• 한국정보과학회:학술대회논문집
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• 한국정보과학회 1999년도 가을 학술발표논문집 Vol.26 No.2 (3)
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• pp.423-426
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• 1999

In offering a statistical end-to-end bandwidth guarantee service, typically called Assured Service, in Differentiated Serviced (Diff-Serv) framework, the biggest issue is its inconsistency. Larger profile TCP flows fail to achieve the guaranteed rate when competing with many smaller profile flows. This phenomenon, which we call "bandwidth skew", stems from the fact that larger profile flows take longer time to recover from the congestion window size backoff after a packet drop. Proposed solutions to this problem, therefore, are focused on modifying the TCP behavior. However, TCP modification is not practicable, mainly due to its large installation base. We look to other mechanisms in the Diff-Serv framework to find more realistic solutions. In particular, we demonstrate that RIO, the de facto standard packet differentiation mechanism used for Assured Service, also contributes to the bandwidth skew. Based on this new finding, we design a modified RIO mechanism called RI+O. RI+O uses OUT queue length in addition to IN and IN+OUT queue length to calculate OUT packet drop probability. We show through extensive simulation that RI+O significantly alleviates the bandwidth skew, expanding the operating regime for Assured Service.d Service.

• 대한기계학회논문집
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• 제13권1호
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• pp.29-39
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• 1989

본 논문에서는 우선 밸브 기구의 동적 특성을 보다 정교하게 묘사하기 위해서 4 자유도 집중 질량 모델을 세우고 시뮬레이션 결과와 실험 결과를 비교하여 실험을 더 잘 묘사할 수 있도록 모델을 개선하였다. 그리고 수립된 모델을 사용하여 밸브 변위, 속도, 가속도 특성 및 밸브 기구의 작동 오차를 정의하였다. 이 평균 자승 오차를 최소함으로써 중어진 캠 변위는 크게 변화시키지 않으면서 가속도 및 속도를 최소화한 캠을 설계하였다.

• 전자공학회논문지
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• 제52권4호
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• pp.23-29
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• 2015

본 논문에서는 수중 위치 추적(Underwater Localization)을 위한 수평거리 추정 방식 중 음선의 각도 변화를 이용하는 방식을 개선하는 Look-up Table(LUT)를 사용하는 방식을 제안하고 기존 방식과의 연산속도 및 수평거리 오차를 비교한다. LUT를 사용하여 추정하는 방식은 수신기의 음파 도달 시간(Time of arrival : ToA)과 깊이에 따른 Sound Speed Profile(SSP)을 이용하여 만들어진 수평 거리-ToA table을 이용한다. 결과적으로, 음선의 각도 변화를 이용하는 방식에 비해 수평거리 추정오차는 다소 증가하게 되지만, 수신된 ToA에 대응되는 수평거리를 사용한다는 점에서 실시간으로 각도 변화를 추정하는 기존방식에 비하여 매우 빠른 처리가 가능하다.

• Molecules and Cells
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• 제40권10호
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• pp.737-751
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• 2017

Histone-modifying enzymes are key players in the field of cellular differentiation. Here, we used GSK-J4 to profile important target genes that are responsible for neural differentiation. Embryoid bodies were treated with retinoic acid ($10{\mu}M$) to induce neural differentiation in the presence or absence of GSK-J4. To profile GSKJ4-target genes, we performed RNA sequencing for both normal and demethylase-inhibited cells. A total of 47 and 58 genes were up- and down-regulated, respectively, after GSK-J4 exposure at a log2-fold-change cut-off value of 1.2 (p-value < 0.05). Functional annotations of all of the differentially expressed genes revealed that a significant number of genes were associated with the suppression of cellular proliferation, cell cycle progression and induction of cell death. We also identified an enrichment of potent motifs in selected genes that were differentially expressed. Additionally, we listed upstream transcriptional regulators of all of the differentially expressed genes. Our data indicate that GSK-J4 affects cellular biology by inhibiting cellular proliferation through cell cycle suppression and induction of cell death. These findings will expand the current understanding of the biology of histone-modifying enzymes, thereby promoting further investigations to elucidate the underlying mechanisms.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제13권1호
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• pp.37-43
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• 1991

두부방사선사진을 이용한 안모의 측모예측은 악교정수술에 있어서 가장 중요한 수술전 치료계획의 한부분으로 술후 경조직과 연조직의 변화를 예상하며 술자와 환자간에 술후 결과를 의논하는 대화의 재료로서도 그 중요성이 크다. 그러나, 술후 환자의 최종적인 측모와 수술 직전에 수술 계획에 따라 시행한 술후 측모의 예측과는 차이가 있다. 이러한 수술 전 시행하는 측모 예측의 부정확성을 감소시키기 위하여 새로운 경조직 대 연조직 변화비율 등을 추정하는 많은 연구가 시행되어 왔으나 측모방사선 예측의 부정확도를 조사하고 이러한 부정확성에 영향을 미치는 변수를 확인함이 측모방사선예측의 부정확성을 이해하고 감소시키는 데에 있어서 그 중요성이 크다고 생각된다. 이에 저자들은, 이미 시행되어 수술에 사용된 술후 측모예측기록을 수술직후 두부방사선 사진 및 술후 최소 6개월 추적 방사선 사진에 중첩하여 측모 예측의 부정확도를 조사한 바 총 30명의 환자에서 20명(66.6%)이 부정확도를 보였고 악골 및 치열의 술후 위치 불안정성도 측모 예측 정확군과 부정확군에 모두 19명(63.3%)에서 발생하여 측모 예측의 부정확도 영향을 주는 중요한 요인으로 확인되었다.

• 한국축산식품학회지
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• 제42권3호
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• pp.504-516
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• 2022

This study aimed to investigate the effect on the chemical quality of whey and Ricotta obtained from ewes fed a red grape pomace (GP) dietary supplementation. The analyses were performed on whey, before and post Ricotta cheese-making, and in Ricotta after 1 (T1) and 5 (T5) d of ripening at 4℃. Moreover, fatty acid profile of whey before ricotta (WBR) cheese-making and Ricotta T1 of ripening and volatile profile of Ricotta T1 and T5 were investigated. The diet did not affect whey and Ricotta lipid content, conversely, significant variations were instead observed with regard to color. A lower amount of total phenolic compounds was found in WBR cheese-making, on the contrary, an opposite trend was highlighted in Ricotta T1 although no variations in antioxidant properties were detected. Moreover, GP modified fatty acid profile of whey and Ricotta but did not have any effect on protein profile of the main whey protein. The reduction of hexanal in Ricotta during the ripening suggest a better oxidative stability. The obtained results therefore suggested that the GP inclusion in the ewes diet, while modifying some chemical parameters, did not induce negative effects on the characteristics and quality of dairy by-products.

• 한국미생물·생명공학회지
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• 제47권4호
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• pp.651-661
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• 2019

Targeting the pathogen viability using drugs is associated with development of drug resistance due to selective pressure. Hence, there is an increased interest in developing agents that target bacterial virulence. In this study, the inhibitory effect of ciclopirox, an antifungal agent with iron chelation potential, on the microbial virulence factors was evaluated in 26 clinical MDR Pseudomonas aeruginosa isolates collected from Alexandria Main University Hospital, a tertiary hospital in Egypt. Treatment with 9 ㎍/ml ciclopirox inhibited the hemolytic activity in 70% isolates, reduced pyocyanin production, decreased protease secretion in 46% isolates, lowered twitching and swarming motility, and decreased biofilm formation by 1.5- to 4.5-fold. The quantitative real-time PCR analysis revealed that treatment with ciclopirox downregulated the expression levels of alkaline protease (aprA) and pyocyanin (phzA1). Ciclopirox is used to treat hematological malignancies and the systemic administration of ciclopirox is reported to have adequate oral absorption with a satisfactory drug safety profile. It is important to calculate the appropriate clinical dose and therapeutic index to reposition ciclopirox from a topical antifungal agent to a promising virulence-modifying agent agent against P. aeruginosa, a problematic Gram-negative pathogen.

• 드라이브 ㆍ 컨트롤
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• 제16권4호
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• pp.80-86
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• 2019

The gerotor type device is mainly used in low-speed, high-torque hydraulic motors, and is also applied as a small priming hydraulic pump. For this reason, many studies have been conducted to increase the efficiency of the gerotor pump. In this paper, we propose a new tooth profile design method different from the existing method. The new tooth design is made by modifying the tooth surface using the amplification function of the trajectories, created along the inner and outer rolling circles around the base circle. The shape of the mate rotor is then created using rotation simulation techniques. Such shapes are described as hypercloid. The designed hypercloid rotor is compared with the existing trochoid rotor, and the characteristics of the parameters and volumetric displacements are analyzed. Through this process, the optimum design with larger volumetric displacement than the existing rotor is achieved.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2014년도 추계학술대회 및 정기총회
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• pp.11-11
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• 2014

Fungal pathogens have huge impact on health and economic wellbeing of human by causing life-threatening mycoses in immune-compromised patients or by destroying crop plants. A key determinant of fungal pathogenesis is their ability to undergo developmental change in response to host or environmental factors. Genetic pathways that regulate such morphological transitions and adaptation are therefore extensively studied during the last few decades. Given that epigenetic as well as genetic components play pivotal roles in development of plants and mammals, contribution of microbial epigenetic counterparts to this morphogenetic process is intriguing yet nearly unappreciated question to date. To bridge this gap in our knowledge, we set out to investigate histone modifications among epigenetic mechanisms that possibly regulate fungal adaptation and processes involved in pathogenesis of a model plant pathogenic fungus, Magnaporthe oryzae. M. oryzae is a causal agent of rice blast disease, which destroys 10 to 30% of the rice crop annually. Since the rice is the staple food for more than half of human population, the disease is a major threat to global food security. In addition to the socioeconomic impact of the disease it causes, the fungus is genetically tractable and can undergo well-defined morphological transitions including asexual spore production and appressorium (a specialized infection structure) formation in vitro, making it a model to study fungal development and pathogenicity. For functional and comparative analysis of histone modifications, a web-based database (dbHiMo) was constructed to archive and analyze histone modifying enzymes from eukaryotic species whose genome sequences are available. Histone modifying enzymes were identified applying a search pipeline built upon profile hidden Markov model (HMM) to proteomes. The database incorporates 22,169 histone-modifying enzymes identified from 342 species including 214 fungal, 33 plants, and 77 metazoan species. The dbHiMo provides users with web-based personalized data browsing and analysis tools, supporting comparative and evolutionary genomics. Based on the database entries, functional analysis of genes encoding histone acetyltransferases and histone demethylases is under way. Here I provide examples of such analyses that show how histone acetylation and methylation is implicated in regulating important aspects of fungal pathogenesis. Current analysis of histone modifying enzymes will be followed by ChIP-Seq and RNA-seq experiments to pinpoint the genes that are controlled by particular histone modifications. We anticipate that our work will provide not only the significant advances in our understanding of epigenetic mechanisms operating in microbial eukaryotes but also basis to expand our perspective on regulation of development in fungal pathogens.

• 자원환경지질
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• 제34권6호
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• pp.595-600
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• 2001

최근 들어, 지하철공사나 폐광의 관리와 같은 지하공간의 공사에 의한 지반침하에 대한 관심이 높아지고 있다 GIS (Geographic Information System; 지리정보시스템)를 이용한 지반침하의 분석은 공간자료의 처리 및 데이터베이스의 구축 차원에서 장점을 지니고 있다. GIS를 이용한 분석에 있어, 보다 나은 결과를 위해서는 기존의 침하 이론이나 모델의 보완이 필요하다. 복잡한 지형을 고려하기 위해서는 표면의 지형 기복을 고려한 모델의 민정이 필요하며, 3차원 상의 분석을 위해서는 2개의 직고하는 2차원 침하곡선을 동시에 고려할 필요성이 있다. 이러한 보완을 통해서 GIS를 이용한 지반침하 분석 모델을 구축할 수 있으며, 이의 실제 적용 가능성의 판단을 위해 이상적인 경우의 지하공동과 지반조건에 대해 분석을 수행하였다. 공동의 특성, 토층의 특성, 지하수 조건 및 지형조건의 현실적인 입력변수로의 활용을 통해, 보다 더 신뢰성 있는 결과와 활용분야의 확대를 기대할 수 있다.