Browse > Article
http://dx.doi.org/10.15204/jkobgy.2021.34.2.124

Jibaekjihwang-hwan and Daeboeum-hwan Combination Therapy on Precocious Puberty: a Systematic Review and Meta-Analysis  

Kang, So-Hyeon (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Se-Myung University)
Seo, Ji-Hye (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Se-Myung University)
Hur, Da-Hee (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Se-Myung University)
Lee, Dong-Nyung (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Se-Myung University)
Kim, Hyeong-Jun (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Se-Myung University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.34, no.2, 2021 , pp. 124-141 More about this Journal
Abstract
Objectives: The purpose of this study is to assess the efficacy of Jibaekjihwang-hwan and Daeboeum-hwan combination therapy for the treatment of precocious puberty. Methods: 6 databases were searched from the date of inception until April 2021 for relevant studies. We included randomized controlled trials (RCTs) and non-randomized controlled trials (nRCTs) which focused on effects of Jibaekjihwang-hwan and Daeboeum-hwan on precocious puberty. Results: Total 8 literatures were included in qualitative analysis and meta analysis on results was conducted on 4 synthesizable studies. The response rate was significantly higher in Jibaekjihwang-hwan and Daeboeum-hwan combination group than in conventional therapy group. Also, serum estradiol and follicle stimulating hormone (FSH) level were significantly lower in Jibaekjihwang-hwan and Daeboeum-hwan combination group than in conventional therapy group. Conclusions: It seems that combination therapy of Jibaekjihwang-hwan and Daeboeum-hwan can effectively reduce serum estradiol and FSH level while increasing response rate significantly. Further high quality studies are needed to supplement the efficacy and safety of combination therapy of Jibaekjihwang-hwan and Daeboeum-hwan on precocious puberty.
Keywords
Precocious Puberty; Herbal Medicine; Systematic Review;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Li C, et al. Zhibaidihuang-pill Combined With Dabuyin-pill Treatment of Children With Central Precocious Puberty: Clinical Analysis of 56Cases. Chinese Journal of Obstetrics & Gynecology and Pediatrics. 2013;9(4):504-6.
2 Korean Society of Pediatric Endocrinology: Pediatric endocrinology. 2nd ed. Seoul:Kwangmoon. 2004:176-93.
3 Korean Society of Gynecology. Gynecology. 6th ed. Seoul:Koonja. 2021:1007-14
4 Heger S, et al. Long-term GnRH agonist treatment for female central precocious puberty does not impair reproductive function. Molecular and cellular endocrinology. 2006;254-255:217-20.   DOI
5 Anik A, et al. Effect of gonadotropin-releasing hormone agonist therapy on body mass index and growth in girls with idiopathic central precocious puberty. Indian J Endocrinol Metab. 2015;19(2):267-71.   DOI
6 John S. Fuqua. Treatment and Outcomes of Precocious Puberty: An Update, The Journal of Clinical Endocrinology & Metabolism. 2013;98(6):2198-207.   DOI
7 Carel JC, et al. GnRH Analogs Consensus Conference Group. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics. 2009;123(4):752-62.
8 Bouvattier C, et al. Lack of effects of GnRH agonists on final height in girls with advanced puberty: a randomized long-term pilot study. J Clin Endocrinol Metab. 1999;84(10):3575-8.   DOI
9 Baek JW, et al. Age of menarche and near adult height after long-term gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty. Ann Pediatr Endocrinol Metab. 2014;19(1):27-31.   DOI
10 Kim EY. Long-term effects of gonadotropin-releasing hormone analogs in girls with central precocious puberty. Korean journal of pediatrics. 2015;58(1):1-7.   DOI
11 Li Z, et al. Recombinant human growth hormone improves growth deceleration in girls with idiopathic central precocious puberty treated by gonadotropin-releasing hormone analogues. Chinese Journal of Rural Medicine and Pharmacy. 2017;24(5):21-2.
12 Kweon JH, et al. The Trend of Clinical Research on Treatment for Precocious Puberty - Focusing on Recent Studies in the Chinese Medical Journal CAJ -. J Pediatr Korean Med. 2017;31(1):63-73.   DOI
13 Yoon JG, et al. Review on the Use of Oriental Herbal Medicine for Female Idiopathic Precocious Puberty. J Korean Obstet Gynecol. 2017;30(3):20-8.   DOI
14 Lee YB, et al. Herbal Medicine for Idiopathic Central Precocious Puberty: A Systematic Review and MetaAnalysis. The Journal of Alternative and Complementary Medicine. 2020;26(11):976-99.   DOI
15 Sun Y, Cui Z. Observation on curative effect of traditional Chinese medicine in treating exogenous precocious puberty caused by contraceptives in girls. Journal of Qiqihar Medicine. 2008;29(10):1175-6.
16 Hu M, Pan W. The clinical effectiveness analysis of Zhibaidihuang-pill and Dabuyin-pill combination treatment of children with central precocious puberty. Chinese Journal of Human Sexuality. 2015;24(3):76-8.
17 Sorensen K, et al. Insulin sensitivity and lipid profiles in girls with central precocious puberty before and during gonadal suppression. J Clin Endocrinol Metab. 2010;95(8):3736-44.   DOI
18 Liu J, Wang H. Clinical effect and safety of Zhibaidihuang-pill combined with Dabuyin-pill in the sexual precocity of girls. Chinese Journal of Human Sexuality. 2018;27(1):64-7.
19 Liu J, Jin M. Clinical Study on Dabuyin-pills Combined with Zhibaidihuang-pills for Precocious Puberty in Girls. Journal of New Chinese Medicine. 2020;52(7):47-50.
20 Wang X, Li P, Feng C. Ultrasonic evaluation of clinical efficacy of Zhibai dihuang-wan combined with Dabuyin-wan on central pubertas praecox in girls. Journal of Pediatrics of Traditional Chinese Medicine. 2020;16(3):72-6.   DOI
21 Lee KH, et al. The Korean society of pediatric endocrinology's precocious puberty clinical guidelines. 1st ed. Seoul:Uihakmoonhwasa. 2011:18-20.
22 Zhang M. Study on the Effect of Zhibaidihuang-pill Combined with Dabuyin-pill in Treating Central Early Precocity. Chinese and Foreign Medical Research. 2017;15(29):10-1.   DOI
23 Kim KB, et al. Textbook of pediatrics of oriental medicine. 1st ed. Seoul:Uisungdang. 2010:852-3.
24 Li J, Lin D, Feng G. Medication rules of traditional Chinese medicine in the treatment of children with idiopathic central precocious puberty based on data mining. Journal of Pediatrics of Traditional Chinese Medicine. 2020;06:40-5.
25 Fu Q, et al. Systematic Review on Effectiveness and Safety of Zhibaidihuang-pills in the Adjuvant Treatment of Children's Central Precocious Puberty. Chinese Journal of Modern Applied Pharmacy. 2020;37(1):85-90.
26 Liang J, Chen J, Ye J. Meta-analysis of the efficacy of Dabuyin-pills in the treatment of central precocious puberty in children. Strait Pharmacy. 2017;29(2):89-91.
27 Song W, et al. Is a Combination of a GnRH Agonist and Recombinant Growth Hormone an Effective Treatment to Increase the Final Adult Height of Girls with Precocious or Early Puberty?. Int J Endocrinol. 2018;2018:1-10. Available from:URL:http://dx.doi.org/10.1155/2018/1708650.   DOI