• Clinical and Experimental Pediatrics
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• 제46권4호
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• pp.400-403
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• 2003

진단이 지연되었거나 적절하게 치료되지 않은 선천성 부신 과형성증을 가진 남아에서 장기간 고농도의 남성호르몬에 노출될 경우 처음에는 가성 성조숙증이었다가 이후 진성 성조숙증으로 전환될 수 있으므로 선천성 부신 과형성증의 조기진단과 치료가 필요하다. 저자들은 가성 성조숙증에서 진성 성조숙증으로 전환된 선천성 부신 과형성증을 가진 남아에서 hydrocortisone과 GnRH 유도체를 사용하여 큰 부작용 없이 2차 성징의 퇴축을 가져온 1례를 경험하고 문헌고찰과 함께 보고하는 바이다.

• 대한한방소아과학회지
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• 제28권4호
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• pp.64-70
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• 2014

Objectives The purpose of this study is to find out how taking oriental herbal medicine may affect the sex hormone levels in a patient who was diagnosed with prematurity. Methods We prescribed 120 cc of oriental herbal medicine twice daily for a month to a patient suspected of the precocious puberty due to 11 pg/ml of the estradiol level. Upon finishing the course of oriental herbal medicine, the patient was retested for the follicular stimulating hormone, luteinizng hormone and estradiol levels. Results After administration, all levels of luteininzing hormone, follicular stimulating hormone and estradiol were decreased. There was no diagnosable evidence for the idiopathic central precocious puberty in the gonadotropin releasing hormone stimulation. Conclusions Oriental herbal medicine is a good alternative treatment of choice for the precocious puberty. However, more in-depth studies are to be followed.

• 한국학교보건학회지
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• 제3권1호
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• pp.119-134
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• 1990

The purpose of this study is to find out the need for sex education of middle school students and their parents. For the data collection, the survey was conducted during the period from September 10 to September 20, 1989 by using prepared questionnaire. A questionnaire was given to 592 students of 1st, 2nd and 3rd grade from four middle schools and to 408 their parents in Suwon City. The major results are summarized as follow; 1. Among the 25 questions were asked about knowledge of sex, the structure of reproductive organs, physical change during puberty, menstruation, Sexually stimulation and family plan were answered correctly by over 50% of the students. The higher the grade, the more the knowledge of sex. There was no significant difference between this knowledge and with eider sister or brother. Among the 20 questions were asked about knowledge of sex, sexually stimulation, pregnancy, emission, induced abortion and sexually transmitted disease were answered correctly by over 50% of the parents. 2. 30 questions were asked about attitude of sex, 47.7% of the students and 53.4% of the parents answered 'positive'. There was no significant difference between grade and sex of students. A significant difference '.vas not also found between years and education level of parents. 3. In case of students, experience of sex education was showed the structure of reproductive organs, physical change during puberty, temper during puberty, menstruation, emission more. In the event of parents, experience of sex education was showed the structure of reproductive organs, temper during puberty, menstruation, emission, relationship with apposite sex more. Most students felt that sex education should begin from the first grade of middle school and the first grade of high school strongly. In parents was showed the need for sex education from the primary school and the first grade of middle school highly. Namely, students and parents felt that sex education should begin from puberty. To help good developments and growth of middle school students with rapid change should be educated sex eduction properly for the occasion.

• 한국발생생물학회지:발생과생식
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• 제17권1호
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• pp.45-53
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• 2013

The action of melatonin within the body of animals is known to be mediated by melatonin receptors. Three different types of melatonin receptors have been identified so far in fish. However, which of these are specifically involved in puberty onset is not known in fish. We cloned and analyzed the sequence of melatonin receptor 1a (mel 1a) gene in Nile tilapia Oreochromis niloticus. In addition, we examined the tissue distribution of gene expressions for three types of receptors, mel 1a, 1b and lc and investigated which of them is involved in the onset of puberty by comparing their expression with that of gonadotropin-releasing hormone receptor I (GnRHr I) gene using quantitative real-time PCR from 1 week post hatch (wph) to 24 wph. The mel 1a gene of Nile tilapia consisted of two exons and one bulky intron between them. Mel 1a gene was found to be highly conserved gene showing high homology with the corresponding genes from different teleost. All three types of melatonin receptor genes were expressed in the brain, eyes and ovary in common. Expression of mel 1a gene was the most abundant and ubiquitous among 3 receptors in the brain, liver, gill, ovary, muscle, eye, heart, intestine, spleen and kidney. Mel 1b and mel 1c genes were, however, expressed in fewer tissues at low level. During the development post hatch, expressions of both mel 1a and GnRHr I genes significantly increased at 13 wph which was close to the putative timing of puberty onset in this species. These results suggest that among three types of receptors mel 1a is most likely associated with the action of melatonin in the onset of puberty in Nile tilapia.

• 디지털융복합연구
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• 제16권7호
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• pp.325-335
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• 2018

본 연구는 호르몬 치료를 받았거나 받고 있는 성조숙증 환아를 대상으로 성조숙증에 대한 이해와 경험적 의미를 이해하는 데 목적을 둔 현상학적 방법론을 적용한 질적 연구이다. 본 연구의 참여자는 성조숙증 진단 받고 치료경험이 있는 6명을 임의 표집방법을 통해 선정하였다. 2016년 10월 12일 부터 2016년 11월 18일 까지 참여자와 개인 심층면담 및 그룹인터뷰를 통하여 자료를 수집하였다. 수집된 자료는 Colaizzi(1978)에 의해 제안된 분석방법을 이용하여 분석하였다. 본 연구결과 성조숙증 치료 경험의 구조는 '엄마가 선택한 치료', '불편한 치료과정', '잘 이해하지 못하는 병', '다시는 받고 싶지 않은 치료' 의 4개의 주제 모음으로 확인되었다. 본 연구 결과를 통하여 성조숙증 치료를 경험한 환아들이 느끼는 여러 가지 정서 및 심리적 어려움을 확인하였다. 추후연구에서는 환아들의 부담감을 감소시키고 치료를 긍정적인 감정으로 받아들일 수 있도록 간호중재 프로그램을 개발하는 연구가 진행되어야 할 것이다.

• 대한한방부인과학회지
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• 제34권2호
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• pp.124-141
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• 2021

Objectives: The purpose of this study is to assess the efficacy of Jibaekjihwang-hwan and Daeboeum-hwan combination therapy for the treatment of precocious puberty. Methods: 6 databases were searched from the date of inception until April 2021 for relevant studies. We included randomized controlled trials (RCTs) and non-randomized controlled trials (nRCTs) which focused on effects of Jibaekjihwang-hwan and Daeboeum-hwan on precocious puberty. Results: Total 8 literatures were included in qualitative analysis and meta analysis on results was conducted on 4 synthesizable studies. The response rate was significantly higher in Jibaekjihwang-hwan and Daeboeum-hwan combination group than in conventional therapy group. Also, serum estradiol and follicle stimulating hormone (FSH) level were significantly lower in Jibaekjihwang-hwan and Daeboeum-hwan combination group than in conventional therapy group. Conclusions: It seems that combination therapy of Jibaekjihwang-hwan and Daeboeum-hwan can effectively reduce serum estradiol and FSH level while increasing response rate significantly. Further high quality studies are needed to supplement the efficacy and safety of combination therapy of Jibaekjihwang-hwan and Daeboeum-hwan on precocious puberty.

• Clinical and Experimental Pediatrics
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• 제59권9호
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• pp.355-361
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• 2016

The menarcheal age of Korean women has been rapidly decreasing for the last 50 years, and the average menarcheal age of women born in the 1990s is approaching 12.6 years. In addition, interest in early puberty has been increasing recently owing to the rapid increase in precocious puberty. Generally, out of concern for short stature and early menarche, idiopathic central precocious puberty in female adolescents is treated with gonadotropin-releasing hormone analogs. Studies to date have described the association between early menarche and psychosocial problems such as delinquency and risky sexual behavior, as well as physical health problems such as obesity, diabetes, cardiovascular diseases, and breast cancer throughout the lifespan of women. However, the pathophysiological mechanism underlying this association has not been clarified thus far. In this article, we review and discuss the existing literature to describe the current understanding of the effects of early menarche on the physical and psychosocial health of adolescent girls and adult women.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제2권2호
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• pp.217-221
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• 1999

저자들은 2주간의 간헐적 상복부 동통과 식욕결핍을 호소하는 15세 남아에서 위 내시경과 조직 생검으로 진단된 원발성 위 림프종 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Molecules and Cells
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• 제42권2호
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• pp.97-103
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• 2019

Androgens act in almost all tissues throughout the lifetime and have important roles in skeletal muscles. The levels of androgens increase during puberty and remain sustained at high levels in adulthood. Because androgens have an anabolic effect on skeletal muscles and muscle stem cells, these increased levels of androgens after puberty should lead to spontaneous muscle hypertrophy and hyperplasia in adulthood. However, the maintenance of muscle volume, myonuclei number per myofiber, and quiescent state of satellite cells in adulthood despite the high levels of androgens produces paradoxical outcomes. Our recent study revealed that the physiological increase of androgens at puberty initiates the transition of muscle stem cells from proliferation to quiescence by the androgen-Mindbomb1-Notch signaling axis. This newly discovered androgen action on skeletal muscles underscores the physiological importance of androgens on muscle homeostasis throughout life. This review will provide an overview of the new androgen action on skeletal muscles and discuss the paradoxical effects of androgens suggested in previous studies.

• Clinical and Experimental Pediatrics
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• 제55권10호
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• pp.388-392
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• 2012

Purpose: Single-nucleotide polymorphism (SNP) markers within LIN28B have been reported to be related to the timing of pubertal growth. However, no study has investigated the frequency of genetic markers in girls with precocious puberty (PP) or early puberty (EP). This study aimed to determine the frequency of putative genetic markers in girls with PP or EP. Methods: Genomic DNAs were obtained from 77 and 109 girls that fulfilled the criteria for PP and EP, respectively. The controls in this study were 144 healthy volunteers between 20 and 30 years of age. The haplotypes were reconstructed using 11 SNPs of LIN28B, and haplotype association analysis was performed. The haplotype frequencies were compared. Differences in the clinical and laboratory parameters were analyzed according to the haplotype dosage. Results: Eleven SNPs in LIN28B were all located in a block that was in linkage disequilibrium. The haplotype could be reconstructed using 2 representative SNPs, rs4946651 and rs369065. The AC haplotype was less frequently observed in the PP group than in the controls (0.069 vs. 0.144, P=0.010). The trend that girls with non-AC haplotypes tended to have earlier puberty onset (P=0.037) was illustrated even in the EP+PP patient group by Kaplan-Meier analysis. Conclusion: The results of the present study showed that non-AC haplotypes of LIN28B had a significant association with PP in girls.