• Pediatric Infection and Vaccine
• /
• 제17권1호
• /
• pp.9-15
• /
• 2010

목 적 : 국내 어린이집을 다니는 소아를 대상으로 황색포도알균의 비강 내 보균율과 이런 보균율에 영향을 끼치는 요인들에 대해 알아보고자 하였다. 방 법: 2008년 9월에서 10월까지 서울 지역에 위치한 7개 어린이집의 소아 중 서면 동의를 받은 428명을 대상으로 설문지를 통해 인구학적 자료 및 의료기관 관련 위험 요인에 대한 자료를 수집하였다. 또한 어린이집의 소아들의 비강을 도찰하여 얻은 검체를 증균 및 선택배지에 접종한 후 생화학적 검사를 통해 황색포도알균을 동정 및 분리하였고 디스크 확산법을 통해 메티실린 감수성을 결정하였다. 결 과:대상 환아의 평균 연령은 55개월 이었으며 남녀비는 1.1:1.0이었고 최근 1년 이내에 입원력 및 수술력이 있는 환아는 각각 9.2%, 3.6%였고 항생제 사용력은 약 40%에서 확인되었다. 전체 428명의 소아 중 163명에서 비강 내 황색포도알균이 분리되어 황색포도알균의 비강 내 보균율은 38.1%였으며 분리된 균주의 24.5%는 메티실린 내성 균주였다. 연령이 증가함에 따라 황색포도알균의 비강 내 보균율도 증가 추세를 보였다. 비강 내 MRSA 보균이 9.3%의 소아에서 확인되었으며 이들 대부분이 의료기관 관련 위험요소가 없는 소아였다. 결 론:국내 소아의 약 38% 및 9%가 비강 내 황색포도알균 및 MRSA 보균자임을 확인하였으며, 특히 분리된 MRSA의 95%가 CA-MRSA 균주였다. 향후 비강내 황색포도알균의 보균율의 변화 및 CA-MRSA 보균율의 변화에 대해 지속적인 연구가 필요하겠다.

• Clinical and Experimental Pediatrics
• /
• 제50권4호
• /
• pp.381-385
• /
• 2007

목 적 : 우리나라에는 전통적으로 내려오는 한약에 대한 선호도가 매우 강하여 남용의 우려가 있다. 이로 인한 의료비 지출 증가 우려와 의료질서의 왜곡현상 마저 생기고 있으나 이에 대한 자료가 부족하여 저자는 초등학교 학생들의 한약 이용 실태에 대한 연구를 실시하였다. 방 법 : 광주 소재 3개의 초등학교 1,508명의 학생들을 대상으로 설문조사를 시행하였다. 설문지가 회수된 905명의 학생들을 대상으로 분석하였다. 결 과 : 남아는 421명, 여아는 484명이었고 출생 후 자녀에게 한약을 먹여본 경우는 590명(65.2%)이었으며, 학년별로는 1학년 74.1%, 2학년 63.0%, 3학년 64.8%, 4학년 63.3%, 5학년 65.5%, 6학년 61.9%였다. 한약의 평균 복용 횟수는 3.2회였으며 6학년은 3.3회, 5학년은 3.9회, 4학년은 3.7회, 3학년은 2.7회, 2학년은 2.7회, 1학년은 2.6회였다. 한약 1회 복용시 평균 비용은 5-10만원이었다. 처음 한약 복용 평균 연령은 55개월이었으며, 6학년은 67개월, 5학년은 58개월, 4학년은 54개월, 3학년은 55개월, 2학년은 51개월, 1학년은 47개월이었다. 한약 복용 이유의 가장 흔한 것은 '병이 없지만 몸이 허약해 보여서'였다. 한약 복용 후 효과를 보았다고 생각한 경우는 63.7%였고, 부작용이 발생한 경우는 4.5%였다. 결 론 : 초등학교 학생들의 한약 복용 비율이 높았으며, 저학년으로 갈수록 한약 복용 비율이 증가하고, 초회 복용 연령도 훨씬 낮아지고 있다. 따라서 임상 의사들이 한약복용에 대해 더 많은 관심을 가지고 연구되어야 할 것으로 생각된다.

• 동의신경정신과학회지
• /
• 제26권4호
• /
• pp.383-406
• /
• 2015

Objectives: People with tension-type headache generally take pain relievers, but long term dependency causes problems as well as side effects. The present study aimed to provide clinical evidence of herbal medicine for tension-type headache by systematic review of randomized controlled trials on the effect of herbal medicine for tension-type headache. Methods: Randomized or quasi-randomized controlled trials that verified effects of herbal medicine intervention on patients with tension-type headache were included in the study. A literature search of English, Japanese, Chinese, Korean databases was performed. The selected literature were assessed by Jadad scale and Risk of Bias. Results: Herein, 40 reports were selected from a total of 157. Meta-analyses of 2 trials indicated that the effective rate was significantly higher in the herbal medicine treatment group, as compared to the placebo control (risk ratio: 1.49, 95% confidence interval (CI): 1.23 to 1.80, p<0.0001, I²=0%). Four trials that compared herbal medicine with routine care with routine care only group showed a significantly higher effective rate of benefits for herbal medicine with routine care, as compared to routine care only (RR: 1.57, 95% CI: 1.18 to 2.10, p=0.002, I²=0%). Conclusions: The effective rate was significantly higher than control and adverse events were less in the treatment group. Pattern analysis (辨證) indicated that the studies on wind-fire pattern (風火證) were highest. Yougeun-bang (柔筋方) in prescription and Paeoniae Radix Alba (白芍藥) in medicinal herbs were most used. This finding could be widely utilized in future clinical practice and form the basis for the development of clinical practice guidelines in advance.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제16권1호
• /
• pp.124-131
• /
• 2005

소아, 청소년기에 발생하는 양극성장애는 주의력결핍/과잉행동장애, 행동장애 뿐만 아니라 불안장애도 중복진단 비율이 높다. 불안장애 중 강박장애, 사회공포증, 공황장애, 분리불안장애가 많이 공존한다고 보고 되었지만 불안장애와 양극성장애 발생사이의 시간적 관련성에 관한 전향적이면서 믿을만한 연구는 드물다. 본 저자는 양극성장애에 선행한 불안증상에 대해 항우울제를 투여하였을 때 발생한 조증삽화 2예를 보고하고자 한다. 기분변화의 과거력이나 양극성장애의 가족력이 없어도 선행된 불안증상에 대해 항우울제를 사용할 때는 조증삽화의 가능성을 염두에 두고 조심스럽게 처방해야 될 필요성이 있으며 향후 소아, 청소년 양극성장애와 불안장애 사이의 시간적 연관성과 약물학적 치료 지침에 대해 포괄적이며 전향적인 연구가 필요할 것이다.

• 한국방사선학회논문지
• /
• 제11권5호
• /
• pp.393-399
• /
• 2017

본 논문에서는 직장암 환자를 대상으로 일반적 치료방식인 3차원입체조형치료법과 선형가속기 기반의 IMRT, 그리고 토모테라피를 이용한 IMRT의 치료계획을 각각 수립하여 직장암 환자에 대한 최적의 치료법을 비교하고자 하였다. 치료법 비교 결과 종양조직에서는 처방선량의 95% 이상의 흡수선량을 만족시키고 있었으며 정상조직인 방광, 소장, 넙다리머리뼈의 정상조직의 합병증 발생율의 기준(V40, V30, V20, V10)을 만족하였다. 다만, 3가지의 치료법에서 선량분포측면에서 가장 효율적인 치료법은 Tomotherapy기반의 IMRT였으며 가장 낮은 효율을 보인 치료법은 3DCRT였다. 직장암의 방사선 치료시 환자의 자세재현성, 개인적인 신체환경 등을 고려하여 가장 적합한 치료방식을 적용한다면 환자의 예후와 삶의 질에 긍정적인 효과가 나타날 것으로 사료된다.

• 한방안이비인후피부과학회지
• /
• 제1권1호
• /
• pp.1-14
• /
• 1988

According to oriental clinic effect findings hitherto, Pilyongbangkamgil-Tang has been curative effects on chronic pharnygitis, acute tensillitis and angina. Auther tried to make clear the anti-inflammatory effect on rat paw which has become edema formation by $5\%$ of acetic acid／saline solution, and the analgesic effect on mouse thorough method of acetic acid because the medicine decoction of Kamipilyongbangkamgil-Tang, Pilyongbangkamgil-Tang, and the extracted powder of Pilyongbangkamgil-Tang are administered to rat and mouse. In present report, anti-inflammatory, analgesic effect of Pilyongbangkamkil-Tang, the extracted powder of the above prescription and Kamipilyongbangkamgil-Tang were estimated by the above test. The results are summarized as follows. 1. Kamipilyongbangkamgil-Tang (liquid), Pilyongbangkamgil-Tang and the extracted powder of Pilyongbangkamgil-Tang were tested for analgesic effects; Kamipilyongbangkamgil-Tang has the most effective analgesic function, then Pilyongbangkamgil-Tang, then the extracted powder, and I found that the t-test of those above prescriptions, in this order, should come to the result of voluntariness P〈0.001, P〈0.02, and P〈0.05 respectively. 2. Analgesic effects of pilyongbangkamgil-Tang and the extracted powder against the mouse pain induced by acetic acid have been strengthened by increase of double dosage and 4 fold dosage. 3. With Pilyongbangkamgil-Tang and Kamipilyongbangkamgil-Tang treated for rat, the increasing and the inhibitory rate of rat paw edema formation showed significantly statistical values, and the anti-inflammatory effect of the extracted powder of Pilyongbangkamgil-Tang is not supported so long than Pilyongbangkamgil-Tang. 4. The anti-inflammatory effect of Kamipilyongkamgil-Tang on the edema formed at the rat paw appeared significantly statistical value than the other sample.

• 한방안이비인후피부과학회지
• /
• 제1권1호
• /
• pp.73-81
• /
• 1988

The study was clinically performed in the 65 outpatients with pruritus who visited the Dept. of Dermatology, Oriental Medicial Hospital, Kyung Hee University and oriental medical clinic of Hang Ki Park from Jan. 1985 through Dec. 1986. The results were summarized as follows: 1. Among 65 outpatients, male was 20 ($30.8\%$) and female was 45 ($69.2\%$). In the distribution of age, 10S was $21.5\%,\;and\;20S\;20\%$ at the first visit. 2. In the distribution of season, the peak incidence occured in Spring ($35.4\%$) and next incidence in Winter ($20\%$). 3. In the distribution of duration, $41.5\%$ was between 1 year and 5 years, $20\%$ between 1 month and 6 months, $12.3\%$ between 6 months and 1 year, $9.2\%$ between 5 years and 10 years, $7.7\%$ over 10 years. 4. In regard to the itching lesion, $66.2\%$ showed pruritus throughout the whole body, including partially $15.4\%$ in their heads and faces, $12.3\%$ in their hands and legs, and $6.3\%$ in their shoulders, sides and hips. 5. The most frequently used prescription, was Gosanhomasan (苦蔘胡麻散) which occupied $60.7\%$ of all, in next order of frequency, Gamisamooltang (加味四物湯 $21.4\%$) Gupoongchongkisan (祛風淸肌散 $12.5\%$) and Bangpoongtongsungsan (防風通聖散 $5.4\%$). 6. In regard to the therapeutic duration, $46.2\%$ was showed under 10 days, $18.5\%$ between 10 days and 20 days, and $16.9\%$ between 30 days and 60 days. 7. In the 35 patients, who were confirmed to show apparent result by continual treatment, curative rate was more than $57.6\%$. According to above results, we can confirm that efficacy of therapeutic measures by the oriental medicine on pruritic dermatoses was increased in proportion to therapeutic duration and we feel sure that the therapeutic efficacy can be gradually increased as we expect to make a deep study of the disease and to give correct medical treatment to the nature of the disease.

• 한국임상약학회지
• /
• 제25권4호
• /
• pp.280-285
• /
• 2015

Objectives: To suggest direction for improving policies by understanding current management of narcotics or psychotropic drugs and analyzing their distributions and usage. Method: We conducted a comparison analysis between health insurance claims and the amount supplied to health care institutions for narcotics or psychotropic drugs through health insurance claims data and drug distribution supply data from 2010 to 2012 collected from Korea Pharmaceutical Information Service Center (KPIS). Furthermore, we carried out literature investigation and online search to comprehend the current management of narcotics drugs in Korea. Results: The amount supplied to medical institutions for all drugs in 2012 was 19.4 trillion won, which increased from 19.5 trillion in 2011 by 0.54%. For narcotic drugs, the amount supplied was 318.4 billion won in 2011 and increased to 335.1 billion won by 5.3% in 2012, which exceeded the rate of increase for the amount supplied for all drugs. The proportion of amount claimed in the total amount supplied to medical institutions for all drugs was 60.5% in 2012, whereas the proportion of amount claimed for narcotic drugs was 55.6%, which showed that narcotic drugs were used relatively less within health insurance. Furthermore, management of the current domestic distribution supply data focuses on manufacturing and medical institution supply stages. Conclusion: Hereafter, the management of narcotics or psychotropic drugs needs to be improved by reinforcing active monitoring in optimal prescription and usage in patients by collecting and analyzing information on drug usage of patients.

• 동의신경정신과학회지
• /
• 제31권1호
• /
• pp.49-61
• /
• 2020

Objectives: The objective of this study is to analyze clinical reports of treatment of menopausal depression in traditional Chinese medicine (TCM). Methods: This study included randomized controlled trials (RCT) in treating menopausal depression. Literature studies of Chinese National Knowledge Infrastructure Database(CNKI) were performed. Clinical reports on menopausal depression treatment were searched using the following key words in the CNKI: 'menopausal depression' and 'postmenopausal depression'. Results and Conclusions: A total of 24 RCT articles on menopausal depression were selected. The most widely used diagnostic tool for menopausal depression was CCMD-3. Effective rate and HAMD were the most commonly used assessment tools. Bosinhaeultang-gagam (Bushenjieyu-tang jiajian) and Gami-gammaegdaejotang(Jiawei ganmaidazao-tang) were used much more than other prescriptions, while Bupleuri Radix was the most used single medicine herb. Additionally, the Chinese medicine treatment group showed less adverse reactions than the control group. As a result, we could know frequently used herbal prescription and single medicinal herbs and this can be helpful in developing more advanced studies in future.

• 대한한방내과학회지
• /
• 제32권2호
• /
• pp.170-187
• /
• 2011

Background : Obesity, the syndrome caused by a high fat diet, is a disease. At the same time, obesity causes diabetes mellitus, hyperlipidemia, and cardiovascular disease. Recently, its prevalence rate is increasing. Yagwan-cheunghyeoltang (YCT) used in this experiment is the prescription of Yagwanmoon added to Cheunghyeol-tang which is reported to be very effective in weight loss controlling and serum cholesterol. It is also reported that Yagwanmoon has significant antioxidant effects and YCT has a significant effect on blood glucose control. Objectives : This study was conducted to experimentally evaluate the effects of YCT on obesity in rats induced by high fat diet. Methods : The experiment was conducted with 4-week-old male rat s divided into 5 groups. They were a normal diet group, a high fat diet group, a positive drug control group, a 1% YCT group, and a YCT 3% group, and were tested for eight weeks. After four weeks of inducing obesity by a high fat diet, rats were allowed to lose weight by following the normal diet group, approximately 30% compared with 10 rats in each group were determined as still obese. Changes in body weight and organ weight and serum cholesterol, triglyceride, glucose-density, low density lipoprotein cholesterol, antioxidant activity were checked. Results : In the experimental groups, we observed weight loss and visceral fat reduction, improvement of liver function, reduction of serum glucose, activation of HMG-CoA reductase inhibitor, reduction of concentrations of leptin and it showed a significant effect on antioxidants and lipid peroxidation. Conclusions : YCT has significant effects on the regulation of hyperlipidemia and lipid peroxidation associated with obesity and has significant effects on, antioxidants and lipid peroxidation, too. Additional clinical studies are needed.