• Journal of Pharmacopuncture
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• v.23 no.4
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• pp.212-219
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• 2020

Objectives: Nowadays cancer treatment is an important challenge in the medical world that needs better therapies. Many active secretions produced by insects such as honey bees used to discover new anticancer drugs. Bee venom (BV) has a potent anti inflammatory, anti cancer and tumor effects. The aim of present study is evaluation of anticancer effects induced by Apis mellifera venom (AmV) on cell Lines. Methods: AmV was selected for study on cancer cell lines. Total protein, molecular weight and LD50 of crude venom were determined. Then, cells were grown in Dulbecco's Modified Eagle medium supplemented with 10% fetal bovine serum and 1% antibiotics. The A549, HeLa and MDA-MB-231 cell Lines were exposed by different concentration of AmV. The morphology of cells was determined and cell viability was studed by MTT assay. Evaluation of cell death was determined by and DNA fragmentation. Results: The results from MTT assay showed that 3.125 ㎍/mL of A549, 12.5 for HeLa and 6.25 ㎍/mL of MDA-MB-231 killed 50% of cells (p < 0.05). Morphological analysis and the results from hoescht staining and DNA fragmentation indicated that cell death induced by AmV was significantly apoptosis. Conclusion: The data showed that using lower dosage of AmV during treatment period cause inhibition of proliferation in time and dose dependant manner. Findings indicated that some ingredients of AmV have anticancer effects and with further investigation it can be used in production of anticancer drugs.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.7
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• pp.930-934
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• 2013

The growth performance of embryo-transferred Japanese Black calves that were born from, and suckled by, Japanese Shorthorn cows in a cow-calf grazing system (BS-group, n = 5) was compared to that of Japanese Black calves from Japanese Black cows in a cowshed (BB-group, n = 5). The daily weight gain from birth to 1 month was higher in the BS-group than in the BB-group (p<0.01), and the same trend (p<0.05) was observed at 2 and 3 months of age. This resulted in body weight that was significantly higher for the BS-group between 1 and 3 months of age than what was observed for the BB-group (p<0.05). Heart girth was significantly greater in the BS-group than in the BB-group throughout the experimental period (p<0.01), and chest depth and withers height in the BS-group were significantly greater from 2 to 4 months of age (p<0.05) and at 4 months of age only (p<0.05). No difference in body length (p>0.05) was observed between the groups. These results suggest that the maternal effect of Japanese Shorthorn cows was positive for embryo-transferred Japanese Black calf growth during the early suckling stage. As Japanese Black calves are traded at a high price on the Japanese market, we conclude that this proposed production system is likely to improve the profitability of herd management in upland Japan.

• Proceedings of the Technology Innovation Conference
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• 2002.02a
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• pp.133-149
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• 2002

This study aims to investigate the impact of wide use of digital technology, in particular, the Internet, on innovation process and corporate strategy in electronics industry. The introduction of digital technology has changed innovation process, business model and organizational structure of the electronics companies. With the introduction of digital technology, the entire value chain of electronics industry from procurement, sales, and marketing to R&D and manufacturing has been restructured. E-commerce has been a major agenda for e-business. Recently, collaboration among electronics companies through e-marketplace has emerged as an important issue. A web-based e-commerce standard, so called RosettaNet, has been developed for facilitating e-transactions of electronics firms. The development of digital technology has dramatically increased the processing speed and sophisticated the virtual reality technology. As simulation becomes easier and more effective, the uncertainty and risk involved in R&D has decreased significantly. Another positive impact is closer cooperation between R&D and manufacturing functions. Taking advantage of automated and flexible production technology, has a new type of firm, so called, EMS (Electronics Manufacturing Services) emerged, whose strategic focus is on manufacturing only. The EMS can be seen as a kind of innovative organization, that is, a modular organization for production function. Digital technology has made convergence of computer and communication possible at early years but right now the convergence has been accelerated in extensive areas of communication, broadcasting, information appliances, software, contents, and services. Firms' effort for an innovative product and service has been intensified and the competition for a new standard product and service has become severe in electronics industry. Business activities are always realized in a specific organizational context. Accordingly building up innovation-friendly organization has emerged as a critical concern. Due to the striking decrease of transaction cost, a network type of organization has proliferated, and a business function turns into a modular organization. As a whole, digital technology has pushed electronics firms into developing their own business model, which takes consideration of standardization of business platform and their core competency.

• Journal of Information Technology Services
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• v.6 no.2
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• pp.49-62
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• 2007

Characteristics of the motivation and performance of Enterprise Resources Planning (ERP) adoption in university organization are explored through case studies in this study. Generally, the modules for production, sales, and logistics management in a manufacturing company are substituted with new modules for student support, lecture operations, and research management in ERP for university organization. The motivation of ERP adoption is closely related to the purpose of improvement of business process operations and information system control rather than the environmental factors such as inter-organizational competition or increase of market uncertainty, differentially from enterprises cases. In addition, the financial performance such as cost reduction, labor substitution, and increase of productivity is relatively lower evaluated than the performance on organizational aspects or information system control.

• Journal of Korean Society for Quality Management
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• v.25 no.4
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• pp.140-153
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• 1997

In this paper, we explain Production Liability(PL) law and research Protection and Deference of Manufacturing Company for Production Liability Law. As Protection of Manufacturing company for PL law, we suggest company wide strategy and check list of organization of PL, design, manufacturing field, explanatory note, warning and instruct passage, sales and after service etc as TQM(total quality management) strategic. TQM of protect management of PL, which are all systematic manage of company. We also suggest defence of PL law as inside of company and insure PL insurance as outside of company.

• Korean journal of communication and information
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• v.38
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• pp.245-275
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• 2007

This study analyzes interactivity between formal policy and informal trade practices at outside production market of broadcasting production environment in Korea. For this, this study raises three topics. First, the trait of historical context of policy making at outside broadcasting production policy: Second, the trait and meaning of path dependency behavior in the process of trade practices between over-the-air TV Organization and independent production companies : Three, the meaning of interactivity between formal policy and informal trade practices at outside broadcasting production market. Major findings of this study are : the trait of policy making was concentrated on the quantitative rates of the outside production program. And, the trait of trade practices was unfair rivalry in accordance with the custom of insider dealing. The chief cause of the conflict structure of outside broadcasting production market is lacked in policy complement at the qualitative dimension.

• Journal of Korean Institute of Industrial Engineers
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• v.16 no.2
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• pp.81-89
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• 1990

Transfer pricing mechanism is applied to the problem of input buffer size in the context of interfacing a flexible manufacturing system with multiple following production lines. The size of the input buffers can be determined economically by using non-linear transfer pricing either in a decentralized organization or in a centralized organization. Under the certain conditions, input buffer size determined from this non-linear transfer pricing is more economical than the traditional economic lot size model. The benefit comes from transferring part of FMS' inventory to the following production lines. And this non-linear transfer pricing makes sense if the FMS' unit inventory holding cost is high enough.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.31 no.2
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• pp.1-10
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• 2008

In the knowledge-based society which recognizes knowledge as a core value, knowledge management is one of the most interesting issues. The creation of knowledge within an organization occurs as a result of interactions of tacit and explicit knowledge, in process of knowledge conversion. One useful model of this process is the SECI model which stands for a process of socialization, externalization, combination and internalization of knowledge. The enterprise competitive power depends on how an organization accelerates the speed of the cycle of knowledge creation well. In this paper we introduce a knowledge management promotion system based on SECI model and proposal system to promote the cycle of knowledge creation in production fields, and study an enterprise case.

• Journal of the Korean Operations Research and Management Science Society
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• v.31 no.2
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• pp.57-67
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• 2006

One of challenging issues of market oriented manufacturing organization is product proliferation. However, increasing product variety not only incurs additional direct and indirect production cost, but also aggravates production system performance such as inventory level, customer lead time and fill rate. Recently, as one of the most beneficial strategic choices to menage the risks associateed with product variety and uncertain sales, special attention is focused on the product/process redesign to delayed product differentiation. In this paper, we develop an analytical model to demonstrate the existence of an optimal level of product differentiation, which can be used to provide theoretical basis in establishing market oriented SCM strategy.

• Journal of Digital Convergence
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• v.7 no.4
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• pp.67-80
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• 2009

The research tried to realize the policy which serves Innovation ability for culture-contents producer, and culture-contents producer's Innovation ability which impacts OSMU of contents in the policies of government for vitalizations of culture-contents industry. As a result, we have reached the conclusion that the supportive policies for technology, exports and marketing were effective to strengthen the innovation ability of management of human resource, creation and production area. Also we have found that content's OSMU has been influenced by innovation ability. The implication of this study are followed. First, the policies which are intended to revitalize the culture content industry by government has the effect that are some different ones from the settlement and intention. Second, the production industry of animation do still passive and closed organization management, without the efforts for opened and cooperative management. Therefore, the efforts of government which are more practical and realistic supports to revitalize and based on strategic cooperation of industry.