• 대한암한의학회지
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• 제11권1호
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• pp.119-134
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• 2006

Shiquandabutang is very famous prescription for tonifying vital energy. We examined the anti-metatstastic effect of Shiquandabutang with in vitro invasion assay model. We performed the following experiments and the results are listed below:Cell viability assay was carried to determine the dose of Shiquandabutang. At lower dose under 200 ${\mu}g/m{\ell}$ (89.6%) viability was very high. But, viability downed as dose grows. At the dose of 600 ${\mu}g/m{\ell}$ (54.2%) viability was almost half of that of control. And at high dose of 1000 ${\mu}g/m{\ell}$ (15.8%) viability was very pure. In BrdU incorporation assay, Shiquandabutang treated groups showed the decreased DNA synthesis rate compared with control group.(200 ${\mu}g/m{\ell}$ (64.4%), 400 ${\mu}g/m{\ell}$ (7.3%)) The results of gelatinase assay showed that Shiquandabutang decreases the gelatinolytic activity of MMP-9. We examined tube formation assay and the result was that Shiquandabutang ihhibits the tube formation at the dose of 200 ${\mu}g/m{\ell}$ and 400 ${\mu}g/m{\ell}$. We examined rat aortic ring assay and the result was that Shiquandabutang ihhibits the angiogenesis of the rat aortic ring at the dose of 400 ${\mu}g/m{\ell}$. From our research, part of the mechanism underlying anti-metastastic effect of Shiquandabutang was proven in vitro. Moreover, we knew that Shiquandabutang is more effectively inhibits the angiogenesis at high dose.

• 한국안광학회지
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• 제17권2호
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• pp.143-151
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• 2012

목적: 각막형상이나 각막난시도, 피팅상태가 구면 RGP 렌즈를 피팅함에 있어서 각막 중앙안정위치(stable centration)에 어떠한 영향을 미치는지를 밝히고자 하였다. 방법: 각막난시가 0.00~2.75 D인 원형 각막 29안 및 대칭나비형 각막 45안을 대상으로 RGP 렌즈를 양호한 피팅상태, 스팁한 피팅상태, 플랫한 피팅상태로 착용시키고 각막에서의 렌즈 위치를 촬영하여 분석하였다. 결과: 구면 RGP 렌즈의 수직방향 렌즈 안정 위치는 모든 경우에 아래 쪽으로 중심이탈되었으며 중심이탈 정도는 일관성이 없었다. 수평방향의 렌즈 안정위치는 렌즈의 베이스커브가 커짐에 따라 귀 쪽으로 렌즈 중심이 이탈되는 정도가 통계적으로 유의하게 커졌으며 각막형상과 난시도, 피팅상태에 따라 렌즈 중심의 이탈 정도에 차이가 있었다. 동일한 난시도를 가진 원형 각막은 대칭나비형 각막에 비해 렌즈 중심이 귀쪽방향으로의 이탈 정도가 더 컸다. 결론: 구면 RGP 렌즈의 피팅상태, 난시도 및 각막형상에 따라 중심안정위치가 달라지며 이를 고려하면 RGP 렌즈 처방 시 성공률을 높일 수 있을 것으로 보인다.

• 한국정보통신학회논문지
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• 제21권11호
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• pp.2095-2102
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• 2017

본 논문에서 구현한 고령자 홈 트레이닝 콘텐츠는 사용자의 운동 능력에 따라 개인별 운동 처방을 하여 이를 통해 노인 개개인에게 맞춤형 프로그램을 제공한다. 고령화 인구 증가와 대비되는 노인의 낮은 건강 수명을 극복하기 위한 건강 증진은 필수적이다. 따라서 노인의 사망 위험 중 높은 비중을 차지하는 낙상을 예방하기 위한 하체 근력 강화운동이 중요하다. 본 논문에서는 노인이 자연환경 속에서 본인이 운동 한다고 느낄 수 있는 홈 트레이닝 콘텐츠 개발을 목표로 하였다. 이를 위해 Kinect 센서를 사용하여 골격 모델의 특징점을 추출하고 특징 벡터를 생성하여 사용자의 운동 횟수를 인식하였다. 제안하는 게임 모델을 사용하여 운동 능력 테스트를 수행하고 이를 기반으로 개인의 능력에 맞는 운동을 처방받아 운동을 수행할 수 있다. 키넥트 센서의 인식 테스트 결과 80%~97%의 정확도를 보였다.

• 간호행정학회지
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• 제6권3호
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• pp.357-374
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• 2000

The purpose of this study was to validate knowledge outcomes included Nursing Outcomes Classification(NOC) developed by Johnson and Maas at the University of Iowa. A sample of 71 nurse experts working in university affiliated hospitals participated in this study. They were asked to rate indicators that examplified the outcomes on a scale of 1(indicator is not all characteristic) to 5(indicator is very characteristic). A questionnaire with an adaptation of Fehring's methodology was used to establish the content validity of outcomes. The results were as follow: 1. All indicators were considered to be 'supporting' and no indicators were considered to be 'nonsupporting'. 2. 'Knowledge: Treatment Regimen' attained and OCV score of 0.816 and was the highest OCV score among outcomes. 3. 'Knowledge: Energy Conservation' attained an OCV score of 0.748 and was the lowest OCV score among abuse outcomes. 4. 'Knowledge: Breastfeeding' attained an OCV score of 0.790 and was the highest indicator was 'description of benefits of breastfeeding'. 5. 'Knowledge: Child Safety' attained an OCV score of 0.778 and was the highest indicator was 'demonstration of first aids techniques'. 6. 'Knowledge: Diet' attained an OCV score of 0.779 and was the highest indicator was 'performance of self-monitoring activities'. 7. 'Knowledge: Disease Process' attained an OCV score of 0.815 and was the highest indicator was 'description of signs and symptoms'. 8. 'Knowledge: Health Behaviors' attained an OCV score of 0.800 and was the highest indicator was 'description of safe use of prescription drugs'. 9. 'Knowledge: Health Resources' attained an OCV score of 0.794 and was the highest indicator was 'description of need for follow-up care'. 10. 'Knowledge: Infection Control' attained an OCV score of 0.793 and was the highest indicator was 'description of signs and symptoms'. 11. 'Knowledge: Medication' attained an OCV score of 0.789 and was the highest indicator was 'description of correct administration of medication'. 12. 'Knowledge: Personal Safety' attained an OCV score of 0.804 and was the highest indicator was 'description of measures to reduce risk of accidental injury'. 13. 'Knowledge: Prescribed Activity' attained an OCV score of 0.810 and was the highest indicator was 'proper performance of exercise'. 14. 'Knowledge: Substance Use Control' attained an OCV score of 0.809 and was the highest indicator was 'description of signs of dependence during substance withdrawl'. 15. 'Knowledge: Treatment Procedure(s)' attained an OCV score of 0.795 and was the highest indicator was 'description of appropriate action for complications'. 16. 'Knowledge: Treatment Regimen' attained an OCV score of 0.816 and was the highest indicator was 'description of self-care responsibilities for emergency situations'. More outcomes need to be validated and outcomes sensitive to Korean culture need to be developed.

• 한국임상약학회지
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• 제26권4호
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• pp.318-323
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• 2016

Background: Multidisciplinary team care (MTC) is a collaborative approach to treatment plan and ongoing care. We aimed to evaluate the clinical effect of MTC on the regulation of chronic kidney disease-mineral and bone disorder (CKD-MBD) complications in dialysis patients. Methods: This retrospective observational study was approved by the institutional review board. Among patients who have undergone dialysis at admission, the patients admitted to the nephrology ward were allocated to MTC group, and the others to usual care (UC) group. The MTC group had collaborative care by nephrologists, nurses, pharmacists, and nutritionists. The endpoints were the regulation of corrected calcium (cCa) and phosphate (P), the percent of patients in target level of cCa-P product ($cCa{\times}P$), and the prescription rate of non-calcium based P-binders. Results: A total of 163 patients were included from January to December 2009. A significant difference was shown in the percentage of patients in target $cCa{\times}P$ level at admission (MTC vs. UC, 81.40% vs. 91.67%; P = 0.038), but there was no significant difference at discharge. During admission, the cCa and P levels of patients in only UC group were significantly changed. In addition, compared with UC group, patients in MTC group were more likely prescribed appropriate P-binders, when they had higher $cCa{\times}P$ levels than $55mg^2/dL^2$ (P <0.001). Conclusion: It was found that MTC had beneficial effect on improving the regulation of CKD-MBD and the appropriate phosphate binder uses. Therefore, application of the MTC is anticipated to enhance quality of clinical care in chronic diseases.

• 한국안광학회지
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• 제15권2호
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• pp.123-130
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• 2010

목적: 학령기 근시 아동을 대상으로 조절마비 전과 후의 자동굴절검사값 및 검영법에 의한 굴절검사값을 비교하였다. 방법: 6~14세 사이의 근시성 굴절이상 아동 105명(210안, $10.28{\pm}1.59$세)을 대상으로 자동굴절검사와 검영기에 의한 굴절검사를 시행하고, 조절마비제를 점안한 후 자동굴절검사기를 이용하여 조절마비굴절검사를 실시하였다. 결과: 자동굴절검사, 검영기에 의한 굴절검사 및 조절마비굴절검사는 서로 유의한 상관성을 보였으나 자동굴절검사기로 측정한 검사값은 조절마비굴절검사값보다 근시도와 난시도에서 모두 큰 값으로 측정되었다(p<0.001). 210 안중 근시도와 난시도에서 -0.5 Diopter(D) 이상의 차이를 보인 경우는 각각 대상자의 40안(19%) 및 19안(9%)로 나타났으며, 근시도와 난시도가 클수록 조절마비제에 의한 측정값의 차이가 더 크게 나타났다. 결론: 학령기 근시아동의 경우 조절마비 전 자동굴절검사값은 검영법 및 조절마비 굴절검사값과 차이가 있기 때문에 안경처방 시 자각식 굴절검사가 반드시 필요하며, 회귀식으로부터 얻은 조절마비굴절검사값은 자각적 굴절검사 시 기초자료로 활용될 수 있을 것으로 사료된다.

• 한국방사선학회논문지
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• 제6권5호
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• pp.395-402
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• 2012

호흡조절 방사선치료는 호흡이나 장기의 움직임을 극복하기 위하여 환자의 호흡주기를 획득하여 종양조직에 처방선량을 부여하며 동시에 주위 정상조직에는 적은 방사선량을 부여하는 방법이다. ABCHES를 이용한 호흡조절 방사선 치료는 호흡을 얕은 호흡으로 유도하며 종양조직의 움직임을 최소화 하는데 도움을 줄 수 있는 부속 장비이다. 한편 복부 압박 기구는 환자의 복부에 압박을 실시함으로 호흡에 제한을 두는 치료보조용 기구이다. 본 논문에서는 ABCHES를 단독으로 사용한 것과 ABCHES와 복부압박 장비를 이용하여 간세포암 환자의 종양의 움직임을 정량적으로 분석하고 그에 해당하는 치료효과를 선량체적곡선으로 분석하려 하였다. ABCHES를 사용한 경우와 ABCHES와 복부압박기구를 동시에 사용한 경우를 비교해본 결과 상하 방향과 앞뒤 방향 그리고 좌우 향으로 각각 평균 1.0 mm, 0.2 mm, 0.2 mm 정도로 그 움직임을 제한 할 수 있음을 확인할 수 있었다. 체적 감소율 또한 ABCHES를 사용한 경우 HPTV와 LPTV가 체적의 변화율을 $16{\pm}2%$ 정도로 줄일 수 있었고, LPTV의 경우 $15.8{\pm}0.8%$의 체적을 제어할 수 있었다. 선량체적 곡선을 분석한 경우 ABCHES만을 사용한 경우보다 ABCHES와 복부압박 기구를 동시에 사용한 경우가 종양조직에는 처방선량에 가까운 선량값을 보였으며 정상조직인 동측 폐, 콩팥, 정상 간조직에는 보다 적은 선량이 부여된 것을 확인 할 수 있었다. 본 논문에 결과 ABCHES를 단독으로 사용하는 것보다 복부압박기구와 ABCHES를 동시에 사용한 경우가 종양 및 정상조직에 부여된 선량 기준에 적합하다고 판명 되었고, 향후 ABCHES와 복부압박 기구에 대한 제한점 즉, 복부의 압박강도에 따른 환자의 불편감, 호흡주기가 정확하지 않은 환자들에게 적용하여야 하는 방법 등이 추후에 논의 되어야 할 것으로 사료된다.

• 한방안이비인후피부과학회지
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• 제29권4호
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• pp.14-23
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• 2016

Objectives : One of major complications of diabetes, diabetic ulcer is also one of the main reasons for amputation, and the prevalence rate is 4-10%. Laser therapy is widely used for leg ulcer and diabetic ulcer, and it is known to improve wound epithelialization, cellular content, and collagen deposition. The purpose of this study is to investigate the properties of the laser and the spectrum of laser instruments for diabetic ulcer. Methods : We performed literature search using the PubMed, Cochrane, CINAHL and Web of science for the data in English. In addition, other databases were checked for different languages such as OASIS and NDSL for the literature in Korean, CNKI in Chinese, and CiNii and J-STAGE written in Japanese. We excluded all review article and experimental studies, and only clinical studies using laser or light emitting diode (LED) for diabetic ulcer were selected. Results : A total twenty papers were selected. Different light sources were used as follows: LED, HeNe, InGaAlP, GaAlAs, GaAs, CO2, and KTP. The number of LED studies was 9, and HeNe laser was 7, and InGaAlP and GaAlAs laser was 2, GaAs, CO2, and KTP laser was 1 for each. Various energy density of the clinical study were reported. Conclusions : It is suggested that to select appropriate laser type and give the adequate output power to treat diabetic ulcer. Further evaluation and research for the condition of laser therapy to treat diabetic ulcers are warranted.

• 대한통합의학회지
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• 제8권1호
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• pp.159-168
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• 2020

Purpose : To provide data on exercise prescription for obesity management and prevention of cardiovascular disease in girl's high school and to prepare basic data for more effective exercise program for lifestyle improvement and prevention of lifestyle-related diseases. This study examines the effects on brain nerve growth factor and inflammatory factors, and the relationship between obesity factor and brain neuron cell production factor and inflammatory factor changes by complex exercise. Methods : The subjects of the study were obese students with a body fat percentage of 30 % or higher after obtaining body fat percentage of high school girls in C-city. Among them, 20 students who wanted to participate in the program of this study and did not participate in special exercise and diet therapy within the last 6 months were radio-sampled into groups of exercise group and control group, but attendance rate was low and The final exercise group (9) and control group (9) were measured, except for one student who did not respond. Results : Analysis of the range of variation in body composition, BMI, lean body mass, and the interaction between the groups showed significant differences (p<.05). TC, TG, HDL-C, and LDL-C as variables of blood lipids, TC and TG were not significantly different and TG was significantly different (p<.05) in interactions. HDL-C showed a significant difference (p<.01) in interactions, an increase in exercise group, and a significant decrease in control group (p<.05). There was a significant difference (p<.05) in BDNF interaction, an increase in the exercise group and a decrease in the control group, but no significant difference. NGF tended to increase in both exercise and control groups. IL-6 had a significant difference in timing (p<.05) and significantly decreased (p<.01) in the exercise group, and TNF-α interacted with timing (p<.05), and a significant increase in the control group. Conclusion : This study confirmed 12-week compound exercise program was effective in increasing the expression of basal fitness or CNS factor, but not enough to actually improve brain function. Fat mass and obesity are also affecting vascular inflammatory factors.

• 한국안광학회지
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• 제7권1호
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• pp.15-20
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• 2002

콘택트렌즈 착용에 따른 사용자의 실태조사는 안경원과 안과에 내원한 콘택트렌즈 사용자 237명(남자 56명, 여자 181명)을 대상으로 문진과 세극 등 검사, 각막곡률 검사, 굴절검사 등을 하였다. 연구 결과 연령에 따른 현재 착용하고 있는 콘택트렌즈 착용률은 10대 40.9%, 20대 52.3%, 30대 5.5%, 40대 1.3%로 조사되었으며, 콘택트렌즈의 종류는 소프트콘택트렌즈의 경우 10대의 착용률은 82.5%, 20대 83.1%, 30대 38.5%이었으며, 하드 콘택트렌즈 착용률은 10대 17.5%, 20대 16.9%, 30대 61.5%로 조사되었다. 콘택트렌즈 착용목적은 전체 조사자의 40.5%는 안경이 불편해서, 32.1%는 미용목적으로 9.7%는 스포츠를 목적으로 17.7%는 시력교정목적으로 착용한 것으로 조사되었으며, 렌즈관리 시스템의 경우 전체 조사자의 16.5%는 매일세척을 하였으며, 29.1%는 매일 세척과 단백질 제거를 한 것으로 조사되었고, 21.9%는 매일세척과 다목적용액을 사용하였으며, 32.5%는 매일세척과 단백질제거 그리고 다목적용액을 사용한 것으로 조사되었다. 렌즈 착용시간은 10시간 이내가 31.6%, 11~13시간 미만의 경우가 41.3%, 14시간이상은 27%로 조사되었다. 콘택트렌즈 보관방법에서 62%는 보존액, 38%는 식염수를 사용하였다. 콘택트렌즈 교체 이유는 렌즈분실 35%, 렌즈손상 37.6% 이물질 침착 21.9%, 5.5%는 렌즈수명의 이유로 렌즈를 교체하였다. 현재 사용 중인 콘택트렌즈의 주요 자각증상은 급성 충혈의 자각증상 21%, 이물감 20.8%, 통증 19.6%, 건조감 9.4%, 흐린 시야 5.5%, 시야감소 3.8%, 유루 3.7%, 삼출물 2.8%, 가려움 2.6%, 자각증상이 없는 착용자는 10.2%로 조사되었다. 콘택트렌즈 사용자의 렌즈관리 교육에 대한 만족도에서 51%는 만족하였으나 28.7%는 불만족을 나타냈다. 착용자의 정기검사에서 81.1%는 정기검사를 하지 않았으며, 18.1%는 정기검사를 하고 있는 것으로 조사되었다.