Pediatric Infection and Vaccine

  • 제17권1호
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  • Pages.9-15
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  • 2010
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  • 2384-1079(pISSN)
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  • 2384-1087(eISSN)
대한소아감염학회 (The Korean Society of Pediatric Infectious Diseases)
권호 표지

어린이집 소아에서의 황색포도알균의 비강 보균율에 관한 연구

Nasal Carriage of Staphylococcus aureus from Healthy Children Attending Day Care Center

  • 김영민 (서울대학교 어린이병원 소아청소년과) ;
  • 오지은 (서울대학교 어린이병원 소아청소년과) ;
  • 김소희 (서울대학교 어린이병원 소아청소년과) ;
  • 이진아 (분당서울대학교병원 소아청소년과) ;
  • 최은화 (서울대학교 어린이병원 소아청소년과) ;
  • 이환종 (서울대학교 어린이병원 소아청소년과)
  • Kim, Young Min (Department of Pediatrics, Seoul National University Children's Hospital) ;
  • Oh, Chi Eun (Department of Pediatrics, Seoul National University Children's Hospital) ;
  • Kim, So Hee (Department of Pediatrics, Seoul National University Children's Hospital) ;
  • Lee, Jina (Department of Pediatrics, Seoul National University Bundang Hospital) ;
  • Choi, Eun Hwa (Department of Pediatrics, Seoul National University Children's Hospital) ;
  • Lee, Hoan Jong (Department of Pediatrics, Seoul National University Children's Hospital)
  • 투고 : 2010.02.05
  • 심사 : 2010.03.25
  • 발행 : 2010.06.25
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초록

목 적 : 국내 어린이집을 다니는 소아를 대상으로 황색포도알균의 비강 내 보균율과 이런 보균율에 영향을 끼치는 요인들에 대해 알아보고자 하였다. 방 법: 2008년 9월에서 10월까지 서울 지역에 위치한 7개 어린이집의 소아 중 서면 동의를 받은 428명을 대상으로 설문지를 통해 인구학적 자료 및 의료기관 관련 위험 요인에 대한 자료를 수집하였다. 또한 어린이집의 소아들의 비강을 도찰하여 얻은 검체를 증균 및 선택배지에 접종한 후 생화학적 검사를 통해 황색포도알균을 동정 및 분리하였고 디스크 확산법을 통해 메티실린 감수성을 결정하였다. 결 과:대상 환아의 평균 연령은 55개월 이었으며 남녀비는 1.1:1.0이었고 최근 1년 이내에 입원력 및 수술력이 있는 환아는 각각 9.2%, 3.6%였고 항생제 사용력은 약 40%에서 확인되었다. 전체 428명의 소아 중 163명에서 비강 내 황색포도알균이 분리되어 황색포도알균의 비강 내 보균율은 38.1%였으며 분리된 균주의 24.5%는 메티실린 내성 균주였다. 연령이 증가함에 따라 황색포도알균의 비강 내 보균율도 증가 추세를 보였다. 비강 내 MRSA 보균이 9.3%의 소아에서 확인되었으며 이들 대부분이 의료기관 관련 위험요소가 없는 소아였다. 결 론:국내 소아의 약 38% 및 9%가 비강 내 황색포도알균 및 MRSA 보균자임을 확인하였으며, 특히 분리된 MRSA의 95%가 CA-MRSA 균주였다. 향후 비강내 황색포도알균의 보균율의 변화 및 CA-MRSA 보균율의 변화에 대해 지속적인 연구가 필요하겠다.

Purpose : This study was performed to investigate the prevalence of Staphylococcus aureus (S. aureus) nasal carriage in Korean children attending day care centers. Methods : During September and October 2009, a survey for nasal carriage of S. aureus and methicillin-resistant S. aureus (MRSA) was conducted among children attending day care centers located in Seoul with questionnaire survey for evaluation of risk factors of acquisition of MRSA was obtained from their guardians. A culture of the anterior nares swabs using enrichment broth was executed for isolating S. aureus and oxacillin susceptibility was assessed by the disk diffusion method. Results : Out of the 428 children enrolled whose mean age was 55 months old, 163 (38.1%) were colonized with S. aureus. Of the 163 isolates, 40 (24.5%) were MRSA. The nasal carriage rate of S. aureus showed an increasing trend with increase of age. Based on the answer to the questionnaire, 9.2% and 3.6% of children had a recent history of hospitalization and surgery, respectively, and approximately 40% of children had a history of prescription of antibiotics within 1 year prior to enrollment. Of the 428 subjects, 40 (9.3%) were MRSA nasal carriers. Conclusion : S. aureus and MRSA carriage rate of children attending day care center in Korea was 38.1% and 9.3%, respectively. Continued surveillance for nasal carriage rate of S. aureus and MRSA (especially community-associated MRSA) is mandatory.

키워드

참고문헌

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