people with disabilities experience difficulties in their daily lives evaluate. To this end, eight people with disabilities in Seoul material by conducting consensual qualitative in-depth interviews (CQR) method of analysis. The findings in the three categories and therefore the region 14 to 48 depending on the frequency analysis. Psychology in everyday life of people with disabilities, lack of self-confidence and emotional experience difficulties, health problems, concerns, marriage (remarriage), and the opposite sex, family relationship difficulties, loneliness, worry about aging issues, respectively. Social and economic difficulties experienced difficulties in the relationship, livelihood issues, childbirth and parenting issues, work-life difficulties, trouble appeared when going out. Process to deal with these experiences of meeting the religious institutions, community system used, was used with the help of the people around. By the results of this study, people with disabilities in everyday life so that you can overcome difficulties that practical help and social services to the community through the ongoing support system was required to suggestions.

• Animal Bioscience
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• v.35 no.10
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• pp.1479-1488
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• 2022

Objective: This work was to determine coat inheritance and evaluate production performance for crossbred pigs from Berkshire×Chenghua (BC) compared with Chinese indigenous Chenghua (CH) pigs. Methods: The coat color phenotypes were recorded for more than 16,000 pigs, and the genotypes of melanocortin 1 receptor (MCIR) gene were identified by sequencing. The reproductive performance of 927 crossbred BC F4 gilts and 320 purebred CH gilts was recorded. Sixty pigs of each breed were randomly selected at approximately 60 days of age to determine growth performance during fattening period, which lasted for 150 days for BC pigs and 240 days for CH pigs. At the end of the fattening period, 30 pigs of each breed were slaughtered to determine carcass composition and meat quality. Results: The coat color of BC pigs exhibits a "dominant black" hereditary pattern, and all piglets derived from boars or sows genotyped E^D1 E^D1 homozygous for MC1R gene showed a uniform black coat phenotype. The BC F4 gilts displayed a good reproductive performance, showing a higher litter and tear size and were heavier at farrowing litter and at weaning litter than the CH gilts, but they reached puberty later than the CH gilts. BC F4 pigs exhibited improved growth and carcass characteristics with a higher average daily live weight gain, lower feed-to-gain ratio, and higher carcass lean meat rate than CH pigs. Like CH pigs, BC F4 pigs produced superior meat-quality characteristics, showing ideal pH and meat-color values, high intramuscular fat content and water-holding capacity, and acceptable muscle-fiber parameters. C18:1, C16:0, C18:0, and C18:2 were the main fatty acids in M. longissimus lumborum in the two breeds, and a remarkably high polyunsaturated/saturated fatty acid ratio of ~0.39 was observed in the BC F4 pigs. Conclusion: The BC F4 pigs exhibit a uniform black coat pattern and acceptable total production performance.

• Journal of Korea Society of Industrial Information Systems
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• v.4 no.3
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• pp.1-7
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• 1999

An important task for any software project manager is to be able to predict and control project size. Unfortunately, there is comparatively little work that deals with the problem of building prediction methods for software size in fourth-generation languages and database projects. In this paper, we propose a new estimation method for estimating for software size based on minimum relative error(MRE) criterion. The characteristic of the proposed method is insensitive to the extreme values of the observed measures which can be obtained early in the development life cycle. In order to verify the performance of the proposed estimation method for software size in terms of both quality of fit and predictive quality, the experiments has been conducted for the dataset Ⅰ and Ⅱ, respectively. For the data set Ⅰ and Ⅱ, our proposed prediction method was shown to be superior to the traditional method LS and RLS in terms of both the quality of fit and predictive quality when applied to data obtained from actual software development projects.

• Proceedings of the Korea Society for Industrial Systems Conference
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• 1999.05a
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• pp.97-105
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• 1999

An important task for any software project manager is to be able to predict and control project size. Unfortunately, there is comparatively little work that deals with the problem of building estimation methods for software size in fourth-generation languages systems. In this paper, we propose a new estimation method for estimating for software size based on minimum relative error(MRE) criterion. The characteristic of the proposed method is insensitive to the extreme values of the observed measures which can be obtained early in the development life cycle. In order to verify the performance of the proposed estimation method for software size in terms of both quality of fit and predictive quality, the experiments has been conducted for the dataset I and II, respectively. For the data set I and II, our proposed estimation method was shown to be superior to the traditional method LS and RLS in terms of both the quality of fit and predictive quality when applied to data obtained from actual software development projects.

• KIEAE Journal
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• v.7 no.5
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• pp.93-98
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• 2007

Effort has been performed for latest 20 years to improve resident's comfort and indoor environment in building. And interest and effort to improve indoor air environment among various indoor environment elements have continuously increased since 1990s, because it is examined scientifically that various contaminants generated indoor affect human body. Specially, indoor air contaminants generated from apartments are those exhausted from resident's indoor environment, closing materials and household. Indoor air environment in buildings is different according to pollution degree, existence availability of pollution source, ventilation amount, and meteorology. It is known that other contaminants more than about 900 kinds generate according to a kind of work or action in a room. Specially, nowadays buildings are well insulated and confidentiality-centered for environment protection and economical side. So indoor air contaminants are generated from indoor air pollution sauces of unprepared ventilation, human body carbon dioxide emissions, and various building materials. when these are accumulated in long term human body, it is harmful to resident's health, but awareness for this is very insufficient. Because bedroom is space that people inhabit for a long time by unconscious state and indoor environment occupies important part for resident's health and quality of life at sleep, the actual condition of air quality is investigated, improvement countermeasure is considered, and ventilation amount is analyzed. In this study, putting case that the most longest stayed time is sleeping time when people inhabit in the apartment, the air quality according to volume of bedroom space at sleep was measured and analyzed, and the data acquired will be the basis for improvement on this.

• International Journal of Computer Science & Network Security
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• v.22 no.7
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• pp.35-42
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• 2022

The article identifies the problem of monitoring the quality of higher education in three main areas, which are comparative pedagogical systems of education. The first direction is determined by dissertation works, the second - monographs and textbooks, and the third reveals scientific periodicals. According to its internal structure, monitoring the quality of education combines important management components identified in the article (analysis, evaluation and forecasting of processes in education; a set of methods for tracking processes in education; collecting and processing information to prepare recommendations for research processes and make necessary adjustments). Depending on the objectives, three areas of monitoring are identified: informational (involves the accumulation, structuring and dissemination of information), basic (aimed at identifying new problems and threats before they are realized at the management level), problematic (clarification of patterns, processes, hazards, those problems that are known and significant from the point of view of management). According to its internal structure, monitoring the quality of education combines the following important management components: analysis, evaluation and forecasting of processes in education; a set of techniques for tracking processes in education; collection and processing of information in order to prepare recommendations for the development of the studied processes and make the necessary adjustments. One of the priorities of the higher education modernization program during the COVID-19 pandemic is distance learning, which is possible due to the existence of information and educational technologies and communication systems, especially for effective education and its monitoring in higher education. The conditions under which the effectiveness of pedagogical support of monitoring activities in the process of distance learning is achieved are highlighted. According to the results of the survey, the problems faced by higher education seekers are revealed. A survey of students was conducted, which had a certain level of subjectivity in personal assessments, but the sample was quite representative.

• Korean Journal of Ecology and Environment
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• v.56 no.3
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• pp.196-206
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• 2023

Benthic attached diatoms (BADs), a major primary producer in lotic stream and river ecosystems are micro-sized organisms and require a highly magnified microscopic technique in the observation work. Thus, it is often not easy to ensure accuracy and precision in both qualitative and quantitative analyses. This study proposed a new technique applicable to improve quality control of aquatic ecosystem monitoring and assessment using BADs. In order to meet the purpose of quality control, we developed a permanent mounting slide technique which can be used for both qualitative and quantitative analyses simultaneously. We designed specimens with the combination of grid on both cover and slide glasses and compared their efficiency. As a result of observation and counting of BADs, the slide glass designed with the color-lined grid showed the highest efficiency compared to other test conditions. We expect that the method developed in this study could be effectively used to analyze BADs and contributed to improve the quality control in aquatic ecosystem health monitoring and assessment.

• Journal of dental hygiene science
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• v.18 no.3
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• pp.172-181
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• 2018

In accordance with the aged society, oral health care for the elderly is considered important to maintain general health. Although the role of dental hygienists is essential for proper health management of the oral cavity, research on the care system for the elderly people's oral health and on the role of dental hygienists in the field of elderly welfare is still insufficient. Hence, the aim of this study is to investigate the status of Korean elderly welfare system and dental hygienists by comparing them with those in Japan, a precedent of aged society. First, we compared and investigated the Japanese long-term insurance system, which provides an institutional basis for a long-term care system for the elderly in Korea. Second, the elderly welfare law and care system, focusing on oral care, were examined. Lastly, in elderly care, we analyzed the distinctions between Korea and Japan regarding dental hygienists' role and scope of work. Taken together, as a precedent of aged society, Japan has shown well-specialized and systematic welfare for the elderly compared with Korea. With the development of the welfare system for the elderly in Japan, the role and the work scope of dental hygienists have been expanded to improve quality of life of elderly people, as a key professional for elderly oral care. Therefore, we should perceive the need for improvement of long-term care insurance and the expansion of dental hygienists' work in Korea. In conclusion, these results could be used as basic data for improving the elderly welfare system and developing dental hygienists in Korea.