• Proceedings of the Ginseng society Conference
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• 1993.09a
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• pp.84-93
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• 1993

It has been reported that ginseng is effective in the central nervous system, immune system, and the strong inflammatory responses. However, there has been no research report yet about the effect of ginseng on allergic hypersensitivity reactivity. To confirm the ginseng effects on the release of mediators(histamine. leukotrienes etc.) which cause the hypersensitivity reactivity and inflammatory response, we used actively sensitized guinea pig airway tissues by utilizing the superfusion technique. In this procedure. the contractile response and mediators released after antigen stimulation of sensitized tissues, and IgG and IgE antibody products were measured in sera of immunized animals. Then the results of the controll group were compared to those of ginseng pretreatment groups. In the total saponin(TS) and panaxatriol(PT) pretreatment, histamine release decreased by $20\%$ in the tracheal tissues after active sensitization by ovalbumin(OVA, 10mg/kg), but in the lung parenchyma, histamine release decreased by $40\%.$ Panaxadiol(PD) significantly decreased histamine release by $40\%$ in the both tissues after active sensitization. TS, PT and PD of ginseng poorly blocked leukotrienes (LTs) and prostagrandin $D_2(PGD_2)$ release(less than $10\%$). Ginseng TS and PT had no effect on the serum IgG antibody production by ovalbumin, whereas PD significantly increased serum IgG antibody contents(approximately by 2 times). However, $IgG_1$ antibody products in the serum of guinea pig actively sensitized with ovalbumin after PD pretreatment were decreased, compared to that with ovalbumin alone. IgE antibody production by passive cutaneous anaphylaxis(PCA) titer in the TS pretreatment increased 3 times more than in the absence of TS(PCA titer by PT was not detected). These studies show that some ginseng saponins can in part act to inhibit mediator release in antigen - induced airway smooth muscle by inducing the IgG antibody production which has been changed in the specificity.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.5
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• pp.1195-1199
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• 2005

In the present study, Inhibitory effects of the ethanol extract of Saussurea lappa (S. lappa) on the growth, acid production, adhesion and water-insoluble glucan synthesis of Streptouccus mutans (S. mutans) were examined. The growth and acid production of S. mutans were Inhibited by the presence of ethanol extract of S. lappa (0.5-4 mg/ml) significantly. The ethanol extract of S. lappa (0.25-4 mg/ml) also significantly lowered the adherence of S. mutans in a dose dependent manner. In water-insoluble glucan synthesis assay, 2-4 mg/ml of the ethanol extract of S. lappa significantly inhibited the formation of water-insoluble glucan. These results suggest that S. lappa may inhibit the caries-inducing properties of S. mutans. Further studies are necessary to clarify the active constituents of S. lappa responsible for such biomolecular activities.

• Korean Journal of Plant Resources
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• v.11 no.1
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• pp.80-85
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• 1998

The influence of elevated CO2 and temperature on growth parameters, biomass production and its partitioning of rice (Oryza sativa L.cv. Chukwangbyeo) were investigated in the three experiments (1991-1993). Rice plants were grown from transplanting to harvest at either ambient(350ppm) or elevated CO2 concentrations (690 or 650ppm) in combination with either four or seven temperature regimes ranging form ambient temperature (AT) to AT plus 3$^{\circ}C$.From transplanting to panicle initiation, crop growth rate (CGR) was enhanced by up to 27% with elevated CO2 , primarily due to an an increase in leaf area index. although net assimilatiion rate was also greater at elevated CO2. The effect of elevated CO2 varied with temperature. During the reproductive phase, CGR declined linearly with increased temperature, and was greater at elevated CO2 . Elevated CO2 increased final crop biomass and panicle weight 30% respectively at AT(27.6$^{\circ}C$ : 1991) . However, there was no significant effect of elevated CO2 on panicle weight at AT plus 3$^{\circ}C$, where severe spikelet sterility occurred. There was no significant effect of elevated CO2 on panicle weight at AT plus 3$^{\circ}C$, where severe spikelet sterility occurred. There was also no effect of CO2 on biomass pratitioning into vegetative and reproductive organs (harvest index)) at AT, although higher temperature could affect that by inducing spikelet sterility. These results suggest that elevated CO2 could enhance rice producivity througth promoted growth and biomass production , but its positive effects may be less at higher temperatures.

• International Journal of Oral Biology
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• v.41 no.1
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• pp.39-43
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• 2016

Dental caries, the most common oral disease, is a multifactorial disease caused by interactions among bacteria within the dental plaque, food, and saliva, resulting in tooth destruction. Streptococcus mutans has been strongly implicated as the causative organism in dental caries and is frequently isolated from human dental plaque. Photodynamic therapy (PDT) is a technique that involves the activation of photosensitizer by light in the presence of tissue oxygen, resulting in the production of reactive radicals capable of inducing cell death. Postantibiotic effect (PAE) is defined as the duration of suppressed bacterial growth following brief exposure to an antibiotic. In this study, the in vitro PAE of PDT using erythrosine and light emitting diode on S. mutans ATCC 25175 was investigated. The PAE of PDT for 1 s irradiation and 3 s irradiation were 1.65 h and 2.1 h, respectively. The present study thus confirmed PAE of PDT using erythrosine on S. mutans.

• The Journal of Fisheries Business Administration
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• v.39 no.3
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• pp.67-90
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• 2008

In this study, we aimed to build the basic calculation model for linkage effects of fishery industry among Korea, China and Japan. For the calculation, we reconstructed the asian international input-output table, and on the basis of the reconstructed table, we made some analyses on the inter-relations among 3 nations focusing fishery industry. As the results, some positive backward linkage offsets of the fishery industries were found among 3 nations, and especially, production inducing effect of Chinese fishery industry to Japanese supplier was remarkable.

• BMB Reports
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• v.52 no.12
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• pp.679-688
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• 2019

The decrease of metabolism in the brain has been observed as the important lesions of Alzheimer's disease (AD) from the early stages of diagnosis. The cumulative evidence has reported that the failure of mitochondria, an organelle involved in diverse biological processes as well as energy production, maybe the cause or effect of the pathogenesis of AD. Both amyloid and tau pathologies have an impact upon mitochondria through physical interaction or indirect signaling pathways, resulting in the disruption of mitochondrial function and dynamics which can trigger AD. In addition, mitochondria are involved in different biological processes depending on the specific functions of each cell type in the brain. Thus, it is necessary to understand mitochondrial dysfunction as part of the pathological phenotypes of AD according to each cell type. In this review, we summarize that 1) the effects of AD pathology inducing mitochondrial dysfunction and 2) the contribution of mitochondrial dysfunction in each cell type to AD pathogenesis.

• Journal of Energy Engineering
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• v.23 no.2
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• pp.74-82
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• 2014

The government is planning to expand the bio-gas supply as a method for mitigating greenhouse gas emissions to deal with climate change. By means of a policy instrument, the government is considering an introduction of the Renewable Fuel Standard (RFS) whose targets include bio-gas. This paper attempts to look into the economic effects of expanding the bio-gas supply by applying an input-output (I-O) analysis using a 2011 I-O table. The bio-gas supply sector consists of liquefied petroleum gas supply sector and city gas supply sector, based on the tenets of introducing the RFS. The production-inducing effect, value-added creation effect, and employment-inducing effect of the bio-gas sector are analyzed. The supply shortage effect and the price pervasive effect are also investigated. The results show that the production or investment of 1.0 won in the bio-gas supply sector induces the production of 1.0539 won and the value-added of 0.1998 won in the national economy. Moreover, the production or investment of 1.0 billion won, supply shortage of 1.0 won, and a price increase of 10.0% in the bio-gas supply sector touch off the employment of 0.5279 person, 1.6229 won, and an increase in overall price level by 0.0183%, respectively.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.1
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• pp.199-203
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• 2007

Dental caries is a major worldwide oral disease problem. Streptococcus mutans (S. mutans) plays an important role in the information of dental plaque and it is being noticed as major causative bacteria of dental caries. Therefore, the development of more effective, substantial and safe preventive agents against dental caries is strongly required. In the present study, inhibitory effects of the ethanol extract of the husk of pomegranate (Punica granatum L.) on the growth, acid production, adhesion and water-insoluble glucan synthesis of Streptococcus mutans (S. mutans) were examined. The ethanol extract of pomegranate husk (250 - 4000 ${\mu}$g/ml) significantly lowered the growth of S. mutans in a dose dependent manner. The acid production of S. mutans were inhibited by the presence of ethanol extract of pomegranate husk (500 - 4000 ${\mu}$g/ml) significantly. The ethanol extract of pomegranate husk (5000 - 4000 ${\mu}$g/ml) also significantly lowered the adherence of S. mutans. In water-insoluble glucan synthesis assay, 1000 - 4000 ${\mu}$g/ml of the ethanol extract of pomegranate husk significantly inhibited the formation of water-insoluble glucan. These results suggest that pomegranate husk may inhibit the caries-inducing properties of S. mutans. Further studies are necessary to clarify the active constituents of pomegranate husk responsible for such biomolecular activities.

• Molecules and Cells
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• v.19 no.3
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• pp.445-451
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• 2005

Activation-induced cytidine deaminase (AID) is needed for Ig class switch recombination (CSR). We explored the effect of LPS on the expression of AID during B cell differentiation, and the role of AID in IgA isotype expression. In normal spleen B cells, LPS increased AID transcription up to 48 h post-stimulation, i.e. around the time of Ig CSR. TGF-${\beta}1$ and AID were required for IgA expression, and LPS contributed to $TGF{\beta}1$-induced IgA production largely by inducing AID. Interestingly, LPS repressed AID transcription in $sIgA^+$ B cells but still stimulated IgA production mainly by increasing the rate of IgA secretion. Our data indicate that LPS contributes to $TGF{\beta}1$-induced IgA isotype expression in at least two ways: by stimulating AID transcription before CSR and by enhancing the IgA secretion rate after CSR.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.41 no.4
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• pp.111-122
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• 2018

The private sector is currently reviewing the feasibility of the project or deciding economic policies by analyzing the economic ripple effects. However, the arms acquisition project focuses on the need for the national defense weapons system by analyzing the costs and the effectiveness of the analysis and reviewing the necessity and feasibility of the project. In order to analyze the economic ripple effects, KB (the Bank of Korea) prepares and publishes an analysis table of industrial associations in a given unit. IAAR (the industrial association analysis report) is difficult to apply directly to the defense weapons system. Therefore, research on the economic ripple effects applicable to the defense arms procurement project was needed. In this study, we propose the generic methodology for estimating economical and technical ripple effects resulted in acquiring new weapon systems. Based on the analysis of inter-industrial relations, economical ripple effects are estimated with production inducing effects, value-induced effects, employment-induced effects and export-induced effects. Also, the technological ripple effects are estimated with technological intensity represented by investment cost in research and development. To show the validity of proposed methodology, a case study of acquiring new weapon systems such as GR (guided rocket), destroyer, and helicopter is accomplished. From the case study, it is concluded that these economical & technological ripple effects can be used as a reference to decision making in the course of acquiring major future defense weapons systems.