• 조명전기설비학회논문지
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• 제24권1호
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• pp.28-34
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• 2010

발광다이오드(LED)의 휘도를 제어하는 기존 방식은 펄스폭변조(PWM)방식이 주로 사용되었다. PWM 방식은 LED의 점등시간비와 휘도가 비례하는 아날로그적인 방식으로 통신 등의 디지털 방식과는 호환이 어려운 단점을 가지고 있다. 본 연구에서는 디지털 방식으로 적, 녹, 청색 LED의 휘도를 제어하는 실험을하였다. 이를 위해 LED 구동회로와 디지털 논리회로로 구성된 LED 디지털제어 장치를 개발하였다. 디지털 입력에 대한 적, 녹, 청색 LED의 점등 펄스 수를 제어하여 다양한 광색을 구현하고, 측정한 광색의 x, y 색도좌표가 원하는 색의 CIE 색도도 영역에 포함될 수 있도록 디지털 코드를 최적화시켰다. 본 연구 결과는 디지털 통신을 이용한 LED 램프의 원격 제어로 풀 컬러를 구현하는데 효과적으로 활용될 수 있다.

• Journal of Microbiology and Biotechnology
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• 제23권5호
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• pp.699-706
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• 2013

We have previously reported that N-acetylcysteine (NAC) not only delayed apoptosis but also enhanced the production of recombinant erythropoietin (EPO) in Chinese hamster ovary (CHO) cell culture. To investigate the production enhancement mechanism, the effects of similar thiol-reducing agents were studied. Intriguingly, all mild reducing agents examined including mercaptoethanesulfonic acid (MESNA), thiolactic acid (TLA), and thioglycolate (TG) were shown to block apoptosis and increase EPO production. A pulse-chase study of EPO secretion revealed that all four thiol-reducing agents increased the EPO secretion rate; among them TLA showed the highest rate. In terms of product quality, the sialic acid content of the glycoprotein is one of the most important factors. It was reported that a number of glycoproteins produced by CHO cells often have incomplete sialylation, particularly under high-producing conditions. Human ${\alpha}2,3$-sialyltransferase (${\alpha}2,3$-ST) was introduced into EPO-producing CHO cells in order to compensate for the reduced sialylation during supplementation with NAC. When ${\alpha}2,3$-ST was expressed in the presence of NAC, reduced sialylation was restored and an even more sialylated EPO was produced. Thus, our study is significant in that it offers increased EPO production while still allowing the prevention of decreased sialylation of EPO.

• Journal of Microbiology and Biotechnology
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• 제30권1호
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• pp.44-53
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• 2020

Calcium is an element that performs many important functions in the human body. A study was conducted on the use of a pulsed electric field (PEF) to enrich cells of Lactobacillus rhamnosus B 442 in calcium ions. The highest concentration of calcium ions in bacterial cells (7.30 mg/g d.m.) was obtained at ion concentration of 200 ㎍/ml of medium and with the use of the following PEF parameters: field strength 3.0 kV/cm, exposure time 10 min, pulse width 75 ms and 20 h of culturing after which bacteria were treated with the field. Cell biomass varied in the range from 0.09 g/g d.m. to 0.252 g/g d.m., and the total number of bacteria ranged from 10¹⁰ CFU/ml to 10¹² CFU/ml. Microscope photographs prove that calcium ions were situated within the cells of the bacteria, and electroporation contributed to an increase in the effectiveness of the ion bioaccumulation process. Samples containing calcium and subjected to electroporation displayed intensive fluorescence. The significance of this research was the possibility of using probiotic bacteria enriched with calcium ions for the production of functional food in subsequent studies.

• 한국항행학회논문지
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• 제20권5호
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• pp.462-467
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• 2016

MSSI (mid-span spectral inversion)와 결합된 분산 제어 (DM; dispersion management)는 광섬유가 갖는 색 분산과 비선형 효과에 기인하는 신호 왜곡을 줄일 수 있는 기술이다. 이러한 전송 링크의 융통적 구성을 위해 단일 모드 광섬유 (SMF; single mode fiber)의 길이와 중계 구간 당 잉여 분산 (RDPS; residual dispersion per span)이 중계 구간이 증가할수록 점진적으로 증가되거나 감소되는 인위적 분포 링크에서 전체 잉여 분산 (NRD; net residual dispersion) 제어 위치에 따른 왜곡된 WDM 채널의 보상 특성을 살펴보았다. 각 전송 반 구획 중 WDM 채널의 광 펄스 폭이 가장 좁아지는 중계 구간이 NRD 조절 위치가 되도록 SMF 길이와 RDPS를 점진적 증가 또는 감소 분포 패턴으로 링크를 구성해야 최상의 보상 효과를 얻을 수 있는 것을 확인하였다.

• 한국농공학회지
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• 제38권5호
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• pp.95-105
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• 1996

This study was performed to evaluate the mechanical properties of permeable polymer concrete using fillers and unsaturated polyester resin. The following conclusions were drawn; 1. The unit weight was in the range of 1, 663~ l, 892kg/$cm^3$, the weights of those concrete were decreased 18~28% than that of the normal cement concrete. 2. The highest strength was achieved by fly ash filled permeable polymer concrete, it was increased 22% by compressive strength, 190% by tensile strength and 192% by bending strength than that of the normal cement concrete, respectively. 3. The external strength of permeable pipe was in the range of 3, 083~3, 793kg/m, the external strengths of those concrete were increased 2~26% than that of the normal cement concrete. Accordingly, these permeable polymer concrete pipe can be used to the members and structures which need external strength. 4. The static modulus of elasticity was in the range of $5.7{\times} 10^4 ~ 15.4{\times} 10{^4}kg/cm^2 $, which was approximately 35~64% of that of the normal cement concrete. Fly ash filled permeable polymer concrete was showed relatively higher elastic modulus. The poisson's number of permeable polymer concrete was less than that of the normal cement concrete. 5. The dynamic modulus of elasticity was in the range of $83{\times} 10^3 ~ 211{\times} 10{^3}kg/cm^2 $, which was approximately Ins compared to that of the normal cement concrete. Fly ash filled permeable polymer concrete was showed higher dynamic modulus. The dynamic modulus of elasticity were increased approximately 22~45% than that of the static modulus. 6. The ultrasonic pulse velocity was in the range of 2, 584 ~ 3, 587m/sec, . which was showed about the same compared to that of the normal cement concrete. Fly ash filled permeable polymer concrete was in the range of$0.58~8.88 {\ell}/cm^2/hr$, , and it was larglely dependent upon the mixing ratio. These concrete can be used to the structures which need water permeability.

• The Korean Journal of Physiology and Pharmacology
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• 제16권5호
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• pp.343-348
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• 2012

Blocking or regulating $K^+$ channels is important for investigating neuronal functions in mammalian brains, because voltage-dependent $K^+$ channels (Kv channels) play roles to regulate membrane excitabilities for synaptic and somatic processings in neurons. Although a number of toxins and chemicals are useful to change gating properties of Kv channels, specific effects of each toxin on a particular Kv subunit have not been sufficiently demonstrated in neurons yet. In this study, we tested electro-physiologically if heteropodatoxin2 ($HpTX_2$), known as one of Kv4-specific toxins, might be effective on various $K^+$ outward currents in CA1 neurons of organotypic hippocampal slices of rats. Using a nucleated-patch technique and a pre-pulse protocol in voltage-clamp mode, total $K^+$ outward currents recorded in the soma of CA1 neurons were separated into two components, transient and sustained currents. The extracellular application of $HpTX_2$ weakly but significantly reduced transient currents. However, when $HpTX_2$ was added to internal solution, the significant reduction of amplitudes were observed in sustained currents but not in transient currents. This indicates the non-specificity of $HpTX_2$ effects on Kv4 family. Compared with the effect of cytosolic 4-AP to block transient currents, it is possible that cytosolic $HpTX_2$ is pharmacologically specific to sustained currents in CA1 neurons. These results suggest that distinctive actions of $HpTX_2$ inside and outside of neurons are very efficient to selectively reduce specific $K^+$ outward currents.

• Journal of Computing Science and Engineering
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• 제5권3호
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• pp.246-256
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• 2011

Due to the increasingly aging population, there is a rising demand for assistive living technologies for the elderly to ensure their health and well-being. The elderly are mostly chronic patients who require frequent check-ups of multiple vital signs, some of which (e.g., blood pressure and blood glucose) vary greatly according to the daily activities that the elderly are involved in. Therefore, the development of novel wearable intelligent systems to effectively monitor the vital signs continuously over a 24 hour period is in some cases crucial for understanding the progression of chronic symptoms in the elderly. In this paper, recent development of Wearable Intelligent Systems for e-Health (WISEs) is reviewed, including breakthrough technologies and technical challenges that remain to be solved. A novel application of wearable technologies for transient cardiovascular monitoring during water drinking is also reported. In particular, our latest results found that heart rate increased by 9 bpm (P < 0.001) and pulse transit time was reduced by 5 ms (P < 0.001), indicating a possible rise in blood pressure, during swallowing. In addition to monitoring physiological conditions during daily activities, it is anticipated that WISEs will have a number of other potentially viable applications, including the real-time risk prediction of sudden cardiovascular events and deaths.

• 대한본초학회지
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• 제30권4호
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• pp.129-135
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• 2015

Objectives : Clerodendron trichotomumThunberg grows wild fields and mountains in South Korea and China. They have been used for anti-hypertension disease. This study was performed in order to observe the effects ofClerodendron trichotomumThunberg tea on anti-hypertension.Methods : For the study ofClerodendron trichotomumThunberg tea, we had divided male SHR (Spontaneously Hypertensive Rat) to ten groups. Control group is SHR. The treatment group is SHR which is administered tea extract at dose of 200 mg/kg/day and 500 mg/kg/day orally for 8 weeks. We measured systolic blood pressure, diastolic blood pressure, number of pulse, body weight, total cholesterol and triglyceride from blood serum.Results : The level of systolic and diastolic blood pressure were significantly decreased by 12.5% and 44.9% inClerodendron trichotomumThunberg tea groups than control group. Heart rate ofClerodendron trichotomumThunberg tea groups, 24.5%, was significantly lower than control group. We found that treatment with the water extract fromClerodendron trichotomumThunberg leave and flower significantly decreased weight of body, total cholesterol and triglyceride to 20.4% and 27.7% compared to untreated control group, significantly (P< 0.05).Conclusions : These results suggest that leaf and flower tea ofClerodendron trichotomumThunberg tea is effective in prevention and treatment of hypertension and decreasing cholesterol. Long term consumption ofClerodendron trichotomumThunberg leaf and flower tea can be help in lowering high systolic and blood diastolic pressure, heart rate and blood serum in SHR.

• 전력전자학회논문지
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• 제8권3호
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• pp.292-298
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• 2003

교류전동기의 가변속 운전에 사용되는 삼상 인버터에는 두개 또는 세개의 전류센서가 장착되며 이를 이용하여 삼상 교류전류를 측정한다. 전류센서의 갯수를 줄이기 위하여 개발된 것이 직류링크에 한개의 전류센서로 직류전류를 측정하고 측정된 전류 값과 스위칭 상태로부터 삼상 교류전류를 추정하는 방법이다. 전류를 정확히 측정하려면 스위칭 상태가 최소 측정시간 이상 유지되어야 하며, 이를 위한 펄스폭 조정과 이에 따른 전압 왜곡의 보상 방법이 연구되어 왔다. 그러나 기존에 발표된 방식들은 공간벡터 전압변조법에는 적합하지만 산업체에서 널리 쓰이는 펄스폭 변조 방식인 삼각파 비교법에 적용하기에는 어려운 면이 많다. 본 연구에서는 삼각파 비교법에 적합한 전류 측정 방식과 전압왜곡 보상 방식을 제안하고 이의 타당성을 실험을 통하여 검증하였다.

• 전자공학회논문지 IE
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• 제47권4호
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• pp.1-9
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• 2010

초음파신호를 이용하여 두 물체 사이의 거리를 측정할 수 있도록 초음파신호를 발생시키고 이를 수신하여 증폭하는 프론트-앤드 IC를 설계하였다. 40[kHz]~300[kHz]의 초음파 신호를 발생시켜서 피에조진동자를 통해 간헐적으로 송신하는 회로와 피에조 수신기에서 받은 미세한 반사 신호를 증폭하여 노이즈를 제거한 후 처음 송신된 신호와의 시간 차이를 펄스폭으로 출력하고 이를 이용하여 물체사이의 거리를 계산할 수 있는 기능을 내장하였다. 본 설계에서는 두 가지 기술을 작용하여 기능을 개선하였다. 첫째, 주파수 자동조정(SFC) 회로이다. OTA회로의 gm을 가변시켜 초음파 신호발생기의 출력주파수와 수신단의 밴드패스필터의 중심주파수가 서로 연동되도록 조정해 줌으로써 신호 복원을 용이하게 하였다. 둘째, 가변 이득 조절회로(VGC)이다. 이 회로는 두 물체사이의 거리에 상관없이 수신되는 신호의 진폭이 일정하도록 동작하는 기능을 한다. 또한, 출력레벨변환회로를 적용하여 송신신호의 진폭을 40[V]로 상승시켜 측정거리를 늘리는 시도를 하였다. 시뮬레이션을 위한 공정은 0.6um] 급, 40[V] CMOS 공정을 사용하였다. 전원전압 5[V], 소비전력은 약 12[mW]정도이다. 회로의 규모가 최소화 되어 있고 외부소자 수를 줄였기 때문에 휴대형기기에 편리하게 사용할 수 있게 하였다.