• BMB Reports
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• v.56 no.11
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• pp.575-583
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• 2023

Mitochondria, fundamental cellular organelles that govern energy metabolism, hold a pivotal role in cellular vitality. While consuming dioxygen to produce adenosine triphosphate (ATP), the electron transfer process within mitochondria can engender the formation of reactive oxygen species that exert dual roles in endothelial homeostatic signaling and oxidative stress. In the context of the intricate electron transfer process, several metal ions that include copper, iron, zinc, and manganese serve as crucial cofactors in mitochondrial metalloenzymes to mediate the synthesis of ATP and antioxidant defense. In this mini review, we provide a comprehensive understanding of the coordination chemistry of mitochondrial cuproenzymes. In detail, cytochrome c oxidase (CcO) reduces dioxygen to water coupled with proton pumping to generate an electrochemical gradient, while superoxide dismutase 1 (SOD1) functions in detoxifying superoxide into hydrogen peroxide. With an emphasis on the catalytic reactions of the copper metalloenzymes and insights into their ligand environment, we also outline the metalation process of these enzymes throughout the copper trafficking system. The impairment of copper homeostasis can trigger mitochondrial dysfunction, and potentially lead to the development of copper-related disorders. We describe the current knowledge regarding copper-mediated toxicity mechanisms, thereby shedding light on prospective therapeutic strategies for pathologies intertwined with copper dyshomeostasis.

• Journal of Power System Engineering
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• v.19 no.2
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• pp.49-56
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• 2015

As an alternative fuel that can be used in SI engine, LPG is one of clean fuels with larger H/C ratio compared to gasoline, low $CO_2$ emission, and small amount of pollutants such as sulfur compounds. When LPG is used in spark ignition engine, volumetric efficiency of the engine can be improved and pumping loss can be reduced by performing direct injection into the combustion chamber instead of port fuel injection. LPG-DI engine allows for lean combustion and stratified combustion under low load. In case of stratified combustion, air fuel ratio can be greatly increased compared to theoretic mixture ratio combustion. Improved thermal efficiency of the engine and reduced pumping loss can be expected from stratified combustion. Accordingly in this study, an experimental apparatus for visualization was designed and manufactured to study the combustion process of LPG after injection and ignition, intended to examine ignition probability and combustion characteristics of spark ignition direct injection(SIDI) LPG fuel. Ambient pressure, ambient temperature and fuel injection pressure were found as important variables that affect ignition probability and flame propagation characteristics of LPG-air mixture. Also, it was verified that the injected LPG fuel can be directly ignited by spark plug under appropriate ambient conditions.

• The KSFM Journal of Fluid Machinery
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• v.17 no.6
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• pp.29-37
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• 2014

Non-Newtonian fluid mechanics takes charge of an important role in the oil industries. Especially in the oil well drilling process, the drilling fluid such as mud keeps the drill bit cool and clean during drilling, with suspending drill cuttings and lubricating a drill bit. The purpose of this study is to examine the effect of fluid mud rheological properties to predict different characteristics of non-Newtonian fluid in the mud mixing tank on offshore drilling platforms. In this paper, ANSYS fluent package was used for the simulation to solve the hydrodynamic force and to evaluate mud mixing time. Prediction of the power consumption and the pumping effectiveness has been presented with different operating fluid models as Newtonian and non-Newtonian fluid. The comparison between Newtonain mud model and non-Newtonian mud model is confirmed by the CFD simulation method of drilling mud mixing tank. The results present useful information for the design of the drilling mud mixing tanks and provide some guidance on the use of CFD tool for such non-Newtonian fluid flow.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.12
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• pp.80-86
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• 2009

In this paper, we present a new charge pump circuit feasible for the implementation with standard twin-well CMOS process technology. The proposed charge pump employs PMOS-switching dual charge-transfer paths and a simple two-phase clock. Since charge transfer switches are fully turned on during each half of clock cycle, they transfer charges completely from the present stage to the next stage without suffering threshold voltage drop. During one clock cycle, the pump transfers charges twice through two pumping paths which are operating alternately. The performance comparison by simulations and measurements demonstrates that the proposed charge pump exhibits the higher output voltage, the larger output current and a better power efficiency over the traditional twin-well charge pumps.

• Journal of the Korean Ceramic Society
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• v.37 no.2
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• pp.111-116
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• 2000

700nm red emission(3F3longrightarrow3H6) in Tm3+ ion with 800 nm(3H6longrightarrow3H4) excitation via upconversion process has been reported only in host materials which have low phonon energies such as halide crystals. However, we observed 700nm and 480nm(1G4longrightarrow3H6) upconverted emission with 800nm excitation in several oxide glasses which has never reported. With spectroscopic analyses and lifetime measurements of each nergy level of Tm3+ ion doped in various oxide glasses, following mechanisms are suggested. For red upconversion, upconversion mechanism changed with Tm3+ concentration. While direct excitation up to 3F3 level via anti-Stokes excitation was dominated at low concentration, two-step excitation via 3H6longrightarrow3H4 and 3F4longrightarrow3F3 transitions was dominated at high concentration. For blue upconversion, two step excitation mechanism up to 1G4 level was suggested as follows : electrons are exciated up to 3H5 with direct excitation with pumping light up to 3H4 followed by multiphonon relaxation, and then additional reabsorption of pumping light excites electrons up to 1G4.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.5
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• pp.50-57
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• 2008

In this paper, a high-efficiency charge pump for use in CMOS image sensor(CIS) is proposed. The proposed charge pump pursues high pumping efficiency by minimizing the switching and reversion losses by taking advantage of operation characteristics of CIS. That is, the proposed charge pump minimizes the switching loss by dynamically controlling the size of clock driver, pumping capacitor, and charge transfer switch based on the operation phase of CIS pixel sensor. The charge pump also minimizes the reversion loss by guaranteeing a sufficient non-overlapping period of local clocks using a tri-state local clock driver adapting the schmitt trigger. Comparison results using a 0.13-um CMOS process technology indicate that the proposed charge pump achieves up to 49.1% reduction on power consumption under no loading current condition as compared to conventional charge pump. They also indicate that the charge pump provides 19.0% reduction on power consumption under the maximum loading current condition.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.2
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• pp.166-174
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• 2014

Fuel injection pressure has steadily increased in diesel engines for the purpose of improving fuel efficiency and cleaning exhaust gas, but it has now reached a point, where the cost for higher pressure does not warrant additional gains. Common rail systems on modern diesel engines have fuel pumps that are mechanically driven by crankshaft. The pumps actually house two pumping module inside: a low pressure pump component and a high pressure pump component. Part of the fuel compressed by the low pressure component returns to the tank in the process of maintaining the pressure in the common rail. Since the returning fuel represents pumping loss, fuel economy improves if the returned fuel can be eliminated by using a properly controled electrical fuel pump. As the first step in developing an electrical fuel pump the fuel supply system on a 6 liter diesel engine was modeled with AMESim to analyze the workload and the fuel feed rate of the injection pump, and the results served as basis for selecting a suitable servo motor and a reducer to drive the pump. A motor controller was built using a DSP and a program which controls the common rail pressure using a proportional control method based on the target fuel pressure information from the engine ECU. A test rig to evaluate performance of the fuel pump is implemented and used to show that the newly developed electrically driven fuel pump can satisfy the fuel flow demand of the engine under various operating conditions when the rotational speed of the pump is adequately controlled.

• Journal of the Optical Society of Korea
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• v.1 no.1
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• pp.5-9
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• 1997

Energy transfer direction in $Er^{3+}-Tm^{3+}$-codoped fluorozirconate glasses has been studied. For $Er^{3+}-Tm^{3+}$-codoped glasses, the dependence of the green emission intensity on the pump power (Pex) of 800 nm has ranged from (Pex)$^2$ to (Pex)$^3$. From this multistep absorption, a 1.48 $\mu m$ emission from the $^3F_4{\rightarrow}^3H_4$ transition on Tm$^{3+}$ ion has been found to transfer into $^4I_{13/2}$, $^4I_{9/2}$ and $^4S_{3/2}$ on $Er^{3+}$ ion. In case of the 1.06 $\mu m$ pumping, the emissin ratio of $^3H_4$ level in $Tm^{3+}$ to $^4I_{13/2}$ in $Er^{3+}$ showed that the amount of the energy transfer from $Tm^{3+}$ into $Er^{3+}$ increased with the increasing concentration of $Tm^{3+}$ ion. Our two kinds of pumping scheme suggest that the direction of dominant energy transfer between $Er^{3+}$ and $Tm^{3+}$ should be dependent on whether the $^3F_4$ level resonates in $Tm^{3+}$ the level or not.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.24 no.3
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• pp.453-460
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• 2014

Fault injection attack is the process of attempting to acquire the information on-chip through inject artificially generated error code into the cryptographic algorithms operation (or perform) which is implemented in hardware or software. From the details above, the laser-assisted failure injection attacks have been proven particularly successful. In this paper, we propose an improved laser probing system for fault injection attack which is called the Dual-Laser FA tool set, a hybrid approach of the Flash-pumping laser and fiber laser. The main concept of the idea is to improve the laser probe through utilizing existing equipment. The proposed laser probe can be divided into two parts, which are Laser-I for laser cutting, and Laser-II for fault injection. We study the advantages of existing equipment, and consider the significant parameters such as energy, repetition rate, wavelength, etc. In this approach, it solves the high energy problem caused by flash-pumping laser in higher repetition frequency from the fiber laser.

• Proceedings of the KIEE Conference
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• 1993.07b
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• pp.1268-1270
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• 1993

In this study, the characteristics of Si-$SiO_2$ interface and its degradation in short channel SONOSFET nonvolatile memory devices, fabricated by 1Mbit CMOS process($1.2{\mu}m$ design rule), with $65{\AA}$ blocking oxide layer, $205{\AA}$ nitride layer, and $30{\AA}$ tunneling oxide layer on the silicon wafer were investigated using the charge pumping method. For investigating the Si-$SiO_2$ interface characteristics before and after write/erase cycling, charge pumping current characteristics with frequencies, write/erase cycles, as a parameters, were measured. As a result, average Si-$SiO_2$ interface trap density and mean value of capture cross section were determined to be $1.203{\times}10^{11}cm^{-2}eV^{-1}\;and\;2.091{\times}10^{16}cm^2$ before write/erase cycling, respectively. After cycling, when the write/erase cycles are $10^4$, average $Si-SiO_2$ interface trap density was $1.901{\times}10^{11}cm^{-2}eV^{-1}$. Incresing write/erase cycles beyond about $10^4$, Si-$SiO_2$ interface characteristics with write/erase cycles was increased logarithmically.