• BMB Reports
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• 제40권4호
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• pp.475-485
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• 2007

Methamphetamine is an illicit drug that is often abused and can cause neuropsychiatric and neurotoxic damage. Repeated administration of psychostimulants such as methamphetamine induces a behavioral sensitization. According to a previous study, Bax was involved in neurotoxicity by methamphetamine, but the function of Bax in rewarding effect has not yet been elucidated. Therefore, we have studied the function of Bax in a rewarding effect model. In the present study, we treated chronic methamphetamine exposure in a Bax-deficient mouse model and examined behavioral change using a conditioned place preference (CPP) test. The CPP score in Bax knockout mice was decreased compared to that of wild-type mice. Therefore, we screened for Bax-related genes that are involved in rewarding effect using microarray technology. In order to confirm microarray data, we applied the RT-PCR method to observe relative changes of Bcl2, a pro-apoptotic family gene. As a result, using our experiment microarray, we selected genes that were associated with Bax in microarray data, and eventually selected the Tgfbr2 gene. Expression of the Tgfbr2 gene was decreased by methamphetamine in Bax knockout mice, and the gene was overexpressed in Bax wild-type mice. Additionally, we confirmed that Creb, FosB, and c-Fos were related to rewarding effect and Bax using immunohistochemistry.

• 대한인간공학회지
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• 제35권6호
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• pp.519-533
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• 2016

Objective: This study lays its aims at the definition of relevant operation method and function by researching on the value to be brought when applying smart device that can hand carry soft and flexible materials like jelly. Background: New technology and material play a role in bringing type transformation of interface and change of operation system. Recently, importance has been increased on the study of Organic User Interface (OUI) that conducts research on the value of new method of input and output adopting soft and flexible materials for various instruments. Method: For fulfillment of the study, 27 kinds of gestures have been defined that are usable in handheld device based on existing studies. Quantitative research of survey was conducted of adult male and female of 20s through 30s and an analysis was done on the function that can be linked to gestures with highest level of satisfaction. In order to analyze needs and hurdles of users for the defined gesture, a focus group interview was conducted aiming at the groups of early adopters and ordinary users. Results: As a result, it was found that users have much value regarding usability and fun for elastic device and analysis could be conducted on preferred gesture and its linkable functions. Conclusion: What is most significant with this study is that it sheds new light on the values of a device made of elastic material. Beyond finding and defining the gestures and functions that can be applied to a handheld elastic device, the present study identified the value elements of an elastic device - 'usability and 'fun' -, which users can basically desire from using it. Application: The data that this study brought forth through preference and satisfaction test with the gestures and associated functions will help commercialize an elastic device in future.

• 복식문화연구
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• 제10권2호
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• pp.132-145
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• 2002

This study conducted a questionnaire survey of family restaurant employees in Seoul on their satisfaction and preference in working uniforms, and analysed the result to suggest adequate designs to serve the purposes of uniforms. The result is as follows - First, many pointed out a need to improve generally showing a low satisfaction with varying degrees according to sexes and ages. More women complained about colors, designs, materials and sizes than men did, and young employees in their twenties wanted better designs, colors and sizes in the order while those in their thirties and forties were dissatisfied mostly with materials. The need fur the improvement was focused on function and designs, and as for uniform materials, perspiration absorbency had the highest level of dissatisfaction. Second, about 40% of the respondents said the skirt width, pants length, and sleeve width were trio small or too big, therefore it is vital to improve uniform sizes. Third, the employees on duty felt uncomfortable mostly when they sat, and the neck and armhole parts were the most uncomfortable. The most easily tainted parts were in the order of the collar, front hem, and sleeve seam for upper garments, and the hip, bottom hem, and pleats for lower ones. Therefore it is required to develop functional uniforms considering the body features and momentum. Fourth, the most preferred material was that guaranteed easy movement and good air-permeability, and colors were in the order of white, beige and black for upper garments, and black, beige and blue for lower ones. And plain, natural and stripped patterns were preferred by both men and women. As seen so far, restaurant employees were mostly dissatisfied with the design, movement, and function of their uniforms demanding functional ones made of better and comfortable material. Uniform designs were suggested based on the analysis of the demonstrative rese.

• 한국컴퓨터정보학회논문지
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• 제23권9호
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• pp.87-96
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• 2018

The purpose of this study was to identify the preferred materials and design characteristics of nursing home clothes in order to collect the basic data necessary for the elderly nursing home clothes. It was to utilize the elderly nursing home clothes considering elderly body shape, hand function, illness. This study was conducted by questionnaire method and SPSS ver. 20.0 program was used. The preference for nursing home clothes material was high for cotton, and it was found that they prefer soft, stretch material, warm feeling material, and lightweight material. In the hygienic aspect, they favored sweat-absorbent materials, and preferred laundry- care-resistant materials with poor wrinkles and dirtiness. The nursing home clothes preferred a two piece form consisting of a round neckline, two pockets on both sides, a waistband of rubber band, long lengths, and a waistline pants. The most important function in the nursing home clothes was recognized as wearing comfort. Aesthetics, symbolism, color and print pattern were recognized as not important functions. Therefore, it is necessary to focus on the functional part such as wearing comfort in the design of the nursing home clothes. The material is also hygienic and comfortable to wear. In the case of the elderly, it is necessary to provide convenience for the wear of clothes through the development of stretchable material and detachment device since the movement range of muscles, arms, and legs is reduced. Based on this study, we will utilize it for the development of nursing home suit considering the characteristics of elderly person in the elderly society. It is to develop functional materials for the elderly in need of nursing home, to develop the pattern considering the elderly body shape, and to develop the desorption device considering the movement of the hand.

• 지능정보연구
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• 제17권1호
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• pp.37-52
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• 2011

공급사슬관리(SCM)는 공급사슬의 가치를 높이고 변화하는 환경에 더 민첩하게 적응할 수 있는 전략적인 접근방식이다. 공급사슬 파트너 간에 중단 없는 파트너쉽과 가치 창출을 위해서는 정보와 지식의 공유 및 적절한 파트너 선정기준이 적용되어야 한다. 따라서 파트너 선정 기준은 제품의 품질과 신뢰도를 유지하기 위해서 아주 중요하다. 제품의 각 부품은 적절한 공급 파트너를 통해서 공급된다. 파트너를 선정하는 기준은 기술적 능력, 품질, 가격, 지속성 등 여러 요인이 있다. 실제로 파트너 선정기준은 구성부품의 특성에 따라서 변화할 수 있다. 그 부품이 핵심 구성품이면 품질이 가격에 비해서 최고 우선순위가 된다. 표준부품은 낮은 가격이 우선순위를 가진다. 간혹 긴급 주문과 같은 예기치 못한 상황이 발생하면 우선순위가 변하게 된다. 따라서 SCM 파트너 선정 기준은 구성부품의 특성과 상황에 따라서 동적으로 결정 되어진다. 이 연구의 목적은 상황과 부품의 특성에 따라서 공급사슬 파트너쉽을 위한 온톨로지 모델을 제시하고자 하는 것이다. 변수의 불확실성은 퍼지이론을 이용하여 나타내고자 하였다. 부품별 우선순위와 상황변수는 웹 온톨로지 언어(OWL : Web Ontology Language)를 이용하여 모델링 하였다. 부품의 우선순위는 퍼지로직을 이용한 퍼지소속함수로 변환 되어진다. 온톨로지의 추론을 위해서 SWRL(Semantic Web Rule Language)을 이용하였다. 제안된 모델의 구현을 위해서 자동차 구성품인 스타트모터 부품을 대상으로 온톨로지를 구축하고 구성 부품별 우선순위에 따른 공급 파트너를 선정하는 과정을 제시하였다.

• 한국조경학회지
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• 제35권5호
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• pp.82-91
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• 2007

Currently, bridges are regarding as the structure with formative, scenic and environmental values more than their function as simple passageways. Because an attempt to work on the diversity of the bridge types and installation of the large structures on bridge are part of the project of the regional amenity enterprises, a study that harmonizes bridges with landscape is needed at this point in time. This background can influence the direction of bridge landscapes that considers local features by analysis of visual preferences on a bridge simulated scene. The results were as follows: analyzing the change of the simulated landscape image, forest landscape are damaged by the input of a bridge which was natural, harmonic and intimate. On the other hand, when a bridge was inserted into the ocean landscape, it was thought to improve the ocean landscape, especially, upper part form of arch bridge various or suspension bridge were improved in polished and various image. The insertion of a bridge into an urban landscape change from a negative image to a beautiful, harmonic and attractive image. The intimate, harmonic and natural image of a rural landscape was damaged by inserting a bridge. As analysis result about change of landscape preference by input of bridge, there is difference between before and after as input the bridge, and bridge influences as main object in the simulated scene. Visual preference was the highest in the ocean landscape, and the lowest in the suspension bridge in the rural landscape. The complicated shape of bridge follows on the background type difference certainly appear. Thee simulated scene preference except the urban landscape of the simulated scene fell generally Especially, fall of preference of girder bridge in the forest and ocean landscape, suspension bridge in the rural landscape appeared notedly.

• 지식경영연구
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• 제21권1호
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• pp.27-40
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• 2020

Response surface methodology (RSM) empirically studies the relationship between a response variable and input variables in the product or process development phase. The ultimate goal of RSM is to find an optimal condition of the input variables that optimizes (maximizes or minimizes) the response variable. RSM can be seen as a knowledge management tool in terms of creating and utilizing data, information, and knowledge about a product production and service operations. In the field of product or process development, most real-world problems often involve a simultaneous consideration of multiple response variables. This is called a multiple response surface (MRS) problem. Various approaches have been proposed for MRS optimization, which can be classified into loss function approach, priority-based approach, desirability function approach, process capability approach, and probability-based approach. In particular, the loss function approach is divided into univariate and multivariate approaches at large. This paper focuses on the univariate approach. The univariate approach first obtains the mean square error (MSE) for individual response variables. Then, it aggregates the MSE's into a single objective function. It is common to employ the weighted sum or the Tchebycheff metric for aggregation. Finally, it finds an optimal condition of the input variables that minimizes the objective function. When aggregating, the relative weights on the MSE's should be taken into account. However, there are few studies on how to determine the weights systematically. In this study, we propose an interactive procedure to determine the weights through considering a decision maker's preference. The proposed method is illustrated by the 'colloidal gas aphrons' problem, which is a typical MRS problem. We also discuss the extension of the proposed method to the weighted MSE (WMSE).

• 한국환경복원기술학회지
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• 제20권6호
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• pp.21-33
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• 2017

The purpose of this study is to find out that it can be provided as a basic data to increase the satisfaction with users in the placement and creation of the Green Buffer Zone. In this study, the research was started on the Green Buffer Zone in Gwanggyo new town, which was rebuilt as the zone to use according to the change of legal installation standard of the zone. The subject of this study is the Green Buffer Zone in Gwanggyo new town, which is expected to be completed in step 4 of 2016. As a result of analysing the location and use characteristics of the Green Buffer Zone, the following conclusions were made. First of all, it is categorized into two categories by Buffering / disaster prevention type and land to use adjustment type. Second, the buffer space of commercial space and housing is satisfying, but in commercial space, there is a need for a cushioning function and housing spaces require improvements in the functioning of the landscape. Third, the function of the Green Buffer Zone resets to cushioning function, disaster prevention function, landscape function, utilization function. and The installation criteria are proposed to environmental pollution, noise abatement, and planting trees, etc. Lastly, the future utilization plan considering the location and use characteristics of the Green Buffer Zone is as follows. In the planning stage, preference is given to the characteristics of use of arranging green facility. It is necessary to manage the planned facilities as much as possible by changing them if necessary. Construction stage, it restrictively reflects landscaping facilities within the Green Buffer Zone function. After stage, This study will prioritize the target areas and select necessary areas and need to make efforts to prevent indiscriminate greenery encroachment.

• International Journal of Industrial Entomology and Biomaterials
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• 제2권1호
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• pp.15-18
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• 2001

Silk fibroin (SF) derided from the domestic silk worm, bombyx mori, is the natural protein and widely used as bio-functional materials as well as apparels. We studied the livers protective effect of SF from alcohol-induced hepatotoxicity in the alcohol preference mouse. To increase more absorption of SF in experimental animals, molecular weight of SF was lowered by 2N of HCI aqueous solution at 10$0^{\circ}C$ for 48 hrs. SF was added to liquid diet with alcohol and fed to the alcohol preference mice for 4 weeks. To assess the liver function, the concentration of alanine aminotransferase (AlT), aspartate aminotransferase (AST) and cholesterol present in either blood or liver tissue were measured. As compared with non-SF treated groups the SF-treated showed significantly low concentrations of ALT, AST, cholesterol and triacylglycerol values, respectively. Histopathological examination revealed that the extent of hepatocyte injury in the SF-treated group was reduced when it was compared with non SF-treated group. These results suggest that SF may have liver protective effects against alcohol-induced hepatotoxicity.

• 대한교통학회지
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• 제27권3호
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• pp.131-140
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• 2009

철도서비스 개선을 위한 기존선의 복선, 전철화, 상호직결운행 등 철도네트워크의 기능강화사업이 활발히 추진되고 있다. 본 논문에서는 철도네트워크 기능강화와 같이 새로운 철도서비스가 제공될 경우 타 교통수단으로부터 어느정도의 전환수요가 발생되며, 철도이용패턴은 어떻게 변화될 것인지에 대해 대구권 철도서비스 개선의 사례연구를 대상으로 SP와 TP자료에 의한 전환수요분석모형을 검토하였다. 모형분석 결과, 총통행시간과 통행비용의 파라미터 추정치가 충분한 설명력을 나타내고 있으며, 특히 SP의 보완적 조사로서 TP데이터를 이용할 경우, 철도요금과 통행시간 설정에 따라 전환수요경계치를 쉽게 파악할 수 있어서 대구권 광역철도를 비롯하여 타 지역에서도 보다 실용적으로 적용할 수 있을 것으로 판단된다.