Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Ethanol Extract of Saussurea lappa on the Growth, Acid Production, Adhesion, and Insoluble Glucan Synthesis of Streptococcus mutans

목향 에탄올 추출물의 Streptococcus mutans에 대한 성장, 산생성, 부착 및 비수용성 글루칸 합성 억제에 미치는 영향

  • Yu Hyeon-Hee (Department of Food and Nutrition, Kunsan National University) ;
  • Kim Yeon-Hwa (Department of Oral Biochemistry & Vestibulocochlear Research Center, School of Dentistry, Wonkwang University) ;
  • Lee Jun-Sup (Department of Oral Biochemistry & Vestibulocochlear Research Center, School of Dentistry, Wonkwang University) ;
  • Lee Ki-Hyun (Department of Oral Biochemistry & Vestibulocochlear Research Center, School of Dentistry, Wonkwang University) ;
  • So Hong-Seob (Vestibulocochlear Research Center & Department of Microbiology, School of Medicine, Wonkwang University) ;
  • Jeon Byung-Hun (Department of Oriental Pathology, College of Oriental Medicine, Wonkwang University) ;
  • You Yong-Ouk (Department of Oral Biochemistry & Vestibulocochlear Research Center, School of Dentistry, Wonkwang University)
  • 유현희 (군산대학교 식품영양학과) ;
  • 김연화 (원광대학교 치과대학 구강생화학교실.VCRC) ;
  • 이준섭 (원광대학교 치과대학 구강생화학교실.VCRC) ;
  • 이기현 (원광대학교 치과대학 구강생화학교실.VCRC) ;
  • 소홍섭 (원광대학교 의과대학 미생물학과.VCRC) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실) ;
  • 유용욱 (원광대학교 치과대학 구강생화학교실.VCRC)
  • Published : 2005.10.01
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Abstract

In the present study, Inhibitory effects of the ethanol extract of Saussurea lappa (S. lappa) on the growth, acid production, adhesion and water-insoluble glucan synthesis of Streptouccus mutans (S. mutans) were examined. The growth and acid production of S. mutans were Inhibited by the presence of ethanol extract of S. lappa (0.5-4 mg/ml) significantly. The ethanol extract of S. lappa (0.25-4 mg/ml) also significantly lowered the adherence of S. mutans in a dose dependent manner. In water-insoluble glucan synthesis assay, 2-4 mg/ml of the ethanol extract of S. lappa significantly inhibited the formation of water-insoluble glucan. These results suggest that S. lappa may inhibit the caries-inducing properties of S. mutans. Further studies are necessary to clarify the active constituents of S. lappa responsible for such biomolecular activities.

Keywords

References

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