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Effects of Ethanol Extract of Saussurea lappa on the Growth, Acid Production, Adhesion, and Insoluble Glucan Synthesis of Streptococcus mutans  

Yu Hyeon-Hee (Department of Food and Nutrition, Kunsan National University)
Kim Yeon-Hwa (Department of Oral Biochemistry & Vestibulocochlear Research Center, School of Dentistry, Wonkwang University)
Lee Jun-Sup (Department of Oral Biochemistry & Vestibulocochlear Research Center, School of Dentistry, Wonkwang University)
Lee Ki-Hyun (Department of Oral Biochemistry & Vestibulocochlear Research Center, School of Dentistry, Wonkwang University)
So Hong-Seob (Vestibulocochlear Research Center & Department of Microbiology, School of Medicine, Wonkwang University)
Jeon Byung-Hun (Department of Oriental Pathology, College of Oriental Medicine, Wonkwang University)
You Yong-Ouk (Department of Oral Biochemistry & Vestibulocochlear Research Center, School of Dentistry, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.5, 2005 , pp. 1195-1199 More about this Journal
Abstract
In the present study, Inhibitory effects of the ethanol extract of Saussurea lappa (S. lappa) on the growth, acid production, adhesion and water-insoluble glucan synthesis of Streptouccus mutans (S. mutans) were examined. The growth and acid production of S. mutans were Inhibited by the presence of ethanol extract of S. lappa (0.5-4 mg/ml) significantly. The ethanol extract of S. lappa (0.25-4 mg/ml) also significantly lowered the adherence of S. mutans in a dose dependent manner. In water-insoluble glucan synthesis assay, 2-4 mg/ml of the ethanol extract of S. lappa significantly inhibited the formation of water-insoluble glucan. These results suggest that S. lappa may inhibit the caries-inducing properties of S. mutans. Further studies are necessary to clarify the active constituents of S. lappa responsible for such biomolecular activities.
Keywords
Cyperus rotundus; dental caries; Streptococcus mutans;
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